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Vol. 57. Issue 2.
Pages 111-115 (April - June 2024)
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Vol. 57. Issue 2.
Pages 111-115 (April - June 2024)
Brief report
Colonic adenomatous polyp with florid presence of monoclonal lambda Russell bodies: Case report and etiopathogenic hypothesis
Pólipo adenomatoso colónico con presencia florida de cuerpos de Russell monoclonales lambda: comunicación de un caso e hipótesis etiopatogénica
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Adriano Martínez-Aracila,, Diego Polanco-Alonsob,, Celina Stayermanc, Carlos Miguela, Guiomar Pérez de Nanclaresb,
Corresponding author
gnanclares@osakidetza.eus

Corresponding author.
a Pathology Service, Bioaraba Research Health Institute, Araba University Hospital, Vitoria-Gasteiz, Alava, Spain
b Molecular (Epi)Genetic Lab, Bioaraba Research Health Institute, Araba University Hospital, Vitoria-Gasteiz, Alava, Spain
c Laboratorio Technipath-Hospital del Valle, San Pedro Sula, Honduras
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Table 1. Summary of the clinicopathological characteristics of reported colorectal polypoids containing Mott cells, including the present case.
Abstract

Russell bodies (RBs) are round eosinophilic intracytoplasmic inclusions formed by condensed immunoglobulins in mature plasma cells, which are called Mott cells. These cells are rarely found in the gastric tract, with even less cases reported in the colorectal region. There are still many questions about this event, as it is still unknown the relationship between the agents reported of increasing the probability of appearance of these cells and the generation of RBs. In this case report we describe the fifth patient presenting an infiltration of Mott cells in a colorectal polyp, being the second case with a monoclonal origin without a neoplastic cause, and the first one monoclonal for lambda. A comparison with previously similar reported cases is also done, and a possible etiopathogenic hypothesis proposed.

Keywords:
Russell bodies
Lambda monoclonal plasma cell proliferation
Colonic adenomatous polyp
Resumen

Los cuerpos de Russell (RB) son inclusiones intracitoplasmáticas eosinofílicas redondas formadas por inmunoglobulinas condensadas en las células plasmáticas maduras, que se denominan células de Mott. Estas células rara vez se encuentran en el tracto gástrico, y son aún más infrecuentes en la región colorrectal. Actualmente hay muchas dudas sobre este evento, ya que se desconoce la relación entre los agentes causantes de aumentar la probabilidad de aparición tanto de estas células como de la de RB. En este caso describimos al quinto paciente con un pólipo colorrectal, localizado en el tracto colorrectal e infiltrado por células de Mott, siendo el segundo caso de origen monoclonal sin causa neoplásica y el primero monoclonal para lambda. También se hace una comparación con casos similares previamente reportados y se propone una hipótesis etiopatogénica.

Palabras clave:
Cuerpos de Russell
Proliferación de células plasmáticas monoclonales lambda
Pólipo adenomatoso colónico

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