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Detection of hyperfunctioning parathyroid tissue by PET/CT with 18F-Fluorocholine
Detección de tejido paratiroideo hiperfuncionante mediante PET/CT con 18F-Fluorocolina
D. Villasboas-Rosciolesia,
Corresponding author
diego.villasboas@gmail.com

Corresponding author.
, A. García-Burilloa, O. González-Lópezb, E. Caubet-Busquetb, J. Castell-Conesaa
a Servicio de Medicina Nuclear, Hospital Universitari Vall d’Hebron, Barcelona, Spain
b Servicio de Cirugía Endocrina, Hospital Universitari Vall d’Hebron, Barcelona, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">A 39-year-old man being studied for cloxacillin allergy&#44; without previous history&#44; showed hypercalcemia &#40;11&#46;9<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#41;&#46; An extended analytical study showed the following values&#58; calcium 11&#46;9<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#59; phosphate&#58; 3&#46;1<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#59; calcidiol 21&#46;8<span class="elsevierStyleHsp" style=""></span>ng&#47;mL&#59; paratirine &#40;PTH&#41; 144<span class="elsevierStyleHsp" style=""></span>pg&#47;mL&#59; urinary calcium 11&#46;8<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#59; and urinary calcium excretion 177<span class="elsevierStyleHsp" style=""></span>mg&#47;24<span class="elsevierStyleHsp" style=""></span>h&#46; Upon the suspicion of primary hyperparathyroidism &#40;PPH&#41;&#44; a cervical ultrasound was requested that was inconclusive &#40;adenopathy versus right parathyroid gland&#41;&#44; and parathyroid scintigraphy &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41; without evidence of parathyroid hyperfunction&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">Minimally invasive surgery was performed with a biopsy taken from both right parathyroid glands &#40;based on the sonographic findings&#41;&#46; The intraoperative monitoring of PTH was&#58; basal 175<span class="elsevierStyleHsp" style=""></span>pg&#47;mL&#44; 5<span class="elsevierStyleHsp" style=""></span>min 205<span class="elsevierStyleHsp" style=""></span>pg&#47;mL and 10<span class="elsevierStyleHsp" style=""></span>min 220<span class="elsevierStyleHsp" style=""></span>pg&#47;mL&#46; The histopathological analysis of the biopsied specimens showed no evidence of adenoma or atypia&#46; During follow-up&#44; hyperparathyroidism persisted &#40;PTH&#58; 177<span class="elsevierStyleHsp" style=""></span>pg&#47;mL&#44; calcium 11&#46;5<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#41;&#44; so a new scintigraphy was requested &#40;12 months postoperatively&#44; <a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41; and two cervical ultrasounds &#40;13 and 24 months after the surgery&#41; which were negative&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">In view of the biochemical persistence of the disease and negativity of conventional tests&#44; a PET&#47;CT with <span class="elsevierStyleSup">18</span>F-Fluorocholine was performed &#40;32 months post-intervention&#44; <a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#44; which showed a focal uptake &#40;SUVmax&#58; 7&#41;&#44; posterior to the left inferior thyroid pole&#46; After surgical exeresis&#44; hyperplasia without atypia was confirmed&#46; The analytical values at 15 days after reintervention were normal &#40;calcium 9&#46;5<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#44; parathyroid hormone&#58; 29&#46;3<span class="elsevierStyleHsp" style=""></span>pg&#47;mL&#41;&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">HPP is a common endocrine disorder&#44; characterized by an increase in PTH secretion by the parathyroid glands and leading to hypercalcemia&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">1</span></a> Up to 84&#37; of cases are caused by an adenoma&#59; less frequently&#44; a hyperplasia&#44; a multiglandular disease and&#44; exceptionally&#44; a carcinoma&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">1</span></a> The preoperative identification of the lesion reduces complications and comorbidity&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">2</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Conventional localization techniques include ultrasound and <span class="elsevierStyleSup">99m</span>Tc-MIBI scintigraphy with a sensitivity of 63&#46;2&#37; and 80&#46;3&#37;&#44; respectively&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">1&#44;3</span></a> In cases where these techniques are negative&#44; PET&#47;CT with <span class="elsevierStyleSup">18</span>F-Fluorocholine is a good alternative&#44; with a sensitivity of 91&#8211;92&#37;&#44;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">1&#8211;3</span></a> if 11C-Methionine is not available &#40;sensitivity 92&#37;&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">2</span></a> In our case&#44; the PET&#47;CT allowed the correct localization and excision of the lesion&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">In conclusion&#44; PET&#47;CT with <span class="elsevierStyleSup">18</span>F-Fluorocholine is a tool to be considered for the localization of hyperfunctioning parathyroid tissue in selected cases &#40;hyperplasia&#44; ectopic glands&#44; cervical surgical history and negativity in conventional techniques&#41;&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Villasboas-Rosciolesi D&#44; Garc&#237;a-Burillo A&#44; Gonz&#225;lez-L&#243;pez O&#44; Caubet-Busquet E&#44; Castell-Conesa J&#46; Detecci&#243;n de tejido paratiroideo hiperfuncionante mediante PET&#47;CT con <span class="elsevierStyleSup">18</span>F-Fluorocolina&#46; Rev Esp Med Nucl Imagen Mol&#46; 2019&#59;38&#58;118&#8211;120&#46;</p>"
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">39-Year-old man with clinical suspicion of primary hyperparathyroidism &#40;calcium 11&#46;9<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#44; phosphate&#58; 3&#46;1<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#44; calcidiol 21&#46;8<span class="elsevierStyleHsp" style=""></span>ng&#47;mL and PTH 144<span class="elsevierStyleHsp" style=""></span>pg&#47;mL&#41;&#44; whose ultrasound study showed a hypoechoic image of 8<span class="elsevierStyleHsp" style=""></span>mm behind the right inferior thyroid pole&#44; without internal vascularization &#40;colour Doppler&#41; suggestive of parathyroid gland versus lymph node image&#46; &#40;A&#41; Anterior planar projection after 15<span class="elsevierStyleHsp" style=""></span>min of intravenous administration of 222<span class="elsevierStyleHsp" style=""></span>MBq of <span class="elsevierStyleSup">99m</span>Tc-Pertechnetate&#46; &#40;B&#41; Anterior planar images after 15 min &#40;B1&#41; and 120 min &#40;B2&#41;<span class="elsevierStyleHsp" style=""></span>of intravenous administration of 666<span class="elsevierStyleHsp" style=""></span>MBq of <span class="elsevierStyleSup">99m</span>Tc-sestaMIBI&#46; &#40;C&#41; Coronal and axial SPECT&#47;CT images 60<span class="elsevierStyleHsp" style=""></span>min after the administration of the radiopharmaceutical&#46; The study does not show the presence of hyperfunctioning parathyroid tissue&#46; The patient underwent surgery&#44; where the parathyroid glands presented a normal appearance&#44; biopsy samples were taken from both right parathyroids&#59; the histopathological analysis showed no evidence of the presence of adenoma or cellular atypia&#46; The ultrasound image corresponded to a lymph node&#46;</p>"
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          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Further imaging studies in the patient with persistent biochemical hyperparathyroidism &#40;PTH&#58; 177<span class="elsevierStyleHsp" style=""></span>pg&#47;mL&#44; calcium 11&#46;5<span class="elsevierStyleHsp" style=""></span>mg&#47;dL&#41;&#44; 12 months after surgery were performed&#46; Thyroid &#40;A&#41; and parathyroid &#40;B1 and B2&#41; scintigraphy were performed&#44; same protocol as in <a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#46; A study was completed with acquisition of SPECT&#47;CT &#40;C&#41;&#44; in which&#44; as in planar images&#44; no parathyroid hyperfunction was evident&#46; Likewise&#44; two cervical ultrasounds were performed &#40;at 13 and 24 months after surgery&#41; that did not show significant lesions&#46;</p> <p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">In view of the persistence of the biochemical alteration and the negativity of the conventional morpho-functional studies&#44; it was decided to perform a PET&#47;CT study with <span class="elsevierStyleSup">18</span>F-Fluorocholine &#40;32 months after the surgery&#44; <a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46;</p>"
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          "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">A PET&#47;CT study with intravenous contrast at 60<span class="elsevierStyleHsp" style=""></span>min after intravenous administration of 370<span class="elsevierStyleHsp" style=""></span>MBq of <span class="elsevierStyleSup">18</span>F-Fluorocholine&#44; in a patient with biochemical persistence of hyperparathyroidism after biopsy of both right parathyroid glands&#44; was performed&#46; &#40;A&#41; Coronal PET image in which a focal paramedial increase uptake &#40;arrow&#41; is observed&#59; in the axial section &#40;PET&#58; B&#44; CT&#58; C and fusion&#58; D&#41; an increase in phospholipid metabolism can be localized in the left prevertebral region &#40;solid black arrow in B&#44; SUVmax&#58; 7&#41;&#44; this finding corresponds to a solid lesion that showed enhancement iodinated contrast &#40;solid white arrow in C&#41; in a left pre-vertebral and paraesophageal location&#46; After surgery&#44; the histopathological report revealed the existence of parathyroid hyperplasia&#44; and the serum levels of calcium and parathyroid hormone normalized &#40;9&#46;5<span class="elsevierStyleHsp" style=""></span>mg&#47;dL and 29&#46;3<span class="elsevierStyleHsp" style=""></span>pg&#47;mL&#44; respectively&#41;&#46;</p>"
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ISSN: 22538089
Original language: English
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