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Beliefs about depression and its treatments: Associated variables and the influence of beliefs on adherence to treatment
Creencias sobre la depresión y sus tratamientos: variables asociadas e influencia de las creencias en la adherencia
Francisco Acostaa,
Corresponding author
fjacostaartiles@hotmail.com

Corresponding author.
, Luciano Rodríguezb, Beatriz Cabrerab
a Servicio de Salud Mental, Dirección General de Programas Asistenciales, Gran Canaria, Canarias, Spain
b Servicio de Psiquiatría, Hospital Universitario de Gran Canaria Dr. Negrín, Gran Canaria, Canarias, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Depression is one of the most prevalent and disabling mental disorders in the general population&#44; with substantial consequences at the individual&#44; family and socioeconomic levels&#46; Adherence to treatment is a key factor in recovery for more favourable clinical results later&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a> For their part&#44; one&#39;s beliefs about depression and treatment &#40;both psychopharmacological and psychotherapeutic&#41; have been considered as the main variables associated with adherence to antidepressant treatment&#46; In turn&#44; there are multiple determining factors for these beliefs&#44; including sociodemographic and cultural factors and those about the illness itself&#44; among others&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">This review addresses the areas of adherence to antidepressant treatment and psychotherapy&#44; the influence that beliefs and attitudes towards treatment have on adherence&#44; beliefs and attitudes towards depression&#44; psychopharmacological treatment and psychotherapy&#44; as well as its evaluation and limitations in the studies available&#46; It also identifies the most relevant findings of the variables related to these beliefs&#44; although not as an independent section&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Adherence to antidepressant treatment</span><p id="par0015" class="elsevierStylePara elsevierViewall">It has been estimated that non-adherence to antidepressant medication oscillates between 30&#37; and 60&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> Among its consequences are increased rate of relapses and recurrences&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a> Despite the fact that 49&#8211;84&#37; of the patients perceive the need for antidepressant treatment&#44;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> 1&#47;3 abandon treatment 3 months after feeling better&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> At 6 months&#44; the rate of non-adherence reaches 55&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> Strikingly&#44; only 1&#8211;2&#37; of publications dedicated to the treatment of affective disorders explore the factors associated with non-adherence to medication&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Non-adherence is a multifactorial phenomenon&#46; The risk factors have been grouped into several categories&#58; those related to the patient&#44; illness&#44; medication&#44; medical and health care&#44; and family and society&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> The most established factors have been the patient&#39;s attitudes and beliefs about health &#40;including the stigma attached to depression&#41;&#44; the patient&#39;s and family&#39;s attitudes and beliefs about depression and medication&#44; a poor doctor&#8211;patient or psychotherapist&#8211;patient relationship and previous non-adherence&#46; Other factors mentioned are side effects of the medication&#44; lower education and economic level &#40;especially in the early stages of treatment&#41;&#44; not being married&#44; depression itself&#44; forgetfulness&#44; certain personality traits&#44; substance abuse&#44; medical comorbidity and somatoform symptoms&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7&#44;8</span></a> Psychoeducation<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> and decision-making in conjunction with the patient<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> are relevant factors for improving adherence&#46; For its part&#44; employment has been associated with a larger social network and a better attitude towards drug treatment and adherence to it&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Both the degree of non-adherence and the risk factors may vary according to the evolutionary moment&#46; Early discontinuation is associated with secondary effects and the perception of medication as ineffective&#46; Patients in the maintenance phase &#40;by definition they are less depressed&#41; reduce their adherence with clinical improvement&#46; Furthermore&#44; they tend to believe that they do not need medication any more or they are less willing to continue tolerating the previously acceptable adverse effects&#44; such as sexual dysfunction&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a> For its part&#44; adherence is greater in cases of more severe symptoms&#44; while it predisposes patients not to start treatment in milder cases&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a></p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Adherence to psychotherapy</span><p id="par0030" class="elsevierStylePara elsevierViewall">Non-adherence is a prevalent phenomenon in the psychotherapeutic process&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> According to meta-analysis&#44; it falls between 35&#37;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a> and 47&#37;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> and may exceed 60&#37; when non-attendance to the first contact appointment is evaluated&#46;<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">16&#44;17</span></a> In other studies&#44; only 11&#37; completed therapy<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a> and only 10&#37; reached the tenth session&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a> Non-adherence occurs in all disorders&#44; treatment programmes and therapy types and formats&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">There are very few studies evaluating adherence in psychotherapy&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> Therefore&#44; there are barely any studies on depression<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a> and most have focused on socio-demographic characteristics&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Findings on risk factors for non-adherence have been inconclusive&#46; Multiple factors have been encompassed in several areas&#58; patient&#44; therapeutic relationship&#44; context&#44; type of psychotherapy and expectations for therapy&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a> However&#44; there is unanimity that the therapeutic relationship&#44; and especially the therapeutic alliance&#44; is a fundamental aspect for adherence&#59; it is also essential&#44; although not itself curative&#44; for the success of psychotherapy&#46;<a class="elsevierStyleCrossRefs" href="#bib0115"><span class="elsevierStyleSup">23&#44;24</span></a></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">How beliefs and attitudes towards treatment influence adherence</span><p id="par0045" class="elsevierStylePara elsevierViewall">Negative beliefs about medication<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> and illness<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">25</span></a> are an important factor for non-adherence&#46; Positive attitudes regarding antidepressants are associated with more active use of mental health services&#46;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">26</span></a> A positive attitude towards drug therapy was the main predictor of adherence in a prospective study&#46;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">27</span></a> In patients with depression&#44; specific beliefs &#40;such as &#8220;my health depends on antidepressants&#8221;&#41; and less concern about being dependent on this medication have been strongly associated with adherence&#46; Beliefs that drugs cause pain that they are over-prescribed the experience of adverse effects and greater severity of depression were associated with poor adherence&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">28</span></a> The main negative belief found consistently regarding antidepressants was the belief that they can cause addiction&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Other authors did not find an association between the belief that treatment is necessary and better adherence&#44; but an association was found between concern about the medication and non-adherence&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">29</span></a> Positive attitudes towards antidepressants have been associated with the use of antidepressants&#44; with patient education about antidepressants being a mediating variable between the 2&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">30</span></a> In this vein&#44; increased adherence was found in clinical trials in patients receiving advice on treatment&#44; compared to those who did not&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">31</span></a> Furthermore&#44; positive changes in beliefs about antidepressants have been found in patients who received an intervention programme that included psychoeducation about antidepressant treatment vs the standard systematic follow-up&#46;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">32</span></a> Patients with greater knowledge on depression and antidepressants and lower perceived stigma adhered better to treatment&#46;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">33</span></a> One of the difficulties in studying stigma and its influence on adherence is differentiating between the stigma associated with antidepressant treatment and that related to depression&#46;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">34</span></a> The following beliefs have been identified as components of the stigma in patients with depression&#58; that others think the person to be responsible for suffering depression that being near people with depression is not desirable and that these people might constitute a danger&#46;<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">35</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">Different models have attempted to give coherent explanatory support to the complex interactions among the various factors involved&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Horne&#39;s theoretical model</span> distinguishes between beliefs about medication in general and beliefs about what is specifically prescribed&#46; The latter includes 2 constructs&#58; perceived need for medication &#40;necessity&#41; and perceived potential for medication to cause problems &#40;concern&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">36</span></a> Beliefs about medication in general seem to be most relevant for adherence at the start of treatment&#46;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">37</span></a> In this acute phase&#44; changes in beliefs about antidepressants occur&#46; Perceptions become more pro-adherence as patients continue to have experience with the treatment&#59; perception of the need for treatment increases and that of harmful potential of drugs weakens&#46; Beliefs in the danger of antidepressants predict the later appearance of side effects&#44; while the occurrence of side effects reinforces the belief of danger&#46;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">38</span></a> In the maintenance phase&#44; the different degrees of adherence are explained by the balance between the perceptions of need and potential harm&#59; adherence is lower when the perceived harm exceeds the perceived need&#44; and higher when the perceived need exceeds the perceived harm&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">The <span class="elsevierStyleItalic">Health Belief Model</span> postulates that the main determinants of the search for treatment and adherence are beliefs about susceptibility to a health problem and its severity&#44; treatment effectiveness&#44; benefits perceived and treatment barriers&#46;<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">39</span></a> Such beliefs may be especially important in mental disorders&#44; which are often stigmatized and not well understood&#46;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">40</span></a> Adherence is correlated with the patient&#39;s beliefs about the severity of the disease to be treated or prevented&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">25</span></a> Four states of subjective positioning have been identified according to the &#8220;perceived need&#8221; and &#8220;perception of harm&#8221; in depressed patients&#58; <span class="elsevierStyleItalic">sceptical</span> &#40;those that consider the need for treatment to be low and have high concern for harm related to treatment&#41;&#44; <span class="elsevierStyleItalic">ambivalent</span> &#40;those that perceive high need and worry&#41;&#44; <span class="elsevierStyleItalic">indifferent</span> &#40;those that assess both the need and concern about harm to be low&#41; and <span class="elsevierStyleItalic">accepting</span> &#40;those that perceive a high necessity and low worry&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a></p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Beliefs and attitudes towards depression&#44; medication and psychotherapy</span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Beliefs about depression</span><p id="par0065" class="elsevierStylePara elsevierViewall">The areas studied have been the aetiology of depression&#44; the usefulness of treatments&#44; the search for help and the perceived stigma&#46; Beliefs about the causes of depression are mostly non-biological&#44; psychological or environmental&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> However&#44; while the general population and patients affected by milder depressive disorders refer to causes or external factors &#40;reactive to interpersonal difficulties and stress&#41;&#44; the more serious patients tend to allude to a biological aetiology and put more trust in drug treatment&#46; For their part&#44; people who suffer from depression tend to have more positive beliefs about treatment than do healthy people&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> The most commonly mentioned causes of depression were stress associated with work&#44; followed by personality and family situation&#44; with only 3&#46;6&#37; of the respondents giving biological reasons&#46;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">41</span></a> However&#44; evolution of beliefs about illness origin has been observed in recent years &#40;1996-2006&#41;&#44; the change being directed towards a more biomedical framework&#46; These changes could be justified according to television campaigns with reference to depression&#59; they could also be due to client-directed marketing by pharmaceutical companies in the United States&#46;<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">42</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">Up to 2&#47;3 of those surveyed in Spain considered depression to be an illness&#44; while the rest considered it a state of mind&#46; Of the same sample&#44; 80&#37; considered it a psychological or mental illness&#46; Furthermore&#44; the respondents unanimously considered depression to be chronic&#46; The causes most frequently indicated were labour&#44; family and economic problems&#44; stress&#44; loss of a loved one and loneliness&#44; confusing triggers with causes&#46;<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">43</span></a></p><p id="par0075" class="elsevierStylePara elsevierViewall">Beliefs about depression are factors associated with requesting professional help&#46; The stigma associated with depression is frequent<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">44</span></a>&#59; the beliefs that it is a stigmatizing condition and that one should be able to control one&#39;s own depressive state are associated with concealing symptoms from the doctor&#46;<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">45</span></a> The most vulnerable groups would be those of extreme age categories &#40;young people and the elderly&#41;&#44; given the lower perception of illness and the attribution of difficulties to &#8220;normalised&#8221; life phases of the individual&#46; This belief extends even to primary health care doctors&#44; among whom difficulties have been identified for establishing treatment for these groups&#46;<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">46</span></a></p><p id="par0080" class="elsevierStylePara elsevierViewall">Beliefs about the causes of depression influence patients&#8217; treatment preferences&#44; as well as their assignment to 1 type of treatment or another&#46; The preference for psychotherapy is associated with attribution of the aetiology to problems in childhood and to more complex aetiologies&#44; compared to patients who prefer drug treatment&#46;<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">47</span></a> Attribution to intra-individual causes is associated with assignment to cognitive behaviour therapy&#44; while attribution to biological causes is associated with psychopharmacological treatment&#46;<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">48</span></a> Beliefs in biomedical causes of depression are associated strongly with preference for antidepressant treatment&#46;<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">49</span></a> For its part&#44; a belief in non-medical models would interfere with standard biomedical treatment&#44; which would be rejected as of little use or even harmful&#46;<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">50</span></a></p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Beliefs about antidepressants</span><p id="par0085" class="elsevierStylePara elsevierViewall">The main negative beliefs about antidepressants are addictive possibilities &#40;especially in males&#41;&#44; over-medication and prescription abuse of antidepressants&#46;<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">51</span></a></p><p id="par0090" class="elsevierStylePara elsevierViewall">More than 2&#47;3 of the population surveyed in Spain demonstrated beliefs regarding dependency caused by antidepressants&#44; with this being the main adverse effect alleged as the reason for discontinuing the drugs after a short time&#46;<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">43</span></a> Similar findings were obtained in older&#44; 60-year-old depressed patients&#44; with negative attitudes towards the treatment&#46; The 2 main reasons for resistance to taking antidepressants were fear of dependence and resistance to seeing depressive symptoms as a medical illness&#46;<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">52</span></a> Adolescents preferred psychotherapy over drugs&#44; and the main adverse effects that would make adherence to antidepressant treatment difficult for them were the increase of weight for girls and the sexual effects for boys&#46;<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">53</span></a> Patients with major depressive disorder appeared to have a more negative view of antidepressants than those with bipolar disorder&#46;<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">54</span></a></p><p id="par0095" class="elsevierStylePara elsevierViewall">Based on Horne&#39;s model&#44; it has been found that the <span class="elsevierStyleItalic">need</span> for antidepressant treatment is associated with older age&#44; greater severity of depressive symptoms&#44; expecting a longer duration of symptoms and attributing the illness to a chemical imbalance&#46; The belief that the treatment is <span class="elsevierStyleItalic">harmful</span> is associated with failing to take antidepressants early&#44; attributing symptoms to random factors and poor understanding of depressive symptoms&#46;<a class="elsevierStyleCrossRef" href="#bib0275"><span class="elsevierStyleSup">55</span></a></p><p id="par0100" class="elsevierStylePara elsevierViewall">It is difficult to differentiate the stigmatizing beliefs related to depression from those related to antidepressants&#46; Resisting or rejecting the use of antidepressants could be a way of avoiding the label of mentally ill&#46;<a class="elsevierStyleCrossRef" href="#bib0280"><span class="elsevierStyleSup">56</span></a> In some cases&#44; depression is seen as a sign of weakness&#44; and antidepressants as indicators of the &#8220;mentally weak&#8221; or &#8220;those unable to cope with their emotional problems&#8221;&#46;<a class="elsevierStyleCrossRefs" href="#bib0215"><span class="elsevierStyleSup">43&#44;57</span></a></p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Beliefs about psychotherapy vs medication</span><p id="par0105" class="elsevierStylePara elsevierViewall">Preferring psychotherapy to drugs is consistently established in studies of patients with depression&#44; primary care patients and the general population&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> It has been found in the Spanish general population&#44; even in relation to schizophrenia and bipolar disorder&#46;<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">58</span></a> The factors associated with this preference include female sex&#44; greater knowledge of psychotherapy or previous experience with it&#44; paid time off and not having been recently treated with antidepressants&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Patients in serious condition also perceive the usefulness of pharmacological and psychotherapeutic co-therapy&#44;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> from which they can learn coping mechanisms and change their thinking patterns&#44; patterns of coping with stress and difficult relationships&#46;<a class="elsevierStyleCrossRefs" href="#bib0295"><span class="elsevierStyleSup">59&#44;60</span></a> This preference is maintained today&#44; including in developed countries&#46; However&#44; there has been a gradual rise in positive assessments of psychotropic drugs&#44; coinciding with increased rates of request for assistance from depressed patients&#46;<a class="elsevierStyleCrossRef" href="#bib0305"><span class="elsevierStyleSup">61</span></a> Consequently&#44; people familiar with treatment of depression tended to be more willing to recommend seeking help from mental health professionals&#44; and to adopt various treatment options&#44; especially medication&#46;<a class="elsevierStyleCrossRef" href="#bib0310"><span class="elsevierStyleSup">62</span></a> This positive correlation in the perceived usefulness of treatment and the possibility of help from mental health professionals appeared more frequently in women&#44;<a class="elsevierStyleCrossRef" href="#bib0315"><span class="elsevierStyleSup">63</span></a> in patients without a partner &#40;separated&#44; divorced or widowed&#41;&#44; those who have received prior psychiatric treatment<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">60</span></a> and in patients with a more serious condition&#46; For the general population or patients with a milder illness&#44; higher importance is attributed to the family figure as support and to social workers or counsellors compared to mental health professionals&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> The perceived efficiency of these types of treatments is also favourable to psychotherapy in the general population and in primary care patients&#44; especially in the case of males and the elderly population&#46; In the case of depressed patients&#44; studies have been heterogeneous&#44; some favouring psychotherapy and others medication&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Symptoms of cluster B personality disorders have been associated with a negative attitude towards psychotherapy and poor adherence to this treatment in patients with major depression&#44; while symptoms from cluster C personality disorders were associated with a positive attitude&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a></p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Assessment</span><p id="par0110" class="elsevierStylePara elsevierViewall">Given the importance of the beliefs and attitudes for adherence&#44; these aspects need to be assessed in all patients&#46; Although the most habitual method will be evaluation in the context of the clinical interview&#44; there are psychometric scales available&#44; some of which are validated in Spain&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">Various factors can affect the validity of the attitudes reported by the patient about the medication&#44; such as certain symptoms&#44; stigma and social desirability&#46; Consequently&#44; using simplified interviews&#44; performing the assessment when the patient is stable or has minimal symptoms and avoiding administering stigmatizing assessments &#40;e&#46;g&#46;&#44; a symptom rating scale&#41; have been recommended when assessing adherence&#46;<a class="elsevierStyleCrossRef" href="#bib0320"><span class="elsevierStyleSup">64</span></a></p><p id="par0120" class="elsevierStylePara elsevierViewall">The <span class="elsevierStyleItalic">Beliefs about Medicines Questionnaire</span> &#40;BMQ&#41;<a class="elsevierStyleCrossRef" href="#bib0325"><span class="elsevierStyleSup">65</span></a> was designed to evaluate beliefs about medication&#46; It consists of 2 scales&#58; 1 that assesses beliefs about medication in general &#40;BMQ-General&#41; and another scale that evaluates the patient&#39;s opinions on their specific treatment &#40;BMQ-Specific&#41;&#46; There is a validated version in Spain&#46; Its study of psychometric properties&#8212;conducted with chronic&#44; hypertensive&#44; diabetic and university student patients&#8212;showed good validity and reliability&#59; however&#44; it would be advisable to carry out studies in other populations and with other types of treatment&#46;<a class="elsevierStyleCrossRef" href="#bib0330"><span class="elsevierStyleSup">66</span></a></p><p id="par0125" class="elsevierStylePara elsevierViewall">The <span class="elsevierStyleItalic">Drug Attitude Inventory</span> &#40;DAI&#41;&#44;<a class="elsevierStyleCrossRef" href="#bib0335"><span class="elsevierStyleSup">67</span></a> a widely used scale&#44; was developed for patients with schizophrenia&#44; although it has been used in different psychiatric disorders&#46;<a class="elsevierStyleCrossRef" href="#bib0335"><span class="elsevierStyleSup">67</span></a> It assesses attitudes&#44; beliefs and feelings in relation to taking medication&#44; as well as the subjective effect of antipsychotics and illness awareness&#46; The most commonly used version is one which is reduced to 10 items&#46;<a class="elsevierStyleCrossRef" href="#bib0320"><span class="elsevierStyleSup">64</span></a> There is a validated version in Spanish&#46;<a class="elsevierStyleCrossRef" href="#bib0340"><span class="elsevierStyleSup">68</span></a></p><p id="par0130" class="elsevierStylePara elsevierViewall">There are other scales&#44; although lacking validation in Spain&#44; such as the <span class="elsevierStyleItalic">Brief Evaluation of Medication Influences and Beliefs</span> &#40;BEMIB&#41;<a class="elsevierStyleCrossRef" href="#bib0345"><span class="elsevierStyleSup">69</span></a> and the <span class="elsevierStyleItalic">Rating of Medication Influences</span> &#40;ROMI&#41;&#44;<a class="elsevierStyleCrossRef" href="#bib0350"><span class="elsevierStyleSup">70</span></a> both based on the Health Belief Model&#46; The <span class="elsevierStyleItalic">Medication Adherence Rating Scale</span> &#40;MARS&#41;&#44;<a class="elsevierStyleCrossRef" href="#bib0355"><span class="elsevierStyleSup">71</span></a> initially developed for use in patients with schizophrenia and psychosis&#44; assesses adherence and attitudes toward medication&#46;</p></span></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Study limitations and methodological difficulties</span><p id="par0135" class="elsevierStylePara elsevierViewall">In studying beliefs towards depression and its treatment&#44; questionnaires created by the authors are frequently used&#44; although they are not validated and difficult to repeat&#46; Only some have used validated belief scales such as the <span class="elsevierStyleItalic">Beliefs about Medicines Questionnaire or the Drug Attitude Inventory</span>&#46;<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">12&#44;27&#44;55</span></a> Most studies on adherence have used self-reported measures of adherence&#44; with which its estimation is probably being over evaluated&#44; given that patient-reported adherence is the least valid<a class="elsevierStyleCrossRef" href="#bib0320"><span class="elsevierStyleSup">64</span></a> and tends to be greater than the real figure&#46;<a class="elsevierStyleCrossRef" href="#bib0360"><span class="elsevierStyleSup">72</span></a> On the other hand&#44; in the articles reviewed&#44; it is difficult to differentiate those beliefs that refer only to antidepressants from those that refer to psychotropic medications in general&#46;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">34</span></a> In the same vein&#44; it is difficult to separate the perceived stigma related to depression from that related to antidepressant treatment&#46; With samples of depressed patients&#44; the study of beliefs about depression&#44; its treatment and the variables related to it has the disadvantage that these beliefs may be influenced by the depression itself&#46; The existence of depression&#44; depressive symptoms<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> and the greater severity of these symptoms<a class="elsevierStyleCrossRef" href="#bib0275"><span class="elsevierStyleSup">55</span></a> have been found to influence beliefs about depression and antidepressant treatment&#44; so it is important to have studies that evaluate these beliefs in the absence of depression&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conclusions</span><p id="par0140" class="elsevierStylePara elsevierViewall">Non-adherence is a frequent phenomenon&#44; both in antidepressant treatment and psychotherapy&#44; reaching 30&#8211;60&#37; overall&#46; It is a multifactorial phenomenon and assessing risk factors is essential to address them later&#46; Non-adherence to psychotherapy is still understudied&#46; Beliefs and attitudes towards medication and psychotherapy potentially influence adherence and should be evaluated in all patients&#46; There are multiple causal factors underlying these beliefs and attitudes and they are still understudied&#46; Each patient should be assessed individually&#44; since each person is unique in their personal history and their way of viewing depression and its treatment&#46; Negative beliefs &#40;misconceptions&#44; prejudices&#41;&#44; negative attitudes and possible stigma perceived towards medication and&#47;or depression must be identified and addressed in the context of an appropriate therapeutic relationship&#46; This is because these factors can be important in non-adherence and identifying them and the patient&#39;s preferences may point towards the type of treatment&#46; Overall&#44; there is currently a preference for psychotherapy&#46; However&#44; the positive assessment of psychopharmaceuticals has increased in the last few years&#44; in line with movement towards a biomedical framework regarding beliefs about the aetiology of depression&#46; On the other hand&#44; given that beliefs and attitudes are changeable&#44; influenced by various factors&#44; they should be assessed throughout the evolution of the illness&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">Patient beliefs about depression and its treatment are an essential factor for adherence to both psychotherapy and psychotropic drugs and&#44; therefore&#44; for the development of the disorder&#46; The search for the best possible adherence should take place in the context of a good therapeutic relationship&#44; psychoeducation&#44; assessing beliefs and attitudes towards medication and psychotherapy&#44; dealing with any negative beliefs and attitudes and considering patient preferences&#46;</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conflict of interests</span><p id="par0150" class="elsevierStylePara elsevierViewall">The authors have no conflict of interest to declare&#46;</p></span></span>"
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          "identificador" => "xres114445"
          "titulo" => "Abstract"
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          "titulo" => "Introduction"
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        5 => array:2 [
          "identificador" => "sec0010"
          "titulo" => "Adherence to antidepressant treatment"
        ]
        6 => array:2 [
          "identificador" => "sec0015"
          "titulo" => "Adherence to psychotherapy"
        ]
        7 => array:2 [
          "identificador" => "sec0020"
          "titulo" => "How beliefs and attitudes towards treatment influence adherence"
        ]
        8 => array:3 [
          "identificador" => "sec0025"
          "titulo" => "Beliefs and attitudes towards depression&#44; medication and psychotherapy"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "sec0030"
              "titulo" => "Beliefs about depression"
            ]
            1 => array:2 [
              "identificador" => "sec0035"
              "titulo" => "Beliefs about antidepressants"
            ]
            2 => array:2 [
              "identificador" => "sec0040"
              "titulo" => "Beliefs about psychotherapy vs medication"
            ]
            3 => array:2 [
              "identificador" => "sec0045"
              "titulo" => "Assessment"
            ]
          ]
        ]
        9 => array:2 [
          "identificador" => "sec0050"
          "titulo" => "Study limitations and methodological difficulties"
        ]
        10 => array:2 [
          "identificador" => "sec0055"
          "titulo" => "Conclusions"
        ]
        11 => array:2 [
          "identificador" => "sec0060"
          "titulo" => "Conflict of interests"
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        12 => array:1 [
          "titulo" => "References"
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    "fechaRecibido" => "2012-06-26"
    "fechaAceptado" => "2012-08-29"
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          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec101759"
          "palabras" => array:6 [
            0 => "Beliefs about illness"
            1 => "Antidepressants"
            2 => "Psychotherapy"
            3 => "Treatment"
            4 => "Depression"
            5 => "Treatment adherence"
          ]
        ]
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          "palabras" => array:6 [
            0 => "Creencias"
            1 => "Antidepresivos"
            2 => "Psicoterapia"
            3 => "Tratamiento"
            4 => "Depresi&#243;n"
            5 => "Adherencia"
          ]
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        "titulo" => "Abstract"
        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Beliefs and attitudes about treatment in patients with depression are significant factors related to treatment adherence&#46; Despite their importance&#44; few studies have evaluated the determining factors of these beliefs&#44; and the positive or negative attitudes towards treatment&#46; This review looks at areas such as&#44; adherence to antidepressants and psychotherapy&#44; influence of beliefs and attitudes on adherence to treatment&#44; beliefs and attitudes about depression and its treatment&#44; their assessment&#44; variables associated with these beliefs&#44; and limitations of available studies&#46; Acknowledging the importance of patient beliefs about depression and treatment&#44; and their assessment are essential to optimize the chances of success of therapy by identifying and addressing misconceptions&#44; prejudices and negative attitudes&#44; as well as the consideration of these aspects in order to improve treatment choice&#46;</p>"
      ]
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Las creencias y actitudes frente al tratamiento en los pacientes con depresi&#243;n son factores de incuestionable importancia para la adherencia al tratamiento&#46; A pesar de su importancia&#44; a&#250;n existen pocos estudios que hayan evaluado los factores determinantes de las creencias y actitudes negativas o positivas frente al tratamiento&#46; En esta revisi&#243;n se abordan las &#225;reas de la adherencia al tratamiento antidepresivo y a la psicoterapia&#44; la influencia de las creencias y actitudes frente al tratamiento sobre la adherencia&#44; las creencias y actitudes frente a la depresi&#243;n y sus tratamientos&#44; su evaluaci&#243;n&#44; las variables relacionadas con estas creencias&#44; y las limitaciones de los estudios disponibles&#46; La consideraci&#243;n y evaluaci&#243;n de las creencias de los pacientes respecto a la depresi&#243;n y los tratamientos es esencial para optimizar las posibilidades de &#233;xito de la terapia mediante la identificaci&#243;n y abordaje de concepciones err&#243;neas&#44; prejuicios y actitudes negativas&#44; as&#237; como la consideraci&#243;n de estos aspectos en la elecci&#243;n del tratamiento&#46;</p>"
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara">Please cite this article as&#58; Acosta F&#44; et al&#46; Creencias sobre la depresi&#243;n y sus tratamientos&#58; variables asociadas e influencia de las creencias en la adherencia&#46; Rev Psiquiatr Salud Ment &#40;Barc&#46;&#41;&#46; 2013&#59;6&#58;86&#8211;92&#46;</p>"
      ]
    ]
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es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos