Article information
Abstract
Over the last few years, there has been a marked increase in the prescription of secondgeneration antipsychotics (SGA) for the treatment of psychotic disorders and other psychiatric conditions in children and adolescents. However, few reports compare the tolerability and efficacy of the different SGAs in this population. We review the literature on the differential characteristics of efficacy and tolerability of SGA in the pediatric population. Our results show that SGAs are not a homogeneous group, but that each drug has a distinct profile, particularly with respect to side effects, especially metabolic complications. Comparisons between SGAs have shown that treatment with olanzapine was associated with greater weight gain and increased cholesterol levels, and that treatment with risperidone was associated with a greater increase in prolactin levels. Therefore, the specific profile of an SGA should be taken into consideration when prescribing these drugs.
Keywords:
Efficacy
Tolerability
Antipsychotic
Psychosis
Pediatric population
Resumen
En los últimos años se ha producido un aumento exponencial en la prescripción de antipsicóticos de segunda generación (ASG) en niños y adolescentes para el tratamiento de trastornos psicóticos y otros trastornos mentales. Sin embargo, hay muy pocos estudios que comparen la tolerabilidad y la eficacia entre los distintos ASG en esta población.Este artículo revisa los datos actuales sobre las características diferenciales de eficacia y tolerabilidad de los ASG en población infanto-juvenil. Los datos muestran que los ASG no forman un grupo homogéneo, sino que cada fármaco de este grupo tiene un perfil característico, sobre todo con respecto a los efectos secundarios, especialmente las complicaciones metabólicas. En concreto, en las comparativas entre ASG, el tratamiento con olanzapina se relacionó con mayor aumento de peso y de colesterol, y el tratamiento con risperidona se asoció con mayor aumento de prolactina. Por ello, antes de prescribir un ASG resulta imprescindible tener en cuenta el perfil diferencial de estos fármacos.
Palabras clave:
Eficacia
Tolerabilidad
Antipsicótico
Psicosis
Población pediátrica
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