Article information
Abstract
Drug induced gingival enlargement (DIGE) is characterized by a gingival enlargementwhich can reach just one area or involve several areas, mainly anterior regions of maxilla and mandible. The cyclosporine, phenytoin and nifedipine are the mainly drugs related with DIGE. Several risk factors are involved, as bacterial plaque. The pathogenesis is controversial, but most of the studies agree with the participation of genetic susceptibility, growth factors and fibroblasts. The prevention approaches in patients under this therapy programme are essential, and also the early diagnosis and follow-up, to minimize the adverse consequences and reduce the prevalence and severity of gingival enlargement.
Key-words:
Drug induced gingival overgrowth
Drug induced gingival enlargement
Gingival diseases
Drugs
Resumo
O aumento de volume gengival induzido por fármacos (AVGIF) caracteriza-se pelo aumento de volume da gengiva que pode ser limitada a uma área ou envolver várias regiões, principalmente nas zonas anteriores da maxila e da mandíbula. A ciclosporina, a fenitoína e a nifedipina são os fármacos principais relacionados com o AVGIF. Vários factores de risco estão envolvidos, tais como a placa bacteriana. A patogénese é controversa, mas a maioria dos estudos é concordante com a participação da susceptibilidade genética, factores de crescimento e fibroblastos. Os regimes preventivos em pacientes sob esse tipo de terapia são fundamentais, bem como o diagnóstico precoce e o follow-up, de modo a minimizar as consequências adversas e diminuir a prevalência e severidade do aumento de volume gengival.
Palavras-Chave:
Aumento de volume gengival induzido por fármacos
Crescimento gengival induzido por fármacos
Doenças gengivais
Fármacos
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(Dias GS, Osório VV, Almeida A. Aumento de Volume Gengival Induzido por Fármacos. Rev Port Estomatol Med Dent Cir Maxilofac 2010;51:177–184)
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