was read the article
array:23 [ "pii" => "S0214158221001456" "issn" => "02141582" "doi" => "10.1016/j.senol.2021.12.005" "estado" => "S300" "fechaPublicacion" => "2022-07-01" "aid" => "398" "copyright" => "SESPM" "copyrightAnyo" => "2021" "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "cita" => "Rev Senol Patol Mamar. 2022;35:175-83" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "itemSiguiente" => array:18 [ "pii" => "S0214158222000470" "issn" => "02141582" "doi" => "10.1016/j.senol.2022.02.003" "estado" => "S300" "fechaPublicacion" => "2022-07-01" "aid" => "409" "copyright" => "SESPM" "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "cita" => "Rev Senol Patol Mamar. 2022;35:184-91" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>" "titulo" => "Knowledge, attitude and acceptance of bilateral prophylactic mastectomy among female staff in a private university in Nigeria" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "184" "paginaFinal" => "191" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Conocimiento, actitud y aceptación de la mastectomía profiláctica bilateral entre el personal femenino de una universidad privada de Nigeria" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Deborah T. Esan, Opeyemi A. Adedeji, Mejeha O. Ihunanyachi, Carlos Ramos" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Deborah T." "apellidos" => "Esan" ] 1 => array:2 [ "nombre" => "Opeyemi A." "apellidos" => "Adedeji" ] 2 => array:2 [ "nombre" => "Mejeha O." "apellidos" => "Ihunanyachi" ] 3 => array:2 [ "nombre" => "Carlos" "apellidos" => "Ramos" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0214158222000470?idApp=UINPBA00004N" "url" => "/02141582/0000003500000003/v3_202207191618/S0214158222000470/v3_202207191618/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0214158221000992" "issn" => "02141582" "doi" => "10.1016/j.senol.2021.09.002" "estado" => "S300" "fechaPublicacion" => "2022-07-01" "aid" => "375" "copyright" => "SESPM" "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "cita" => "Rev Senol Patol Mamar. 2022;35:167-74" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "es" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original</span>" "titulo" => "Evolución y resultados del tratamiento neoadyuvante en cáncer de mama durante un periodo de 10 años" "tienePdf" => "es" "tieneTextoCompleto" => "es" "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "167" "paginaFinal" => "174" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Progress and oncological outcome of neoadjuvant therapy in breast cancer patients during a 10-year period" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "f0015" "etiqueta" => "Figura 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 704 "Ancho" => 1900 "Tamanyo" => 197305 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "al0015" "detalle" => "Figura " "rol" => "short" ] ] "descripcion" => array:1 [ "es" => "<p id="sp0015" class="elsevierStyleSimplePara elsevierViewall">SG y SLP por periodo estimadas mediante Kaplan Meier.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Ana Isabel Ballesteros, M. Pilar López, Rebeca Mondejar, Vilma Pacheco-Barcia, Olga Donnay, Berta Hernández, Nuria Romero-Laorden, Beatriz Doblado, Rosa María Álvarez López, Elia Pérez-Fernández, R. Colomer" "autores" => array:11 [ 0 => array:2 [ "nombre" => "Ana Isabel" "apellidos" => "Ballesteros" ] 1 => array:2 [ "nombre" => "M. Pilar" "apellidos" => "López" ] 2 => array:2 [ "nombre" => "Rebeca" "apellidos" => "Mondejar" ] 3 => array:2 [ "nombre" => "Vilma" "apellidos" => "Pacheco-Barcia" ] 4 => array:2 [ "nombre" => "Olga" "apellidos" => "Donnay" ] 5 => array:2 [ "nombre" => "Berta" "apellidos" => "Hernández" ] 6 => array:2 [ "nombre" => "Nuria" "apellidos" => "Romero-Laorden" ] 7 => array:2 [ "nombre" => "Beatriz" "apellidos" => "Doblado" ] 8 => array:2 [ "nombre" => "Rosa María" "apellidos" => "Álvarez López" ] 9 => array:2 [ "nombre" => "Elia" "apellidos" => "Pérez-Fernández" ] 10 => array:2 [ "nombre" => "R." "apellidos" => "Colomer" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0214158221000992?idApp=UINPBA00004N" "url" => "/02141582/0000003500000003/v3_202207191618/S0214158221000992/v3_202207191618/es/main.assets" ] "en" => array:19 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>" "titulo" => "Covariate clustering: Women with breast cancer in southwestern Paraná, Brazil" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "175" "paginaFinal" => "183" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Neyva Maria Lopes Romeiro, Carolina Panis, Mara Caroline Torres dos Santos, Daniel Rech, Paulo Laerte Natti, Eliandro Rodrigues Cirilo" "autores" => array:6 [ 0 => array:4 [ "nombre" => "Neyva Maria Lopes" "apellidos" => "Romeiro" "email" => array:1 [ 0 => "nromeiro@uel.br" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "af0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cr0005" ] ] ] 1 => array:3 [ "nombre" => "Carolina" "apellidos" => "Panis" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "af0010" ] ] ] 2 => array:3 [ "nombre" => "Mara Caroline Torres" "apellidos" => "dos Santos" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "af0005" ] ] ] 3 => array:3 [ "nombre" => "Daniel" "apellidos" => "Rech" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "af0010" ] ] ] 4 => array:3 [ "nombre" => "Paulo Laerte" "apellidos" => "Natti" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "af0005" ] ] ] 5 => array:3 [ "nombre" => "Eliandro Rodrigues" "apellidos" => "Cirilo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "af0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Mathematics Department, Universidade Estadual de Londrina, Campus Universitário, Londrina, Brazil" "etiqueta" => "a" "identificador" => "af0005" ] 1 => array:3 [ "entidad" => "Laboratory of tumor biology, Universidade Estadual do Oeste do Paraná, UNIOESTE and Cancer Hospital, Francisco Beltrão, Brazil" "etiqueta" => "b" "identificador" => "af0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cr0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Agrupamiento covariado: mujeres con cáncer de mama en el suroeste de paraná, Brasil" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "f0010" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1338 "Ancho" => 1772 "Tamanyo" => 217842 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "al0010" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="sp0010" class="elsevierStyleSimplePara elsevierViewall">Distribution of categorical and quantitative variables of clusters C<span class="elsevierStyleInf">1</span> (blue), C<span class="elsevierStyleInf">2</span> (black) and C<span class="elsevierStyleInf">3</span> (red). (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="s0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0065">Introduction</span><p id="p0005" class="elsevierStylePara elsevierViewall">Breast cancer is the most common malignant neoplasm in women.<a class="elsevierStyleCrossRef" href="#bb0005"><span class="elsevierStyleSup">1</span></a> Age, over 50 years old, is the most critical risk factor.<a class="elsevierStyleCrossRef" href="#bb0010"><span class="elsevierStyleSup">2</span></a> Other determining factors for the development of the disease are genetic, hereditary, late menopause, obesity, sedentary lifestyle, and frequent exposure to ionizing radiation.<a class="elsevierStyleCrossRef" href="#bb0015"><span class="elsevierStyleSup">3</span></a><span class="elsevierStyleSup">,</span><a class="elsevierStyleCrossRef" href="#bb0020"><span class="elsevierStyleSup">4</span></a> Such factors are mainly responsible for the clinicopathological differences found in the literature on breast cancer.<a class="elsevierStyleCrossRefs" href="#bb0025"><span class="elsevierStyleSup">5–11</span></a></p><p id="p0010" class="elsevierStylePara elsevierViewall">Specific studies involving the Brazilian population point to classic risk factors, such as aging and menopausal status.<a class="elsevierStyleCrossRef" href="#bb0060"><span class="elsevierStyleSup">12</span></a><span class="elsevierStyleSup">,</span><a class="elsevierStyleCrossRef" href="#bb0065"><span class="elsevierStyleSup">13</span></a> Other studies show more complex associations, also observed worldwide, such as the development of tumors with a worse prognosis, such as triple-negative, in obese and overweight women.<a class="elsevierStyleCrossRef" href="#bb0055"><span class="elsevierStyleSup">11</span></a><span class="elsevierStyleSup">,</span><a class="elsevierStyleCrossRef" href="#bb0070"><span class="elsevierStyleSup">14</span></a> Factors such as social vulnerability<a class="elsevierStyleCrossRef" href="#bb0075"><span class="elsevierStyleSup">15</span></a> and a history of psychological stress<a class="elsevierStyleCrossRef" href="#bb0080"><span class="elsevierStyleSup">16</span></a> have also been reported as possible risks associated with the presence of breast cancer in women living in southern Brazil. However, studies referring to regional risk factors are rare and inconclusive.</p><p id="p0015" class="elsevierStylePara elsevierViewall">In this context, it is intended to categorize, through statistical analysis, possible risk factors for breast cancer, targeting patients in the southwest region of Paraná, Brazil. It is known that mathematical analysis can be a powerful tool to assess patient data, providing reliable associations between variables that often cannot be understood in isolation. Considering that physicians may not be familiar with statistical analysis, such interdisciplinary studies become essential.</p><p id="p0020" class="elsevierStylePara elsevierViewall">Data from breast cancer patients can be analyzed using various mathematical tools. We highlight the multivariate analysis that studies the correlation of two or more variables with different information.<a class="elsevierStyleCrossRef" href="#bb0085"><span class="elsevierStyleSup">17</span></a><span class="elsevierStyleSup">,</span><a class="elsevierStyleCrossRef" href="#bb0090"><span class="elsevierStyleSup">18</span></a> The analysis of these groups can provide relevant information about part of the total sample. In this way, clustering performs a more specific descriptive analysis of the groups within the sample.</p><p id="p0025" class="elsevierStylePara elsevierViewall">It is observed that many studies perform statistical analysis considering correlations of a few variables.<a class="elsevierStyleCrossRef" href="#bb0025"><span class="elsevierStyleSup">5</span></a><span class="elsevierStyleSup">,</span><a class="elsevierStyleCrossRefs" href="#bb0040"><span class="elsevierStyleSup">8–11</span></a><span class="elsevierStyleSup">,</span><a class="elsevierStyleCrossRef" href="#bb0095"><span class="elsevierStyleSup">19</span></a> In this line of study, to categorize possible risk factors identified in women diagnosed with breast cancer, an exploratory data study is presented considering 11 clinicopathological variables.</p></span><span id="s0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0070">Materials and methods</span><span id="s0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0075">Sample</span><p id="p0030" class="elsevierStylePara elsevierViewall">The sequential data used contain information from biopsy samples taken serially from women who had lesions suggestive of breast cancer, visualized by imaging tests and physical examinations, in the period from May 2015 to March 2020. Data confidentiality was maintained following clinical research guidelines. The Institutional Ethics Board approved the study under the number CAAE 35524814.4.0000.0107, including 155 patients with a confirmed breast cancer diagnóstico through biopsy. These patients from the 8<span class="elsevierStyleSup">th</span> Health Regional of the State of Paraná, which covers 25 municipalities, divided into three regions, were treated at the Oncology hospital in Francisco Beltrão, Paraná, Brazil. Medical records were consulted to obtain data. All patients signed consent, and each protocol followed the principles of medical research involving humans described in the Declaration of Helsinki.</p></span><span id="s0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0080">Variables</span><p id="p0035" class="elsevierStylePara elsevierViewall">In this study, variables with different characteristics and applications are considered. The clinical and pathological variables were used to characterize patients and tumors (breast cancer). The spatial distribution of breast cancer cases in the three regions and municipalities of the 8<span class="elsevierStyleSup">th</span> Health Region of the State of Paraná was also analyzed. Numbers labeled patients.</p><p id="p0040" class="elsevierStylePara elsevierViewall">Furthermore, 11 clinicopathological variables are used to describe characteristics of the disease, such as the presence of intratumoral emboli, the presence of lymph nodes, the menopausal status, the molecular subtype, the histological grade, the TNM staging of the disease, tumor size (cm), age at diagnóstico (years), weight (kg), height (m) and body mass index (BMI) in (kg/m<span class="elsevierStyleSup">2</span>).</p><p id="p0045" class="elsevierStylePara elsevierViewall">Histopathological evaluation is essential for the diagnóstico of neoplasia. In this context, for the histological grade variable, the criteria were adopted as being well, moderately, and little differentiated. For molecular subtype, variables were determined as recommended by the St Gallen Consensus.<a class="elsevierStyleCrossRef" href="#bb0100"><span class="elsevierStyleSup">20</span></a> The TNM staging variable was classified concerning the stages of the disease as described by the American Joint Committee on Cancer, Breast Cancer Staging System.<a class="elsevierStyleCrossRef" href="#bb0105"><span class="elsevierStyleSup">21</span></a></p><p id="p0050" class="elsevierStylePara elsevierViewall">For a better understanding of the work, the variables are classified as:</p><p id="p0055" class="elsevierStylePara elsevierViewall">Binary: intratumoral emboli, lymph node invasion, and menopausal status;</p><p id="p0060" class="elsevierStylePara elsevierViewall">Categorical: molecular subtype, histological grade, and TNM staging;</p><p id="p0065" class="elsevierStylePara elsevierViewall">Quantitative: tumor size, age at diagnóstico, weight, height, and BMI.</p></span><span id="s0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0085">Statistical methods</span><p id="p0070" class="elsevierStylePara elsevierViewall">Several methodologies analyze characteristics that differentiate the data from a sample, dividing it into clusters.<a class="elsevierStyleCrossRef" href="#bb0085"><span class="elsevierStyleSup">17</span></a><span class="elsevierStyleSup">,</span><a class="elsevierStyleCrossRef" href="#bb0090"><span class="elsevierStyleSup">18</span></a><span class="elsevierStyleSup">,</span><a class="elsevierStyleCrossRef" href="#bb0110"><span class="elsevierStyleSup">22</span></a> In this article, we used the software R.<a class="elsevierStyleCrossRef" href="#bb0115"><span class="elsevierStyleSup">23</span></a> The packages Hmisc<a class="elsevierStyleCrossRef" href="#bb0120"><span class="elsevierStyleSup">24</span></a> and Agricolae<a class="elsevierStyleCrossRef" href="#bb0125"><span class="elsevierStyleSup">25</span></a> were used to facilitate the interpretation of the analysis performed on the data. Cluster analysis was performed by calculating the Euclidean distance between clinicopathological variables.</p><p id="p0075" class="elsevierStylePara elsevierViewall">Initially, to determine which data are more homogeneous with each other, the Euclidean distance method is used. Next, Ward's hierarchical agglomerative method is used to generate the heterogeneous groups among themselves. The result of the analysis, presented in a dendrogram, helps identify the division of groups, thus generating clusters.</p><p id="p0080" class="elsevierStylePara elsevierViewall">Once the clusters were obtained, the calculation of Spearman's lineal correlation between the variables allowed us to understand the influence that one variable exerts over another, enabling the identification of possible risk factors associated with the groups.<a class="elsevierStyleCrossRef" href="#bb0130"><span class="elsevierStyleSup">26</span></a> The Spearman's correlation coefficient varies between −<span class="elsevierStyleHsp" style=""></span>1 and 1, where, to determine the significance of the correlations, the <span class="elsevierStyleItalic">p</span>-value was calculated.</p><p id="p0085" class="elsevierStylePara elsevierViewall">To extract characteristics that distinguish the data from different clusters and calculate the correlation, the test of means was used. This procedure allows us to calculate, for each cluster variable, those that present different significant means and those that are just sample variations.</p></span></span><span id="s0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0090">Results</span><p id="p0090" class="elsevierStylePara elsevierViewall">Approximately 31% of the patients had tumors containing intratumoral emboli. It is also noted that the presence of positive lymph nodes was observed in 41% of patients and that 70% are classified as menopausal women at diagnóstico.</p><p id="p0095" class="elsevierStylePara elsevierViewall">On average, the patients in this study have a higher frequency of tumors of the Luminal B molecular subtype, intermediate histological grade, moderately differentiated, and a median TNM stage II, with variations between 0 and IV.</p><p id="p0100" class="elsevierStylePara elsevierViewall">The dispersion of tumor size was observed, ranging from 0.9 cm to 15 cm. The average age of patients is 56.6 years, and the prevalence of the disease was higher in women aged over 45 years, representing 75% of cases. The average weight, when diagnosed, was close to 72.5 kg, but one of the patients weighed 120 kg. Furthermore, only 25% of patients had a BMI of less than 24.8 kg/m<span class="elsevierStyleSup">2</span>.</p></span><span id="s0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0095">Clinicopathological correlations</span><p id="p0105" class="elsevierStylePara elsevierViewall">Checking the influence that one variable exerts on the other allows a better understanding of the data from a sample, making it possible to identify possible risk factors. Thus, Spearman's lineal correlation is used to estimate the correlation between each pair of variables, evaluating possible connections between clinicopathological variables.</p><p id="p0110" class="elsevierStylePara elsevierViewall">Statistical analysis reveals the existence of significant associations between some of the variables in the sample. These results can be seen through the color map in <a class="elsevierStyleCrossRef" href="#t0005">Table 1</a>, where stronger colors reveal the existence of significant associations (<span class="elsevierStyleItalic">p</span> < 0.01) between the variables.</p><elsevierMultimedia ident="t0005"></elsevierMultimedia><p id="p0115" class="elsevierStylePara elsevierViewall">We should highlight the positive and significant correlations of intratumoral emboli with the presence of lymph node invasion and TNM staging. The formation of intratumoral emboli occurs due to tumor-induced coagulation changes. This event facilitates the spread of the disease, explaining its correlation with lymph node invasion.<a class="elsevierStyleCrossRef" href="#bb0135"><span class="elsevierStyleSup">27</span></a></p><p id="p0120" class="elsevierStylePara elsevierViewall">TNM staging variable presents a positive and significant correlation with the lymph node invasion variable. This correlation was also expected, as the TNM staging calculation uses lymph node invasion as one of its parameters. These results show that the mathematical model follows the clinical classification used to establish the TNM staging.</p><p id="p0125" class="elsevierStylePara elsevierViewall">It is noted that the correlations involving the variables presence of intratumoral emboli, lymph node invasion, and TNM staging did not show significant connections with the variables age and BMI, so that the correlations presented describe risk factors independent of age and the patients' body weight at diagnóstico. However, it is known that both age and obesity are considered determinant risk factors. <a class="elsevierStyleCrossRef" href="#t0005">Table 1</a> shows a positive and robust correlation between menopause and the patient's age. It is an expected association, as women experience hormonal failure with aging. On the other hand, the data do not show a significant correlation between menopause and being overweight.</p><p id="p0130" class="elsevierStylePara elsevierViewall">Due to the heterogeneity of the behavior patterns of the clinical parameters evaluated in breast cancer, it is necessary to analyze the sample data in smaller groups. Thus, probably more specific correlations can be evidenced from the data.</p><p id="p0135" class="elsevierStylePara elsevierViewall">Considering the data from the complete sample, Ward's method resulted in the formation of hierarchical groups by similarities, suggesting a marked reduction in similarity when 2 or 3 clusters are obtained, as shown in <a class="elsevierStyleCrossRef" href="#f0005">Fig. 1</a>. The dendrogram graphically indicates the evolutionary history of the distance matrix; that is, the observations of each group are similar to each other, and each group is heterogeneous compared to the other, so three groups were the ideal choice. In addition to the dendrogram, the fusion test was performed, indicating that the first most significant distance between the groups is found in the third group. Thus, it was decided to keep 3 clusters, denoted by C<span class="elsevierStyleInf">1</span>, C<span class="elsevierStyleInf">2</span>, and C<span class="elsevierStyleInf">3</span>, respectively, even because, clinically, there was a better representation of information about the patients.</p><elsevierMultimedia ident="f0005"></elsevierMultimedia><p id="p0140" class="elsevierStylePara elsevierViewall">From the descriptive means and test of means, <a class="elsevierStyleCrossRef" href="#t0010">Table 2</a>, it appears that clusters C<span class="elsevierStyleInf">1</span>, C<span class="elsevierStyleInf">2</span>, and C<span class="elsevierStyleInf">3</span> do not show significant differences in the variables intratumoral emboli, presence of lymph node invasion, molecular subtype, grade, TNM staging, tumor size, and height. On the other hand, all clusters show significant differences in the menopausal status, age, weight, and BMI variables, in bold in <a class="elsevierStyleCrossRef" href="#t0010">Table 2</a>. Thus, in our mathematical modeling, the variable menopause, age, and BMI at diagnóstico were selected based on their contribution to characterizing the influence of each variable in breast cancer prognosis.</p><elsevierMultimedia ident="t0010"></elsevierMultimedia></span><span id="s0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0100">Discussion</span><p id="p0145" class="elsevierStylePara elsevierViewall">In this study, we showed that cluster analysis is an interesting approach to categorizing breast cancer patients according to combined clinicopathological features. This analysis resulted in 3 utterly distinct clusters. C<span class="elsevierStyleInf">1</span> was formed by 99% of menopausal women, older, with a mean age of 67 years, and overweight, with a mean BMI of 27.14 kg/m<span class="elsevierStyleSup">2</span>. C<span class="elsevierStyleInf">2</span> included younger women with a mean of 42.57 years; most were not in menopause, had lymph node invasion, and had average weight. C<span class="elsevierStyleInf">3</span> was composed of women of middle ages, obese, in menopause, and with lymph node invasion.</p><p id="p0150" class="elsevierStylePara elsevierViewall">Information regarding the categorical and quantitative variables in each cluster is shown in <a class="elsevierStyleCrossRef" href="#f0010">Fig. 2</a>. Note that <a class="elsevierStyleCrossRef" href="#f0010">Fig. 2</a>(a) shows the prevalence of tumors of the Luminal A and B subtypes in C<span class="elsevierStyleInf">1</span> and C<span class="elsevierStyleInf">3</span> and Luminal B in C<span class="elsevierStyleInf">2</span>. It means that considering the molecular subtype of breast cancer, C<span class="elsevierStyleInf">2</span> has patients with the worst clinical prognosis compared to the others since Luminal B tumors are very aggressive.<a class="elsevierStyleCrossRef" href="#bb0140"><span class="elsevierStyleSup">28</span></a></p><elsevierMultimedia ident="f0010"></elsevierMultimedia><p id="p0155" class="elsevierStylePara elsevierViewall">It was observed that with the division of clusters, it was possible to characterize the heterogeneity of behavior between the clinicopathological variables. Quantifying the intensity of the statistical dependence of the set of variables in each cluster will allow us to understand the influence that one variable exerts over another, making it possible to identify possible risk factors associated with the groups.</p><p id="p0160" class="elsevierStylePara elsevierViewall">Thus, from the analysis of each cluster, where stronger colors reveal the existence of significant associations (<span class="elsevierStyleItalic">p</span> < 0.01) between the variables, as shown in <a class="elsevierStyleCrossRef" href="#t0015">Table 3</a>, the data confirm some common characteristics, highlighting the strong correlation between the variables weight and BMI in all clusters, and the correlation between menopausal status and age at diagnóstico, in C<span class="elsevierStyleInf">3</span>. Similarly, correlations between intratumoral emboli, the presence of lymph node invasion, and TNM staging are present in almost all clusters. It is worth mentioning that, despite these characteristics having already been observed in the data of the complete sample, <a class="elsevierStyleCrossRef" href="#t0005">Table 1</a>, it is now possible to analyze these correlations in the context of the particularities of each cluster. Next, the analysis of each cluster was carried out.</p><elsevierMultimedia ident="t0015"></elsevierMultimedia><p id="p0165" class="elsevierStylePara elsevierViewall">In C<span class="elsevierStyleInf">1</span>, menopausal, older, and overweight patients, significant correlations between the variables intratumoral emboli, lymph node invasion, and TNM staging are observed. This statement is justified by the analysis of the correlations obtained in <a class="elsevierStyleCrossRef" href="#t0015">Table 3</a>, that is, the correlation of:</p><p id="p0170" class="elsevierStylePara elsevierViewall">(a) intratumoral emboli with lymph node invasion and TNM staging,</p><p id="p0175" class="elsevierStylePara elsevierViewall">(b) TNM staging with lymph node invasion, tumor grade, and size.</p><p id="p0180" class="elsevierStylePara elsevierViewall">It is known that, clinically, the formation of intratumoral emboli occurs due to coagulation alterations induced by tumors, facilitating the process of spreading the disease. Furthermore, the larger the tumor size, the more advanced the TNM stage of the disease is.</p><p id="p0185" class="elsevierStylePara elsevierViewall">In C<span class="elsevierStyleInf">2</span>, composed of patients aged between 31 and 52 years, most of them not menopausal and with an average BMI of 24.11 kg/m<span class="elsevierStyleSup">2</span>. There are significant correlations between intratumoral emboli and lymph node invasion, without association with the obesity variable. This statement is justified by the analysis of the correlations obtained in <a class="elsevierStyleCrossRef" href="#t0015">Table 3</a>, that is, the correlation of:<ul class="elsevierStyleList" id="l0005"><li class="elsevierStyleListItem" id="li0005"><span class="elsevierStyleLabel">(a)</span><p id="p0190" class="elsevierStylePara elsevierViewall">intratumoral emboli with lymph node invasion,</p></li><li class="elsevierStyleListItem" id="li0010"><span class="elsevierStyleLabel">(b)</span><p id="p0195" class="elsevierStylePara elsevierViewall">TNM staging with lymph node invasion and tumor size.</p></li></ul></p><p id="p0200" class="elsevierStylePara elsevierViewall">Clinically, these correlations act in favor of the same biological event, which in this case would be favoring tumor spread. In addition, this association has a significant clinical meaning since this cluster is characterized by the incidence of the disease in young women, which gives them a risk of highly aggressive tumors.<a class="elsevierStyleCrossRef" href="#bb0145"><span class="elsevierStyleSup">29</span></a> Thus, these women are not in menopause at diagnóstico is another factor of worse prognosis because estrogen acts as fuel for breast cancer.<a class="elsevierStyleCrossRef" href="#bb0150"><span class="elsevierStyleSup">30</span></a></p><p id="p0205" class="elsevierStylePara elsevierViewall">In C<span class="elsevierStyleInf">3</span>, composed of patients considered young, obese, and with a prevalence of TNM staging in stages, II and III, presents a strong correlation between the menopausal status variables and age at diagnóstico, in addition to other correlations previously observed in the preceding clusters. This statement is justified by the analysis of the correlations obtained in <a class="elsevierStyleCrossRef" href="#t0015">Table 3</a>, that is, the correlation of:<ul class="elsevierStyleList" id="l0010"><li class="elsevierStyleListItem" id="li0015"><span class="elsevierStyleLabel">(a)</span><p id="p0210" class="elsevierStylePara elsevierViewall">intratumoral emboli with lymph node invasion and TNM staging,</p></li><li class="elsevierStyleListItem" id="li0020"><span class="elsevierStyleLabel">(b)</span><p id="p0215" class="elsevierStylePara elsevierViewall">TNM staging with intratumoral emboli, lymph node invasion, and molecular subtype,</p></li><li class="elsevierStyleListItem" id="li0025"><span class="elsevierStyleLabel">(c)</span><p id="p0220" class="elsevierStylePara elsevierViewall">menopausal status with age at diagnóstico.</p></li></ul></p><p id="p0225" class="elsevierStylePara elsevierViewall">Clinically, the strong correlation between the variables menopausal status and age at diagnóstico configures a worse disease prognosis for non-menopausal women. There is no correlation between obesity and variables associated with breast cancer in these data. On the other hand, in the literature, it is observed that obesity is a risk factor for breast cancer and is associated with the occurrence of highly aggressive tumors.<a class="elsevierStyleCrossRef" href="#bb0155"><span class="elsevierStyleSup">31</span></a><span class="elsevierStyleSup">,</span><a class="elsevierStyleCrossRef" href="#bb0160"><span class="elsevierStyleSup">32</span></a></p></span><span id="s0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0105">Spatial distribution of clinicopathological variables</span><p id="p0230" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#t0020">Table 4</a> presents the descriptive means of the variables considered in each cluster for the three regions of the 8<span class="elsevierStyleSup">th</span> Health Regional of the State of Paraná, that are: Fronteira, Vale do Iguaçu, and Vale do Marrecas. Note that the means of the variables in each region that stand out the most are cluster C<span class="elsevierStyleInf">2</span>, in bold in <a class="elsevierStyleCrossRef" href="#t0020">Table 4</a>. Although the Vale do Iguaçu region contains the smallest number of patients, those in C<span class="elsevierStyleInf">2</span> of this region showed that the youngest patients are in a very advanced stage of the disease, TNM III, with the worst prognosis.</p><elsevierMultimedia ident="t0020"></elsevierMultimedia><p id="p0235" class="elsevierStylePara elsevierViewall">Regarding the high frequency of patients who developed the disease in the Vale do Marrecas region, this area is reported as the highest pesticide trade in in Paraná state, and it includes all municipalities in the 8<span class="elsevierStyleSup">th</span> Health Regional.<a class="elsevierStyleCrossRef" href="#bb0165"><span class="elsevierStyleSup">33</span></a> Therefore, knowledge about the spatial distribution of pesticide use can be used as a variable for the prognosis of breast cancer and give a possible interpretation of the data presented in <a class="elsevierStyleCrossRef" href="#t0020">Table 4</a>. Thus, new analyzes are suggested to assess the impacts of extrinsic factors on breast cancer patients, especially environmental factors, health habits, and diet.</p></span><span id="s0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0110">Conclusion</span><p id="p0240" class="elsevierStylePara elsevierViewall">The cluster analysis allowed us to identify essential factors in breast cancer and their relationship with characteristics of worse prognosis, such as BMI, TNM staging, the presence of intratumoral emboli, and lymph nodal invasion. Due to the heterogeneity of the clinical parameters evaluated, the sample data was analyzed in smaller groups, which resulted in three hierarchical groups categorized by similarities based on cluster analysis. All groups showed significant differences in menopausal status, age and BMI; therefore, these variables were selected.</p><p id="p0245" class="elsevierStylePara elsevierViewall">Through the statistical analysis, it was possible to determine the heterogeneity of the data, so the patients were separated into three clusters. This analysis identified that the group composed of older, postmenopausal and obese patients with intratumoral emboli, and lymph node invasion, configured characteristics of worse prognosis. As young, non-menopausal, and eutrophic patients who presented intratumoral emboli and lymph node invasion had characteristics associated with the development of tumors with poor clinical prognosis, regardless of obesity. Another group was formed by patients considered young, in menopause, and obese who presented a prevalence of TNM staging in stages II and III, reflecting the failures in the late search for health services for screening the disease at earlier stages. When analyzing the obtained clusters, each one of them had singular characteristics. Thus, with the division of the groups, it was possible to characterize the heterogeneity of characteristics of the clinicopathological variables, especially when considering that BMI is not a classical risk factor used to predict patients' prognosis in breast cancer. Quantifying the intensity of the statistical dependence of the set of variables in each cluster allowed us to understand the influence that one variable exerts over another, enabling the identification of possible risk factors associated with the groups.</p></span><span id="s0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0115">Funding</span><p id="p0250" class="elsevierStylePara elsevierViewall">The authors declare that they have not received funding for this study.</p></span><span id="s0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0120">Ethical disclosures</span><p id="p0255" class="elsevierStylePara elsevierViewall">All patients signed consent forms. The study was approved by the Institutional Ethical Committee. The authors have no ethical issues to declare.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:14 [ 0 => array:3 [ "identificador" => "xres1748480" "titulo" => "Abstract" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "as0005" "titulo" => "Introduction" ] 1 => array:2 [ "identificador" => "as0010" "titulo" => "Material and Methods" ] 2 => array:2 [ "identificador" => "as0015" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "as0020" "titulo" => "Conclusion" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec1540211" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres1748481" "titulo" => "Resumen" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "as0025" "titulo" => "Introducción" ] 1 => array:2 [ "identificador" => "as0030" "titulo" => "Material y métodos" ] 2 => array:2 [ "identificador" => "as0035" "titulo" => "Resultados" ] 3 => array:2 [ "identificador" => "as0040" "titulo" => "Conclusión" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec1540212" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "s0005" "titulo" => "Introduction" ] 5 => array:3 [ "identificador" => "s0010" "titulo" => "Materials and methods" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "s0015" "titulo" => "Sample" ] 1 => array:2 [ "identificador" => "s0020" "titulo" => "Variables" ] 2 => array:2 [ "identificador" => "s0025" "titulo" => "Statistical methods" ] ] ] 6 => array:2 [ "identificador" => "s0030" "titulo" => "Results" ] 7 => array:2 [ "identificador" => "s0035" "titulo" => "Clinicopathological correlations" ] 8 => array:2 [ "identificador" => "s0040" "titulo" => "Discussion" ] 9 => array:2 [ "identificador" => "s0045" "titulo" => "Spatial distribution of clinicopathological variables" ] 10 => array:2 [ "identificador" => "s0050" "titulo" => "Conclusion" ] 11 => array:2 [ "identificador" => "s0055" "titulo" => "Funding" ] 12 => array:2 [ "identificador" => "s0060" "titulo" => "Ethical disclosures" ] 13 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2021-11-24" "fechaAceptado" => "2021-12-14" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1540211" "palabras" => array:5 [ 0 => "Breast cancer" 1 => "Clusters" 2 => "Body mass index" 3 => "TNM staging" 4 => "Menopause" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec1540212" "palabras" => array:5 [ 0 => "Cáncer de mama" 1 => "Clústeres" 2 => "Índice de masa corporal" 3 => "Estadificación de TNM" 4 => "Menopausia" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:3 [ "titulo" => "Abstract" "resumen" => "<span id="as0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0010">Introduction</span><p id="sp0055" class="elsevierStyleSimplePara elsevierViewall">Due to the high incidence and aggressiveness of breast cancer, understanding specific factors associated with the profile of the disease is necessary. Thus, the study aimed to analyze data from 155 patients with breast cancer, grouping them according to their clinicopathological characteristics, attended at a reference hospital for Oncology, in 2015–2020, in the southwest region of Paraná, Brazil.</p></span> <span id="as0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0015">Material and Methods</span><p id="sp0060" class="elsevierStyleSimplePara elsevierViewall">Using multivariate statistical analysis, sample data were divided into three clusters. The heterogeneity between clusters was obtained by Ward's method. The clinicopathological variables obtained from the patients' medical records were: the presence of intratumoral emboli and lymph nodes, menopausal status, molecular subtype, histological grade, TNM staging of the disease, tumor size, age at diagnóstico, weight, height, and body mass index.</p></span> <span id="as0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0020">Results</span><p id="sp0065" class="elsevierStyleSimplePara elsevierViewall">It is observed that 70% of the patients were in menopause at diagnóstico, 31.5% had tumors containing emboli, and 41% had positive lymph nodes. The prevalence of Luminal B subtype, intermediate histological grade, and TNM staging II was verified. The prevalence of the disease was higher in women aged over 50 years, representing 66% of cases. The BMI of the patients ranged from 17.63 kg/m<span class="elsevierStyleSup">2</span> to 51.26 kg/m<span class="elsevierStyleSup">2</span>, with 73.55% above 25 kg/m<span class="elsevierStyleSup">2</span>. Using the spatial distribution of patients, cluster analysis identified the regions with the worst averages of clinicopathological variables and the highest number of cancer cases.</p></span> <span id="as0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0025">Conclusion</span><p id="sp0070" class="elsevierStyleSimplePara elsevierViewall">Through the statistical analysis, it was possible to determine the heterogeneity of the data, so the patients were separated into three clusters. When analyzing the obtained clusters, each one of them had specific characteristics.</p></span>" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "as0005" "titulo" => "Introduction" ] 1 => array:2 [ "identificador" => "as0010" "titulo" => "Material and Methods" ] 2 => array:2 [ "identificador" => "as0015" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "as0020" "titulo" => "Conclusion" ] ] ] "es" => array:3 [ "titulo" => "Resumen" "resumen" => "<span id="as0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0035">Introducción</span><p id="sp0075" class="elsevierStyleSimplePara elsevierViewall">Debido a la alta incidencia y agresividad del cáncer de mama, es necesario el conocimiento de factores específicos asociados al perfil de la enfermedad. Así, el objetivo del estudio fue analizar datos de 155 pacientes con cáncer de mama, agrupándolas según sus características clínico-patológicas, atendidas en un hospital de referencia en Oncología, en el período 2015–2020, en la región suroeste de Paraná, Brasil.</p></span> <span id="as0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0040">Material y métodos</span><p id="sp0080" class="elsevierStyleSimplePara elsevierViewall">A partir de la utilización de un análisis estadístico multivariado, los datos de la muestra se dividieron en tres grupos. La heterogeneidad entre clústeres se obtuvo mediante el método de Ward. Las variables clínico-patológicas obtenidas de la historia clínica de las pacientes fueron: presencia de émbolos y ganglios linfáticos intratumorales, estado menopáusico, subtipo molecular, grado histológico, estadificación TNM de la enfermedad, tamaño tumoral, edad al momento del diagnóstico, peso, talla, e índice de masa corporal.</p></span> <span id="as0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0045">Resultados</span><p id="sp0085" class="elsevierStyleSimplePara elsevierViewall">Se observa que el 70% de las pacientes se encontraba en menopausia al momento del diagnóstico, el 31,5% tenía tumores con émbolos y el 41% tenía ganglios positivos. Se verificó la prevalencia de subtipo luminal B, grado histológico intermedio y estadificación TNM II. La prevalencia de la enfermedad fue mayor en mujeres mayores de 50 años, lo que representa el 66% de los casos. El IMC de los pacientes osciló entre 17,63 kg/m<span class="elsevierStyleSup">2</span> y 51,26 kg/m<span class="elsevierStyleSup">2</span>, con un 73,55% encima de 25 kg/m<span class="elsevierStyleSup">2</span>. El análisis de clúster, utilizando la distribución espacial de pacientes, identificó las regiones con los peores promedios de variables clínico-patológicas y el mayor número de casos de cáncer.</p></span> <span id="as0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0050">Conclusión</span><p id="sp0090" class="elsevierStyleSimplePara elsevierViewall">A través del análisis estadístico fue posible determinar la heterogeneidad de los datos, por lo que las pacientes fueron separadas en tres grupos. Al analizar los clústeres obtenidos, pudo verificarse que cada uno de ellos presentaba características específicas.</p></span>" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "as0025" "titulo" => "Introducción" ] 1 => array:2 [ "identificador" => "as0030" "titulo" => "Material y métodos" ] 2 => array:2 [ "identificador" => "as0035" "titulo" => "Resultados" ] 3 => array:2 [ "identificador" => "as0040" "titulo" => "Conclusión" ] ] ] ] "multimedia" => array:6 [ 0 => array:8 [ "identificador" => "f0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 862 "Ancho" => 1614 "Tamanyo" => 114570 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "al0005" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="sp0005" class="elsevierStyleSimplePara elsevierViewall">Hierarchical formation of groups by similarity, using Euclidean distance.</p>" ] ] 1 => array:8 [ "identificador" => "f0010" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1338 "Ancho" => 1772 "Tamanyo" => 217842 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "al0010" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="sp0010" class="elsevierStyleSimplePara elsevierViewall">Distribution of categorical and quantitative variables of clusters C<span class="elsevierStyleInf">1</span> (blue), C<span class="elsevierStyleInf">2</span> (black) and C<span class="elsevierStyleInf">3</span> (red). (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)</p>" ] ] 2 => array:8 [ "identificador" => "t0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "al0015" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "<p id="sp0020" class="elsevierStyleSimplePara elsevierViewall">Stronger colors reveal the existence of significant associations (<span class="elsevierStyleItalic">p</span> < 0.01) between the variables.</p>" "tablatextoimagen" => array:1 [ 0 => array:1 [ "tablaImagen" => array:1 [ 0 => array:4 [ "imagenFichero" => "fx1.jpeg" "imagenAlto" => 1556 "imagenAncho" => 2993 "imagenTamanyo" => 400880 ] ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="sp0015" class="elsevierStyleSimplePara elsevierViewall">Spearman's correlations and <span class="elsevierStyleItalic">p</span>-value (in parentheses) for the 155 patients diagnosed with breast cancer.</p>" ] ] 3 => array:8 [ "identificador" => "t0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "al0020" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "<p id="sp0030" class="elsevierStyleSimplePara elsevierViewall">Different letters indicate a significant difference between the means of a variable in the different clusters (<span class="elsevierStyleItalic">p</span> < 0.01). This table aims to verify, using a hypothesis test, whether there is a difference between groups depending on the evaluated covariate. In this way, the means of each group are compared, in which equal letters mean that statistically, there is no difference. Otherwise, different letters mean that there are differences between the groups. It is observed that this comparison occurs between groups two by two for each variable analyzed.</p>" "tablatextoimagen" => array:1 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Full sample \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">C<span class="elsevierStyleInf">1</span> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">C<span class="elsevierStyleInf">2</span> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">C<span class="elsevierStyleInf">3</span> \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Number of patients \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">155 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">79 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">35 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">41 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleBold">Binary variables</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Intratumoral emboli \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.31 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.27 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.31 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.39 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Lymph node invasion \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.41 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.33 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.51 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.49 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Menopausal status \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.70 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleBold">0.99</span><span class="elsevierStyleSup"><span class="elsevierStyleBold">a</span></span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleBold">0.26</span><span class="elsevierStyleSup"><span class="elsevierStyleBold">c</span></span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleBold">0.51</span><span class="elsevierStyleSup"><span class="elsevierStyleBold">b</span></span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleBold">Categorical variables</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Molecular subtype \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.43 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.34 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.66 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.39 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Grade \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.93 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.95 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.91 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.90 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">TNM staging \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.06 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.96 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.09 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.22 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " colspan="2" align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleBold">Quantitative variables</span></td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Tumor size (cm) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.18 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.11 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.51 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.03 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Age (years) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">56.64 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleBold">67.06</span><span class="elsevierStyleSup"><span class="elsevierStyleBold">a</span></span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleBold">42.57</span><span class="elsevierStyleSup"><span class="elsevierStyleBold">c</span></span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleBold">48.56</span><span class="elsevierStyleSup"><span class="elsevierStyleBold">b</span></span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Weight (kg) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">72.54 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleBold">68.66</span><span class="elsevierStyleSup"><span class="elsevierStyleBold">b</span></span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleBold">62.59</span><span class="elsevierStyleSup"><span class="elsevierStyleBold">c</span></span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleBold">88.54</span><span class="elsevierStyleSup"><span class="elsevierStyleBold">a</span></span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Height (m) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.60 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.59 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.61 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.62 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">BMI (kg/m<span class="elsevierStyleSup">2</span>) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">28.25 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleBold">27.14</span><span class="elsevierStyleSup"><span class="elsevierStyleBold">b</span></span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleBold">24.11</span><span class="elsevierStyleSup"><span class="elsevierStyleBold">c</span></span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleBold">33.94</span><span class="elsevierStyleSup"><span class="elsevierStyleBold">a</span></span> \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="sp0025" class="elsevierStyleSimplePara elsevierViewall">Descriptive means and test of the means of variables for each cluster.</p>" ] ] 4 => array:8 [ "identificador" => "t0015" "etiqueta" => "Table 3" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "al0025" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "<p id="sp0040" class="elsevierStyleSimplePara elsevierViewall">Stronger colors reveal the existence of significant associations (<span class="elsevierStyleItalic">p</span> < 0.01) between the variables.</p>" "tablatextoimagen" => array:1 [ 0 => array:1 [ "tablaImagen" => array:1 [ 0 => array:4 [ "imagenFichero" => "fx2.jpeg" "imagenAlto" => 4354 "imagenAncho" => 2993 "imagenTamanyo" => 1104467 ] ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="sp0035" class="elsevierStyleSimplePara elsevierViewall">Spearman's correlations and <span class="elsevierStyleItalic">p</span>-value (in parentheses) of variables for clusters C<span class="elsevierStyleInf">1</span>, C<span class="elsevierStyleInf">2</span> and C<span class="elsevierStyleInf">3</span>.</p>" ] ] 5 => array:8 [ "identificador" => "t0020" "etiqueta" => "Table 4" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "al0030" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "<p id="sp0050" class="elsevierStyleSimplePara elsevierViewall">The means of the variables that stood out among the clusters in the respective regions are shown in bold. Higher mean frequencies of patients who presented the presence of intratumoral emboli and lymph node; higher means for categorical variables Molecular subtype, grad, and TNM staging, configuring worse prognosis. Largest tumor size averages. Lower and higher mean age and BMI, respectively.</p>" "tablatextoimagen" => array:1 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td-with-role" title="\n \t\t\t\t\ttable-head\n \t\t\t\t ; entry_with_role_colgroup " colspan="3" align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Fronteira</th><th class="td-with-role" title="\n \t\t\t\t\ttable-head\n \t\t\t\t ; entry_with_role_colgroup " colspan="3" align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Vale do Iguaçu</th><th class="td-with-role" title="\n \t\t\t\t\ttable-head\n \t\t\t\t ; entry_with_role_colgroup " colspan="3" align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Vale do Marrecas</th></tr><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">C<span class="elsevierStyleInf">1</span> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">C<span class="elsevierStyleInf">2</span> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">C<span class="elsevierStyleInf">3</span> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">C<span class="elsevierStyleInf">1</span> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">C<span class="elsevierStyleInf">2</span> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">C<span class="elsevierStyleInf">3</span> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">C<span class="elsevierStyleInf">1</span> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">C<span class="elsevierStyleInf">2</span> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">C<span class="elsevierStyleInf">3</span> \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Number of patients \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">30 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">10 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">15 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">17 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">32 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">20 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">17 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_colgroup " colspan="10" align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleBold">Binary variables</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Intratumoral emboli \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.30 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.40 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleBold">0.47</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.18 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleBold">0.40</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.33 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.28 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.25 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleBold">0.35</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Lymph node invasion \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.30 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleBold">0.60</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.47 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.29 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleBold">0.80</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.67 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.38 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.40 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.41 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Menopausal status \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.97 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.10 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.33 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.00 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.40 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.67 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.00 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.30 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.59 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_colgroup " colspan="10" align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleBold">Categorical variables</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Molecular subtype \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.27 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.70 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.27 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.29 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.40 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleBold">2.78</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.44 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.70 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.29 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Grade \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.87 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleBold">2.30</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.93 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.76 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.60 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleBold">1.89</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleBold">2.13</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.80 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.88 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">TNM staging \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.93 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.00 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.27 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.76 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleBold">3.00</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.22 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.09 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.90 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.18 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_colgroup " colspan="10" align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleBold">Quantitative variables</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Tumor size (cm) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleBold">3.22</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.38 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.99 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.84 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleBold">3.80</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.50 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.15 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleBold">4.00</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.81 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Age (years) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">65.60 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleBold">43.00</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">46.87 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">69.59 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleBold">42.40</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">50.44 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">67.09 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleBold">42.40</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">49.06 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Weight (kg) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">71.07 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">60.62 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">84.91 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">66.48 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">56.88 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">83.90 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">67.55 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">65.00 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">94.19 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Height (m) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.59 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.59 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.62 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.58 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.62 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.61 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.60 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.62 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.63 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">BMI (kg/m<span class="elsevierStyleSup">2</span>) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">28.24 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">23.92 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleBold">32.76</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">26.63 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">21.58 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleBold">32.58</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">26.37 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">24.84 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleBold">35.70</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="sp0045" class="elsevierStyleSimplePara elsevierViewall">Means of the variables in each cluster for the regions of the 8<span class="elsevierStyleSup">th</span> Health Regional of the State of Paraná.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bs0005" "bibliografiaReferencia" => array:33 [ 0 => array:3 [ "identificador" => "bb0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cancer statistics. 2020" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "R.L. Siegel" 1 => "K.D. Miller" 2 => "A. Jemal" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3322/caac.21590" "Revista" => array:7 [ "tituloSerie" => "CA Cancer J Clin" "fecha" => "2020" "volumen" => "70" "numero" => "1" "paginaInicial" => "7" "paginaFinal" => "30" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31912902" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bb0010" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Instituto Nacional de Câncer José Alencar Gomes da Silva" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "INCA" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "WWW" => array:2 [ "link" => "https://www.inca.gov.br/institucional" "fecha" => "2020" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bb0015" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "F. Bray" 1 => "J. Ferlay" 2 => "I. Soerjomataram" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3322/caac.21492" "Revista" => array:6 [ "tituloSerie" => "<span class="elsevierStyleItalic">CA Cancer J Clin</span> Hoboken" "fecha" => "2018" "volumen" => "68" "numero" => "6" "paginaInicial" => "394" "paginaFinal" => "424" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bb0020" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "J. Ferlay" 1 => "M. Colombet" 2 => "I. Soerjomataram" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/ijc.31937" "Revista" => array:6 [ "tituloSerie" => "<span class="elsevierStyleItalic">Int J Cancer</span> New York" "fecha" => "2018" "volumen" => "144" "numero" => "8" "paginaInicial" => "1941" "paginaFinal" => "1953" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bb0025" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Stage 0 to stage III breast cancer in young women" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "C. Gajdos" 1 => "P.I. Tartter" 2 => "I.J. Bleiweiss" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S1072-7515(00)00257-X" "Revista" => array:7 [ "tituloSerie" => "J Am Coll Surgeons" "fecha" => "2000" "volumen" => "190" "numero" => "5" "paginaInicial" => "523" "paginaFinal" => "529" "itemHostRev" => array:3 [ "pii" => "S0735109718395366" "estado" => "S300" "issn" => "07351097" ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bb0030" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Impact of body mass index on the clinical outcomes of patients with HER2-positive metastatic breast cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "S. Martel" 1 => "E. Poletto" 2 => "A.R. Ferreira" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.breast.2017.11.004" "Revista" => array:6 [ "tituloSerie" => "Breast" "fecha" => "2018" "volumen" => "37" "paginaInicial" => "142" "paginaFinal" => "147" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29161652" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bb0035" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Impact of obesity on prognosis of breast cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "A.M. Papa" 1 => "C.B.L. Pirfo" 2 => "A.M. Murad" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Rev Bras Oncologia Clin" "fecha" => "2013" "volumen" => "9" "numero" => "31" "paginaInicial" => "25" "paginaFinal" => "30" "itemHostRev" => array:3 [ "pii" => "S0735109712052862" "estado" => "S300" "issn" => "07351097" ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bb0040" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Adult weight gain accelerates the onset of breast cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "M. Azrad" 1 => "C.K. Blair" 2 => "C.L. Rock" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s10549-019-05268-y" "Revista" => array:7 [ "tituloSerie" => "Breast Cancer Res Treat" "fecha" => "2019" "volumen" => "176" "numero" => "3" "paginaInicial" => "649" "paginaFinal" => "656" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31073792" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bb0045" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Age and body mass index may increase the chance of failure in sentinel lymph node biopsy for women with breast cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "C.E. Cox" 1 => "E. Dupont" 2 => "G.F. Whitehead" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1046/j.1524-4741.2002.08203.x" "Revista" => array:7 [ "tituloSerie" => "The Breast J" "fecha" => "2002" "volumen" => "8" "numero" => "2" "paginaInicial" => "88" "paginaFinal" => "91" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11896753" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bb0050" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The associations of obesity lymph node status and prognosis in breast cancer patients: Dependence on estrogen and progesterone receptor status" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "B.O. Maehle" 1 => "S. Tretli" 2 => "T. Thorsen" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1600-0463.2004.apm1120605.x" "Revista" => array:6 [ "tituloSerie" => "APMIS." "fecha" => "2004" "volumen" => "112" "paginaInicial" => "349" "paginaFinal" => "357" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15511272" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bb0055" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Triple-negative breast cancer and its association with obesity (Review)" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "H. Sun" 1 => "J. Zou" 2 => "L. Chen" 3 => "X. Zu" 4 => "G. Wen" 5 => "J. Zhong" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3892/mco.2017.1429" "Revista" => array:7 [ "tituloSerie" => "Mol Clin Oncol" "fecha" => "2017" "volumen" => "7" "numero" => "6" "paginaInicial" => "935" "paginaFinal" => "942" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29285353" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bb0060" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Risk factors for breast cancer in postmenopausal women in Brazil" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "D.H. Borghesan" 1 => "C.M. Agnolo" 2 => "A.A. Gravena" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:8 [ "tituloSerie" => "Asian Pac J Cancer Prev" "fecha" => "2016" "volumen" => "17" "numero" => "7" "paginaInicial" => "3587" "paginaFinal" => "3593" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27510013" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0167527318349921" "estado" => "S300" "issn" => "01675273" ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bb0065" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The obesity and the risk of breast cancer among pre and postmenopausal women" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "A.A.F. Gravena" 1 => "T.C. Romeiro Lopes" 2 => "M.O. Demitto" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.22034/APJCP.2018.19.9.2429" "Revista" => array:7 [ "tituloSerie" => "Asian Pac J Cancer Prev" "fecha" => "2018" "volumen" => "19" "numero" => "9" "paginaInicial" => "2429" "paginaFinal" => "2436" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30255696" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bb0070" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Differential association of the lifestyle-related risk factors smoking and obesity with triple negative breast cancer in a Brazilian population" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A.F.A. Jerônimo" 1 => "M. Weller" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.22034/APJCP.2017.18.6.1585" "Revista" => array:8 [ "tituloSerie" => "Asian Pac J Cancer Prev" "fecha" => "2017" "volumen" => "18" "numero" => "6" "paginaInicial" => "1585" "paginaFinal" => "1593" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28669172" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0167527318358601" "estado" => "S300" "issn" => "01675273" ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bb0075" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Body weight and breast cancer: Nested case-control study in southern Brazil" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "N.L. Kops" 1 => "M. Bessel" 2 => "M. Caleffi" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.clbc.2018.04.014" "Revista" => array:6 [ "tituloSerie" => "Clin Breast Cancer" "fecha" => "2018" "volumen" => "18" "numero" => "5" "paginaInicial" => "797" "paginaFinal" => "803" ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bb0080" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Chronic psychological stress and its impact on the development of aggressive breast cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "T.F. Cormanique" 1 => "L.E.D.F. Almeida" 2 => "C.A. Rech" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1590/S1679-45082015AO3344" "Revista" => array:6 [ "tituloSerie" => "<span class="elsevierStyleItalic">Einstein</span> (São Paulo)" "fecha" => "2015" "volumen" => "13" "numero" => "3" "paginaInicial" => "352" "paginaFinal" => "356" ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bb0085" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Introduction to Multivariate Analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "C. Chatfield" 1 => "A.J. Collins" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:3 [ "fecha" => "1980" "editorial" => "Springer" "editorialLocalizacion" => "US" ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bb0090" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Applied Multivariate Statistical Analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "R.A. Johnson" 1 => "D.W. Wichern" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:3 [ "fecha" => "2007" "editorial" => "PEARSON" "editorialLocalizacion" => "Prentice Hall Upper Saddle River NJ" ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bb0095" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Body mass index had different effects on premenopausal and postmenopausal breast cancer risks: a dose-response meta-analysis with 3.318.796 subjects from 31 cohort studies" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:4 [ 0 => "Y. Chen" 1 => "L. Liu" 2 => "Q. Zhou" 3 => "M.U. Imam" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/s12889-017-4953-9" "Revista" => array:4 [ "tituloSerie" => "BMC Public Health" "fecha" => "2017" "volumen" => "17" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29017473" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bb0100" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "St. Gallen/Vienna 2021: A brief summary of the consensus discussion on customizing therapies for women with early breast cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "C. Thomssen" 1 => "M. Balic" 2 => "N. Harbeck" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1159/000516114" "Revista" => array:5 [ "tituloSerie" => "Breast Care" "fecha" => "2021" "numero" => "16" "paginaInicial" => "135" "paginaFinal" => "143" ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bb0105" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "AJCC Cancer Staging Manual" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "M.B. Amin" 1 => "S.B. Edge" 2 => "F.L. Greene" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:6 [ "edicion" => "8th ed." "fecha" => "2017" "paginaInicial" => "563" "paginaFinal" => "5854" "editorial" => "Springer International Publishing" "editorialLocalizacion" => "New York" ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bb0110" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Introducción al análisis de clúster" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J.L.V. Villardón" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:4 [ "fecha" => "2007" "paginaInicial" => "1" "paginaFinal" => "22" "editorial" => "Departamento de Estadística Universidad de Salamanca" ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bb0115" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "R: A language and environment for statistical computing" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "R Core Team" ] ] ] ] ] "host" => array:2 [ 0 => array:1 [ "Libro" => array:3 [ "fecha" => "2020" "editorial" => "R Foundation for Statistical Computing" "editorialLocalizacion" => "Vienna, Austria" ] ] 1 => array:1 [ "WWW" => array:1 [ "link" => "https://www.R-project.org/" ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bb0120" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "<span class="elsevierStyleItalic">R package</span> version 4.4–0" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "Hmisc: Harrell M, Frank E, Harrell Jr and with contributions from Dupont C and many others" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "WWW" => array:2 [ "link" => "https://CRAN.R-project.org/package=Hmisc" "fecha" => "2020" ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bb0125" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "<span class="elsevierStyleItalic">R package</span> version 1.3-3" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "Agricolae: Statistical Procedures for Agricultural Research, Felipe de Mendiburu" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "WWW" => array:2 [ "link" => "https://CRAN.R-project.org/package=agricolae" "fecha" => "2020" ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bb0130" "etiqueta" => "26." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Kendall’s tau correlation analysis on structure-activity relationships of biologic active compounds" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "S.D. Bolboacă" 1 => "L. Jäntschi" 2 => "Pearson versus Spearman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Leonardo J Sci" "fecha" => "2006" "volumen" => "5" "numero" => "9" "paginaInicial" => "179" "paginaFinal" => "200" ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bb0135" "etiqueta" => "27." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Disseminated tumor embolism from breast cancer leading to multiorgan failure" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "D.T. Tsoi" 1 => "C. Rowsell" 2 => "C. Mcgregor" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1200/JCO.2009.25.1009" "Revista" => array:8 [ "tituloSerie" => "J Clin Oncol" "fecha" => "2010" "volumen" => "28" "numero" => "12" "paginaInicial" => "e180" "paginaFinal" => "e183" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20124175" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0735109709034706" "estado" => "S300" "issn" => "07351097" ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bb0140" "etiqueta" => "28." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prognostic parameters of luminal A and luminal B intrinsic breast cancer subtypes of Pakistani patients" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "A.A. Hashmi" 1 => "S. Aijaz" 2 => "S.M. Khan" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/s12957-017-1299-9" "Revista" => array:7 [ "tituloSerie" => "World J Surg Oncol" "fecha" => "2018" "volumen" => "16" "numero" => "1" "paginaInicial" => "1" "paginaFinal" => "6" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29291744" "web" => "Medline" ] ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bb0145" "etiqueta" => "29" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Incidence and prognosis in early onset breast cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "M. Sundquist" 1 => "S. Thorstenson" 2 => "L. Brudin" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1054/brst.2001.0358" "Revista" => array:7 [ "tituloSerie" => "The Breast" "fecha" => "2002" "volumen" => "11" "numero" => "1" "paginaInicial" => "30" "paginaFinal" => "35" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14965642" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bb0150" "etiqueta" => "30." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "How estrogen fuels breast cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A. Rana" 1 => "V. Rangasamy" 2 => "R. Mishra" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.2217/fon.10.112" "Revista" => array:7 [ "tituloSerie" => "Future Oncol" "fecha" => "2010" "volumen" => "6" "numero" => "9" "paginaInicial" => "1369" "paginaFinal" => "1371" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20919821" "web" => "Medline" ] ] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bb0155" "etiqueta" => "31." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Obesity-associated Breast Cancer: Analysis of risk factors" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "A. Engin" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/978-3-319-48382-5_25" "Revista" => array:6 [ "tituloSerie" => "Adv Exp Med Biol" "fecha" => "2017" "volumen" => "960" "paginaInicial" => "571" "paginaFinal" => "606" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28585217" "web" => "Medline" ] ] ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bb0160" "etiqueta" => "32." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cluster analysis evidences body mass index as an independent variable related to disease prognosis in breast cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "N.M.L. Romeiro" 1 => "M.C.T. dos Santos" 2 => "C. Panis" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.28951/rbb.v39i4.596" "Revista" => array:7 [ "tituloSerie" => "Rev Bras Biom Lavras" "fecha" => "2021" "volumen" => "39" "numero" => "4" "paginaInicial" => "536" "paginaFinal" => "555" "itemHostRev" => array:3 [ "pii" => "S016752731737434X" "estado" => "S300" "issn" => "01675273" ] ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bb0165" "etiqueta" => "33." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Profile of pesticides use in the southwest of Paraná (2011-2016)" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "S.C. Gaboardi" 1 => "L. Zanetti" 2 => "P. Candiotto" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.47946/rnera.v0i46.5566" "Revista" => array:6 [ "tituloSerie" => "Rev NERA" "fecha" => "2019" "volumen" => "22" "numero" => "46" "paginaInicial" => "13" "paginaFinal" => "40" ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/02141582/0000003500000003/v3_202207191618/S0214158221001456/v3_202207191618/en/main.assets" "Apartado" => array:4 [ "identificador" => "94085" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Originales" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/02141582/0000003500000003/v3_202207191618/S0214158221001456/v3_202207191618/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0214158221001456?idApp=UINPBA00004N" ]
Year/Month | Html | Total | |
---|---|---|---|
2024 November | 5 | 0 | 5 |
2024 October | 17 | 4 | 21 |
2024 September | 30 | 8 | 38 |
2024 August | 21 | 6 | 27 |
2024 July | 34 | 6 | 40 |
2024 June | 17 | 3 | 20 |
2024 May | 13 | 8 | 21 |
2024 April | 38 | 10 | 48 |
2024 March | 45 | 2 | 47 |
2024 February | 35 | 2 | 37 |
2024 January | 26 | 4 | 30 |
2023 December | 10 | 5 | 15 |
2023 November | 14 | 7 | 21 |
2023 October | 19 | 6 | 25 |
2023 September | 14 | 7 | 21 |
2023 August | 19 | 9 | 28 |
2023 July | 25 | 6 | 31 |
2023 June | 35 | 4 | 39 |
2023 May | 56 | 6 | 62 |
2023 April | 34 | 8 | 42 |
2023 March | 17 | 3 | 20 |
2023 February | 12 | 4 | 16 |
2023 January | 19 | 13 | 32 |
2022 December | 25 | 9 | 34 |
2022 November | 23 | 7 | 30 |
2022 October | 22 | 13 | 35 |
2022 September | 34 | 17 | 51 |
2022 August | 28 | 16 | 44 |
2022 July | 27 | 15 | 42 |
2022 June | 13 | 10 | 23 |
2022 May | 12 | 9 | 21 |
2022 April | 13 | 16 | 29 |
2022 March | 23 | 18 | 41 |
2022 February | 24 | 20 | 44 |
2022 January | 10 | 6 | 16 |