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Vol. 10. Issue 1.
Pages 2-7 (March 2009)
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Vol. 10. Issue 1.
Pages 2-7 (March 2009)
Revisión
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Metodología de presentación de los resultados de progresión radiológica en estudios clínicos
Methodology for presenting the results of radiological progression in clinical trials
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Miriam Almirall Bernabé
Corresponding author
malmirall@imas.imim.es

Autor para correspondencia.
, Joan Maymó Guasch, Carolina Pérez-García, María Pilar Lisbona Pérez, Jordi Carbonell Abelló
Servicio de Reumatología, IMAS, Hospitales del Mar y la Esperanza, Barcelona, España
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Resumen

Los últimos estudios clínicos que evalúan la eficacia de los diferentes tratamientos para la artritis reumatoide valoran la eficacia clínica y también la progresión del daño estructural articular, calculando la progression radiológica observada en un período determinado. En este artículo revisamos 3 aspectos importantes desarrollados recientemente de la metodología de lectura y presentación de la progresión: la guía preliminary de Van der Heijde de presentación de los resultados radiológicos en estudios clínicos, establecida en el año 2002, y los nuevos conceptos añadidos, como la utilización de los índices de progresión anual estimada y la presentación de los datos mediante los diagramas de probabilidad acumulada.

Palabras clave:
Artritis reumatoide
Progresión radiologica
Diagramas de probabilidad acumulada
Abstract

Recent clinical trials that evaluate treatment effectiveness in rheumatoid arthritis assess clinical response and progression of structural damage to joints by calculating radiographic progression over a given time period. In this article, we review three important features that have recently been developed in the methodology of scoring progression: presentation of radiographic data in clinical trials, following the preliminary guideline of van der Heijde, established in 2002, and additional new concepts such as estimated yearly progression rates and probability plots.

Keywords:
Rheumatoid arthritis
Radiographic progression
Probability plots
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Copyright © 2009. Sociedad Española de Reumatología
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