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99mTc-MIP-1404 CZT SPECT/CT versus 68Ga/PSMA-11 PET/CT: Imaging of prostate cancer metastasis
99mTc-MIP-1404 CZT SPECT/TC versus 68Ga-PSMA-11 PET/TC: diagnóstico por imagen de las metástasis en el cáncer de próstata
a Division of Urology, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden
b Department of Radiology in Linköping, and Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden
c Department of Clinical Physiology in Linköping, and Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden
d Center for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden
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"apellidos" => "Ochoa-Figueroa" "email" => array:1 [ 0 => "miguel.ochoa.figueroa@regionostergotland.se" ] "referencia" => array:4 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] 3 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] ] "afiliaciones" => array:4 [ 0 => array:3 [ "entidad" => "Division of Urology, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Department of Radiology in Linköping, and Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Department of Clinical Physiology in Linköping, and Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden" "etiqueta" => "c" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Center for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden" "etiqueta" => "d" "identificador" => "aff0020" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "<span class="elsevierStyleSup">99m</span>Tc-MIP-1404 CZT SPECT/TC versus <span class="elsevierStyleSup">68</span>Ga-PSMA-11 PET/TC: diagnóstico por imagen de las metástasis en el cáncer de próstata" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2050 "Ancho" => 3341 "Tamanyo" => 218221 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">CZT SPECT/CT whole body bone scan performed after the intravenous administration of 500 MBq <span class="elsevierStyleSup">99m</span>Tc-HDP, showing no uptake suspicious for skeletal metastases. The axial CZT SPECT/CT shows no signs of metastases in the right scapula.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">72-year-old male with prostate cancer cT3b, Gleason 7b and PSA level of 23 µg/l. Two weeks after diagnosis, a <span class="elsevierStyleSup">99m</span>Tc-HDP whole body bone CZT SPECT/CT scan (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>) and a computed tomography (CT) scan (no image) were performed to investigate metastases, both scans were negative. Radical prostatectomy was performed and confirmed the finding of pT3b, Gleason score 7b with negative margins, but the PSA level after surgery remained elevated at 22 µg/l. A <span class="elsevierStyleSup">68</span>Ga-PSMA-11 PET/CT (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>) and a <span class="elsevierStyleSup">99m</span>Tc-MIP-1404 CZT SPECT/CT (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>) scan were performed postoperatively to investigate possible metastasis and both scans reveal hypermetabolic activity in a 9 mm lymph node in the perirectal fat and in the right scapula with obvious clinical suspicion of metastasis. Previous studies have investigated <span class="elsevierStyleSup">99m</span>Tc-MIP-1404 and conventional SPECT/CT for staging prostate cancer with promising results <a class="elsevierStyleCrossRefs" href="#bib0005">[1,2]</a>. Furthermore, general-purpose CZT SPECT/CT cameras have shown high sensitivity and might be a good alternative to conventional cameras <a class="elsevierStyleCrossRef" href="#bib0015">[3]</a>. In this case, <span class="elsevierStyleSup">68</span>Ga-PSMA-11 PET/CT using a GE Discovery D710 (GE Healthcare; Milwaukee, WI, USA) and <span class="elsevierStyleSup">99m</span>Tc-MIP-1404 CZT SPECT/CT using a CZT Veriton (Spectrum Dynamics, Caesaria, Israel) have shown comparable findings without inferiority with high lesion uptake in the metastatic lesions compared to the background, which raises the question of whether <span class="elsevierStyleSup">99m</span>Tc-MIP-1404 CZT SPECT/CT could be an alternative to conventional imaging (<span class="elsevierStyleSup">99m</span>Tc-HDP whole body bone scan and CT) and possibly to <span class="elsevierStyleSup">68</span>Ga-PSMA-11 PET/CT for prostate cancer staging, emphasizing the need for further studies. To the authors knowledge this the first prostate cancer patient undergoing the combination of <span class="elsevierStyleSup">99m</span>Tc-MIP-1404 and CZT SPECT/CT in the scientific literature.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Funding</span><p id="par0010" class="elsevierStylePara elsevierViewall">Department of Urology and Department of Clinical Physiology, Linköping University Hospital, Region Östergötland. Faculty of Medicine and Health Sciences, LinkÖping University, Sweden.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Ethics approval</span><p id="par0015" class="elsevierStylePara elsevierViewall">The study was approved by the Swedish Ethical Review Authority (approval number 2021-01642) and the Swedish Medical Products Agency (EudraCT-number 2021-001059-15).</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Consent to participate</span><p id="par0020" class="elsevierStylePara elsevierViewall">Written consent was obtained from the patient.</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Conflicts of interest/Competing interests</span><p id="par0025" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:6 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Funding" ] 1 => array:2 [ "identificador" => "sec0010" "titulo" => "Ethics approval" ] 2 => array:2 [ "identificador" => "sec0015" "titulo" => "Consent to participate" ] 3 => array:2 [ "identificador" => "sec0020" "titulo" => "Conflicts of interest/Competing interests" ] 4 => array:2 [ "identificador" => "xack700090" "titulo" => "Acknowledgments" ] 5 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "multimedia" => array:3 [ 0 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2050 "Ancho" => 3341 "Tamanyo" => 218221 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">CZT SPECT/CT whole body bone scan performed after the intravenous administration of 500 MBq <span class="elsevierStyleSup">99m</span>Tc-HDP, showing no uptake suspicious for skeletal metastases. The axial CZT SPECT/CT shows no signs of metastases in the right scapula.</p>" ] ] 1 => array:8 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1805 "Ancho" => 3341 "Tamanyo" => 383849 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">PET/CT performed after the administration of 220 MBq of <span class="elsevierStyleSup">68</span>Ga-PSMA-11 showing high uptake in the right scapula (red arrow) and in a 9 mm lymph node in the perirectal fat (green arrow), suggesting metastases.</p>" ] ] 2 => array:8 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 1847 "Ancho" => 3341 "Tamanyo" => 440549 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0015" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">CZT SPECT-CT scan performed after the intravenous administration of 750 MBq <span class="elsevierStyleSup">99m</span>Tc-MIP-1404 showing high uptake in the right scapula (red arrow) and in a 9 mm lymph node in the perirectal fat (green arrow), suggesting metastases.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:3 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "<span class="elsevierStyleSup">99m</span>Tc-MIP-1404-SPECT/CT for the detection of PSMA-positive lesions in 225 patients with biochemical recurrence of prostate cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C. Schmidkonz" 1 => "C. Hollweg" 2 => "M. Beck" 3 => "J. Reinfelder" 4 => "T.I. Goetz" 5 => "J.C. Sanders" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/pros.23444" "Revista" => array:5 [ "tituloSerie" => "Prostate" "fecha" => "2018" "volumen" => "78" "paginaInicial" => "54" "paginaFinal" => "63" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "SPECT/CT with the PSMA ligand <span class="elsevierStyleSup">99</span>mTc-MIP-1404 for whole-body primary staging of patients with prostate cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C. Schmidkonz" 1 => "M. Cordes" 2 => "M. Beck" 3 => "T.I. Goetz" 4 => "D. Schmidt" 5 => "O. Prante" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/RLU.0000000000001991" "Revista" => array:6 [ "tituloSerie" => "Clin Nucl Med" "fecha" => "2018" "volumen" => "43" "paginaInicial" => "225" "paginaFinal" => "231" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29401151" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Recent developments in SPECT/CT" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "P. 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 7 | 2 | 9 |
| 2024 October | 28 | 10 | 38 |
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| 2024 May | 33 | 28 | 61 |
| 2024 April | 5 | 2 | 7 |
