Neuropsychological functioning in methadone maintenance patients with HIV

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Isabel Soler Sánchez, Mariano Meseguer de Pedro, Mariano García Izquierdo" "autores" => array:3 [ 0 => array:2 [ "nombre" => "M. Isabel" "apellidos" => "Soler Sánchez" ] 1 => array:2 [ "nombre" => "Mariano" "apellidos" => "Meseguer de Pedro" ] 2 => array:2 [ "nombre" => "Mariano" "apellidos" => "García Izquierdo" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0120053415000345?idApp=UINPBA00004N" "url" => "/01200534/0000004800000003/v1_201607230745/S0120053415000345/v1_201607230745/es/main.assets" ] "en" => array:20 [ "idiomaDefecto" => true "cabecera" => "Original article" "titulo" => "Neuropsychological functioning in methadone maintenance patients with HIV" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "147" "paginaFinal" => "158" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Enrique Vázquez-Justo, Esperanza Vergara-Moragues, Adolfo Piñón Blanco, Carlos Guillén Gestoso, Miguel Pérez-García" "autores" => array:5 [ 0 => array:3 [ "nombre" => "Enrique" "apellidos" => "Vázquez-Justo" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "b" "identificador" => "aff0010" ] ] ] 1 => array:4 [ "nombre" => "Esperanza" "apellidos" => "Vergara-Moragues" "email" => array:1 [ 0 => "esperanza.vergara@unir.net" ] "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "c" "identificador" => "aff0015" ] 1 => array:2 [ "etiqueta" => "d" "identificador" => "aff0020" ] 2 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 2 => array:3 [ "nombre" => "Adolfo Piñón" "apellidos" => "Blanco" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "b" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "Carlos Guillén" "apellidos" => "Gestoso" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "e" "identificador" => "aff0025" ] ] ] 4 => array:3 [ "nombre" => "Miguel" "apellidos" => "Pérez-García" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "f" "identificador" => "aff0030" ] 1 => array:2 [ "etiqueta" => "g" "identificador" => "aff0035" ] ] ] ] "afiliaciones" => array:7 [ 0 => array:3 [ "entidad" => "Portucalense Institute of Neuropsychology, Universidade Portucalense, Portugal" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Policínico Êbam, Poio, Pontevedra, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Departamento de Educación y Psicobiologia. Universidad Internacional de la Rioja (UNIR), Spain" "etiqueta" => "c" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Clinic Unit of Infectious Diseases, Clinical Hospital of Puerto Real (Cádiz), Spain" "etiqueta" => "d" "identificador" => "aff0020" ] 4 => array:3 [ "entidad" => "Faculty of Labour, University of Cádiz, Spain" "etiqueta" => "e" "identificador" => "aff0025" ] 5 => array:3 [ "entidad" => "Centro de Investigación Mente, Cerebro y Comportamiento (CIMCYC), University of Granada (UGR), Spain" "etiqueta" => "f" "identificador" => "aff0030" ] 6 => array:3 [ "entidad" => "Centro de Investigaciones Biomédicas en Red de Salud Mental, CIBERSAM, University of Granada (UGR), Spain" "etiqueta" => "g" "identificador" => "aff0035" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Función neuropsicológica en el tratamiento de mantenimiento con metadona en pacientes con VIH" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1383 "Ancho" => 3397 "Tamanyo" => 277884 ] ] "descripcion" => array:1 [ "en" => "Neuropsychological Z scores for groups. Influence of the situation with respect to drug use." ] ] ] "textoCompleto" => "The human immunodeficiency virus (HIV) infection is associated with a wide range of neuropsychological deficits: psychomotor functioning, information processing speed, attention, executive functioning, information processing speed, attention, executive functioning and working memory (<a class="elsevierStyleCrossRefs" href="#bib0010">Al-Khindi, Zakzanis, & Van Gorp, 2011; Blackstone et al., 2012; Cysique, Marruf, & Brew, 2006; Heaton et al., 2011</a>;<a class="elsevierStyleCrossRef" href="#bib0305">Vázquez-Justo, Piñón-Blanco, Vergara-Moragues, Guillén-Gestoso, & Pérez-García, 2014</a>). The nature of these deficits is compatible with an affection of the frontal-subcortical brain disturbances, including cerebral metabolite abnormalities (<a class="elsevierStyleCrossRefs" href="#bib0080">Cohen et al., 2010; Paul et al., 2008</a>) and white matter damage (<a class="elsevierStyleCrossRefs" href="#bib0075">Coughlin et al., 2014; Fellows, Byrd, & Morgello, 2014</a>) and their prevalence varies considerably (<a class="elsevierStyleCrossRefs" href="#bib0085">Cohen et al., 2015; Heaton et al., 2010; Woods, Moore, Weber, & Grant, 2009</a>).The variability of the data on the prevalence of these alterations leads us to consider, as <a class="elsevierStyleCrossRef" href="#bib0020">Anand, Springer, Copenhaver, and Altice (2010)</a> put forward, that these may be modulated by the coexistence of factors other than HIV. No definitive risk factors are yet available to indicate the development of these neuropsychological alterations and, bearing in mind that the presence of cognitive disturbances is a risk factor of early death in all stages of the infection (<a class="elsevierStyleCrossRefs" href="#bib0185">Lescure et al., 2011; Sevigny et al., 2007</a>), there is a pressing need to determine those factors, either related or foreign to HIV, which help to explain the intra-group differences that exist and which may also be associated with the development and progression of the dysfunction (<a class="elsevierStyleCrossRefs" href="#bib0020">Anand et al., 2010; Byrd et al., 2011; Muñoz-Moreno et al., 2008</a>). The identification of these risk factors will help us to outline the characteristics of the seropositive subjects who are neuropsychologically more vulnerable.Research dealing with this sphere of work has mainly studied the influence of variables related to the infection, such as the stage of infection (<a class="elsevierStyleCrossRefs" href="#bib0265">Selnes et al., 1997; Spudich & Ances, 2015</a>), the level of immunosuppression (<a class="elsevierStyleCrossRefs" href="#bib0125">Farinpour et al., 2000; Grassi, Perin, Borlla, & Mangoni, 1999</a>), the combined effects of HIV infection and APOE ¿4 may lead to greater cognitive deficits, especially in those with greater neuroinflammation (<a class="elsevierStyleCrossRef" href="#bib0065">Chang, Connaghan, Wei, & Li, 2014</a>) and the viral load (<a class="elsevierStyleCrossRefs" href="#bib0115">Ellis et al., 1997; Muñoz-Moreno et al., 2008; Stankoff et al., 1999</a>). However, they have also dealt with determining the influence of other variables such as depressed mood (<a class="elsevierStyleCrossRefs" href="#bib0130">Fellows et al., 2014; Vázquez-Justo, Rodríguez-Álvarez, & Carro-Ramos, 2003; Vázquez-Justo, Rodríguez Álvarez, & Ferraces Otero, 2003</a>), history of neurological pathology (<a class="elsevierStyleCrossRef" href="#bib0175">Hestad, Updike, Selnes, & Royal III, 1995</a>) and of psychiatric pathology (<a class="elsevierStyleCrossRef" href="#bib0030">Baldeweg et al., 1997</a>); variables related to drug use (<a class="elsevierStyleCrossRefs" href="#bib0140">García-Torres, Vergara-Moragues, Piñón-Blanco, & Pérez-García, 2015; Rodríguez, 2000; Vázquez-Justo, Rodríguez Álvarez, & Rodríguez Salgado, 2000</a>; Vergara-Moragues, Vergara de Campos, & Girón-González, 2008), high psychosocial stress and lower socioeconomic status (<a class="elsevierStyleCrossRef" href="#bib0255">Rubin et al., 2015</a>) and educational level (<a class="elsevierStyleCrossRef" href="#bib0260">Satz et al., 1993</a>). The findings of these studies reveal that the neuropsychological performance of seropositive subjects may vary according to their situation with respect to each of these variables, although the results are not consistent.We know that HIV infection in drug users is associated with neuropsychological alterations that cannot be attributed to the history of drug abuse (<a class="elsevierStyleCrossRefs" href="#bib0315">Vázquez-Justo et al., 2003a, 2003b; Vergara-Moragues, Vergara de Campos, & Girón-González, 2010</a>). When evaluating the neuropsychological performance of seropositive drug users, a variable that may affect their performance is their current situation with respect to drug consumption, i.e. whether they continue to use drugs or whether they are abstaining at the time of evaluation. In this sense, the current consumption of drugs is related to a poorer performance in neuropsychological tasks than abstinence (<a class="elsevierStyleCrossRefs" href="#bib0025">Ardila, Rosselli, & Strumwasser, 1991; Grassi et al., 1995</a>). The Methadone Maintenance Programmes (MMP) offer us a suitable framework for evaluating the neuropsychological consequences of the active consumption of opiates. For example, chronic crack cocaine use seems to disrupt general cognitive functioning (MMSE), verbal memory, and attentional resources, but findings suggest that some of these effects could be reversed by abstinence (<a class="elsevierStyleCrossRef" href="#bib0095">De Oliveira et al., 2009</a>). In addition, <a class="elsevierStyleCrossRef" href="#bib0325">Vázquez-Justo et al. (2000)</a> evaluated the cognitive functioning of drug users in MMP and noted a significantly poorer performance in these subjects as compared to those in abstinence. Likewise, <a class="elsevierStyleCrossRef" href="#bib0245">Rodríguez (2000)</a> pointed out that the rate of neuropsychological affection of seropositive subjects in MMP is double that of abstaining seropositive subjects, observing greater difficulty in attention, coordination and visual-motor speed, memory, conceptualisation and verbal fluency in the seropositive subjects in MMP than in those abstaining.The aim of this study is not only to contribute to clarifying the effect of some factors in the neuropsychological performance of Spanish seropositive subjects but also to make progress in this line of research by providing evidence of the multifactorial nature of neuropsychological deterioration associated with HIV infection.MethodIn order to carry out this research, a sample comprising 138 male volunteers was used. All subjects provided written informed consent. These subjects were distributed in two groups: one group of drug users with HIV infection (n=90), referred to as seropositive (HIV+), of this group of 48 subjects were on the drug-free treatment programme and 42 were on methadone maintenance programme. A second group of controls (HIV−), formed by HIV seronegative drug users (n=48), of this group of 27 subjects were on the drug-free treatment programme and 21 were on methadone maintenance programme. The drug dependent subjects were recruited in the HIV services at Hospitals and at units for the care of drug users in Galicia (Spain). To be included in the study the intravenous drug users should be diagnosed as opiate-dependent according to DSM-IV criteria. Before starting on heroin, all had taken cannabis, amphetamines, cocaine, or barbiturics, either simultaneously or consecutively, without becoming dependents on any of these other drugs, and primary drug of choice was cannabis or alcohol for all the drug user subjects.Diagnosis of seropositivity and the classification of the subjects regarding phase of infection was carried out according to standard procedures (<a class="elsevierStyleCrossRef" href="#bib0060">Centers for Disease Control [CDC], 1992</a>), and was based on the medical report from the hospitals where the subjects were recruited.Those subjects who presented, or had presented, neurological or medical pathologies that could affect the CNS, including HIV-associated dementia, psychiatric disturbances (psychotic symptoms), history of craneo-encephalic trauma requiring hospitalization owing to neurological complication, and antisocial personality disorder according to DSM-IV criteria (<a class="elsevierStyleCrossRef" href="#bib0015">American Psychiatric Association, 2002</a>) were excluded from the study. Finally, taking as a basis the report from the units for the care of drug addicts, those dependent on drugs who were currently consuming psychotropic substances (illegal drugs or alcohol) other than methadone were excluded. In the other hand, three months drug-free was required to be considered in abstinence.Examination of each subject consisted of a semi-structured interview on socio-demographic, clinical and toxicological aspects and a neuropsychological evaluation with a battery of tests designed for this study, chosen for their validity and for having been shown to be sensitive to neuropsychological deterioration in HIV-infected patients in other studies. The neuropsychological domains and tests and comprising the battery are as follows:<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005">1.AttentionVisual Search and Attention Test (VSAT) (<a class="elsevierStyleCrossRef" href="#bib0300">Trenerry, Crosson, Beboe, & Leber, 1990</a>).</li><li class="elsevierStyleListItem" id="lsti0010">2.Visual-motor integration:Block Design and Object Assembly subtests of the Wechsler Adult Intelligence Scale – WAIS – (<a class="elsevierStyleCrossRef" href="#bib0340">Wechsler, 1999</a>).</li><li class="elsevierStyleListItem" id="lsti0015">3.Motor coordination:Purdue Pegboard Test (<a class="elsevierStyleCrossRef" href="#bib0290">Tiffin, 1948</a>).Finger Tapper Test (<a class="elsevierStyleCrossRef" href="#bib0230">Reitan, 1979</a>).</li><li class="elsevierStyleListItem" id="lsti0020">4.Language:Comprehension subtest of the Wechsler Adult Intelligence Scale – WAIS – (<a class="elsevierStyleCrossRef" href="#bib0340">Wechsler, 1999</a>).Verbal Fluency Test (<a class="elsevierStyleCrossRef" href="#bib0035">Cuadrado, Esteba-Castillo, Böhm, Cejudo-Bolívar, & Peña-Casanova, 2002</a>).Boston Naming Test (<a class="elsevierStyleCrossRef" href="#bib0180">Kaplan, Goodglass, & Weintraub, 2001</a>).</li><li class="elsevierStyleListItem" id="lsti0025">5.Memory:Rey Auditory Verbal Learning Test – AVLT – (<a class="elsevierStyleCrossRef" href="#bib0235">Rey, 1964</a>).Rey Osterrieth Complex Figure – ROCF – (<a class="elsevierStyleCrossRef" href="#bib0240">Rey, 1987</a>).Benton Visual Retention Test – BVRT –: Form C, Administration A (<a class="elsevierStyleCrossRef" href="#bib0040">Benton, 1981</a>).</li><li class="elsevierStyleListItem" id="lsti0030">6.Executive Functions:Similarities, Digit Span, Digit Symbol subtests of the Wechsler Adult Intelligence Scale –WAIS – (<a class="elsevierStyleCrossRef" href="#bib0340">Wechsler, 1999</a>).Trail Making Test – TMT – (<a class="elsevierStyleCrossRef" href="#bib0295">Tombaugh, 2004</a>)Stroop Test (<a class="elsevierStyleCrossRef" href="#bib0145">Golden, 1994</a>).Wisconsin Card Sorting Test – WCST – (<a class="elsevierStyleCrossRef" href="#bib0160">Heaton, Chelune, Talley, Kay, & Curtiss, 2001</a>).</li><li class="elsevierStyleListItem" id="lsti0035">7.Cognitive reserve:Vocabulary subtest of the Wechsler Adult Intelligence Scale (WAIS) (<a class="elsevierStyleCrossRef" href="#bib0340">Wechsler, 1999</a>).</li><li class="elsevierStyleListItem" id="lsti0040">8.Handeness:Edinburgh Handedness Inventory (<a class="elsevierStyleCrossRef" href="#bib0220">Oldfield, 1971</a>).</li></ul>ResultsBearing in mind the objectives posed, and in order to respond to them, diverse data analyses were carried out using the SPSS statistical packet for Windows.Characteristics of the SampleFirst, an analysis of variance (ANOVA), chi squared or Student t test was performed when needed in order to determine whether there were differences between the seropositive and seronegative groups in the different socio-demographic and clinical variables. Statistically significant differences were observed between the groups in age, addiction time and months of abstinence. <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> gives the mean scores and standard deviation in each group for these variables, and the significant differences observed are indicated. Moreover, Chi-square analyses revealed significant differences between occupational attainments.<elsevierMultimedia ident="tbl0005"></elsevierMultimedia>Influence of the situation with respect to drug useIn order to determine the influence of the situation with respect to drug use in the neuropsychological performance of seropositive and seronegative drug users, the drug users were divided into two groups according to whether they were abstaining from drug use (Drug-free treatment programme [FTP]) or were included in a Methadone Maintenance Programme (MMP).According to these results, we found differences between the groups in tests that assess attention, language, memory, visual-engine integration. Motor coordination and executive functions. In resume, the FTP/HIV-group performances the best and MMP/HIV+ group obtained the worst scores. <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a> shows the mean scores and standard deviations obtained for the four groups in each measurement, and gives the significant differences noted in the “post hoc” multiple comparison tests. <a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a> represents performance in the different neuropsychological tasks for each of the groups, after the direct scores were transformed to Z scores and their direction corrected.<elsevierMultimedia ident="tbl0010"></elsevierMultimedia><elsevierMultimedia ident="fig0005"></elsevierMultimedia>DiscussionIn this study we have attempted to be specially careful with some methodological aspects, hence we followed the recommendations made in the literature in this respect (<a class="elsevierStyleCrossRefs" href="#bib0050">Bornstein, 1994; Egan, Deary, & Brettle, 1992; Newman, Lunn, & Harrison, 1995; Stern, 1994; White, Heaton, Monsch, & The HNRC Group, 1995</a>). Along these lines, we used a single risk group, that of intravenous drug users, taking into account that it has been pointed out that their neuropsychological performance could be different from that of other risk groups (<a class="elsevierStyleCrossRef" href="#bib0105">Egan, Brettle, & Goodwin, 1992</a>); the control groups have the same socio-demographic characteristics as the seropositive one (<a class="elsevierStyleCrossRef" href="#bib0050">Bornstein, 1994</a>); the size of the sample is greater than one hundred subjects, as recommended (<a class="elsevierStyleCrossRef" href="#bib0215">Newman et al., 1995</a>); and, finally, the criteria for inclusion and exclusion were carefully selected, without disregarding the importance of the representativeness of the sample (<a class="elsevierStyleCrossRef" href="#bib0050">Bornstein, 1994</a>).In this research our aim was to study the group of intravenous drug users, first, because they represent the greatest percentage of HIV seropositive subjects and AIDS patients in Spain. Secondly, since most research studies use samples of homosexual and bisexual subjects, their results are not applicable to the risk group of intravenous drug users. With respect to sociodemographic characteristics and drug consumption history, the sample used in this research can be said to be representative of the population of intravenous drug users in Spain (<a class="elsevierStyleCrossRefs" href="#tbl0005">Tables 1 and 2</a>).In order to be able to evaluate the neuropsychological consequences of HIV infection, it is important to determine the influence of other variables, whether related to the infection or not, which are also associated with the development of neuropsychological disturbances and which may make the seropositive subject more vulnerable neuropsychologically (<a class="elsevierStyleCrossRefs" href="#bib0085">Cohen et al., 2015; Rodríguez-Álvarez & Vázquez-Justo, 2002; Vázquez-Justo & Rodríguez-Álvarez, 2002</a>;). One of the first studies in this line was that of <a class="elsevierStyleCrossRef" href="#bib0350">Wilkins et al. (1990)</a>, who observed a significant relation between the degree of neuropsychological deterioration and the presence of contaminating factors. In our research we studied the influence of the current situation with respect to drug consumption on the neuropsychological performance of seropositive drug users, in order to help to clarify the influence of that factor on their neuropsychological performance.With respect to the influence of drug use, several studies have disclosed that the use of drugs, past or present, can facilitate the appearance of neuropsychological disturbances (<a class="elsevierStyleCrossRefs" href="#bib0005">Albein-Urios, Marinez-González, Lozano, Clark, & Verdejo-García, 2012; Devlin et al., 2012; Ersche, Clark, London, Robbins, & Sahakian, 2006; Fernandez-Serrano, Perez-Garcia, Schmidt Rio-Valle, & Verdejo-Garcia, 2010; López, Ravindran, Mrudula, & Priya, 2014; Lundqvist, 2005; Verdejo-García et al., 2012</a>). Although there is no evidence that the use of opiates may be the direct cause of these disturbances, the poly-toxicomania pattern these subjects usually present, the high frequency of cranial traumatism and the nutritional deficiencies associated with their lifestyle makes them a risk group for neuropsychological impairment (<a class="elsevierStyleCrossRefs" href="#bib0100">Devlin et al., 2012; Ersche et al., 2006; Lundqvist, 2005; Rodríguez-Álvarez & Vázquez-Justo, 2002</a>).Bearing in mind that drug users who maintain current drug consumption showed poorer performance in neuropsychological tasks than those in abstinence (<a class="elsevierStyleCrossRefs" href="#bib0150">Grassi et al., 1995; Verdejo-García et al., 2012</a>), chronic heroin-dependent subjects had widespread disruption of white matter structural connectivity located mainly in anterior and superior regions of the brain (<a class="elsevierStyleCrossRef" href="#bib0190">Lin et al., 2013</a>) and heroin users on MMP have low grey matter volume (GMV) in brain regions that are hypothesized to influence cognition and emotion, and the GMV findings might be involved comorbid disorders in the MMP group (<a class="elsevierStyleCrossRef" href="#bib0195">Lin et al., 2012</a>), we posit the interest of taking into account this situation when evaluating the neuropsychological performance of seropositive drug users. Along this line the MMP offer a suitable setting for evaluating the neuropsychological consequences associated with the active consumption of opiates.In this research we sought to study the effect of the situation regarding drug consumption in seropositive drug users. These results reveal that the use of methadone is related to problems of attention, language, visual memory, motor speed, visual-motor integration and executives functions, along the lines of the results obtained in the works cited (<a class="elsevierStyleCrossRefs" href="#bib0245">Rodríguez, 2000; Vázquez-Justo et al., 2014</a>). It has also been demonstrated, that the duration of MMP was associated with declining diffusion tensor image (DTI) indices in the superior longitudinal fasciculus and para-hippocampus (<a class="elsevierStyleCrossRef" href="#bib0195">Lin et al., 2012</a>).Nevertheless, when we studied the influence of this variable on seronegative drug users we did not observe any differences between subjects in MMP and in period of abstinence in any of the tasks applied. These findings reveal that continuing in MMP makes the seropositive subjects more vulnerable neuropsychologically, but do not allow us to consider the use of methadone in itself as a risk factor for neuropsychological disturbances, inasmuch as we have not observed its influence in the group of seronegative drug users. Therefore we can consider it to be a risk factor for neuropsychological disturbances only in seropositive subjects.Not only can the influence of the current situation as regards drug consumption on the neuropsychological performance of seropositive subjects be estimated by the differences observed in the two groups of drug users, but also important information can be provided by the comparison of the groups, taking into consideration not only seropositivity but also their situation regarding drug consumption. In this respect we noted that seropositive subjects in MMP showed a poorer performance than seronegative subjects in MMP and in period of abstinence, whereas the performance of seropositive subjects in abstinence is similar to that of seronegative subjects in MMP and in abstinence.The interpretation of these results leads us to think that staying in MMP can be considered a risk factor for neuropsychological disturbances in seropositive subjects owing to the fact that seropositive subjects in MMP are those that show the poorest performance. These findings are in agreement with those studies that show a negative effect of current drug consumption on cognitive function (<a class="elsevierStyleCrossRefs" href="#bib0110">Egan, Deary, & Brettle, 1996; Grassi et al., 1995; Rodríguez, 2000; Vázquez-Justo et al., 2000</a>).While we identified methadone use as a risk factor in seropositive subjects, our results also reveal that giving up drugs seems to have a protective effect against the presence of neuropsychological disturbances associated with HIV. Once again we only identified its protective effect in seropositive subjects. This leads us to think that the situation with respect to drug consumption cannot in itself be considered a factor of risk or protection in the face of neuropsychological disturbances, inasmuch as its effect is only observed in seropositive subjects. We think that its influence may be due to a cumulative effect or to the effect of interaction with seropositivity. In any case, our data do not allow us to establish a causal relationship between the use of methadone and a poor neuropsychological performance, owing to the fact that, besides the direct effects of the substance on the organism, there could be other indirect effects related to lifestyle and/or the polyconsumption pattern so characteristic of the subjects in MMP.This article shows some limitations, while assessment tools are widely used in other similar studies may have been advisable to include tests that deepen in very subtle aspects of cognitive change in the evolution of individuals in this type of methadone programmes, such as tests to discriminate processing speed, decision making, problem solving and reaction times. However it is appropriate to use batteries for attention and inhibitory control function that it was used in the sample. In addition, the sample size is not so broad as to allow conclusive findings but is interesting to continue this line of research.Furthermore, the mechanisms by which the use of methadone makes a seropositive subject more vulnerable neuropsychologically remain to be determined. We posit, as a hypothesis to be confirmed in future studies, that the underlying mechanism may be related to the immune system, in which these two factors, seropositivity and methadone consumption, could be acting together and altering cognitive functioning in a way as yet unexplained.To sum up, our results lead us to point out that there are certain factors that make the seropositive subject neuropsychologically vulnerable, regardless of seropositivity. We have identified some risk factors for seropositive drug users whose effects are not seen in seronegative drug users, such as the use of methadone. On the other hand, we identified two factors that protect against neuropsychological manifestations such as giving up drugs. The identification of these factors allows us to propose that seropositivity is not sufficient to explain the neuropsychological disturbances of seropositive drug users, suggesting that these may be of a multifactorial nature.Hence, we feel that this research helps to clarify the lack of agreement in the literature on the presence of neuropsychological disturbances in seropositive subjects, thus revealing the importance of considering the neuropsychological effect of multiple factors which, finally, are those that will determine the presence of these cognitive deficits inasmuch as they coexist with HIV itself. This lack of control over them in the research designs could explain, at least partly, the disparity of results in the abundant literature to this respect. Moreover, this study helps to outline the characteristics of the more neuropsychologically vulnerable seropositive subjects. The purpose of determining a profile of neuropsychological vulnerability in seropositive subjects is early detection with a view to preventing the manifestation of neuropsychological disturbances, and offer swift, suitable treatment. Furthermore, it can be used for planning intervention strategies not only in health or work behaviour but also in specific aspects related to infection." "textoCompletoSecciones" => array:1 [ "secciones" => array:8 [ 0 => array:3 [ "identificador" => "xres700425" "titulo" => "Abstract" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0005" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec710017" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres700426" "titulo" => "Resumen" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0010" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec710018" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Method" ] 5 => array:3 [ "identificador" => "sec0010" "titulo" => "Results" "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0015" "titulo" => "Characteristics of the Sample" ] 1 => array:2 [ "identificador" => "sec0020" "titulo" => "Influence of the situation with respect to drug use" ] ] ] 6 => array:2 [ "identificador" => "sec0025" "titulo" => "Discussion" ] 7 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2015-01-28" "fechaAceptado" => "2015-06-24" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec710017" "palabras" => array:5 [ 0 => "HIV infection" 1 => "Neuropsychological performance" 2 => "Intravenous drug users" 3 => "Cognitive reserve" 4 => "Methadone maintenance" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec710018" "palabras" => array:5 [ 0 => "Infección por VIH" 1 => "Rendimiento neuropsicológico" 2 => "Consumidores de drogas por vía intravenosa" 3 => "Reserva cognitiva" 4 => "Tratamiento de mantenimiento con metadona" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "Although highly active antiretroviral therapy (HAART) has improved survival rates of HIV patients, HIV-associated neurocognitive disorders (HAND) still exist in a highly prevalent group of persons with this disease. In this study we seek to evaluate the influence of drug use in the neuropsychological performance of seropositive drug users. We carried out an extensive neuropsychological evaluation and compared the performance of seropositive drug users (n=90) with that of a control group of seronegative drug users (n=48). The results reveal that methadone maintenance programmes can make the seropositive subject neuropsychologically vulnerable. Likewise, we found that giving up drugs have a protective effect in the presence of neuropsychological alterations associated with HIV. These findings lead us to suggest that seropositivity is not sufficient to explain the neuropsychological alterations of seropositive drug users, noting that these alterations are multifactorial." ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "Aunque la terapia antirretroviral de gran actividad (TARGA) ha mejorado los índices de supervivencia de los pacientes infectados por el VIH, los trastornos neurocognitivos asociados con el VIH (TNAV) todavía existen en un grupo de personas altamente prevalente a esta enfermedad. En este estudio buscamos evaluar la influencia del consumo de drogas en el rendimiento neuropsicológico de los usuarios de drogas seropositivos. Llevamos a cabo una amplia evaluación neuropsicológica, y el rendimiento de los usuarios de drogas seropositivos (n=90) se comparó con la de un grupo control de usuarios de drogas seronegativos (n=48). Los resultados demuestran que los programas de tratamiento de mantenimiento con metadona pueden convertir en vulnerable a nivel neuropsicológico al individuo seropositivo. Asimismo, descubrimos que abandonar las drogas provoca un efecto protector frente a la existencia de alteraciones neuropsicológicas asociadas con el VIH. Estos resultados nos llevan a sugerir que la seropositividad no basta para explicar las alteraciones neuropsicológicas de los usuarios de drogas seropositivos, ya que estas alteraciones al parecer son multifactoriales." ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "Best Article of the Issue Award." ] ] "multimedia" => array:3 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1383 "Ancho" => 3397 "Tamanyo" => 277884 ] ] "descripcion" => array:1 [ "en" => "Neuropsychological Z scores for groups. Influence of the situation with respect to drug use." ] ] 1 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at1" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:3 [ "leyenda" => "Numbers express means and (standard deviations) for quantitative variables and percentages for qualitative variables." "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td-with-role" title="table-head ; entry_with_role_rowhead " align="left" valign="top" scope="col">n=138 \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " colspan="2" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">HIV+ n=90</th><th class="td" title="table-head " colspan="2" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">HIV− n=48</th><th class="td" title="table-head " rowspan="2" align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Statistic</th><th class="td" title="table-head " rowspan="2" align="left" valign="top" scope="col" style="border-bottom: 2px solid black">p</th><th class="td" title="table-head " rowspan="2" align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Bonferroni posthoc</th></tr><tr title="table-row"><th class="td" title="table-head " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Drug-free treatment programme (FTP) n=48 \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Methadone maintenance programme (MMP) n=42 \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Drug-free treatment programme (FTP) n=27 \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Methadone maintenance programme (MMP) n=21 \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Age (years) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">33 (4.8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">34 (5.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">26 (3.8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">32 (4.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">F=18.7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><.05 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">FTP/HIV+>FTP/HIV; MMP/HIV+>FTP/HIV−; FTP/HIV− \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Education (years) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">10 (3.4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">10 (2.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">10.5 (2.7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">10 (2.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">F=0.166 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">>.05 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="5" align="left" valign="top">Occupational attainment</td><td class="td" title="table-entry " rowspan="3" align="left" valign="top">χ2=15.20</td><td class="td" title="table-entry " rowspan="3" align="char" valign="top">.005<a class="elsevierStyleCrossRef" href="#tblfn0005">*</a></td><td class="td" title="table-entry " rowspan="3" align="left" valign="top">–</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Unemployed \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">24 (50) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">36 (85.7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">13 (48.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">13 (61.9) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Employed \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">24 (50) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">6 (14.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">14 (51.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">8 (38.1) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="8" align="left" valign="top"></td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="5" align="left" valign="top">Economic level</td><td class="td" title="table-entry " rowspan="3" align="left" valign="top">χ2=1.339</td><td class="td" title="table-entry " rowspan="3" align="char" valign="top">.720</td><td class="td" title="table-entry " rowspan="3" align="left" valign="top">–</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Low \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">15 (32.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">18 (43.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">10 (37) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">7 (33.3) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Middle \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">31 (67.4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">23 (56.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">17 (63) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">14 (66.7) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="8" align="left" valign="top"></td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="5" align="left" valign="top">Manual dominance</td><td class="td" title="table-entry " rowspan="3" align="left" valign="top">χ2=2.997</td><td class="td" title="table-entry " rowspan="3" align="char" valign="top">.392</td><td class="td" title="table-entry " rowspan="3" align="left" valign="top">–</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Right \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">44 (93.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">35 (89.7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">27 (100) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">19 (90.5) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Left \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3 (6.4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">4 (10.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2 (9.5) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="8" align="left" valign="top"></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Addiction time (years) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">8.7 (3.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">10.7 (4.7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">6.1 (3.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">10.9 (4.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">F=8.603 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><.05 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">MMP/HIV+>FTP/HIV−; FTP/HIV− \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Age at onset drug use \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">16 (2.7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">16 (2.7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">15 (3.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">16 (3.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">F=0.405 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">>.05 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Months of abstinence \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">64.04 (41.22) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">11.69 (8.89) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">t=6.496 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.000<a class="elsevierStyleCrossRef" href="#tblfn0005">*</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Months in Methadone Maintenance Programme \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">30.81 (34.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">23.38 (26.8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">t=939 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.392 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">CD4 count \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">358 (318.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">298 (315.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">t=851 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.397 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="8" align="left" valign="top"></td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="5" align="left" valign="top">Plasma viral loads</td><td class="td" title="table-entry " rowspan="3" align="left" valign="top">χ2=0.254</td><td class="td" title="table-entry " rowspan="3" align="char" valign="top">.614</td><td class="td" title="table-entry " rowspan="3" align="left" valign="top">–</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Detectable \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">18 (52.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">12 (60) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Undetectable \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">16 (47.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">8 (40) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="8" align="left" valign="top"></td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="5" align="left" valign="top">Antirretroviral therapy</td><td class="td" title="table-entry " rowspan="3" align="left" valign="top">χ2=0.068</td><td class="td" title="table-entry " rowspan="3" align="char" valign="top">.795</td><td class="td" title="table-entry " rowspan="3" align="left" valign="top">–</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Receiving \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">27 (60) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">22 (62.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">No Receiving \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">18 (40) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">13 (37.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1149857.png" ] ] ] "notaPie" => array:1 [ 0 => array:3 [ "identificador" => "tblfn0005" "etiqueta" => "*" "nota" => "p<.0." ] ] ] "descripcion" => array:1 [ "en" => "Group comparisons on demographic and clinical variables." ] ] 2 => array:8 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at2" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " rowspan="2" align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Neuropsychological test</th><th class="td" title="table-head " colspan="2" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">HIV+</th><th class="td" title="table-head " colspan="2" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">HIV−</th><th class="td" title="table-head " rowspan="2" align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Statistic</th><th class="td" title="table-head " rowspan="2" align="left" valign="top" scope="col" style="border-bottom: 2px solid black">p</th><th class="td" title="table-head " rowspan="2" align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Bonferroni posthoc</th></tr><tr title="table-row"><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Drug-free treatment programme (FTP) n=48 \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Methadone maintenance programme (MMP) n=42 \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Drug-free treatment programme (FTP) n=27 \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Methadone maintenance programme (MMP) n=21 \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry " colspan="8" align="left" valign="top">Neuropsychological domains</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="8" align="left" valign="top">Attention</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">VSAT \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">123.48 (32.42) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">104.36 (35.37) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">140.22 (18.86) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">132.67 (27.14) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">F=8.78 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><.05 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">FTP/HIV+>MMP/HIV+; MMP/HIV+ MMP/HIV+ \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="8" align="left" valign="top"></td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="8" align="left" valign="top">Language</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">WAIS: comprehension \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">13.98 (3.76) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">14.10 (4.05) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">17.37 (2.84) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">16.81 (3.56) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">F=7.52 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><.05 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">FTP/HIV+ FTP/HIV+ MMP/HIV+ MMP/HIV+/MMP/HIV− \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Verbal fluency \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">29.69 (9.03) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">26.93 (11.04) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">34.00 (7.17) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">33.71 (9.67) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">F=4.11 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><.05 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">MMP/HIV+ \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Boston naming \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">53.38 (4.97) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">52.28 (5.43) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">54.44 (3.00) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">53.76 (2.39) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">F=1.35 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">>.05 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="8" align="left" valign="top"></td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="8" align="left" valign="top">Memory</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">AVLT, 5–6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.85 (2.08) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.93 (1.84) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2.07 (2.00) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2.67 (2.11) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">F=0.87 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">>.05 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">AVLT, total \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">42.38 (8.07) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">37.24 (10.98) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">45.19 (7.68) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">49.00 (6.72) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">F=9.60 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><.05 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">FTP/HIV +>MMP/HIV+; FTP/HIV + MMP/HIV+ MMP/HIV+ \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">BVRT, correct \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">6.90 (1.80) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">5.55 (2.10) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">7.15 (1.03) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">6.76 (1.79) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">F=6.14 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><.05 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">FTP/HIV +>MMP/HIV+; MMP/HIV+ \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">BVRT, errors \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">4.83 (3.17) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">7.81 (4.29) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">4.11 (1.85) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">4.71 (3.12) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">F=9.15 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><.05 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">FTP/HIV+ MMP/HIV+ MMP/HIV+ \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">ROCF: copy \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">30.89 (3.26) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">30.28 (4.24) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">32.79 (2.43) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">31.59 (3.33) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">F=3.08 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><.05 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">MMP/HIV+ \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">ROCF: delay \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">15.51 (6.30) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">14.45 (5.03) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">18.81 (6.68) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">17.38 (5.63) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">F=3.42 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><.05 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">MMP/HIV+ \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="8" align="left" valign="top"></td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="8" align="left" valign="top">Visual-motor integration</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">WAIS: block design \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">33.25 (8.53) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">28.90 (8.76) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">37.15 (7.41) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">33.57 (7.14) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">F=5.79 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><.05 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">MMP/HIV+ \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">WAIS: object assembly \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">30.60 (7.38) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">26.55 (9.24) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">33.74 (6.18) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">32.10 (6.83) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">F=5.49 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><.05 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">MMP/HIV+ MMP/HIV+ \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="8" align="left" valign="top"></td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="8" align="left" valign="top">Motor coordination</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Purdue: dominant \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">13.85 (2.39) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">12.79 (2.48) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">15.15 (1.73) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">14.52 (2.16) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">F=6.61 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><.05 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">MMP/HIV+ MMP/HIV+ \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Purdue: nondominant \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">12.90 (2.42) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">12.14 (2.04) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">14.22 (1.69) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">13.14 (1.56) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">F=5.65 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><.05 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">MMP/HIV+ \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Finger: dominant \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">43.62 (11.63) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">39.85 (9.58) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">49.05 (5.03) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">46.00 (5.99) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">F=5.83 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><.05 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">MMP/HIV+ \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Finger: nondominant \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">40.32 (9.02) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">34.66 (8.49) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">43.33 (5.49) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">39.47 (6.94) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">F=7.25 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><.05 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">FTP/HIV + MMP/HIV+ \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="8" align="left" valign="top"></td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="8" align="left" valign="top">Executive functions</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">WAIS: similarities \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">13.63 (4.53) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">12.02 (5.60) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">16.63 (3.22) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">16.48 (3.25) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">F=7.89 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><.05 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">FTP/HIV + MMP/HIV+ MMP/HIV+ \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">WAIS: direct digit span \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">6.15 (1.05) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">5.62 (1.27) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">6.44 (1.15) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">6.48 (1.03) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">F=4.10 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><.05 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">MMP/HIV+ MMP/HIV+ \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">WAIS: indirect digit span \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">4.35 (1.08) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3.93 (0.95) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">4.41 (1.05) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">4.24 (1.26) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">F=1.58 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">>.05 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">WAIS: digit symbol \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">48.00 (11.66) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">37.96 (15.40) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">53.78 (9.22) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">48.38 (14.14) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">F=9.31 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><.05 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">FTP/HIV +>FTP/HIV−; MMP/HIV+ MMP/HIV+ \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Trails A \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">40.50 (15.75) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">52.69 (25.44) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">33.35 (10.12) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">38.52 (18.05) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">F=6.73 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><.05 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">FTP/HIV + MMP/HIV+>FTP/HIV−; MMP/HIV+>MMP/HIV− \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Trails B \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">84.60 (34.63) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">138.86 (79.74) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">79.41 (27.30) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">82.33 (32.81) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">F=11.57 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><.05 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">FTP/HIV+ MMP/HIV+>FTP/HIV−; MMP/HIV+>MMP/HIV− \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Stroop 1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">99.83 (15.75) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">90.52 (21.85) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">105.85 (11.18) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">104.81 (11.86) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">F=6.02 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><.05 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">FTP/HIV +>FTP/HIV−; MMP/HIV+ MMP/HIV+ \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Stroop 2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">66.25 (12.97) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">58.64 (17.77) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">70.56 (11.75) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">68.38 (11.24) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">F=4.71 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><.05 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">MMP/HIV+ MMP/HIV+ \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Stroop 3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">39.94 (10.12) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">32.12 (13.80) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">41.11 (9.32) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">40.14 (8.28) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">F=5.45 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><.05 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">FTP/HIV+>FTP/HIV−; MMP/HIV+ MMP/HIV+ \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Stroop: interference \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.23 (7.62) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">−2.85 (7.41) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.34 (7.74) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">−1.13 (5.84) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">F=1.64 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">>.05 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">WCST – number of categories \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">4.29 (1.80) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3.00 (2.13) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">5.33 (1.07) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">4.81 (1.81) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">F=10.65 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><.05 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">FTP/HIV+>FTP/HIV−; MMP/HIV+ MMP/HIV+ \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">WCST – learning to learn \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">−6.18 (10.25) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">−6.31 (9.39) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">−2.12 (5.35) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">−0.04 (5.60) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">F=3.31 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">>.05 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">WCST-% perseverative errors \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">18.85 (11.64) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">23.06 (14.45) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">13.30 (6.59) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">13.59 (8.65) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">F=5.35 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><.05 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">MMP/HIV+>FTP/HIV−; MMP/HIV+>MMP/HIV− \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">WCST-% nonperseverative errors \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">15.14 (9.39) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">19.59 (12.52) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">14.30 (7.26) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">15.65 (13.77) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">F=1.80 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">>.05 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">WCST-failure to maintain set \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.83 (1.10) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.07 (1.39) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.63 (0.79) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.19 (1.54) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">F=1.15 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">>.05 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">WCST-% conceptual level responses \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">55.01 (22.63) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">42.59 (22.07) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">63.79 (16.31) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">64.42 (19.01) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">F=7.94 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><.05 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">FTP/HIV+>FTP/HIV−; MMP/HIV+ MMP/HIV+ \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">WCST-% perseverative responses \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">21.66 (14.67) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">26.76 (19.26) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">15.13 (8.86) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">13.13 (6.94) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">F=5.71 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><.05 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">MMP/HIV+>FTP/HIV−; MMP/HIV+>MMP/HIV− \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="8" align="left" valign="top"></td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="8" align="left" valign="top">Cognitive reserve</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">WAIS: vocabulary \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">43.92 (11.61) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">41.33 (13.20) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">48.67 (7.62) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">51.05 (10.85) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">F=4.50 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top"><.05 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">MMP/HIV+ \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1149858.png" ] ] ] ] "descripcion" => array:1 [ "en" => "Group comparisons on neuropsychological measures (Mean and SD) influence of the situation with respect to drug use." ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:70 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "Albein-Urios et al., 2012" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Comparison of impulsivity and working memory in cocaine addiction and pathological gambling: Implications for cocaine-induced neurotoxicity" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "N. 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Función neuropsicológica en el tratamiento de mantenimiento con metadona en pacientes con VIH

Enrique Vázquez-Justoa,b, Esperanza Vergara-Moraguesc,d,

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esperanza.vergara@unir.net

Corresponding author.

, Adolfo Piñón Blancoa,b, Carlos Guillén Gestosoe, Miguel Pérez-Garcíaf,g

a Portucalense Institute of Neuropsychology, Universidade Portucalense, Portugal

b Policínico Êbam, Poio, Pontevedra, Spain

c Departamento de Educación y Psicobiologia. Universidad Internacional de la Rioja (UNIR), Spain

d Clinic Unit of Infectious Diseases, Clinical Hospital of Puerto Real (Cádiz), Spain

e Faculty of Labour, University of Cádiz, Spain

f Centro de Investigación Mente, Cerebro y Comportamiento (CIMCYC), University of Granada (UGR), Spain

g Centro de Investigaciones Biomédicas en Red de Salud Mental, CIBERSAM, University of Granada (UGR), Spain

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          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Neuropsychological <span class="elsevierStyleItalic">Z</span> scores for groups&#46; Influence of the situation with respect to drug use&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">The human immunodeficiency virus &#40;HIV&#41; infection is associated with a wide range of neuropsychological deficits&#58; psychomotor functioning&#44; information processing speed&#44; attention&#44; executive functioning&#44; information processing speed&#44; attention&#44; executive functioning and working memory &#40;<a class="elsevierStyleCrossRefs" href="#bib0010">Al-Khindi&#44; Zakzanis&#44; &#38; Van Gorp&#44; 2011&#59; Blackstone et al&#46;&#44; 2012&#59; Cysique&#44; Marruf&#44; &#38; Brew&#44; 2006&#59; Heaton et al&#46;&#44; 2011</a>&#59;<a class="elsevierStyleCrossRef" href="#bib0305">V&#225;zquez-Justo&#44; Pi&#241;&#243;n-Blanco&#44; Vergara-Moragues&#44; Guill&#233;n-Gestoso&#44; &#38; P&#233;rez-Garc&#237;a&#44; 2014</a>&#41;&#46; The nature of these deficits is compatible with an affection of the frontal-subcortical brain disturbances&#44; including cerebral metabolite abnormalities &#40;<a class="elsevierStyleCrossRefs" href="#bib0080">Cohen et al&#46;&#44; 2010&#59; Paul et al&#46;&#44; 2008</a>&#41; and white matter damage &#40;<a class="elsevierStyleCrossRefs" href="#bib0075">Coughlin et al&#46;&#44; 2014&#59; Fellows&#44; Byrd&#44; &#38; Morgello&#44; 2014</a>&#41; and their prevalence varies considerably &#40;<a class="elsevierStyleCrossRefs" href="#bib0085">Cohen et al&#46;&#44; 2015&#59; Heaton et al&#46;&#44; 2010&#59; Woods&#44; Moore&#44; Weber&#44; &#38; Grant&#44; 2009</a>&#41;&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">The variability of the data on the prevalence of these alterations leads us to consider&#44; as <a class="elsevierStyleCrossRef" href="#bib0020">Anand&#44; Springer&#44; Copenhaver&#44; and Altice &#40;2010&#41;</a> put forward&#44; that these may be modulated by the coexistence of factors other than HIV&#46; No definitive risk factors are yet available to indicate the development of these neuropsychological alterations and&#44; bearing in mind that the presence of cognitive disturbances is a risk factor of early death in all stages of the infection &#40;<a class="elsevierStyleCrossRefs" href="#bib0185">Lescure et al&#46;&#44; 2011&#59; Sevigny et al&#46;&#44; 2007</a>&#41;&#44; there is a pressing need to determine those factors&#44; either related or foreign to HIV&#44; which help to explain the intra-group differences that exist and which may also be associated with the development and progression of the dysfunction &#40;<a class="elsevierStyleCrossRefs" href="#bib0020">Anand et al&#46;&#44; 2010&#59; Byrd et al&#46;&#44; 2011&#59; Mu&#241;oz-Moreno et al&#46;&#44; 2008</a>&#41;&#46; The identification of these risk factors will help us to outline the characteristics of the seropositive subjects who are neuropsychologically more vulnerable&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Research dealing with this sphere of work has mainly studied the influence of variables related to the infection&#44; such as the stage of infection &#40;<a class="elsevierStyleCrossRefs" href="#bib0265">Selnes et al&#46;&#44; 1997&#59; Spudich &#38; Ances&#44; 2015</a>&#41;&#44; the level of immunosuppression &#40;<a class="elsevierStyleCrossRefs" href="#bib0125">Farinpour et al&#46;&#44; 2000&#59; Grassi&#44; Perin&#44; Borlla&#44; &#38; Mangoni&#44; 1999</a>&#41;&#44; the combined effects of HIV infection and APOE ¿4 may lead to greater cognitive deficits&#44; especially in those with greater neuroinflammation &#40;<a class="elsevierStyleCrossRef" href="#bib0065">Chang&#44; Connaghan&#44; Wei&#44; &#38; Li&#44; 2014</a>&#41; and the viral load &#40;<a class="elsevierStyleCrossRefs" href="#bib0115">Ellis et al&#46;&#44; 1997&#59; Mu&#241;oz-Moreno et al&#46;&#44; 2008&#59; Stankoff et al&#46;&#44; 1999</a>&#41;&#46; However&#44; they have also dealt with determining the influence of other variables such as depressed mood &#40;<a class="elsevierStyleCrossRefs" href="#bib0130">Fellows et al&#46;&#44; 2014&#59; V&#225;zquez-Justo&#44; Rodr&#237;guez-&#193;lvarez&#44; &#38; Carro-Ramos&#44; 2003&#59; V&#225;zquez-Justo&#44; Rodr&#237;guez &#193;lvarez&#44; &#38; Ferraces Otero&#44; 2003</a>&#41;&#44; history of neurological pathology &#40;<a class="elsevierStyleCrossRef" href="#bib0175">Hestad&#44; Updike&#44; Selnes&#44; &#38; Royal III&#44; 1995</a>&#41; and of psychiatric pathology &#40;<a class="elsevierStyleCrossRef" href="#bib0030">Baldeweg et al&#46;&#44; 1997</a>&#41;&#59; variables related to drug use &#40;<a class="elsevierStyleCrossRefs" href="#bib0140">Garc&#237;a-Torres&#44; Vergara-Moragues&#44; Pi&#241;&#243;n-Blanco&#44; &#38; P&#233;rez-Garc&#237;a&#44; 2015&#59; Rodr&#237;guez&#44; 2000&#59; V&#225;zquez-Justo&#44; Rodr&#237;guez &#193;lvarez&#44; &#38; Rodr&#237;guez Salgado&#44; 2000</a>&#59; Vergara-Moragues&#44; Vergara de Campos&#44; &#38; Gir&#243;n-Gonz&#225;lez&#44; 2008&#41;&#44; high psychosocial stress and lower socioeconomic status &#40;<a class="elsevierStyleCrossRef" href="#bib0255">Rubin et al&#46;&#44; 2015</a>&#41; and educational level &#40;<a class="elsevierStyleCrossRef" href="#bib0260">Satz et al&#46;&#44; 1993</a>&#41;&#46; The findings of these studies reveal that the neuropsychological performance of seropositive subjects may vary according to their situation with respect to each of these variables&#44; although the results are not consistent&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">We know that HIV infection in drug users is associated with neuropsychological alterations that cannot be attributed to the history of drug abuse &#40;<a class="elsevierStyleCrossRefs" href="#bib0315">V&#225;zquez-Justo et al&#46;&#44; 2003a&#44; 2003b&#59; Vergara-Moragues&#44; Vergara de Campos&#44; &#38; Gir&#243;n-Gonz&#225;lez&#44; 2010</a>&#41;&#46; When evaluating the neuropsychological performance of seropositive drug users&#44; a variable that may affect their performance is their current situation with respect to drug consumption&#44; i&#46;e&#46; whether they continue to use drugs or whether they are abstaining at the time of evaluation&#46; In this sense&#44; the current consumption of drugs is related to a poorer performance in neuropsychological tasks than abstinence &#40;<a class="elsevierStyleCrossRefs" href="#bib0025">Ardila&#44; Rosselli&#44; &#38; Strumwasser&#44; 1991&#59; Grassi et al&#46;&#44; 1995</a>&#41;&#46; The Methadone Maintenance Programmes &#40;MMP&#41; offer us a suitable framework for evaluating the neuropsychological consequences of the active consumption of opiates&#46; For example&#44; chronic crack cocaine use seems to disrupt general cognitive functioning &#40;MMSE&#41;&#44; verbal memory&#44; and attentional resources&#44; but findings suggest that some of these effects could be reversed by abstinence &#40;<a class="elsevierStyleCrossRef" href="#bib0095">De Oliveira et al&#46;&#44; 2009</a>&#41;&#46; In addition&#44; <a class="elsevierStyleCrossRef" href="#bib0325">V&#225;zquez-Justo et al&#46; &#40;2000&#41;</a> evaluated the cognitive functioning of drug users in MMP and noted a significantly poorer performance in these subjects as compared to those in abstinence&#46; Likewise&#44; <a class="elsevierStyleCrossRef" href="#bib0245">Rodr&#237;guez &#40;2000&#41;</a> pointed out that the rate of neuropsychological affection of seropositive subjects in MMP is double that of abstaining seropositive subjects&#44; observing greater difficulty in attention&#44; coordination and visual-motor speed&#44; memory&#44; conceptualisation and verbal fluency in the seropositive subjects in MMP than in those abstaining&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The aim of this study is not only to contribute to clarifying the effect of some factors in the neuropsychological performance of Spanish seropositive subjects but also to make progress in this line of research by providing evidence of the multifactorial nature of neuropsychological deterioration associated with HIV infection&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Method</span><p id="par0030" class="elsevierStylePara elsevierViewall">In order to carry out this research&#44; a sample comprising 138 male volunteers was used&#46; All subjects provided written informed consent&#46; These subjects were distributed in two groups&#58; one group of drug users with HIV infection &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>90&#41;&#44; referred to as seropositive &#40;HIV&#43;&#41;&#44; of this group of 48 subjects were on the drug-free treatment programme and 42 were on methadone maintenance programme&#46; A second group of controls &#40;HIV&#8722;&#41;&#44; formed by HIV seronegative drug users &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>48&#41;&#44; of this group of 27 subjects were on the drug-free treatment programme and 21 were on methadone maintenance programme&#46; The drug dependent subjects were recruited in the HIV services at Hospitals and at units for the care of drug users in Galicia &#40;Spain&#41;&#46; To be included in the study the intravenous drug users should be diagnosed as opiate-dependent according to DSM-IV criteria&#46; Before starting on heroin&#44; all had taken cannabis&#44; amphetamines&#44; cocaine&#44; or barbiturics&#44; either simultaneously or consecutively&#44; without becoming dependents on any of these other drugs&#44; and primary drug of choice was cannabis or alcohol for all the drug user subjects&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Diagnosis of seropositivity and the classification of the subjects regarding phase of infection was carried out according to standard procedures &#40;<a class="elsevierStyleCrossRef" href="#bib0060">Centers for Disease Control &#91;CDC&#93;&#44; 1992</a>&#41;&#44; and was based on the medical report from the hospitals where the subjects were recruited&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Those subjects who presented&#44; or had presented&#44; neurological or medical pathologies that could affect the CNS&#44; including HIV-associated dementia&#44; psychiatric disturbances &#40;psychotic symptoms&#41;&#44; history of craneo-encephalic trauma requiring hospitalization owing to neurological complication&#44; and antisocial personality disorder according to DSM-IV criteria &#40;<a class="elsevierStyleCrossRef" href="#bib0015">American Psychiatric Association&#44; 2002</a>&#41; were excluded from the study&#46; Finally&#44; taking as a basis the report from the units for the care of drug addicts&#44; those dependent on drugs who were currently consuming psychotropic substances &#40;illegal drugs or alcohol&#41; other than methadone were excluded&#46; In the other hand&#44; three months drug-free was required to be considered in abstinence&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Examination of each subject consisted of a semi-structured interview on socio-demographic&#44; clinical and toxicological aspects and a neuropsychological evaluation with a battery of tests designed for this study&#44; chosen for their validity and for having been shown to be sensitive to neuropsychological deterioration in HIV-infected patients in other studies&#46; The neuropsychological domains and tests and comprising the battery are as follows&#58;<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">1&#46;</span><p id="par0050" class="elsevierStylePara elsevierViewall">Attention</p><p id="par0055" class="elsevierStylePara elsevierViewall">Visual Search and Attention Test &#40;VSAT&#41; &#40;<a class="elsevierStyleCrossRef" href="#bib0300">Trenerry&#44; Crosson&#44; Beboe&#44; &#38; Leber&#44; 1990</a>&#41;&#46;</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">2&#46;</span><p id="par0060" class="elsevierStylePara elsevierViewall">Visual-motor integration&#58;</p><p id="par0065" class="elsevierStylePara elsevierViewall">Block Design and Object Assembly subtests of the Wechsler Adult Intelligence Scale &#8211; WAIS &#8211; &#40;<a class="elsevierStyleCrossRef" href="#bib0340">Wechsler&#44; 1999</a>&#41;&#46;</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">3&#46;</span><p id="par0070" class="elsevierStylePara elsevierViewall">Motor coordination&#58;</p><p id="par0075" class="elsevierStylePara elsevierViewall">Purdue Pegboard Test &#40;<a class="elsevierStyleCrossRef" href="#bib0290">Tiffin&#44; 1948</a>&#41;&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">Finger Tapper Test &#40;<a class="elsevierStyleCrossRef" href="#bib0230">Reitan&#44; 1979</a>&#41;&#46;</p></li><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">4&#46;</span><p id="par0085" class="elsevierStylePara elsevierViewall">Language&#58;</p><p id="par0090" class="elsevierStylePara elsevierViewall">Comprehension subtest of the Wechsler Adult Intelligence Scale &#8211; WAIS &#8211; &#40;<a class="elsevierStyleCrossRef" href="#bib0340">Wechsler&#44; 1999</a>&#41;&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">Verbal Fluency Test &#40;<a class="elsevierStyleCrossRef" href="#bib0035">Cuadrado&#44; Esteba-Castillo&#44; B&#246;hm&#44; Cejudo-Bol&#237;var&#44; &#38; Pe&#241;a-Casanova&#44; 2002</a>&#41;&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">Boston Naming Test &#40;<a class="elsevierStyleCrossRef" href="#bib0180">Kaplan&#44; Goodglass&#44; &#38; Weintraub&#44; 2001</a>&#41;&#46;</p></li><li class="elsevierStyleListItem" id="lsti0025"><span class="elsevierStyleLabel">5&#46;</span><p id="par0105" class="elsevierStylePara elsevierViewall">Memory&#58;</p><p id="par0110" class="elsevierStylePara elsevierViewall">Rey Auditory Verbal Learning Test &#8211; AVLT &#8211; &#40;<a class="elsevierStyleCrossRef" href="#bib0235">Rey&#44; 1964</a>&#41;&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">Rey Osterrieth Complex Figure &#8211; ROCF &#8211; &#40;<a class="elsevierStyleCrossRef" href="#bib0240">Rey&#44; 1987</a>&#41;&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">Benton Visual Retention Test &#8211; BVRT &#8211;&#58; Form C&#44; Administration A &#40;<a class="elsevierStyleCrossRef" href="#bib0040">Benton&#44; 1981</a>&#41;&#46;</p></li><li class="elsevierStyleListItem" id="lsti0030"><span class="elsevierStyleLabel">6&#46;</span><p id="par0125" class="elsevierStylePara elsevierViewall">Executive Functions&#58;</p><p id="par0130" class="elsevierStylePara elsevierViewall">Similarities&#44; Digit Span&#44; Digit Symbol subtests of the Wechsler Adult Intelligence Scale &#8211;WAIS &#8211; &#40;<a class="elsevierStyleCrossRef" href="#bib0340">Wechsler&#44; 1999</a>&#41;&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">Trail Making Test &#8211; TMT &#8211; &#40;<a class="elsevierStyleCrossRef" href="#bib0295">Tombaugh&#44; 2004</a>&#41;</p><p id="par0140" class="elsevierStylePara elsevierViewall">Stroop Test &#40;<a class="elsevierStyleCrossRef" href="#bib0145">Golden&#44; 1994</a>&#41;&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">Wisconsin Card Sorting Test &#8211; WCST &#8211; &#40;<a class="elsevierStyleCrossRef" href="#bib0160">Heaton&#44; Chelune&#44; Talley&#44; Kay&#44; &#38; Curtiss&#44; 2001</a>&#41;&#46;</p></li><li class="elsevierStyleListItem" id="lsti0035"><span class="elsevierStyleLabel">7&#46;</span><p id="par0150" class="elsevierStylePara elsevierViewall">Cognitive reserve&#58;</p><p id="par0155" class="elsevierStylePara elsevierViewall">Vocabulary subtest of the Wechsler Adult Intelligence Scale &#40;WAIS&#41; &#40;<a class="elsevierStyleCrossRef" href="#bib0340">Wechsler&#44; 1999</a>&#41;&#46;</p></li><li class="elsevierStyleListItem" id="lsti0040"><span class="elsevierStyleLabel">8&#46;</span><p id="par0160" class="elsevierStylePara elsevierViewall">Handeness&#58;</p><p id="par0165" class="elsevierStylePara elsevierViewall">Edinburgh Handedness Inventory &#40;<a class="elsevierStyleCrossRef" href="#bib0220">Oldfield&#44; 1971</a>&#41;&#46;</p></li></ul></p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Results</span><p id="par0170" class="elsevierStylePara elsevierViewall">Bearing in mind the objectives posed&#44; and in order to respond to them&#44; diverse data analyses were carried out using the SPSS statistical packet for Windows&#46;</p><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Characteristics of the Sample</span><p id="par0175" class="elsevierStylePara elsevierViewall">First&#44; an analysis of variance &#40;ANOVA&#41;&#44; chi squared or Student <span class="elsevierStyleItalic">t</span> test was performed when needed in order to determine whether there were differences between the seropositive and seronegative groups in the different socio-demographic and clinical variables&#46; Statistically significant differences were observed between the groups in age&#44; addiction time and months of abstinence&#46; <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> gives the mean scores and standard deviation in each group for these variables&#44; and the significant differences observed are indicated&#46; Moreover&#44; Chi-square analyses revealed significant differences between occupational attainments&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Influence of the situation with respect to drug use</span><p id="par0180" class="elsevierStylePara elsevierViewall">In order to determine the influence of the situation with respect to drug use in the neuropsychological performance of seropositive and seronegative drug users&#44; the drug users were divided into two groups according to whether they were abstaining from drug use &#40;Drug-free treatment programme &#91;FTP&#93;&#41; or were included in a Methadone Maintenance Programme &#40;MMP&#41;&#46;</p><p id="par0185" class="elsevierStylePara elsevierViewall">According to these results&#44; we found differences between the groups in tests that assess attention&#44; language&#44; memory&#44; visual-engine integration&#46; Motor coordination and executive functions&#46; In resume&#44; the FTP&#47;HIV-group performances the best and MMP&#47;HIV&#43; group obtained the worst scores&#46; <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a> shows the mean scores and standard deviations obtained for the four groups in each measurement&#44; and gives the significant differences noted in the &#8220;post hoc&#8221; multiple comparison tests&#46; <a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a> represents performance in the different neuropsychological tasks for each of the groups&#44; after the direct scores were transformed to <span class="elsevierStyleItalic">Z</span> scores and their direction corrected&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Discussion</span><p id="par0190" class="elsevierStylePara elsevierViewall">In this study we have attempted to be specially careful with some methodological aspects&#44; hence we followed the recommendations made in the literature in this respect &#40;<a class="elsevierStyleCrossRefs" href="#bib0050">Bornstein&#44; 1994&#59; Egan&#44; Deary&#44; &#38; Brettle&#44; 1992&#59; Newman&#44; Lunn&#44; &#38; Harrison&#44; 1995&#59; Stern&#44; 1994&#59; White&#44; Heaton&#44; Monsch&#44; &#38; The HNRC Group&#44; 1995</a>&#41;&#46; Along these lines&#44; we used a single risk group&#44; that of intravenous drug users&#44; taking into account that it has been pointed out that their neuropsychological performance could be different from that of other risk groups &#40;<a class="elsevierStyleCrossRef" href="#bib0105">Egan&#44; Brettle&#44; &#38; Goodwin&#44; 1992</a>&#41;&#59; the control groups have the same socio-demographic characteristics as the seropositive one &#40;<a class="elsevierStyleCrossRef" href="#bib0050">Bornstein&#44; 1994</a>&#41;&#59; the size of the sample is greater than one hundred subjects&#44; as recommended &#40;<a class="elsevierStyleCrossRef" href="#bib0215">Newman et al&#46;&#44; 1995</a>&#41;&#59; and&#44; finally&#44; the criteria for inclusion and exclusion were carefully selected&#44; without disregarding the importance of the representativeness of the sample &#40;<a class="elsevierStyleCrossRef" href="#bib0050">Bornstein&#44; 1994</a>&#41;&#46;</p><p id="par0195" class="elsevierStylePara elsevierViewall">In this research our aim was to study the group of intravenous drug users&#44; first&#44; because they represent the greatest percentage of HIV seropositive subjects and AIDS patients in Spain&#46; Secondly&#44; since most research studies use samples of homosexual and bisexual subjects&#44; their results are not applicable to the risk group of intravenous drug users&#46; With respect to sociodemographic characteristics and drug consumption history&#44; the sample used in this research can be said to be representative of the population of intravenous drug users in Spain &#40;<a class="elsevierStyleCrossRefs" href="#tbl0005">Tables 1 and 2</a>&#41;&#46;</p><p id="par0200" class="elsevierStylePara elsevierViewall">In order to be able to evaluate the neuropsychological consequences of HIV infection&#44; it is important to determine the influence of other variables&#44; whether related to the infection or not&#44; which are also associated with the development of neuropsychological disturbances and which may make the seropositive subject more vulnerable neuropsychologically &#40;<a class="elsevierStyleCrossRefs" href="#bib0085">Cohen et al&#46;&#44; 2015&#59; Rodr&#237;guez-&#193;lvarez &#38; V&#225;zquez-Justo&#44; 2002&#59; V&#225;zquez-Justo &#38; Rodr&#237;guez-&#193;lvarez&#44; 2002</a>&#59;&#41;&#46; One of the first studies in this line was that of <a class="elsevierStyleCrossRef" href="#bib0350">Wilkins et al&#46; &#40;1990&#41;</a>&#44; who observed a significant relation between the degree of neuropsychological deterioration and the presence of contaminating factors&#46; In our research we studied the influence of the current situation with respect to drug consumption on the neuropsychological performance of seropositive drug users&#44; in order to help to clarify the influence of that factor on their neuropsychological performance&#46;</p><p id="par0205" class="elsevierStylePara elsevierViewall">With respect to the influence of drug use&#44; several studies have disclosed that the use of drugs&#44; past or present&#44; can facilitate the appearance of neuropsychological disturbances &#40;<a class="elsevierStyleCrossRefs" href="#bib0005">Albein-Urios&#44; Marinez-Gonz&#225;lez&#44; Lozano&#44; Clark&#44; &#38; Verdejo-Garc&#237;a&#44; 2012&#59; Devlin et al&#46;&#44; 2012&#59; Ersche&#44; Clark&#44; London&#44; Robbins&#44; &#38; Sahakian&#44; 2006&#59; Fernandez-Serrano&#44; Perez-Garcia&#44; Schmidt Rio-Valle&#44; &#38; Verdejo-Garcia&#44; 2010&#59; L&#243;pez&#44; Ravindran&#44; Mrudula&#44; &#38; Priya&#44; 2014&#59; Lundqvist&#44; 2005&#59; Verdejo-Garc&#237;a et al&#46;&#44; 2012</a>&#41;&#46; Although there is no evidence that the use of opiates may be the direct cause of these disturbances&#44; the poly-toxicomania pattern these subjects usually present&#44; the high frequency of cranial traumatism and the nutritional deficiencies associated with their lifestyle makes them a risk group for neuropsychological impairment &#40;<a class="elsevierStyleCrossRefs" href="#bib0100">Devlin et al&#46;&#44; 2012&#59; Ersche et al&#46;&#44; 2006&#59; Lundqvist&#44; 2005&#59; Rodr&#237;guez-&#193;lvarez &#38; V&#225;zquez-Justo&#44; 2002</a>&#41;&#46;</p><p id="par0210" class="elsevierStylePara elsevierViewall">Bearing in mind that drug users who maintain current drug consumption showed poorer performance in neuropsychological tasks than those in abstinence &#40;<a class="elsevierStyleCrossRefs" href="#bib0150">Grassi et al&#46;&#44; 1995&#59; Verdejo-Garc&#237;a et al&#46;&#44; 2012</a>&#41;&#44; chronic heroin-dependent subjects had widespread disruption of white matter structural connectivity located mainly in anterior and superior regions of the brain &#40;<a class="elsevierStyleCrossRef" href="#bib0190">Lin et al&#46;&#44; 2013</a>&#41; and heroin users on MMP have low grey matter volume &#40;GMV&#41; in brain regions that are hypothesized to influence cognition and emotion&#44; and the GMV findings might be involved comorbid disorders in the MMP group &#40;<a class="elsevierStyleCrossRef" href="#bib0195">Lin et al&#46;&#44; 2012</a>&#41;&#44; we posit the interest of taking into account this situation when evaluating the neuropsychological performance of seropositive drug users&#46; Along this line the MMP offer a suitable setting for evaluating the neuropsychological consequences associated with the active consumption of opiates&#46;</p><p id="par0215" class="elsevierStylePara elsevierViewall">In this research we sought to study the effect of the situation regarding drug consumption in seropositive drug users&#46; These results reveal that the use of methadone is related to problems of attention&#44; language&#44; visual memory&#44; motor speed&#44; visual-motor integration and executives functions&#44; along the lines of the results obtained in the works cited &#40;<a class="elsevierStyleCrossRefs" href="#bib0245">Rodr&#237;guez&#44; 2000&#59; V&#225;zquez-Justo et al&#46;&#44; 2014</a>&#41;&#46; It has also been demonstrated&#44; that the duration of MMP was associated with declining diffusion tensor image &#40;DTI&#41; indices in the superior longitudinal fasciculus and para-hippocampus &#40;<a class="elsevierStyleCrossRef" href="#bib0195">Lin et al&#46;&#44; 2012</a>&#41;&#46;</p><p id="par0220" class="elsevierStylePara elsevierViewall">Nevertheless&#44; when we studied the influence of this variable on seronegative drug users we did not observe any differences between subjects in MMP and in period of abstinence in any of the tasks applied&#46; These findings reveal that continuing in MMP makes the seropositive subjects more vulnerable neuropsychologically&#44; but do not allow us to consider the use of methadone in itself as a risk factor for neuropsychological disturbances&#44; inasmuch as we have not observed its influence in the group of seronegative drug users&#46; Therefore we can consider it to be a risk factor for neuropsychological disturbances only in seropositive subjects&#46;</p><p id="par0225" class="elsevierStylePara elsevierViewall">Not only can the influence of the current situation as regards drug consumption on the neuropsychological performance of seropositive subjects be estimated by the differences observed in the two groups of drug users&#44; but also important information can be provided by the comparison of the groups&#44; taking into consideration not only seropositivity but also their situation regarding drug consumption&#46; In this respect we noted that seropositive subjects in MMP showed a poorer performance than seronegative subjects in MMP and in period of abstinence&#44; whereas the performance of seropositive subjects in abstinence is similar to that of seronegative subjects in MMP and in abstinence&#46;</p><p id="par0230" class="elsevierStylePara elsevierViewall">The interpretation of these results leads us to think that staying in MMP can be considered a risk factor for neuropsychological disturbances in seropositive subjects owing to the fact that seropositive subjects in MMP are those that show the poorest performance&#46; These findings are in agreement with those studies that show a negative effect of current drug consumption on cognitive function &#40;<a class="elsevierStyleCrossRefs" href="#bib0110">Egan&#44; Deary&#44; &#38; Brettle&#44; 1996&#59; Grassi et al&#46;&#44; 1995&#59; Rodr&#237;guez&#44; 2000&#59; V&#225;zquez-Justo et al&#46;&#44; 2000</a>&#41;&#46;</p><p id="par0235" class="elsevierStylePara elsevierViewall">While we identified methadone use as a risk factor in seropositive subjects&#44; our results also reveal that giving up drugs seems to have a protective effect against the presence of neuropsychological disturbances associated with HIV&#46; Once again we only identified its protective effect in seropositive subjects&#46; This leads us to think that the situation with respect to drug consumption cannot in itself be considered a factor of risk or protection in the face of neuropsychological disturbances&#44; inasmuch as its effect is only observed in seropositive subjects&#46; We think that its influence may be due to a cumulative effect or to the effect of interaction with seropositivity&#46; In any case&#44; our data do not allow us to establish a causal relationship between the use of methadone and a poor neuropsychological performance&#44; owing to the fact that&#44; besides the direct effects of the substance on the organism&#44; there could be other indirect effects related to lifestyle and&#47;or the polyconsumption pattern so characteristic of the subjects in MMP&#46;</p><p id="par0240" class="elsevierStylePara elsevierViewall">This article shows some limitations&#44; while assessment tools are widely used in other similar studies may have been advisable to include tests that deepen in very subtle aspects of cognitive change in the evolution of individuals in this type of methadone programmes&#44; such as tests to discriminate processing speed&#44; decision making&#44; problem solving and reaction times&#46; However it is appropriate to use batteries for attention and inhibitory control function that it was used in the sample&#46; In addition&#44; the sample size is not so broad as to allow conclusive findings but is interesting to continue this line of research&#46;</p><p id="par0245" class="elsevierStylePara elsevierViewall">Furthermore&#44; the mechanisms by which the use of methadone makes a seropositive subject more vulnerable neuropsychologically remain to be determined&#46; We posit&#44; as a hypothesis to be confirmed in future studies&#44; that the underlying mechanism may be related to the immune system&#44; in which these two factors&#44; seropositivity and methadone consumption&#44; could be acting together and altering cognitive functioning in a way as yet unexplained&#46;</p><p id="par0250" class="elsevierStylePara elsevierViewall">To sum up&#44; our results lead us to point out that there are certain factors that make the seropositive subject neuropsychologically vulnerable&#44; regardless of seropositivity&#46; We have identified some risk factors for seropositive drug users whose effects are not seen in seronegative drug users&#44; such as the use of methadone&#46; On the other hand&#44; we identified two factors that protect against neuropsychological manifestations such as giving up drugs&#46; The identification of these factors allows us to propose that seropositivity is not sufficient to explain the neuropsychological disturbances of seropositive drug users&#44; suggesting that these may be of a multifactorial nature&#46;</p><p id="par0255" class="elsevierStylePara elsevierViewall">Hence&#44; we feel that this research helps to clarify the lack of agreement in the literature on the presence of neuropsychological disturbances in seropositive subjects&#44; thus revealing the importance of considering the neuropsychological effect of multiple factors which&#44; finally&#44; are those that will determine the presence of these cognitive deficits inasmuch as they coexist with HIV itself&#46; This lack of control over them in the research designs could explain&#44; at least partly&#44; the disparity of results in the abundant literature to this respect&#46; Moreover&#44; this study helps to outline the characteristics of the more neuropsychologically vulnerable seropositive subjects&#46; The purpose of determining a profile of neuropsychological vulnerability in seropositive subjects is early detection with a view to preventing the manifestation of neuropsychological disturbances&#44; and offer swift&#44; suitable treatment&#46; Furthermore&#44; it can be used for planning intervention strategies not only in health or work behaviour but also in specific aspects related to infection&#46;</p></span></span>"
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              "titulo" => "Influence of the situation with respect to drug use"
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    "fechaRecibido" => "2015-01-28"
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            1 => "Neuropsychological performance"
            2 => "Intravenous drug users"
            3 => "Cognitive reserve"
            4 => "Methadone maintenance"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Although highly active antiretroviral therapy &#40;HAART&#41; has improved survival rates of HIV patients&#44; HIV-associated neurocognitive disorders &#40;HAND&#41; still exist in a highly prevalent group of persons with this disease&#46; In this study we seek to evaluate the influence of drug use in the neuropsychological performance of seropositive drug users&#46; We carried out an extensive neuropsychological evaluation and compared the performance of seropositive drug users &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>90&#41; with that of a control group of seronegative drug users &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>48&#41;&#46; The results reveal that methadone maintenance programmes can make the seropositive subject neuropsychologically vulnerable&#46; Likewise&#44; we found that giving up drugs have a protective effect in the presence of neuropsychological alterations associated with HIV&#46; These findings lead us to suggest that seropositivity is not sufficient to explain the neuropsychological alterations of seropositive drug users&#44; noting that these alterations are multifactorial&#46;</p></span>"
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        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Aunque la terapia antirretroviral de gran actividad &#40;TARGA&#41; ha mejorado los &#237;ndices de supervivencia de los pacientes infectados por el VIH&#44; los trastornos neurocognitivos asociados con el VIH &#40;TNAV&#41; todav&#237;a existen en un grupo de personas altamente prevalente a esta enfermedad&#46; En este estudio buscamos evaluar la influencia del consumo de drogas en el rendimiento neuropsicol&#243;gico de los usuarios de drogas seropositivos&#46; Llevamos a cabo una amplia evaluaci&#243;n neuropsicol&#243;gica&#44; y el rendimiento de los usuarios de drogas seropositivos &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>90&#41; se compar&#243; con la de un grupo control de usuarios de drogas seronegativos &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>48&#41;&#46; Los resultados demuestran que los programas de tratamiento de mantenimiento con metadona pueden convertir en vulnerable a nivel neuropsicol&#243;gico al individuo seropositivo&#46; Asimismo&#44; descubrimos que abandonar las drogas provoca un efecto protector frente a la existencia de alteraciones neuropsicol&#243;gicas asociadas con el VIH&#46; Estos resultados nos llevan a sugerir que la seropositividad no basta para explicar las alteraciones neuropsicol&#243;gicas de los usuarios de drogas seropositivos&#44; ya que estas alteraciones al parecer son multifactoriales&#46;</p></span>"
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          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Neuropsychological <span class="elsevierStyleItalic">Z</span> scores for groups&#46; Influence of the situation with respect to drug use&#46;</p>"
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                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td-with-role" title="table-head ; entry_with_role_rowhead " align="left" valign="top" scope="col"><span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>138&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " colspan="2" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">HIV&#43;<br><span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>90</th><th class="td" title="table-head  " colspan="2" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">HIV&#8722;<br><span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>48</th><th class="td" title="table-head  " rowspan="2" align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Statistic</th><th class="td" title="table-head  " rowspan="2" align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span></th><th class="td" title="table-head  " rowspan="2" align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Bonferroni posthoc</th></tr><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Drug-free treatment programme &#40;FTP&#41; <span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>48&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Methadone maintenance programme &#40;MMP&#41; <span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>42&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Drug-free treatment programme &#40;FTP&#41; <span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>27&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Methadone maintenance programme &#40;MMP&#41; <span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Age &#40;years&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">34 &#40;5&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">26 &#40;3&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">32 &#40;4&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">F</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>18&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;&#46;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">FTP&#47;HIV&#43;&#62;FTP&#47;HIV&#59;<br>MMP&#47;HIV&#43;&#62;FTP&#47;HIV&#8722;&#59;<br>FTP&#47;HIV&#8722;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Education &#40;years&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">10 &#40;3&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">10 &#40;2&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">10&#46;5 &#40;2&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">10 &#40;2&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">F</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;166&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#62;&#46;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="5" align="left" valign="top"><span class="elsevierStyleItalic">Occupational attainment</span></td><td class="td" title="table-entry  " rowspan="3" align="left" valign="top"><span class="elsevierStyleItalic">&#967;</span><span class="elsevierStyleSup">2</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>15&#46;20</td><td class="td" title="table-entry  " rowspan="3" align="char" valign="top">&#46;005<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">&#42;</span></a></td><td class="td" title="table-entry  " rowspan="3" align="left" valign="top">&#8211;</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Unemployed&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">24 &#40;50&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">36 &#40;85&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">13 &#40;48&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">13 &#40;61&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Employed&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">24 &#40;50&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6 &#40;14&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">14 &#40;51&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8 &#40;38&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="8" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="5" align="left" valign="top"><span class="elsevierStyleItalic">Economic level</span></td><td class="td" title="table-entry  " rowspan="3" align="left" valign="top"><span class="elsevierStyleItalic">&#967;</span><span class="elsevierStyleSup">2</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#46;339</td><td class="td" title="table-entry  " rowspan="3" align="char" valign="top">&#46;720</td><td class="td" title="table-entry  " rowspan="3" align="left" valign="top">&#8211;</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Low&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">15 &#40;32&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">18 &#40;43&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">10 &#40;37&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7 &#40;33&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Middle&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">31 &#40;67&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">23 &#40;56&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">17 &#40;63&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">14 &#40;66&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="8" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="5" align="left" valign="top"><span class="elsevierStyleItalic">Manual dominance</span></td><td class="td" title="table-entry  " rowspan="3" align="left" valign="top"><span class="elsevierStyleItalic">&#967;</span><span class="elsevierStyleSup">2</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>2&#46;997</td><td class="td" title="table-entry  " rowspan="3" align="char" valign="top">&#46;392</td><td class="td" title="table-entry  " rowspan="3" align="left" valign="top">&#8211;</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Right&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">44 &#40;93&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">35 &#40;89&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">27 &#40;100&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">19 &#40;90&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Left&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3 &#40;6&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4 &#40;10&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2 &#40;9&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="8" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Addiction time &#40;years&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8&#46;7 &#40;3&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">10&#46;7 &#40;4&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6&#46;1 &#40;3&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">10&#46;9 &#40;4&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">F</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>8&#46;603&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;&#46;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">MMP&#47;HIV&#43;&#62;FTP&#47;HIV&#8722;&#59; FTP&#47;HIV&#8722;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Age at onset drug use</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">16 &#40;2&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">16 &#40;2&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">15 &#40;3&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">16 &#40;3&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">F</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;405&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#62;&#46;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Months of abstinence</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">64&#46;04 &#40;41&#46;22&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11&#46;69 &#40;8&#46;89&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">t</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>6&#46;496&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;000<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">&#42;</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Months in Methadone Maintenance Programme</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">30&#46;81 &#40;34&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">23&#46;38 &#40;26&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">t</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>939&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;392&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>CD4 count&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">358 &#40;318&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">298 &#40;315&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">t</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>851&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#46;397&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="8" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="5" align="left" valign="top"><span class="elsevierStyleItalic">Plasma viral loads</span></td><td class="td" title="table-entry  " rowspan="3" align="left" valign="top"><span class="elsevierStyleItalic">&#967;</span><span class="elsevierStyleSup">2</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;254</td><td class="td" title="table-entry  " rowspan="3" align="char" valign="top">&#46;614</td><td class="td" title="table-entry  " rowspan="3" align="left" valign="top">&#8211;</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Detectable&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">18 &#40;52&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">12 &#40;60&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Undetectable&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">16 &#40;47&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8 &#40;40&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="8" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="5" align="left" valign="top"><span class="elsevierStyleItalic">Antirretroviral therapy</span></td><td class="td" title="table-entry  " rowspan="3" align="left" valign="top"><span class="elsevierStyleItalic">&#967;</span><span class="elsevierStyleSup">2</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;068</td><td class="td" title="table-entry  " rowspan="3" align="char" valign="top">&#46;795</td><td class="td" title="table-entry  " rowspan="3" align="left" valign="top">&#8211;</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Receiving&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">27 &#40;60&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">22 &#40;62&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>No Receiving&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">18 &#40;40&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">13 &#40;37&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " rowspan="2" align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Neuropsychological test</th><th class="td" title="table-head  " colspan="2" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">HIV&#43;</th><th class="td" title="table-head  " colspan="2" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">HIV&#8722;</th><th class="td" title="table-head  " rowspan="2" align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Statistic</th><th class="td" title="table-head  " rowspan="2" align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span></th><th class="td" title="table-head  " rowspan="2" align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Bonferroni posthoc</th></tr><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Drug-free treatment programme<br>&#40;FTP&#41;<br><span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>48&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Methadone maintenance programme<br>&#40;MMP&#41;<br><span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>42&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Drug-free treatment programme<br>&#40;FTP&#41;<br><span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>27&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Methadone maintenance programme<br>&#40;MMP&#41;<br><span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " colspan="8" align="left" valign="top"><span class="elsevierStyleBold">Neuropsychological domains</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="8" align="left" valign="top"><span class="elsevierStyleItalic">Attention</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>VSAT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">123&#46;48 &#40;32&#46;42&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">104&#46;36 &#40;35&#46;37&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">140&#46;22 &#40;18&#46;86&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">132&#46;67 &#40;27&#46;14&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">F</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>8&#46;78&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;&#46;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">FTP&#47;HIV&#43;&#62;MMP&#47;HIV&#43;&#59;<br>MMP&#47;HIV&#43;<br>MMP&#47;HIV&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="8" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="8" align="left" valign="top"><span class="elsevierStyleItalic">Language</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>WAIS&#58; comprehension&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">13&#46;98 &#40;3&#46;76&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">14&#46;10 &#40;4&#46;05&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">17&#46;37 &#40;2&#46;84&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">16&#46;81 &#40;3&#46;56&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">F</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>7&#46;52&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;&#46;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">FTP&#47;HIV&#43;<br>FTP&#47;HIV&#43;<br>MMP&#47;HIV&#43;<br>MMP&#47;HIV&#43;&#47;MMP&#47;HIV&#8722;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Verbal fluency&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">29&#46;69 &#40;9&#46;03&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">26&#46;93 &#40;11&#46;04&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">34&#46;00 &#40;7&#46;17&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">33&#46;71 &#40;9&#46;67&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">F</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>4&#46;11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;&#46;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">MMP&#47;HIV&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Boston naming&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">53&#46;38 &#40;4&#46;97&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">52&#46;28 &#40;5&#46;43&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">54&#46;44 &#40;3&#46;00&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">53&#46;76 &#40;2&#46;39&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">F</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#46;35&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#62;&#46;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="8" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="8" align="left" valign="top"><span class="elsevierStyleItalic">Memory</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>AVLT&#44; 5&#8211;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;85 &#40;2&#46;08&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;93 &#40;1&#46;84&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&#46;07 &#40;2&#46;00&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&#46;67 &#40;2&#46;11&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">F</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;87&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#62;&#46;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>AVLT&#44; total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">42&#46;38 &#40;8&#46;07&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">37&#46;24 &#40;10&#46;98&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">45&#46;19 &#40;7&#46;68&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">49&#46;00 &#40;6&#46;72&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">F</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>9&#46;60&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;&#46;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">FTP&#47;HIV &#43;&#62;MMP&#47;HIV&#43;&#59;<br>FTP&#47;HIV &#43;<br>MMP&#47;HIV&#43;<br>MMP&#47;HIV&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>BVRT&#44; correct&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6&#46;90 &#40;1&#46;80&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5&#46;55 &#40;2&#46;10&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7&#46;15 &#40;1&#46;03&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6&#46;76 &#40;1&#46;79&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">F</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>6&#46;14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;&#46;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">FTP&#47;HIV &#43;&#62;MMP&#47;HIV&#43;&#59;<br>MMP&#47;HIV&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>BVRT&#44; errors&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&#46;83 &#40;3&#46;17&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7&#46;81 &#40;4&#46;29&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&#46;11 &#40;1&#46;85&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&#46;71 &#40;3&#46;12&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">F</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>9&#46;15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;&#46;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">FTP&#47;HIV&#43;<br>MMP&#47;HIV&#43;<br>MMP&#47;HIV&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>ROCF&#58; copy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">30&#46;89 &#40;3&#46;26&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">30&#46;28 &#40;4&#46;24&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">32&#46;79 &#40;2&#46;43&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">31&#46;59 &#40;3&#46;33&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">F</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>3&#46;08&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;&#46;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">MMP&#47;HIV&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>ROCF&#58; delay&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">15&#46;51 &#40;6&#46;30&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">14&#46;45 &#40;5&#46;03&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">18&#46;81 &#40;6&#46;68&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">17&#46;38 &#40;5&#46;63&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">F</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>3&#46;42&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;&#46;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">MMP&#47;HIV&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="8" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="8" align="left" valign="top"><span class="elsevierStyleItalic">Visual-motor integration</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>WAIS&#58; block design&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">33&#46;25 &#40;8&#46;53&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">28&#46;90 &#40;8&#46;76&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">37&#46;15 &#40;7&#46;41&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">33&#46;57 &#40;7&#46;14&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">F</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>5&#46;79&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;&#46;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">MMP&#47;HIV&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>WAIS&#58; object assembly&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">30&#46;60 &#40;7&#46;38&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">26&#46;55 &#40;9&#46;24&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">33&#46;74 &#40;6&#46;18&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">32&#46;10 &#40;6&#46;83&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">F</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>5&#46;49&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;&#46;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">MMP&#47;HIV&#43;<br>MMP&#47;HIV&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="8" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="8" align="left" valign="top"><span class="elsevierStyleItalic">Motor coordination</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Purdue&#58; dominant&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">13&#46;85 &#40;2&#46;39&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">12&#46;79 &#40;2&#46;48&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">15&#46;15 &#40;1&#46;73&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">14&#46;52 &#40;2&#46;16&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">F</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>6&#46;61&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;&#46;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">MMP&#47;HIV&#43;<br>MMP&#47;HIV&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Purdue&#58; nondominant&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">12&#46;90 &#40;2&#46;42&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">12&#46;14 &#40;2&#46;04&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">14&#46;22 &#40;1&#46;69&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">13&#46;14 &#40;1&#46;56&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">F</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>5&#46;65&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;&#46;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">MMP&#47;HIV&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Finger&#58; dominant&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">43&#46;62 &#40;11&#46;63&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">39&#46;85 &#40;9&#46;58&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">49&#46;05 &#40;5&#46;03&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">46&#46;00 &#40;5&#46;99&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">F</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>5&#46;83&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;&#46;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">MMP&#47;HIV&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Finger&#58; nondominant&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">40&#46;32 &#40;9&#46;02&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">34&#46;66 &#40;8&#46;49&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">43&#46;33 &#40;5&#46;49&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">39&#46;47 &#40;6&#46;94&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">F</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>7&#46;25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;&#46;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">FTP&#47;HIV &#43;<br>MMP&#47;HIV&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="8" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="8" align="left" valign="top"><span class="elsevierStyleItalic">Executive functions</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>WAIS&#58; similarities&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">13&#46;63 &#40;4&#46;53&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">12&#46;02 &#40;5&#46;60&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">16&#46;63 &#40;3&#46;22&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">16&#46;48 &#40;3&#46;25&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">F</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>7&#46;89&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;&#46;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">FTP&#47;HIV &#43;<br>MMP&#47;HIV&#43;<br>MMP&#47;HIV&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>WAIS&#58; direct digit span&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6&#46;15 &#40;1&#46;05&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5&#46;62 &#40;1&#46;27&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6&#46;44 &#40;1&#46;15&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6&#46;48 &#40;1&#46;03&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">F</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>4&#46;10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;&#46;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">MMP&#47;HIV&#43;<br>MMP&#47;HIV&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>WAIS&#58; indirect digit span&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&#46;35 &#40;1&#46;08&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&#46;93 &#40;0&#46;95&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&#46;41 &#40;1&#46;05&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&#46;24 &#40;1&#46;26&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">F</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#46;58&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#62;&#46;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>WAIS&#58; digit symbol&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">48&#46;00 &#40;11&#46;66&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">37&#46;96 &#40;15&#46;40&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">53&#46;78 &#40;9&#46;22&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">48&#46;38 &#40;14&#46;14&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">F</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>9&#46;31&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;&#46;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">FTP&#47;HIV &#43;&#62;FTP&#47;HIV&#8722;&#59;<br>MMP&#47;HIV&#43;<br>MMP&#47;HIV&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Trails A&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">40&#46;50 &#40;15&#46;75&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">52&#46;69 &#40;25&#46;44&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">33&#46;35 &#40;10&#46;12&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">38&#46;52 &#40;18&#46;05&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">F</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>6&#46;73&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;&#46;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">FTP&#47;HIV &#43;<br>MMP&#47;HIV&#43;&#62;FTP&#47;HIV&#8722;&#59;<br>MMP&#47;HIV&#43;&#62;MMP&#47;HIV&#8722;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Trails B&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">84&#46;60 &#40;34&#46;63&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">138&#46;86 &#40;79&#46;74&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">79&#46;41 &#40;27&#46;30&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">82&#46;33 &#40;32&#46;81&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">F</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>11&#46;57&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;&#46;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">FTP&#47;HIV&#43;<br>MMP&#47;HIV&#43;&#62;FTP&#47;HIV&#8722;&#59;<br>MMP&#47;HIV&#43;&#62;MMP&#47;HIV&#8722;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Stroop 1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">99&#46;83 &#40;15&#46;75&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">90&#46;52 &#40;21&#46;85&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">105&#46;85 &#40;11&#46;18&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">104&#46;81 &#40;11&#46;86&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">F</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>6&#46;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;&#46;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">FTP&#47;HIV &#43;&#62;FTP&#47;HIV&#8722;&#59;<br>MMP&#47;HIV&#43;<br>MMP&#47;HIV&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Stroop 2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">66&#46;25 &#40;12&#46;97&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">58&#46;64 &#40;17&#46;77&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">70&#46;56 &#40;11&#46;75&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">68&#46;38 &#40;11&#46;24&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">F</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>4&#46;71&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;&#46;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">MMP&#47;HIV&#43;<br>MMP&#47;HIV&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Stroop 3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">39&#46;94 &#40;10&#46;12&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">32&#46;12 &#40;13&#46;80&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">41&#46;11 &#40;9&#46;32&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">40&#46;14 &#40;8&#46;28&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">F</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>5&#46;45&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;&#46;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">FTP&#47;HIV&#43;&#62;FTP&#47;HIV&#8722;&#59;<br>MMP&#47;HIV&#43;<br>MMP&#47;HIV&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Stroop&#58; interference&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;23 &#40;7&#46;62&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;2&#46;85 &#40;7&#46;41&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;34 &#40;7&#46;74&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;1&#46;13 &#40;5&#46;84&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">F</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#46;64&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#62;&#46;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>WCST &#8211; number of categories&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&#46;29 &#40;1&#46;80&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&#46;00 &#40;2&#46;13&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5&#46;33 &#40;1&#46;07&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&#46;81 &#40;1&#46;81&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">FTP&#47;HIV&#43;&#62;FTP&#47;HIV&#8722;&#59;<br>MMP&#47;HIV&#43;<br>MMP&#47;HIV&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>WCST &#8211; learning to learn&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;6&#46;31 &#40;9&#46;39&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;2&#46;12 &#40;5&#46;35&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#46;04 &#40;5&#46;60&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">F</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>3&#46;31&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#62;&#46;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>WCST-&#37; perseverative errors&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">23&#46;06 &#40;14&#46;45&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">13&#46;30 &#40;6&#46;59&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;&#46;05&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">15&#46;14 &#40;9&#46;39&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">19&#46;59 &#40;12&#46;52&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">15&#46;65 &#40;13&#46;77&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">F</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#46;80&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;07 &#40;1&#46;39&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;63 &#40;0&#46;79&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;19 &#40;1&#46;54&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;&#46;05&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#60;&#46;05&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr></tbody></table>
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                      "titulo" => "Neurocognitive impairment and HIV risk factors&#58; A reciprocal relationship"
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                      "titulo" => "Diagnosing symptomatic HIV-associated neurocognitive disorders&#58; Self-report versus performance-based assessment of everyday functioning"
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                            2 => "R&#46;K&#46; Heaton"
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Article information

ISSN: 01200534
Original language: English

DOI:10.1016/j.rlp.2015.06.008

The statistics are updated each day

Year/Month	Html	Pdf	Total

2024 November	3	0	3
2024 October	15	5	20
2024 September	32	11	43
2024 August	22	6	28
2024 July	14	6	20
2024 June	30	7	37
2024 May	49	4	53
2024 April	23	4	27
2024 March	43	13	56
2024 February	27	6	33
2024 January	34	12	46
2023 December	21	6	27
2023 November	16	10	26
2023 October	22	3	25
2023 September	14	15	29
2023 August	15	11	26
2023 July	12	16	28
2023 June	22	17	39
2023 May	30	8	38
2023 April	39	7	46
2023 March	37	10	47
2023 February	32	6	38
2023 January	22	5	27
2022 December	40	21	61
2022 November	41	50	91
2022 October	31	11	42
2022 September	53	10	63
2022 August	51	14	65
2022 July	25	9	34
2022 June	21	16	37
2022 May	63	8	71
2022 April	17	16	33
2022 March	19	27	46
2022 February	42	14	56
2022 January	65	13	78
2021 December	49	11	60
2021 November	77	16	93
2021 October	46	71	117
2021 September	21	31	52
2021 August	33	20	53
2021 July	16	9	25
2021 June	32	10	42
2021 May	34	8	42
2021 April	48	33	81
2021 March	38	8	46
2021 February	33	11	44
2021 January	40	12	52
2020 December	42	9	51
2020 November	26	10	36
2020 October	18	8	26
2020 September	19	10	29
2020 August	25	19	44
2020 July	23	10	33
2020 June	20	18	38
2020 May	34	11	45
2020 April	22	9	31
2020 March	37	3	40
2020 February	25	4	29
2020 January	30	8	38
2019 December	29	19	48
2019 November	24	11	35
2019 October	27	6	33
2019 September	42	9	51
2019 August	30	8	38
2019 July	25	25	50
2019 June	55	12	67
2019 May	154	4	158
2019 April	72	13	85
2019 March	22	6	28
2019 February	16	8	24
2019 January	19	3	22
2018 December	15	9	24
2018 November	15	5	20
2018 October	15	21	36
2018 September	6	1	7
2018 August	8	12	20
2018 July	15	4	19
2018 June	10	1	11
2018 May	13	7	20
2018 April	10	0	10
2018 March	21	2	23
2018 February	5	2	7
2018 January	8	4	12
2017 December	7	1	8
2017 November	14	7	21
2017 October	11	3	14
2017 September	29	10	39
2017 August	9	5	14
2017 July	17	5	22
2017 June	22	22	44
2017 May	21	14	35
2017 April	25	4	29
2017 March	16	11	27
2017 February	79	6	85
2017 January	408	5	413
2016 December	65	8	73
2016 November	137	12	149
2016 October	124	13	137
2016 September	113	31	144
2016 August	143	27	170
2016 July	30	10	40

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