The objective of SD, INTERNATIONAL MEDICAL REVIEW ON DOWN SYNDROME is, first, to gather current knowledge about the medical aspects of Down syndrome, to ongoing review and update from the most promising advances in basic sciences such as molecular biology and genetics, to clinical practice, and, secondly, treating those psycho-pedagogical aspects by his relationship with the medical field may be of practical interest to pediatricians and pediatric specialists associated with Down syndrome. SD will consider for publication clinical research articles related to Down syndrome in all its branches work.