Article information
Resumo
Evidências recentes sugerem que a periodontite é um potencial factor de risco para as doenças induzidas por aterosclerose, nomeadamente o acidente vascular cerebral (AVC). Assim sendo, este trabalho tem como objectivo determinar a existência de uma associação entre a periodontite, a segunda maior patologia dentária e o AVC, a primeira causa de morte em Portugal.
Os possíveis mecanismos fisiopatológicos que estão na base desta possível associação são a acção directa dos microorganismos, a predisposição genética, o mimetismo molecular e a hiperlipidémia.
Contudo, mais estudos são necessários de forma a identificar a verdadeira natureza desta possível associação.
Palavras-chave:
Periodontite
Acidente Vascular Cerebral
Aterosclerose
Mecanismos fisiopatológicos
Infecção
Bactérias periodontais
Abstract
Recent evidence suggests that periodontitis is a potential risk factor for atherosclerosis induced diseases, namely stroke. This way, the study's objective is to determine the existence of association between periodontitis, the second most dental's pathology and stroke, Portugal's primary cause of death.
The possible pathophysiological mechanisms under this association are the direct role of microorganisms, the genetic predisposition, the molecular mimicry and the hyperlipidaemia. However, more studies are needed to identify the true nature of this association.
Keywords:
Periodontitis
Stroke
Atherosclerosis
Pathophysiological mechanisms
Infection
Periodontal pathogens
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