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Letter to the editor
Multivalent vaccines against new SARS-CoV-2 hybrid variants
Vacunas multivalentes contra las nuevas variantes híbridas de SARS-CoV-2
Kiarash Ghazvinia,b, Masoud Keikhaa,b,
Corresponding author
keikham971@mums.ac.ir

Corresponding author.
a Antimicrobial Resistance Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
b Department of Microbiology and Virology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="p0005" class="elsevierStylePara elsevierViewall">On December 2019&#44; severe acute respiratory syndrome coronavirus 2 &#40;SARS-CoV-2&#41; emerged as causative agent of atypical pneumonia in Wuhan&#44; China and by March 11 2020&#44; the World Health Organization &#40;WHO&#41; announced that the disease caused by the SARS CoV2&#44; COVID-19&#44; had become a pandemic&#46; According to available reports&#44; more than 531 million cases were confirmed as well as 6&#46;3 million deaths has been registered over the worldwide&#46; Continuous evaluation and emergence of new SARS-CoV-2 variants followed by mixed-infections has become a serious global threat that causes new epidemic waves throughout the world&#46;<a class="elsevierStyleCrossRef" href="#bb0005"><span class="elsevierStyleSup">1</span></a> Although vaccines developed to prevent SARS-CoV-2 infection are available&#44; genetic recombination and spontaneous mutations in SARS-CoV-2 viral genome can lead to increase of pathogenicity&#44; transmissibility&#44; and immune evasion&#46;<a class="elsevierStyleCrossRef" href="#bb0005"><span class="elsevierStyleSup">1</span></a></p><p id="p0010" class="elsevierStylePara elsevierViewall">Current available vaccines i&#46;e&#46; nucleic acid-based vaccines&#44; viral vector based vaccines&#44; subunit vaccines&#44; and inactivated vaccines are established based on induction of strong immune responses against the spike &#40;S&#41; protein of SARS-CoV-2&#46;<a class="elsevierStyleCrossRef" href="#bb0010"><span class="elsevierStyleSup">2</span></a> The surge of new SARS-CoV-2 variants harboring new mutations&#44; particularly some variants presenting attractive mutations uniformly called variants of concerns &#40;VOCs&#41;&#44; have been considered as available spike protein for antigen based vaccines&#46; The SARS-CoV-2 facilitates viral entry to host cell by the interaction between the spike &#40;S&#41; antigen and the binding domain of the angiotensin-converting enzyme 2 &#40;ACE-2&#41;<a class="elsevierStyleCrossRef" href="#bb0015"><span class="elsevierStyleSup">3</span></a>&#59; However&#44; the subsequent emergence of SARS-CoV-2 variants containing new mutations in the receptor binding domain &#40;RBD&#41; of spike protein are the main reasons for resistance to neutralizing antibodies&#44; immune escape and low inefficacy of available vaccines to prevent infection&#46;<a class="elsevierStyleCrossRef" href="#bb0020"><span class="elsevierStyleSup">4</span></a> Current evidences suggested that Omicron sub-lineages can easily recombine and fuse with each other in SARSCoV-2 cases of co-infection leading to a new phase of the SARS-CoV-2 pandemic&#46; Thus&#44; multivalent based vaccine can be an efficient approach for optimal vaccine development to combat with new SARSCoV-2 variants that mainly evolved in results of recombination between hybrid variants&#46; The Moderna company recently developed new multivalent vaccine e&#46;g&#46; mRNA-1273&#46;351 &#40;targeting the B&#46;1&#46;351&#41;&#44; or and mRNA-1273&#46;351 &#40;targeting B&#46;1&#46;351&#41; to provide a broader range of protection against new SARS-CoV-2 variants&#46;<a class="elsevierStyleCrossRef" href="#bb0025"><span class="elsevierStyleSup">5</span></a></p><p id="p0015" class="elsevierStylePara elsevierViewall">Multivalent vaccines could be providing more robust immune protection against SARS-CoV-2 novel variants due to 1&#41; a much larger fraction containing essential all RBD epitopes&#44; 2&#41; much easier to be produced&#44; 3&#41; lower costs of production&#44; and 4&#41; more immunogenic&#46;</p><p id="p0020" class="elsevierStylePara elsevierViewall">For the first time&#44; Xiang et al&#46;&#44; 2020 showed the efficacy of Versatile&#44; a multivalent cocktails nanoparticle against SARS-CoV-2 during in vitro examination&#46;<a class="elsevierStyleCrossRef" href="#bb0030"><span class="elsevierStyleSup">6</span></a> According to recent Immunoinformatics studies&#44; the multi-epitope peptide vaccine construct &#40;MEPVC&#41; has shown strong immune system induction with high binding affinity to TLR3&#46;<a class="elsevierStyleCrossRef" href="#bb0005"><span class="elsevierStyleSup">1</span></a><span class="elsevierStyleSup">&#44;</span><a class="elsevierStyleCrossRef" href="#bb0020"><span class="elsevierStyleSup">4</span></a><span class="elsevierStyleSup">&#44;</span><a class="elsevierStyleCrossRef" href="#bb0035"><span class="elsevierStyleSup">7</span></a> Yu et al&#46;&#44; 2022 were recognized the presence of 8 cytotoxic T lymphocyte epitopes&#44; 17 helper T lymphocyte epitopes&#44; 9 lineal B-cell epitopes&#44; as well as 4 conformational B-cell epitopes within nucleotide sequence of SARS-CoV-2 virus strains&#46;<a class="elsevierStyleCrossRef" href="#bb0005"><span class="elsevierStyleSup">1</span></a> Furthermore&#44; Uttamrao et al&#46;&#44; 2021 suggested several immune dominant epitopes of SARS-CoV-2 with suitable characteristics using unannotated open reading frames &#40;uORFs&#41;&#46;<a class="elsevierStyleCrossRef" href="#bb0020"><span class="elsevierStyleSup">4</span></a></p><p id="p0025" class="elsevierStylePara elsevierViewall">Regarding animal investigations&#44; Chiba et al&#46;&#44; 2021 recently developed nanoparticles which consist of multiple copies of the SARS-CoV-2 spike &#40;S&#41; protein covered with protein of the MS2 bacteriophages&#59; this nanoparticle generated high neutralizing antibody titers in Syrian hamsters after a single immunization&#46;<a class="elsevierStyleCrossRef" href="#bb0010"><span class="elsevierStyleSup">2</span></a> The MS2 bacteriophage is icosahedral virus that has been modified extensively for targeted delivery applications&#59; Its capsid consists of a 27&#8239;nm with 32 pores that allows small molecules to diffuse out of the capsid&#46; The MS2 viral capsid has been used for development of vaccines&#44; delivery of very hydrophobic anticancer drug Taxol or imaging applications&#46;<a class="elsevierStyleCrossRef" href="#bb0040"><span class="elsevierStyleSup">8</span></a> Guo et al&#46;&#44; 2021 was also engineered a 197-amino-acid fragment of RBD conjugated with two carrier proteins that elicited robust neutralizing antibodies &#40;nAbs&#41; in immunized mice model after two doses&#46;<a class="elsevierStyleCrossRef" href="#bb0045"><span class="elsevierStyleSup">9</span></a> Yuan et al&#46;&#44; 2022 construct a bivalent multivalent vaccine based on the RBD sequence of D614G and B&#46;1&#46;351 that elicits induce robust immune responses against SARS-CoV-2 variants&#46; The D614G&#47;B&#46;1&#46;351 bivalent vaccine could protect mice in a prime-boost manner as well elicit robust nAbs response as third-dose booster in rhesus macaques&#46;<a class="elsevierStyleCrossRef" href="#bb0015"><span class="elsevierStyleSup">3</span></a> Hunt et al&#46;&#44; 2022 recently introduced multivalent designed proteins neutralize SARS-CoV-2 variants of concern &#40;B&#46;1&#46;1&#46;529&#44; and B&#46;1&#46;617&#46;2&#41; with strong immune protection that administered with intranasal route in mice&#46; It deals with two strategies for generating multivalent S protein binders from miniproteins&#44; self-assembling homotrimers &#40;TRI&#41; and multidomain fusions &#40;FUS&#41;&#46;<a class="elsevierStyleCrossRef" href="#bb0050"><span class="elsevierStyleSup">10</span></a> these miniprotein receptors could be a broadly appropriate for antiviral therapeutic purpose particularly for VOCs with superior resistance to immune escape&#44; high antigenic drift&#44; and lower probabilities of autoimmune responses&#46;</p><p id="p0030" class="elsevierStylePara elsevierViewall">The global spread of SARS-CoV-2 in short span has intensified an urgent need for development of officious vaccines&#59; several vaccine platforms have been introduced against COVID-19&#46; However&#44; additional vaccine platforms are under investigation to produce safer and more effective vaccine against newly emerged Omicron sub-lineages&#46; Recently&#44; nanoparticle-based vaccine as well as virus-like particle have shown robust immune response&#46;<a class="elsevierStyleCrossRef" href="#bb0050"><span class="elsevierStyleSup">10</span></a><span class="elsevierStyleSup">&#44;</span><a class="elsevierStyleCrossRef" href="#bb0055"><span class="elsevierStyleSup">11</span></a> Nanoparticle-based vaccine used self-assembling scaffold constructions containing entire spike protein or receptor-binding domain of SARS-CoV-2 of various variants&#46; On the other hand&#44; virus-like particle vaccines are replication-defective viruses that stimulates immune response due to their microbial origin&#46;<a class="elsevierStyleCrossRef" href="#bb0055"><span class="elsevierStyleSup">11</span></a> In summary&#44; multivalent SARS-CoV-2 vaccine contains full set of RBD domain of various variants that highly capable to elicit a strong cross-reactive immune response against new SARS-CoV-2 variants&#46;</p><span id="s0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0005">Conflict of interest statement</span><p id="p0035" class="elsevierStylePara elsevierViewall">There is no to declare&#46;</p></span></span>"
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Article information
ISSN: 15769887
Original language: English
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