Effects of the administration of (RS)-3,4-DCPG, a mixed AMPA receptor antagonist/mGluR8 receptor agonist, on aggressive behaviour in mice
Efectos de la administración de (RS)-3,4-DCPG, un antagonista mixto de los receptores AMPA y agonista de los receptores mGlu8, en la conducta agresiva de los ratones
José Francisco Navarro
, Vanessa de Castro, Mercedes Martín-López
Corresponding author
Department of Psychobiology, Faculty of Psychology, University of Málaga, Málaga, Spain
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Thus, recent studies found reduced aggression in AMPA-type glutamate receptor GluR-A subunit-deficient mice. Likewise, mGlu1 and 5 receptors have also been implicated in aggression regulation. (RS)-3,4-DCPG is a mixed antagonist of AMPA receptors and an agonist of mGluR8. The AMPA antagonist activity of this compound is determined by its R isomer while the S isomer is responsible for its mGluR8 agonistic properties.</p> <span class="elsevierStyleSectionTitle">Methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">We analyzed the effects of (RS)-3,4-DCPG (5, 10 and 20<span class="elsevierStyleHsp" style=""></span>mg/kg, ip) on agonistic encounters between male mice. Individually housed mice were exposed to anosmic opponents 30<span class="elsevierStyleHsp" style=""></span>min after drug administration. Ten min of dyadic interactions were staged between a singly housed and an anosmic mouse in a neutral area. The encounters were videotaped and the accumulated time allocated by subjects to 10 broad behavioral categories was estimated using an ethologically based analysis.</p> <span class="elsevierStyleSectionTitle">Results and conclusions</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">The results indicated that (RS)-3,4-DCPG produced no significant behavioral changes, suggesting that antagonism of AMPA receptors by the R isomer and stimulation of mGluR8 by the S isomer do not act synergistically on aggression in the racemic form of 3,4-DCPG.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Introducción</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Los receptores ionotrópicos y metabotrópicos (mGlu) de glutamato han sido implicados en la modulación de la agresión. Así, estudios recientes han encontrado una reducción de la agresión en ratones que carecen de la subunidad GluR-A de los receptores AMPA. Asimismo, los receptores mGlu1 y mGlu5 también se han involucrado en la regulación de la agresión. (RS)-3,4-DCPG es un antagonista mixto de receptores AMPA y agonista de receptores mGlu8. Su actividad antagonista AMPA está determinada por su isómero R, mientras que el isómero S es causal de sus propiedades agonistas mGlu8.</p> <span class="elsevierStyleSectionTitle">Métodos</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">En este estudio, se analiza el efecto de la administración de (RS)-3,4-DCPG (5, 10 y 20<span class="elsevierStyleHsp" style=""></span>mg/kg, intraperitoneal) en los encuentros agonistas entre ratones machos; 30<span class="elsevierStyleHsp" style=""></span>min después de la administración del fármaco se llevaron a cabo interacciones agonistas de 10<span class="elsevierStyleHsp" style=""></span>min de duración entre un animal aislado y un oponente anósmico en un área neutral. Dichos encuentros se grabaron en vídeo para su análisis etológico mediante un programa de ordenador y se estimó el tiempo pasado por los ratones en cada una de diez categorías conductuales.</p> <span class="elsevierStyleSectionTitle">Resultados y conclusiones</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Los resultados indicaron que el (RS)-3,4-DCPG no produjo cambios conductuales significativos, esto apunta a que el antagonismo de los receptores AMPA por el isómero R y la estimulación de los receptores mGlu8 por el isómero S no parecen actuar sinérgicamente sobre la agresión en la forma racémica del 3,4-DCPG.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:27 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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| Year/Month | Html | Total | |
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| 2024 October | 4 | 1 | 5 |
| 2024 September | 14 | 9 | 23 |
| 2024 August | 8 | 7 | 15 |
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| 2023 November | 6 | 6 | 12 |
| 2023 October | 9 | 11 | 20 |
| 2023 September | 3 | 1 | 4 |
| 2023 August | 6 | 1 | 7 |
| 2023 July | 1 | 10 | 11 |
| 2023 June | 3 | 2 | 5 |
| 2023 May | 3 | 5 | 8 |
| 2023 April | 3 | 6 | 9 |
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| 2023 February | 3 | 6 | 9 |
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| 2022 October | 8 | 9 | 17 |
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| 2022 June | 6 | 8 | 14 |
| 2022 May | 15 | 7 | 22 |
| 2022 April | 4 | 8 | 12 |
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| 2021 December | 8 | 14 | 22 |
| 2021 November | 5 | 8 | 13 |
| 2021 October | 6 | 15 | 21 |
| 2021 September | 5 | 11 | 16 |
| 2021 August | 5 | 4 | 9 |
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| 2021 June | 8 | 8 | 16 |
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| 2021 April | 37 | 21 | 58 |
| 2021 March | 5 | 10 | 15 |
| 2021 February | 6 | 10 | 16 |
| 2021 January | 3 | 12 | 15 |
| 2020 December | 5 | 11 | 16 |
| 2020 November | 6 | 7 | 13 |
| 2020 October | 6 | 10 | 16 |
| 2020 September | 7 | 7 | 14 |
| 2020 August | 9 | 9 | 18 |
| 2020 July | 4 | 10 | 14 |
| 2020 June | 1 | 1 | 2 |
| 2020 May | 3 | 13 | 16 |
| 2020 April | 4 | 4 | 8 |
| 2020 March | 3 | 4 | 7 |
| 2020 February | 4 | 4 | 8 |
| 2020 January | 4 | 6 | 10 |
| 2019 December | 7 | 10 | 17 |
| 2019 November | 1 | 6 | 7 |
| 2019 October | 2 | 7 | 9 |
| 2019 September | 0 | 8 | 8 |
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| 2019 June | 1 | 28 | 29 |
| 2019 May | 6 | 59 | 65 |
| 2019 April | 4 | 25 | 29 |
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| 2019 February | 0 | 9 | 9 |
| 2019 January | 1 | 0 | 1 |
| 2018 December | 3 | 6 | 9 |
| 2018 November | 3 | 5 | 8 |
| 2018 October | 8 | 5 | 13 |
| 2018 September | 2 | 1 | 3 |
| 2018 August | 2 | 1 | 3 |
| 2018 July | 3 | 4 | 7 |
| 2018 June | 2 | 4 | 6 |
| 2018 May | 2 | 3 | 5 |
| 2018 April | 1 | 1 | 2 |
| 2018 March | 1 | 2 | 3 |
| 2018 February | 3 | 0 | 3 |
| 2018 January | 1 | 0 | 1 |
| 2017 December | 6 | 2 | 8 |
| 2017 November | 5 | 0 | 5 |
| 2017 October | 4 | 1 | 5 |
| 2017 September | 2 | 0 | 2 |
| 2017 August | 6 | 3 | 9 |
| 2017 July | 7 | 1 | 8 |
| 2017 June | 10 | 3 | 13 |
| 2017 May | 14 | 1 | 15 |
| 2017 April | 9 | 1 | 10 |
| 2017 March | 11 | 3 | 14 |
| 2017 February | 13 | 0 | 13 |
| 2017 January | 5 | 1 | 6 |
| 2016 December | 8 | 0 | 8 |
| 2016 November | 19 | 0 | 19 |
| 2016 October | 14 | 0 | 14 |
| 2016 September | 7 | 1 | 8 |
| 2016 August | 6 | 0 | 6 |
| 2016 July | 2 | 0 | 2 |
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