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Células gigantes multinucleadas, inflamación granulomatosa crónica no caseificante. C y D) Plata metenamina de Grocott Gromori. Levaduras en timón de barco.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Alberto Jesús Reyes-Correa, Nelson Hernández-Flórez, Cristian Javier Hernández-Espinosa, Ernesto García-Ayala" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Alberto Jesús" "apellidos" => "Reyes-Correa" ] 1 => array:2 [ "nombre" => "Nelson" "apellidos" => "Hernández-Flórez" ] 2 => array:2 [ "nombre" => "Cristian Javier" "apellidos" => "Hernández-Espinosa" ] 3 => array:2 [ "nombre" => "Ernesto" "apellidos" => "García-Ayala" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699885521000283?idApp=UINPBA00004N" "url" => "/16998855/0000005500000004/v1_202209230649/S1699885521000283/v1_202209230649/es/main.assets" ] "en" => array:20 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Brief report</span>" "titulo" => "Organoid (hypermature) ovarian teratomas: Report of four cases, one of which harbored a well-differentiated neuroendocrine tumor" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "240" "paginaFinal" => "244" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Francesc Tresserra, Maria Angeles Martinez-Lanao, Melissa Fernandez-Acevedo, Francesc Fargas, Alicia Ubeda" "autores" => array:5 [ 0 => array:4 [ "nombre" => "Francesc" "apellidos" => "Tresserra" "email" => array:1 [ 0 => "francesc.tresserra@quironsalud.es" ] "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Maria Angeles" "apellidos" => "Martinez-Lanao" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "Melissa" "apellidos" => "Fernandez-Acevedo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "Francesc" "apellidos" => "Fargas" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 4 => array:3 [ "nombre" => "Alicia" "apellidos" => "Ubeda" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Pathology Service, Dexeus University Hospital, Barcelona, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Department of Obstetrics, Gynecology and Reproductive Medicine, Dexeus University Hospital, Barcelona, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Teratoma hipermaduro u organoide del ovario: descripción de cuatro casos, con un tumor neuroendocrino bien diferenciado en uno de ellos" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 516 "Ancho" => 1505 "Tamanyo" => 290648 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">(Case 3) Gross appearance of the surgically removed specimen with intestinal loops-like structures (a). Intestinal wall with large bowel type mucosa, muscular layers and serosa (b) (H&E ×40). Nest of neuroendocrine cells growing in the mucosa and submucosa of the intestinal wall (c) (H&E ×100).</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Teratomas are germinal tumors that can form elements of any of the three germinal layers: endoderm, mesoderm, and ectoderm. They are usually benign and the most common germ cell tumors in the ovary.<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Among the ectodermal tissues most frequently found are: skin, nervous tissue, and choroidal epithelium. From the mesodermal layer may be seen adipose tissue, hematopoietic tissue, cartilage and, striated and smooth muscle. Finally, from the endoderm they can have thyroid, respiratory, and gastrointestinal epithelium. Elements derived from the ectoderm are the most frequent, followed by the mesodermal, being the endodermal derivatives the most uncommon.<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">1</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Rarely, complete organs such as intestinal loops, gastric wall, bronchial wall, lung, nephroblastic components, male genitourinary organs including, prostate and penis, and jaws with dental structures can be found in a teratoma.<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">2–11</span></a> On these occasions the lesion has been named highly differentiated, hypermature or organoid teratomas.<a class="elsevierStyleCrossRefs" href="#bib0090"><span class="elsevierStyleSup">3,7,9</span></a> Occasionally the differentiation is such that they become part of the fetus and are called fetiform or homunculus teratomas, in which upper or lower part of the body is usually reproduced with the presence of extremities.<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">8</span></a> On infrequent occasion, tumoral growing in such differentiated organs have been reported.<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">12,13</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">We present four cases of organoid teratoma of the ovary: one of them with the formation of an osseous structure with teeth inserted like a jawbone, the second one with small intestine loops, another with large bowel loops harboring a well-differentiated neuroendocrine tumor, and the last one with fragments of intestinal and bronchial walls.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Cases</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Case 1</span><p id="par0025" class="elsevierStylePara elsevierViewall">A 29-year-old female who consulted after being diagnosed with abdominal calcification during an exploration for an injury of traumatic origin.The gynecological ultrasound described a 40<span class="elsevierStyleHsp" style=""></span>mm left adnexal tumor with a probable diagnosis of an ovarian teratoma.</p><p id="par0030" class="elsevierStylePara elsevierViewall">One month later, gynecological laparoscopy was performed, showing abdominal adherences with an enlarged and stone-like left ovary. Although the initial approach of performing a cystectomy, a total left adnexectomy was done taking into account the absence of healthy ovarian tissue. During the extraction of the piece, it was necessary to increase the size of the left supra-inguinal incision due to the hardness of the specimen.</p><p id="par0035" class="elsevierStylePara elsevierViewall">Grossly, the specimen showed an irregular osseous jawbone-like structure of 5<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>3<span class="elsevierStyleHsp" style=""></span>cm with three inserted tooth formations (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Case 2</span><p id="par0040" class="elsevierStylePara elsevierViewall">A 30-year-old female who came to our Center for an ovarian cyst second opinion. The ultrasound showed an ovarian tumor of 16<span class="elsevierStyleHsp" style=""></span>cm, which could be a cystoadenofibroma or struma ovarii.</p><p id="par0045" class="elsevierStylePara elsevierViewall">Tumor markers: BHCG, AFP, CEA, CA 125, CA 19.9, HE-4 and SCC, were all negative except for CA 12.5 which was 44<span class="elsevierStyleHsp" style=""></span>IU/ml (normal value less than 35).</p><p id="par0050" class="elsevierStylePara elsevierViewall">CT scan showed a large right adnexal lesion suggesting an atypical teratoma versus serous cystadenoma. No pathological lymph nodes or ascitic fluid were identified in significant amounts.</p><p id="par0055" class="elsevierStylePara elsevierViewall">The patient underwent diagnostic laparoscopy, in which a unilateral oophorectomy was performed. Grossly the specimen was formed by several capsular fragments of tissue measuring 18<span class="elsevierStyleHsp" style=""></span>cm. There were hairy structures and sebum.</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Case 3</span><p id="par0060" class="elsevierStylePara elsevierViewall">A 56-year-old female, asymptomatic, who comes for a gynecological examination. The transvaginal ultrasound was visualized a unilateral cyst of 138<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>119<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>109<span class="elsevierStyleHsp" style=""></span>mm that showed minimum peripheral vascularization in color Doppler study. The image obtained suggested a dermoid cyst. Tumor markers were all negative (AFP: 1.6; CEA 1.22, CA 15.3: 14.6, CA 125: 24, HE-4 of 33). The patient underwent diagnostic laparoscopy with adnexectomy. The surgically removed specimen was a cystic lesion of 17<span class="elsevierStyleHsp" style=""></span>cm with intestinal loops-like structures with abundant hairy structures and sebum (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>).</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Case 4</span><p id="par0065" class="elsevierStylePara elsevierViewall">A 39-year-old female, who comes from other Center, due to a casual finding of an ovarian cyst in an abdominal ultrasound. The patient was treated for endometriosis with desogestrel. In a vaginal ultrasound, a cyst in the left ovary was observed, and more studies were recommended to rule out neoformative growth. Endometriotic implants were observed in the rectum extending to the right uterine-sacral ligament.</p><p id="par0070" class="elsevierStylePara elsevierViewall">Tumor markers were normal (CEA 2.6, CA 125: 19; CA 19.9: 8, HE-4 of 71.4).</p><p id="par0075" class="elsevierStylePara elsevierViewall">CT scan showed a heterogeneous density nodule in the left adnexal region. No evidence of suspicious adenopathies or distant disease were seen. The patient was submitted to laparoscopy surgery with ovariectomy. Grossly the specimen showed several capsular fragments of tissue measuring 4<span class="elsevierStyleHsp" style=""></span>cm with an irregular surface and yellowish material attached.</p></span></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Histopathological findings</span><p id="par0080" class="elsevierStylePara elsevierViewall">In all four cases, elements derived from the three germinal layers were observed: skin with appendages, adipose tissue, cartilage, and mature neural tissue. In addition, in case 1 there was trabecular bone with the presence of intralacunar osteocytes surrounded by soft parts in which dental structures were inserted in a jawbone-like structure. In case 2, fragments of small bowel wall were identified with the presence of villi with Paneth cells, muscularis mucosae, and muscularis propria with an inner circular and an outer longitudinal layer in which the presence of nervous plexus was evident.</p><p id="par0085" class="elsevierStylePara elsevierViewall">In case 3, the loops grossly describe were segments of large bowel wall with muscularis mucosa, muscular propria with nervous plexus and serosa. Focally involving the mucosa and submucosa there were nests of small cells with round nuclei and granular chromatin measuring 6<span class="elsevierStyleHsp" style=""></span>mm. These cells expressed chromogranin, neuron specific enolase and the proliferative index evaluated with Ki67 was of 3% (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>).</p><p id="par0090" class="elsevierStylePara elsevierViewall">Finally, in case 4 it was identified a large bowel wall with all the layers, as well as a bronchial wall with a cylindrical lining epithelium of respiratory type, accessory glands and cartilage (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>).</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0095" class="elsevierStylePara elsevierViewall">All cases were diagnosed as organoid teratomas, and in case 3 with a well-differentiated neuroendocrine tumor arising in the large bowel wall.</p><p id="par0100" class="elsevierStylePara elsevierViewall">This study is exempt of Ethics Committee approval because it is a retrospective case report in which all the clinical information has been treated in a codified way.</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Discussion</span><p id="par0105" class="elsevierStylePara elsevierViewall">The presence of organ differentiation in teratomas has been described in those tumors affecting the ovary,<a class="elsevierStyleCrossRefs" href="#bib0105"><span class="elsevierStyleSup">6–9</span></a> placenta,<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">3</span></a> mediastinum,<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">5</span></a> retroperitoneum,<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">4</span></a> sacrococcygeal region.<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">2,14</span></a></p><p id="par0110" class="elsevierStylePara elsevierViewall">Although the presence of gastrointestinal epithelium is found in 7-13% of teratomas, the presence of well architected gastrointestinal tract wall is rare. In a case description reported by Kwon et al. in 2009,<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">6</span></a> they found a series of 15 previously described cases.<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">15</span></a> Since then, only isolated cases<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">2,12,13</span></a> up to a total of 25 cases have been reported. The patient's ages range from 5 days to 65 years.<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">2,5</span></a> These tumors have been described in the ovary, mediastinum, retroperitoneum, sacrococcygeal region, and placenta. All cases of extra-ovarian location have occurred in women.<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">2,14</span></a> Most of the tumors showed small intestine, although colon, appendix, stomach, and esophagus have also been described. There is a case in which the colonic wall developed an adenocarcinoma infiltrating muscular and serous layers.<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">12</span></a> In another case the intestinal wall showed a mucinous cystadenoma.<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">13</span></a> In one of the cases herein presented a well-differentiated neuroendocrine tumor was seen involving the mucosa and submucosa of the large bowel wall.</p><p id="par0115" class="elsevierStylePara elsevierViewall">We have only found one case in the literature of a mediastinal teratoma with bronchial wall, in which intestinal wall also existed.<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">5</span></a> There is a report describing an ovarian teratoma with lung differentiation that cites four similar cases in which there is lung and bronchial wall.<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">11</span></a></p><p id="par0120" class="elsevierStylePara elsevierViewall">The presence of a structure similar to a jawbone in a teratoma has been described on two occasions,<a class="elsevierStyleCrossRefs" href="#bib0110"><span class="elsevierStyleSup">7,8</span></a> both in ovarian location.</p><p id="par0125" class="elsevierStylePara elsevierViewall">Many terms have been used to name these tumors such as: well-differentiated teratoma, teratoma with high level of differentiation, hypermature teratoma or organoid teratoma.<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">2,7,9</span></a> They must be distinguished from fetiform teratomas or teratoma with homunculus<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">8</span></a> which can be organoid or differentiated teratomas according to the degree of differentiation of the tissue structures that they have. In general, fetiform teratomas reproduce parts of the upper or lower body without internal organs.<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">8</span></a></p><p id="par0130" class="elsevierStylePara elsevierViewall">The origin of teratomas is discussed. The most accepted is the parthenogenetic theory that establishes its origin in primordial germinal cells. This theory is corroborated by the location of these tumors in the germ cell migration line and that they occur mostly in early reproductive age. However, their origin could also be in blastomeres dispersed in early stages or embryonic remnants.<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">1,9,10</span></a> The fact that structures that reproduce complete organs are formed is not known.</p><p id="par0135" class="elsevierStylePara elsevierViewall">The differential diagnosis of these lesions should be established with the presence of bronchopulmonary foregut malformations that include a wide spectrum of malformations originating during the fourth and fifth weeks of embryogenesis that give rise to cystic structures with gastrointestinal or bronchial wall. However, the presence of other tissues derived from the three germinal layers of teratomas distinguishes them from these malformations.<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">5</span></a></p><p id="par0140" class="elsevierStylePara elsevierViewall">The behavior of these lesions is generally benign and, in any case, it will depend on the evolution of immature or malignant elements found in the context of the teratoma or the tumor associated in well differentiated organ formation.<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">1,7</span></a></p><p id="par0145" class="elsevierStylePara elsevierViewall">In conclusion, hypermature or organoid teratomas are rare tumors that reproduce organs, generally the digestive tract or bronchial wall, affecting any location where conventional teratomas can be found. Although their behavior is benign, they can harbor neoplastic growth.</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Authors’ contributions</span><p id="par0150" class="elsevierStylePara elsevierViewall">All the authors signing the manuscript (FT, MAM, MF, FF, AU) have contributed in the conception, design and data acquisition or data analysis. Also have participated in drafting the manuscript and in the final version approval.</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Conflict of interest</span><p id="par0155" class="elsevierStylePara elsevierViewall">All the authors participating in the study declare to have no conflict of interest in any product mentioned in the manuscript.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:12 [ 0 => array:3 [ "identificador" => "xres1773494" "titulo" => "Abstract" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0005" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec1557795" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres1773495" "titulo" => "Resumen" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0010" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec1557796" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:3 [ "identificador" => "sec0010" "titulo" => "Cases" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "sec0015" "titulo" => "Case 1" ] 1 => array:2 [ "identificador" => "sec0020" "titulo" => "Case 2" ] 2 => array:2 [ "identificador" => "sec0025" "titulo" => "Case 3" ] 3 => array:2 [ "identificador" => "sec0030" "titulo" => "Case 4" ] ] ] 6 => array:2 [ "identificador" => "sec0035" "titulo" => "Histopathological findings" ] 7 => array:2 [ "identificador" => "sec0040" "titulo" => "Discussion" ] 8 => array:2 [ "identificador" => "sec0045" "titulo" => "Authors’ contributions" ] 9 => array:2 [ "identificador" => "sec0050" "titulo" => "Conflict of interest" ] 10 => array:2 [ "identificador" => "xack626628" "titulo" => "Acknowledgement" ] 11 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2020-11-29" "fechaAceptado" => "2021-01-20" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1557795" "palabras" => array:3 [ 0 => "Teratoma" 1 => "Organoid" 2 => "Ovary" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec1557796" "palabras" => array:3 [ 0 => "Teratoma" 1 => "Organoide" 2 => "Ovario" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Organoid (hypermature) teratomas are highly specialized teratomas showing organ formation, most frequently from the digestive tract or bronchial wall.</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">We present four cases of ovarian organoid teratomas, one with a distinguishable mandible with teeth, one with small intestine, one with large intestine containing a well differentiated neuroendocrine tumor and another with both large intestine and bronchial wall.</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">These tumors have a distribution similar to conventional teratomas and usually behave benignly, although cases of malignancy have been reported.</p></span>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Los teratomas hipermaduros u organoides son teratomas altamente especializados en los que existe formación de órganos. Los más comunes son del tracto digestivo y de la pared bronquial. Presentamos cuatro casos de teratomas organoides del ovario: uno con formación de mandíbula con estructuras dentales, otro con intestino delgado, otro con intestino grueso con un tumor neuroendocrino bien diferenciado, y otro intestino grueso y pared bronquial. Estos tumores son de comportamiento benigno, aunque se han descrito casos con malignización. Pueden ocurrir en cualquier lugar donde se localicen los teratomas convencionales.</p></span>" ] ] "multimedia" => array:3 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 435 "Ancho" => 1305 "Tamanyo" => 80151 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">(Case 1) Radiological image of a jawbone like structure with teeth (a). Gross appearance of the surgical specimen where dental structures can be seen surrounded by soft tissue (b).</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 516 "Ancho" => 1505 "Tamanyo" => 290648 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">(Case 3) Gross appearance of the surgically removed specimen with intestinal loops-like structures (a). Intestinal wall with large bowel type mucosa, muscular layers and serosa (b) (H&E ×40). Nest of neuroendocrine cells growing in the mucosa and submucosa of the intestinal wall (c) (H&E ×100).</p>" ] ] 2 => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 778 "Ancho" => 1305 "Tamanyo" => 397168 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">(Case 4) Intestinal wall with large bowel type mucosa (a) (H&E ×200). Bronchial wall with accessory glands and cartilage (b) (H&E ×100).</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:15 [ 0 => array:3 [ "identificador" => "bib0080" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mature cystic teratoma: a clinicopathologic evaluation of 517 cases and review of the literature" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J.T. Comerci" 1 => "F. Licciardi" 2 => "P.A. Bergh" 3 => "C. Gregori" 4 => "J.L. 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Autonomous University of Barcelona.</p>" "vista" => "all" ] ] ] "idiomaDefecto" => "en" "url" => "/16998855/0000005500000004/v1_202209230649/S1699885521000064/v1_202209230649/en/main.assets" "Apartado" => array:4 [ "identificador" => "5740" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Artículos breves" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/16998855/0000005500000004/v1_202209230649/S1699885521000064/v1_202209230649/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699885521000064?idApp=UINPBA00004N" ]
Journal Information
Brief report
Organoid (hypermature) ovarian teratomas: Report of four cases, one of which harbored a well-differentiated neuroendocrine tumor
Teratoma hipermaduro u organoide del ovario: descripción de cuatro casos, con un tumor neuroendocrino bien diferenciado en uno de ellos