metricas
covid
Buscar en
Revista Española de Medicina Nuclear e Imagen Molecular (English Edition)
Toda la web
Inicio Revista Española de Medicina Nuclear e Imagen Molecular (English Edition) Corticobasal syndrome: A case of discordance between the clinical findings and t...
Journal Information

Statistics

Follow this link to access the full text of the article

Interesting images
Corticobasal syndrome: A case of discordance between the clinical findings and the imaging biomarkers
Síndrome córticobasal: un caso de discordancia entre la clínica y los biomarcadores de imagen
E. Carrillo-Villamizara,
Corresponding author
elicavi88@gmail.com

Corresponding author.
, A. Cardozo-Saavedraa, C. Lorenzo-Bosqueta, S. Lucas del Pozob, E. Martínez-Sáezc, J. Hernández-Varad
a Servicio de Medicina Nuclear, Hospital Universitari Vall d’Hebron, Barcelona, Spain
b Grupo de Investigación en Enfermedades Neurodegenerativas, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain
c Servicio de Anatomía Patológica, Sección Neuropatología, Hospital Universitari Vall d’Hebron, Banco de Tejidos Neurológicos, Barcelona, Spain
d Servicio de Neurología, Hospital Universitari Vall d’Hebron, Grupo de Investigación en Enfermedades Neurodegenerativas, Vall d’Hebron Institut de Recerca (VHIR), Banco de Tejidos Neurológicos, Barcelona, Spain
Read
9
Times
was read the article
2
Total PDF
7
Total HTML
Share statistics
 array:24 [
  "pii" => "S2253808921001038"
  "issn" => "22538089"
  "doi" => "10.1016/j.remnie.2021.05.002"
  "estado" => "S300"
  "fechaPublicacion" => "2022-01-01"
  "aid" => "1280"
  "copyright" => "Sociedad Española de Medicina Nuclear e Imagen Molecular"
  "copyrightAnyo" => "2021"
  "documento" => "article"
  "crossmark" => 1
  "subdocumento" => "sco"
  "cita" => "Rev Esp Med Nucl Imagen Mol. 2022;41:52-4"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:1 [
    "total" => 0
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S2253654X21000573"
      "issn" => "2253654X"
      "doi" => "10.1016/j.remn.2021.02.015"
      "estado" => "S300"
      "fechaPublicacion" => "2022-01-01"
      "aid" => "1280"
      "copyright" => "Sociedad Española de Medicina Nuclear e Imagen Molecular"
      "documento" => "article"
      "crossmark" => 1
      "subdocumento" => "sco"
      "cita" => "Rev Esp Med Nucl Imagen Mol. 2022;41:52-4"
      "abierto" => array:3 [
        "ES" => false
        "ES2" => false
        "LATM" => false
      ]
      "gratuito" => false
      "lecturas" => array:1 [
        "total" => 0
      ]
      "es" => array:11 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Im&#225;genes de inter&#233;s</span>"
        "titulo" => "S&#237;ndrome corticobasal&#58; un caso de discordancia entre la cl&#237;nica y los biomarcadores de imagen"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "52"
            "paginaFinal" => "54"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Corticobasal syndrome&#58; A case of discordance between the clinical findings and the imaging biomarkers"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0010"
            "etiqueta" => "Figura 2"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr2.jpeg"
                "Alto" => 3199
                "Ancho" => 2500
                "Tamanyo" => 686615
              ]
            ]
            "descripcion" => array:1 [
              "es" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">PET cerebral con <span class="elsevierStyleSup">18</span>F-FDG&#46; An&#225;lisis cuantitativo mediante MI Neurology de Siemens&#174; sin alteraciones estad&#237;sticamente significativas&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "E&#46; Carrillo-Villamizar, A&#46; Cardozo-Saavedra, C&#46; Lorenzo-Bosquet, S&#46; Lucas del Pozo, E&#46; Mart&#237;nez-S&#225;ez, J&#46; Hern&#225;ndez-Vara"
            "autores" => array:6 [
              0 => array:2 [
                "nombre" => "E&#46;"
                "apellidos" => "Carrillo-Villamizar"
              ]
              1 => array:2 [
                "nombre" => "A&#46;"
                "apellidos" => "Cardozo-Saavedra"
              ]
              2 => array:2 [
                "nombre" => "C&#46;"
                "apellidos" => "Lorenzo-Bosquet"
              ]
              3 => array:2 [
                "nombre" => "S&#46;"
                "apellidos" => "Lucas del Pozo"
              ]
              4 => array:2 [
                "nombre" => "E&#46;"
                "apellidos" => "Mart&#237;nez-S&#225;ez"
              ]
              5 => array:2 [
                "nombre" => "J&#46;"
                "apellidos" => "Hern&#225;ndez-Vara"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S2253808921001038"
          "doi" => "10.1016/j.remnie.2021.05.002"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => false
            "ES2" => false
            "LATM" => false
          ]
          "gratuito" => false
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2253808921001038?idApp=UINPBA00004N"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2253654X21000573?idApp=UINPBA00004N"
      "url" => "/2253654X/0000004100000001/v1_202201060709/S2253654X21000573/v1_202201060709/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S2253808921001646"
    "issn" => "22538089"
    "doi" => "10.1016/j.remnie.2021.11.001"
    "estado" => "S300"
    "fechaPublicacion" => "2022-01-01"
    "aid" => "1348"
    "copyright" => "Sociedad Espa&#241;ola de Medicina Nuclear e Imagen Molecular"
    "documento" => "article"
    "crossmark" => 1
    "subdocumento" => "fla"
    "cita" => "Rev Esp Med Nucl Imagen Mol. 2022;41:55-65"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Continuing Education</span>"
      "titulo" => "Peptide receptor radionuclide therapy with &#91;<span class="elsevierStyleSup">177</span>Lu&#93;Lu-DOTA-TATE"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "55"
          "paginaFinal" => "65"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Terapia con p&#233;ptidos radiomarcados con &#91;<span class="elsevierStyleSup">177</span>Lu&#93;Lu-DOTA-TATE"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:8 [
          "identificador" => "fig0010"
          "etiqueta" => "Figure 2"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr2.jpeg"
              "Alto" => 1761
              "Ancho" => 2500
              "Tamanyo" => 279049
            ]
          ]
          "detalles" => array:1 [
            0 => array:3 [
              "identificador" => "at0010"
              "detalle" => "Figure "
              "rol" => "short"
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Mechanism of action of &#91;<span class="elsevierStyleSup">177</span>Lu&#93;Lu-DOTA-TATE&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "S&#46; Prado-Wohlwend, J&#46;C&#46; Bernal-Vergara, A&#46; Utrera-Costero, J&#46;R&#46; Ca&#241;&#243;n-S&#225;nchez, M&#46; Agudelo-Cifuentes, P&#46; Bello-Arques"
          "autores" => array:7 [
            0 => array:2 [
              "nombre" => "S&#46;"
              "apellidos" => "Prado-Wohlwend"
            ]
            1 => array:2 [
              "nombre" => "J&#46;C&#46;"
              "apellidos" => "Bernal-Vergara"
            ]
            2 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Utrera-Costero"
            ]
            3 => array:2 [
              "nombre" => "J&#46;R&#46;"
              "apellidos" => "Ca&#241;&#243;n-S&#225;nchez"
            ]
            4 => array:2 [
              "nombre" => "M&#46;"
              "apellidos" => "Agudelo-Cifuentes"
            ]
            5 => array:2 [
              "nombre" => "P&#46;"
              "apellidos" => "Bello-Arques"
            ]
            6 => array:1 [
              "colaborador" => "on behalf of the Endocrinology Working Group of the SEMNIM"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S2253654X21001943"
        "doi" => "10.1016/j.remn.2021.11.001"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => false
          "ES2" => false
          "LATM" => false
        ]
        "gratuito" => false
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2253654X21001943?idApp=UINPBA00004N"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2253808921001646?idApp=UINPBA00004N"
    "url" => "/22538089/0000004100000001/v1_202201040537/S2253808921001646/v1_202201040537/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S2253808920301130"
    "issn" => "22538089"
    "doi" => "10.1016/j.remnie.2020.09.009"
    "estado" => "S300"
    "fechaPublicacion" => "2022-01-01"
    "aid" => "1199"
    "copyright" => "Sociedad Espa&#241;ola de Medicina Nuclear e Imagen Molecular"
    "documento" => "article"
    "crossmark" => 1
    "subdocumento" => "sco"
    "cita" => "Rev Esp Med Nucl Imagen Mol. 2022;41:50-1"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Interesting image</span>"
      "titulo" => "Duplicated common bile duct detected by hepatobiliary scintigraphy and SPECT&#47;CT"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "50"
          "paginaFinal" => "51"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Conducto biliar com&#250;n duplicado detectado mediante gammagraf&#237;a hepatobiliar y SPECT&#47;CT"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Fig&#46; 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 2349
              "Ancho" => 2917
              "Tamanyo" => 211546
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar1055" class="elsevierStyleSimplePara elsevierViewall">Anterior dynamic images of the patient&#46; Arrow points to the aberrant drainage pathway&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "S&#46; Barashki, A&#46; Jangjou, F&#46; Nesari Javan, H&#46;O&#46; Roustaei, Y&#46; Fakhar, R&#46; Sadeghi"
          "autores" => array:6 [
            0 => array:2 [
              "nombre" => "S&#46;"
              "apellidos" => "Barashki"
            ]
            1 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Jangjou"
            ]
            2 => array:2 [
              "nombre" => "F&#46;"
              "apellidos" => "Nesari Javan"
            ]
            3 => array:2 [
              "nombre" => "H&#46;O&#46;"
              "apellidos" => "Roustaei"
            ]
            4 => array:2 [
              "nombre" => "Y&#46;"
              "apellidos" => "Fakhar"
            ]
            5 => array:2 [
              "nombre" => "R&#46;"
              "apellidos" => "Sadeghi"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S2253654X20301268"
        "doi" => "10.1016/j.remn.2020.07.002"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => false
          "ES2" => false
          "LATM" => false
        ]
        "gratuito" => false
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2253654X20301268?idApp=UINPBA00004N"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2253808920301130?idApp=UINPBA00004N"
    "url" => "/22538089/0000004100000001/v1_202201040537/S2253808920301130/v1_202201040537/en/main.assets"
  ]
  "en" => array:14 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Interesting images</span>"
    "titulo" => "Corticobasal syndrome&#58; A case of discordance between the clinical findings and the imaging biomarkers"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "52"
        "paginaFinal" => "54"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "E&#46; Carrillo-Villamizar, A&#46; Cardozo-Saavedra, C&#46; Lorenzo-Bosquet, S&#46; Lucas del Pozo, E&#46; Mart&#237;nez-S&#225;ez, J&#46; Hern&#225;ndez-Vara"
        "autores" => array:6 [
          0 => array:4 [
            "nombre" => "E&#46;"
            "apellidos" => "Carrillo-Villamizar"
            "email" => array:1 [
              0 => "elicavi88@gmail.com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "&#42;"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "A&#46;"
            "apellidos" => "Cardozo-Saavedra"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "C&#46;"
            "apellidos" => "Lorenzo-Bosquet"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "S&#46;"
            "apellidos" => "Lucas del Pozo"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "E&#46;"
            "apellidos" => "Mart&#237;nez-S&#225;ez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
          5 => array:3 [
            "nombre" => "J&#46;"
            "apellidos" => "Hern&#225;ndez-Vara"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">d</span>"
                "identificador" => "aff0020"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:4 [
          0 => array:3 [
            "entidad" => "Servicio de Medicina Nuclear&#44; Hospital Universitari Vall d&#8217;Hebron&#44; Barcelona&#44; Spain"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Grupo de Investigaci&#243;n en Enfermedades Neurodegenerativas&#44; Vall d&#8217;Hebron Institut de Recerca &#40;VHIR&#41;&#44; Barcelona&#44; Spain"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Servicio de Anatom&#237;a Patol&#243;gica&#44; Secci&#243;n Neuropatolog&#237;a&#44; Hospital Universitari Vall d&#8217;Hebron&#44; Banco de Tejidos Neurol&#243;gicos&#44; Barcelona&#44; Spain"
            "etiqueta" => "c"
            "identificador" => "aff0015"
          ]
          3 => array:3 [
            "entidad" => "Servicio de Neurolog&#237;a&#44; Hospital Universitari Vall d&#8217;Hebron&#44; Grupo de Investigaci&#243;n en Enfermedades Neurodegenerativas&#44; Vall d&#8217;Hebron Institut de Recerca &#40;VHIR&#41;&#44; Banco de Tejidos Neurol&#243;gicos&#44; Barcelona&#44; Spain"
            "etiqueta" => "d"
            "identificador" => "aff0020"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "S&#237;ndrome c&#243;rticobasal&#58; un caso de discordancia entre la cl&#237;nica y los biomarcadores de imagen"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:8 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 3199
            "Ancho" => 2500
            "Tamanyo" => 686615
          ]
        ]
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0010"
            "detalle" => "Figure "
            "rol" => "short"
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Brain PET with <span class="elsevierStyleSup">18</span>F-FDG&#46; Quantitative analysis using MI Neurology from Siemens&#174; without statistically significant alterations&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">We present a 59-year-old man who consulted for a clinical condition that had started in the previous 6 months&#44; consisting of motor clumsiness and gait disorder&#46; The physical examination highlighted a predominantly left akinetic-rigid syndrome&#44; ipsilateral hemiapraxia&#44; left hand pyramidalism with dystonic posture&#44; and the &#34;Alien Hand&#34; phenomenon&#46; General laboratory tests were normal&#46; Brain MRI showed a moderate&#47;severe degree of symmetric global brain atrophy and signs of leukoaraiosis&#46; The presynaptic dopamine transporters SPECT &#40;123I-FP-CIT SPECT&#41; showed no alterations &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">Brain PET with <span class="elsevierStyleSup">18</span>F-FDG showed no alterations in brain metabolism &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; The electromyogram showed a marked impairment of the first motor neuron in the left lower limb&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Clinically&#44; the patient fulfilled the clinical criteria for a probable corticobasal syndrome &#40;CBS&#41;&#46; In the following months&#44; he presented a progressive clinical worsening&#44; dying due to a hematoma secondary to traumatic brain injury&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">In the anatomopathological study&#44; a systematic sampling of different areas was carried out&#44; finding abundant phosphorylated tau deposits in the form of neurofibrillary tangles and pretangles&#44; balloonized neurons&#44; tufted astrocytes and oligodendroglial inclusions&#46; The distribution of this deposits was mainly brainstem&#44; with little cortical involvement&#46; It was compatible with progressive supranuclear palsy &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">The <span class="elsevierStyleSup">123</span>I-FP-CIT SPECT evaluates the presynaptic integrity of the nigrostriatal dopaminergic neurons of the pars compact of the substantia nigra&#44; showing a high sensitivity for parkinsonisms&#59; however&#44; in some series&#44; as many as 10&#37; of patients with diagnosis of CBS did not present a pathological result&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">On the other hand&#44; brain PET with <span class="elsevierStyleSup">18</span>F-FDG evaluates different patterns of brain hypometabolism with a sensitivity up to 93&#37; and specificity up to 90&#37; for differentiating the different atypical parkinsonisms &#40;PSP&#44;<a class="elsevierStyleCrossRef" href="#fn0005"><span class="elsevierStyleSup">1</span></a> MSA<a class="elsevierStyleCrossRef" href="#fn0010"><span class="elsevierStyleSup">2</span></a> and CBD<a class="elsevierStyleCrossRef" href="#fn0015"><span class="elsevierStyleSup">3</span></a>&#41;&#59; likewise&#44; some series have established different patterns of hypometabolism in relation to the underlying primary neurodegenerative pathology&#44; correlating these findings with a post-mortem neuropathological examination and thus demonstrating that brain PET scan with <span class="elsevierStyleSup">18</span>F-FDG is an effective complementary tool in differentiation of atypical parkinsonisms&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">From the clinical point of view&#44; the absence of alterations in the brain <span class="elsevierStyleSup">18</span>F- FDG PET could lead to reconsideration of the diagnosis of a CBS&#44; regardless of the underlying pathological substrate &#40;CBD&#44; Alzheimer&#39;s Disease&#44; PSP&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Atypical parkinsonisms are complex pathologies whose phenotypic overlap and pathophysiological mechanisms&#44; not yet fully clarified&#44; make their &#34;in vivo&#34; diagnosis remain a clinical challenge&#44; despite the currently available biomarkers that have improved the diagnostic approaches and characterization of the different entities&#46; These should not be considered as definitive and excluding criteria&#44; since&#44; as we exemplify with the current case&#44; despite the negativity of all of all these tests&#44; finally&#44; the histopathological study can confirm the presence of a taupathy that&#44; in this patient&#44; explained the neurological symptoms and his clinical evolution&#46;</p></span>"
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "NotaPie" => array:4 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Carrillo-Villamizar E&#44; Cardozo-Saavedra A&#44; Lorenzo-Bosquet C&#44; Lucas del Pozo S&#44; Mart&#237;nez-S&#225;ez E&#44; Hern&#225;ndez-Vara J&#46; S&#237;ndrome C&#243;rticobasal&#58; un caso de discordancia entre la cl&#237;nica y los biomarcadores de imagen&#46; Rev Esp Med Nucl Imagen Mol&#46; 2022&#59;41&#58;51&#8211;53&#46;</p>"
      ]
      1 => array:3 [
        "etiqueta" => "1"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Progressive supranuclear palsy&#46;</p>"
        "identificador" => "fn0005"
      ]
      2 => array:3 [
        "etiqueta" => "2"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0015">Multiple system atrophy&#46;</p>"
        "identificador" => "fn0010"
      ]
      3 => array:3 [
        "etiqueta" => "3"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0020">Corticobasal degeneration&#46;</p>"
        "identificador" => "fn0015"
      ]
    ]
    "multimedia" => array:3 [
      0 => array:8 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1797
            "Ancho" => 2500
            "Tamanyo" => 329048
          ]
        ]
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0005"
            "detalle" => "Figure "
            "rol" => "short"
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleSup">123</span>I-FP-CIT SPECT without presynaptic dopaminergic involvement&#46;</p>"
        ]
      ]
      1 => array:8 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 3199
            "Ancho" => 2500
            "Tamanyo" => 686615
          ]
        ]
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0010"
            "detalle" => "Figure "
            "rol" => "short"
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Brain PET with <span class="elsevierStyleSup">18</span>F-FDG&#46; Quantitative analysis using MI Neurology from Siemens&#174; without statistically significant alterations&#46;</p>"
        ]
      ]
      2 => array:8 [
        "identificador" => "fig0015"
        "etiqueta" => "Figure 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 1122
            "Ancho" => 1500
            "Tamanyo" => 318935
          ]
        ]
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0015"
            "detalle" => "Figure "
            "rol" => "short"
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Histologically&#44; scarce deposits of phosphorylated tau were observed in the frontal cortex&#44; mainly in the pretangles form &#40;A&#44; AT8&#44; 100x&#41;&#44; somewhat more abundant in the caudate nucleus &#40;B&#44; AT8&#44; 100&#215;&#41; and very frequent in the midbrain &#40;C&#44; red nucleus&#44; AT8&#44; 100&#215;&#41; and the pons &#40;D&#44; base nuclei&#44; AT8&#44; 100&#215;&#41;&#44; with abundant pretangles&#44; ovoid tangles&#44; tufted astrocytes and oligodendroglial inclusions&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:3 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Dopamine transporter SPECT imaging in corticobasal syndrome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46; Cilia"
                            1 => "C&#46; Rossi"
                            2 => "D&#46; Frosini"
                            3 => "D&#46; Volterrani"
                            4 => "C&#46; Siri"
                            5 => "C&#46; Pagni"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1371/journal.pone.0018301"
                      "Revista" => array:5 [
                        "tituloSerie" => "PLoS One"
                        "fecha" => "2011"
                        "volumen" => "6"
                        "paginaInicial" => "e18301"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21559307"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Radiological biomarkers for diagnosis in PSP&#58; where are we and where do we need to be&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;L&#46; Whitwell"
                            1 => "G&#46;U&#46; H&#246;glinger"
                            2 => "A&#46; Antonini"
                            3 => "Y&#46; Bordelon"
                            4 => "A&#46;L&#46; Boxer"
                            5 => "C&#46; Colosimo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/mds.27038"
                      "Revista" => array:6 [
                        "tituloSerie" => "Mov Disord"
                        "fecha" => "2017"
                        "volumen" => "32"
                        "paginaInicial" => "955"
                        "paginaFinal" => "971"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28500751"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "FDG-PET patterns associated with underlying pathology in corticobasal syndrome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Pardini"
                            1 => "E&#46;D&#46; Huey"
                            2 => "S&#46; Spina"
                            3 => "W&#46;C&#46; Kreisl"
                            4 => "S&#46; Morbelli"
                            5 => "E&#46;M&#46; Wassermann"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1212/WNL.0000000000007038"
                      "Revista" => array:5 [
                        "tituloSerie" => "Neurology"
                        "fecha" => "2019"
                        "volumen" => "92"
                        "paginaInicial" => "1"
                        "paginaFinal" => "15"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/22538089/0000004100000001/v1_202201040537/S2253808921001038/v1_202201040537/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "7927"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Interesting images"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/22538089/0000004100000001/v1_202201040537/S2253808921001038/v1_202201040537/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2253808921001038?idApp=UINPBA00004N"
]
Article information
ISSN: 22538089
Original language: English
The statistics are updated each day
Year/Month Html Pdf Total
2024 June 7 0 7
2023 March 0 2 2

Follow this link to access the full text of the article

es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos