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array:23 [ "pii" => "S2173505009700445" "issn" => "21735050" "doi" => "10.1016/S2173-5050(09)70044-5" "estado" => "S300" "fechaPublicacion" => "2009-01-01" "aid" => "70044" "copyright" => "SEP y SEPB" "copyrightAnyo" => "2009" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Rev Psiquiatr Salud Ment. 2009;2:133-7" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 456 "formatos" => array:3 [ "EPUB" => 6 "HTML" => 213 "PDF" => 237 ] ] "itemSiguiente" => array:18 [ "pii" => "S2173505009700457" "issn" => "21735050" "doi" => "10.1016/S2173-5050(09)70045-7" "estado" => "S300" "fechaPublicacion" => "2009-01-01" "aid" => "70045" "copyright" => "SEP y SEPB" "documento" => "article" "crossmark" => 0 "subdocumento" => "rev" "cita" => "Rev Psiquiatr Salud Ment. 2009;2:138-45" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 561 "formatos" => array:3 [ "EPUB" => 8 "HTML" => 304 "PDF" => 249 ] ] "en" => array:10 [ "idiomaDefecto" => true "titulo" => "Use of antipsychotics during pregnancy and breastfeeding" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "138" "paginaFinal" => "145" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Uso de antipsicóticos durante el embarazo y la lactancia" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "José Manuel Bertolín Guillén, Enrique Soler Company" "autores" => array:2 [ 0 => array:2 [ "nombre" => "José Manuel" "apellidos" => "Bertolín Guillén" ] 1 => array:2 [ "nombre" => "Enrique" "apellidos" => "Soler Company" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173505009700457?idApp=UINPBA00004N" "url" => "/21735050/0000000200000003/v1_201305031513/S2173505009700457/v1_201305031513/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S2173505009700433" "issn" => "21735050" "doi" => "10.1016/S2173-5050(09)70043-3" "estado" => "S300" "fechaPublicacion" => "2009-01-01" "aid" => "70043" "copyright" => "SEP y SEPB" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Rev Psiquiatr Salud Ment. 2009;2:128-32" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 454 "formatos" => array:3 [ "EPUB" => 6 "HTML" => 179 "PDF" => 269 ] ] "en" => array:10 [ "idiomaDefecto" => true "titulo" => "Bipolar patients in specialised units and mental health centres: are they comparable?" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "128" "paginaFinal" => "132" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Pacientes bipolares de unidades especializadas y de centros de salud mental. ¿Se pueden comparar?" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Lorenzo Livianos Aldana, Pilar Sierra San Miguel, Matías Real López, María Luisa Serrano Raya, Gema Piera Martínez, Paola Rubio Sanjaime, Luis Rojo Moreno" "autores" => array:7 [ 0 => array:2 [ "nombre" => "Lorenzo" "apellidos" => "Livianos Aldana" ] 1 => array:2 [ "nombre" => "Pilar Sierra" "apellidos" => "San Miguel" ] 2 => array:2 [ "nombre" => "Matías" "apellidos" => "Real López" ] 3 => array:2 [ "nombre" => "María Luisa" "apellidos" => "Serrano Raya" ] 4 => array:2 [ "nombre" => "Gema" "apellidos" => "Piera Martínez" ] 5 => array:2 [ "nombre" => "Paola" "apellidos" => "Rubio Sanjaime" ] 6 => array:2 [ "nombre" => "Luis" "apellidos" => "Rojo Moreno" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173505009700433?idApp=UINPBA00004N" "url" => "/21735050/0000000200000003/v1_201305031513/S2173505009700433/v1_201305031513/en/main.assets" ] "en" => array:14 [ "idiomaDefecto" => true "titulo" => "Effects of the administration of (RS)-3,4-DCPG, a mixed AMPA receptor antagonist/mGluR8 receptor agonist, on aggressive behaviour in mice" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "133" "paginaFinal" => "137" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "José Francisco Navarro, Vanessa de Castro, Mercedes Martín-López" "autores" => array:3 [ 0 => array:4 [ "nombre" => "José" "apellidos" => "Francisco Navarro" "email" => array:1 [ 0 => "navahuma@uma.es" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "Vanessa" "apellidos" => "de Castro" ] 2 => array:2 [ "nombre" => "Mercedes" "apellidos" => "Martín-López" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Department of Psychobiology, Faculty of Psychology, University of Málaga, Málaga, Spain" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Efectos de la administración de (RS)-3,4-DCPG, un antagonista mixto de los receptores AMPA y agonista de los receptores mGlu8, en la conducta agresiva de los ratones" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2009-01-20" "fechaAceptado" => "2009-05-06" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec102026" "palabras" => array:5 [ 0 => "Aggression" 1 => "Glutamate" 2 => "mGlu8 receptor" 3 => "AMPA receptor" 4 => "Agonistic behavior" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec102025" "palabras" => array:5 [ 0 => "Agresión" 1 => "Glutamato" 2 => "Receptores mGlu8" 3 => "Receptores AMPA" 4 => "Conducta agonista" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Ionotropic and metabotropic (mGlu) receptors of glutamate have been suggested to be involved in the modulation of aggression. Thus, recent studies found reduced aggression in AMPA-type glutamate receptor GluR-A subunit-deficient mice. Likewise, mGlu1 and 5 receptors have also been implicated in aggression regulation. (RS)-3,4-DCPG is a mixed antagonist of AMPA receptors and an agonist of mGluR8. The AMPA antagonist activity of this compound is determined by its R isomer while the S isomer is responsible for its mGluR8 agonistic properties.</p> <span class="elsevierStyleSectionTitle">Methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">We analyzed the effects of (RS)-3,4-DCPG (5, 10 and 20<span class="elsevierStyleHsp" style=""></span>mg/kg, ip) on agonistic encounters between male mice. Individually housed mice were exposed to anosmic opponents 30<span class="elsevierStyleHsp" style=""></span>min after drug administration. Ten min of dyadic interactions were staged between a singly housed and an anosmic mouse in a neutral area. The encounters were videotaped and the accumulated time allocated by subjects to 10 broad behavioral categories was estimated using an ethologically based analysis.</p> <span class="elsevierStyleSectionTitle">Results and conclusions</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">The results indicated that (RS)-3,4-DCPG produced no significant behavioral changes, suggesting that antagonism of AMPA receptors by the R isomer and stimulation of mGluR8 by the S isomer do not act synergistically on aggression in the racemic form of 3,4-DCPG.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Introducción</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Los receptores ionotrópicos y metabotrópicos (mGlu) de glutamato han sido implicados en la modulación de la agresión. Así, estudios recientes han encontrado una reducción de la agresión en ratones que carecen de la subunidad GluR-A de los receptores AMPA. Asimismo, los receptores mGlu1 y mGlu5 también se han involucrado en la regulación de la agresión. (RS)-3,4-DCPG es un antagonista mixto de receptores AMPA y agonista de receptores mGlu8. Su actividad antagonista AMPA está determinada por su isómero R, mientras que el isómero S es causal de sus propiedades agonistas mGlu8.</p> <span class="elsevierStyleSectionTitle">Métodos</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">En este estudio, se analiza el efecto de la administración de (RS)-3,4-DCPG (5, 10 y 20<span class="elsevierStyleHsp" style=""></span>mg/kg, intraperitoneal) en los encuentros agonistas entre ratones machos; 30<span class="elsevierStyleHsp" style=""></span>min después de la administración del fármaco se llevaron a cabo interacciones agonistas de 10<span class="elsevierStyleHsp" style=""></span>min de duración entre un animal aislado y un oponente anósmico en un área neutral. Dichos encuentros se grabaron en vídeo para su análisis etológico mediante un programa de ordenador y se estimó el tiempo pasado por los ratones en cada una de diez categorías conductuales.</p> <span class="elsevierStyleSectionTitle">Resultados y conclusiones</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Los resultados indicaron que el (RS)-3,4-DCPG no produjo cambios conductuales significativos, esto apunta a que el antagonismo de los receptores AMPA por el isómero R y la estimulación de los receptores mGlu8 por el isómero S no parecen actuar sinérgicamente sobre la agresión en la forma racémica del 3,4-DCPG.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:27 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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