Original article
Prefrontal abnormalities, executive dysfunction and symptoms severity are modulated by COMT Val158Met polymorphism in first episode psychosis
Modulación de alteraciones prefrontales por el polimorfismo COMT Val158Met en los primeros episodios psicóticos
Elisa Rodríguez-Toscanoa,b,1,
, Kenia Martíneza,c,1, David Fraguasa,c,d, Joost Janssena,c, Laura Pina-Camachoa,c,e, Bárbara Ariasf, Eduard Vietac,g, Gisela Mezquidac,g,h,i, Silvia Amorettic,g,h,i, Miguel Bernardoc,g,h,i,j, Josefina Castro-Fornielesk, Manuel Jesús Cuesta-Zorital,m, Antonio Lobon,o, Ana González-Pintoc,p, Iluminada Corripio Colladoq, Anna Manéc,r,s, Celso Arangoa,c,d, Mara Parelladaa,c,d, PEPs Group
Corresponding author
a Department of Child and Adolescent Psychiatry, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain
b Experimental Psychology, Cognitive Psychology and Speech & Language Therapy Immunology, Faculty of Psychology, Universidad Complutense Madrid, Spain
c Ciber del Area de Salud Mental (CIBERSAM), Spain
d School of Medicine, Universidad Complutense, Madrid, Spain
e Department of Child and Adolescent Psychiatry, Institute of Psychiatry Psychology and Neuroscience, King's College London, London, UK
f Departament Biologia Evolutiva, Ecologia i Ciències Ambientals, Facultat de Biologia, Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, CIBERSAM, Barcelona, Spain
g Hospital Clinic, Institute of Neuroscience, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain
h Barcelona Clinic Schizophrenia Unit, Hospital Clinic of Barcelona, Neuroscience Institute, Spain
i Department of Medicine, Institut de Neurociències, Universitat de Barcelona, Spain
j August Pi I Sunyer Biomedical Research Institute (IDIBAPS), Spain
k Department of Child and Adolescent Psychiatry and Psychology, Clínic Institute of Neurosciences, Hospital Clínic de Barcelona, 2017SGR881, University of Barcelona, CIBERSAM, IDIBAPS, Barcelona, Spain
l Department of Psychiatry, Complejo Hospitalario de Navarra, Pamplona, Spain
m IdiSNA, Navarra Institute for Health Research, Pamplona, Spain
n Department of Medicine and Psychiatry, Zaragoza University, Spain
o Instituto de Investigación Sanitaria Aragón (IIS Aragón), Zaragoza, CIBERSAM, Madrid, Spain
p Department of Psychiatry, Araba University Hospital, Bioaraba Research Institute, Department of Neurociences, University of the Basque Country, Vitoria, Spain
q Department of Psychiatry, Sant Pau Hospital, Biomedical Research Networking Center for Mental Health Network (CIBERSAM), Barcelona, Spain
r Hospital del Mar Medical Research Institute (IMIM), Spain
s Autonomous University of Barcelona, Spain
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