In silico designed novel multi epitope vaccine construct towards Bundibugyo Ebolavirus

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Maximum number of overlapping epitopes were predicted in Asia 1 IND 63/72 strain" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Manikandan Mohan, Praseetha Sivakumar, Govindasamy Damotharan Dilip, Joseph Christina Rosy, Richard Coico, Krishnan Sundar" "autores" => array:6 [ 0 => array:2 [ "nombre" => "Manikandan" "apellidos" => "Mohan" ] 1 => array:2 [ "nombre" => "Praseetha" "apellidos" => "Sivakumar" ] 2 => array:2 [ "nombre" => "Govindasamy Damotharan" "apellidos" => "Dilip" ] 3 => array:2 [ "nombre" => "Joseph Christina" "apellidos" => "Rosy" ] 4 => array:2 [ "nombre" => "Richard" "apellidos" => "Coico" ] 5 => array:2 [ "nombre" => "Krishnan" "apellidos" => "Sundar" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2445146022000966?idApp=UINPBA00004N" "url" => "/24451460/0000002300000003/v3_202302191852/S2445146022000966/v3_202302191852/en/main.assets" ] "en" => array:19 [ "idiomaDefecto" => true "cabecera" => "Original" "titulo" => "In silico designed novel multi epitope vaccine construct towards Bundibugyo Ebolavirus" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "194" "paginaFinal" => "207" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Rajaguru Arivuselvam, A. Mohamed Sheik Tharik, S.B. Santhosh, S.N. Meyyanathan, Raman Rajeshkumar" "autores" => array:5 [ 0 => array:3 [ "nombre" => "Rajaguru" "apellidos" => "Arivuselvam" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "af0005" ] ] ] 1 => array:3 [ "nombre" => "A." "apellidos" => "Mohamed Sheik Tharik" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "b" "identificador" => "af0010" ] ] ] 2 => array:3 [ "nombre" => "S.B." "apellidos" => "Santhosh" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "c" "identificador" => "af0015" ] ] ] 3 => array:3 [ "nombre" => "S.N." "apellidos" => "Meyyanathan" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "b" "identificador" => "af0010" ] ] ] 4 => array:4 [ "nombre" => "Raman" "apellidos" => "Rajeshkumar" "email" => array:2 [ 0 => "ramanrajeshkumarbiotech@gmail.com" 1 => "bathmic@jssuni.edu.in" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "af0005" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cr0005" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Department of Pharmaceutical Biotechnology, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Ooty, Tamilnadu, India" "etiqueta" => "a" "identificador" => "af0005" ] 1 => array:3 [ "entidad" => "Department of Pharmaceutical Analysis, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Ooty, Tamilnadu, India" "etiqueta" => "b" "identificador" => "af0010" ] 2 => array:3 [ "entidad" => "Department of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Ooty, Tamilnadu, India" "etiqueta" => "c" "identificador" => "af0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cr0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "f0035" "etiqueta" => "Fig. 7" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr7.jpeg" "Alto" => 2204 "Ancho" => 1949 "Tamanyo" => 284763 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "al0035" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "Immune simulation caused by constructed vaccine. (A) Immune response patterns on exposure to antigens. (B) The effector B- cells consistency (C) Immune reaction of Plasma B-cell. (D) Cytotoxic CD4+ cell population. (E) Cytotoxic CD8+ cell population. (F) Cytokine generation." ] ] ] "textoCompleto" => "IntroductionEbola virus (EBOV) a deadly virus belonging to the Filoviridae family, within the order of Mononegavirales.<a class="elsevierStyleCrossRef" href="#bb0005">1</a> EBOV have been reported most commonly with the size of 19 k and consists of undifferentiated RNA negative-strand.<a class="elsevierStyleCrossRef" href="#bb0010">2</a> The genome of EBOV contains eight monocistronic genes that encode eight viral proteins namely nucleoprotein (N), glycoprotein (GP), Transcription factor Vp30, polymerase cofactor Vp35, VP24, polymerase L, Glycoprotein (GP),<a class="elsevierStyleCrossRef" href="#bb0005">1</a> non-structural glycoprotein.<a class="elsevierStyleCrossRef" href="#bb0010">2</a> The outermost layer of the EBOVconsists of GP, which helps the virus to bind its target site and it also acts as a mediator of virus in order to deliver their genetic pattern to the host cells. However, the three forms of protein, namely attachment protein (GP1), entry/fusion protein (GP2), and soluble GP (sGP) were expressed by the GP. Further, GP1 and GP2 are synthesized from non-template adenosine-containing messenger RNA. Except in the case of sGP, the transcript is synthesized from unedited RNA.<a class="elsevierStyleCrossRef" href="#bb0015">3</a> In addition, GP also acts as a target for immune cells to produce their immunogenic effect against the EBOV. As a result, GP is considered a crucial factor in the proposal of vaccines.<a class="elsevierStyleCrossRefs" href="#bb0020">4–6</a> However, Ellen et al. recently published a review article related to the topic of the clinical trial of the Ebola vaccine. In the review article, it is mentioned that among the EBOV strains, the vaccine did not become effective against Bundibugyo Ebolaviruses strains. So, due to the fatality rate of Bundibugyo Ebolaviruses strains, now it is of very much priority to make a vaccine against these virus strains.<a class="elsevierStyleCrossRef" href="#bb0035">7</a>Nowadays, multi-epitope-based vaccine design is considered to be a promising approach due to the long-lasting capability.<a class="elsevierStyleCrossRef" href="#bb0040">8</a> Epitope is the tiny immunogenic portion of a protein sequence that precisely generates precise immune responses.<a class="elsevierStyleCrossRef" href="#bb0045">9</a> Several studies have recently confirmed that the epitope-based vaccination mechanism effectively produces protective immune responses against various pathogens.<a class="elsevierStyleCrossRefs" href="#bb0050">10–13</a> In this regard, vaccine design process, forecasting of epitopes through in-silico techniques may greatly reduce the time and expense for the vaccine production. Thus, in this present study we tried to develop a successful epitope-related protein-vaccines (T-cell and B-cell epitope) by utilizing several in-silico tools based on the available EBOV GP sequences. These findings have given new candidates for epitope vaccines for EBOV vaccine development.<a class="elsevierStyleCrossRef" href="#bb0070">14</a>Selection of adjuvant: we have selected the adjuvant Mycobacterium tuberculosis as this adjuvant gives further efficacy to the constructed vaccine. Moreover, Toll-like receptor-4, which is present in the antigen-presenting cells recognizes M. tuberculosis and stimulates the immune cells against M. tuberculosis.<a class="elsevierStyleCrossRef" href="#bb0075">15</a> Importantly, Toll-like receptors-3, -4, and -7 detects the EBOV antigen or genetic pattern, which further stimulates the immune cells against them. Particularly, Toll-like receptor-4, first detects the genetic pattern of EBOV antigen of EBOV compared to other Toll-like receptors-3, -7.<a class="elsevierStyleCrossRef" href="#bb0080">16</a>Materials and methodsProtein sequence retrieval, antigenicity and physicochemical properties evaluationComplete amino acid sequence of EBOV Glycoprotein (GP) (Accession No: AGL73474) was taken in FASTA format from the NCBI (<a href="https://www.ncbi.nlm.nih.gov/protein/AGL73474.1">https://www.ncbi.nlm.nih.gov/protein/AGL73474.1</a>) server. The functional and structural features of a protein reflect physicochemical properties. However, in the next step, predicted GP sequence was further submitted to the ProtParamtool of ExPASy Proteomics Server (<a href="https://web.expasy.org/protparam/">https://web.expasy.org/protparam/</a>) for the evaluation of physicochemical properties. Different physicochemical parameters of the GP were evaluated which includes, total amino acid length, molecular weight, theoretical PI, negative and positive residues, solubility, instability index, and half-life.<a class="elsevierStyleCrossRef" href="#bb0085">17</a> Furthermore, GP sequence were analyzed with vaxiJen v2.0 server (<a href="http://www.ddg-pharmfac.net/vaxijen/VaxiJen/VaxiJen.html">http://www.ddg-pharmfac.net/vaxijen/VaxiJen/VaxiJen.html</a>).<a class="elsevierStyleCrossRef" href="#bb0090">18</a> The threshold value of 0.4 was used for the accuracy rate to validate the antigenicity of the full-length sequence. It shows GP amino acid sequences with an antigenic score of >0.5. These GP sequences were selected for further study.Retrieval of binding site of CD8+, CD4+, lineal B-cell from GP sequenceThe selected GP protein sequence was introduced to BCpreds (<a href="http://ailab-projects1.ist.psu.edu:8080/bcpred/predict.html">http://ailab-projects1.ist.psu.edu:8080/bcpred/predict.html</a>) for the detection of lineal B-cell epitopes. Predicted lineal B-cell epitopes with appropriate length of 20 amino acid with a cut-off score >0.9 were selected.<a class="elsevierStyleCrossRef" href="#bb0095">19</a> The Immune Epitope Database (IEDB) (<a href="https://www.iedb.org/">https://www.iedb.org/</a>) is an immunoinformatic tool used to identify the T-cell epitope. The selected GP sequence was introduced to MHC-I binding predictions server (<a href="http://tools.iedb.org/mhci/">http://tools.iedb.org/mhci/</a>) for the analysis using NetMHCPan 4.1 EL (2020.09 (current)) method. Moreover, we have selected the common allele with appropriate amino acid length (9).<a class="elsevierStyleCrossRef" href="#bb0100">20</a> Alleles which includes HLA-A*02:01, HLA-A*02:02, HLA-A*02:06 are commonly found on the 90% of the human population in the world. Finally, we retrieved the CD8+ epitope sequence which is commonly interacting with above-mentioned allele.<a class="elsevierStyleCrossRefs" href="#bb0105">21–24</a> The retrieved GP sequence was subjected to MHC-II binding predictions server (<a href="http://tools.iedb.org/mhcii/">http://tools.iedb.org/mhcii/</a>) for the analysis using Consensus method. Apparently, we have selected the common allele with appropriate amino acid length (15).<a class="elsevierStyleCrossRef" href="#bb0125">25</a> HLA-DRB1*01:01 allele are commonly found on 90% of the human population in the world.<a class="elsevierStyleCrossRef" href="#bb0130">26</a>,<a class="elsevierStyleCrossRef" href="#bb0135">27</a> Further, we retrieved the CD4+ epitope sequence which is commonly interacting with above-mentioned allele. Using VaxiJenv2.0 <a href="http://www.ddg-pharmfac.net/vaxijen/VaxiJen/VaxiJen.html">http://www.ddg-pharmfac.net/vaxijen/VaxiJen/VaxiJen.html</a>) at threshold 0.4 to check the antigenicity of predicted T-cell and lineal B-cell epitopes were analyzed.<a class="elsevierStyleCrossRef" href="#bb0090">18</a> Furthermore, predicted T-cell and lineal B-cell epitopes protein sequence was then subjected to allergen and toxicity analysis using AllerTOP v. 2.0 (<a href="https://www.ddg-pharmfac.net/AllerTOP/">https://www.ddg-pharmfac.net/AllerTOP/</a>)<a class="elsevierStyleCrossRef" href="#bb0140">28</a> & TOXINPRED (<a href="http://crdd.osdd.net/raghava/toxinpred/">http://crdd.osdd.net/raghava/toxinpred/</a>).<a class="elsevierStyleCrossRef" href="#bb0145">29</a> Finally, predicted T-cell and lineal B-cell epitope was submitted to the protein BLAST server (<a href="https://blast.ncbi.nlm.nih.gov/Blast.cgi?PAGE=Proteins">https://blast.ncbi.nlm.nih.gov/Blast.cgi?PAGE=Proteins</a>) against the non-radiant protein sequence within the organism (Homo sapiens (taxid: 9606)). T-cell and lineal B-cell epitope amino acid sequence cut-off score > 0.05 was selected and represents non-homologous. However, the selected T-cell and lineal B-cell epitope was antigen, non-allergen, non-toxic, and non-homologous sequence and was selected for vaccine construction.Adjuvant selection and vaccine constructionComplete protein sequence of Mycobacterium tuberculosis lipoprotein LprG (Accession no: KBJ35626) was taken in FASTA format from the NCBI (<a href="https://www.ncbi.nlm.nih.gov/protein/KBJ35626.1">https://www.ncbi.nlm.nih.gov/protein/KBJ35626.1</a>) website. Predicted M. tuberculosis lipoprotein sequence was further submitted to the ProtParam tool of ExPASy Proteomics Server (<a href="https://web.expasy.org/protparam/">https://web.expasy.org/protparam/</a>) for the evaluation of physicochemical properties as discussed earlier.<a class="elsevierStyleCrossRef" href="#bb0085">17</a>M. tuberculosis lipoprotein was introduced as an adjuvant to strengthen the vaccines immunogenicity ahead of the first EAAAK linkers epitope. Followed by the powerful T-cell (CD8+, CD4+) and lineal B-cell epitopes with suitable adjuvants and linkers, a multi-epitope vaccine was constructed. While doing so, epitopes of CD8+ were connected to AAY linkers, although GPGPG linkers were used to connect CD4+ epitopes. In addition, to fuse lineal B-cell epitopes, KK linkers were used. Finally, our construct was submitted to the ProtParam tool of ExPASy Proteomics Server (<a href="https://web.expasy.org/protparam/">https://web.expasy.org/protparam/</a>) for the evaluation of physicochemical properties as discussed earlier.<a class="elsevierStyleCrossRef" href="#bb0085">17</a> Antigen assessment was conducted out using VaxiJenv2.0 (<a href="http://www.ddg-pharmfac.net/vaxijen/VaxiJen/VaxiJen.html">http://www.ddg-pharmfac.net/vaxijen/VaxiJen/VaxiJen.html</a>) at threshold 0.4 to validate the antigenicity of the constructed vaccine.<a class="elsevierStyleCrossRef" href="#bb0095">19</a> AlgPred (<a href="https://webs.iiitd.edu.in/raghava/algpred/submission.html">https://webs.iiitd.edu.in/raghava/algpred/submission.html</a>) with the MEME/MAST motif approach was used to investigate the allergenicity of the constructed vaccine.<a class="elsevierStyleCrossRef" href="#bb0150">30</a>Protein structure prediction, refinement, and validation of constructed vaccinePSIPRED 4.0 (<a href="http://bioinf.cs.ucl.ac.uk/psipred/">http://bioinf.cs.ucl.ac.uk/psipred/</a>) and SOPMA (<a href="https://npsa-prabi.ibcp.fr/cgi-bin/npsa_automat.pl?page=/NPSA/npsa_sopma.html">https://npsa-prabi.ibcp.fr/cgi-bin/npsa_automat.pl?page=/NPSA/npsa_sopma.html</a>) is the most commonly used server to forecast the constructed vaccine secondary structure.<a class="elsevierStyleCrossRef" href="#bb0155">31</a>,<a class="elsevierStyleCrossRef" href="#bb0160">32</a> The 3D structure of the constructed vaccine was forecasted by RaptorX web server (<a href="http://raptorx.uchicago.edu/ContactMap/">http://raptorx.uchicago.edu/ContactMap/</a>). It uses various template stitching iterative to select the optimum template on the basis of which the protein is constructed by arranging iterative template pieces and offers a rank for each projected 3D model.<a class="elsevierStyleCrossRef" href="#bb0165">33</a> The rudimentary structure of the 3D vaccine was quite well with Galaxy Refine tool (<a href="http://galaxy.seoklab.org/cgi-bin/submit.cgi?type=REFINE">http://galaxy.seoklab.org/cgi-bin/submit.cgi?type=REFINE</a>).<a class="elsevierStyleCrossRef" href="#bb0155">31</a> This database uses systemic dynamic analysis which repacks the side chain, replaces inaccurate loops, and soothes the framework. Further, we have sent the structure of the refined vaccine for validation purposes to the ProSA-web server (<a href="https://prosa.services.came.sbg.ac.at/prosa.php">https://prosa.services.came.sbg.ac.at/prosa.php</a>)<a class="elsevierStyleCrossRef" href="#bb0170">34</a> and the PROCHEK web-server (<a href="https://saves.mbi.ucla.edu/">https://saves.mbi.ucla.edu/</a>) to confirm the structure was refined.<a class="elsevierStyleCrossRef" href="#bb0175">35</a> By comparing the protein structure with the X-ray and NMR crystallography derived evaluated structures; the ProSA-web server assesses the protein structure and gave a score as an appropriate performance variable.<a class="elsevierStyleCrossRef" href="#bb0170">34</a> A Ramachandran plot was generated by the PROCHECK server and the number of residues energetically preferred, permitted, and disallowed region was observed with significant values.<a class="elsevierStyleCrossRef" href="#bb0175">35</a>Conformational B-cell epitope predictionThe unique portion of refined protein structure is the conformational (discrete) B-cell epitope (CBE) that was able to promote the production of antibody. The occurrence of CBE in the vaccine is, therefore, important. To calculate the CBE, the ElliPro (<a href="http://tools.iedb.org/ellipro/">http://tools.iedb.org/ellipro/</a>) framework accessible on the IEDB sever is to be used.<a class="elsevierStyleCrossRef" href="#bb0180">36</a>Molecular docking and dynamic stimulationMolecular docking is an online assessment analytical tool to assess the binding energy and interlinkage between the ligand and receptor. As we all know, toll-like receptor recognizes the viral cells and it gives activation to the monocyte gate. So, in this computer-based molecular docking studies, we have used a common toll-like receptor, which always recognizes the EBOV. We therefore considered TLR3, TLR4, and TLR7 as the receptor, while the ligand was the vaccine protein. The TLR3 (PDB ID: <a href="pdb:3ULU">3ULU</a>), <a href="pdb:TLR4">TLR4</a> (PDB ID: <a href="pdb:4G8A">4G8A</a>), <a href="pdb:TLR7">TLR7</a> (PDB ID: <a href="pdb:7CYN">7CYN</a>) molecule was acquired from the RCSB PDB server.<a class="elsevierStyleCrossRef" href="#bb0185">37</a> Finally, the binding affinity and interlinkage among the vaccine and the TLR3, TLR4, TLR7 receptor was anticipated using the web-based Patchdock docking server (<a href="https://bioinfo3d.cs.tau.ac.il/PatchDock/">https://bioinfo3d.cs.tau.ac.il/PatchDock/</a>). The finest-docked complex with an acceptable pose was calculated based on the global energy ranking.<a class="elsevierStyleCrossRef" href="#bb0190">38</a> We have simulated molecular dynamics (MD) to evaluate the structural integrity and stability of the docked multiplex andthe highest TLR3, TLR4, TLR7 global energy complex has been introduced into the iMODS server ((<a href="http://imods.chaconlab.org/">http://imods.chaconlab.org/</a>)). Depending upon the NMA (normal mode analysis) method, it offers deformability, Eigenvalues, to evaluate deformation and fluctuations in protein movement.<a class="elsevierStyleCrossRef" href="#bb0195">39</a>Evaluation of immune stimulationThe selected GP protein sequence (<a href="http://150.146.2.1/C-IMMSIM/">http://150.146.2.1/C-IMMSIM/</a>) was introduced to the C-ImmSim server to authenticate the vaccine's feasibility in exacerbating an immune response. For agent-based dynamics simulation, the C-ImmSim server uses ML techniques and PSSM (position-specific scoring matrix) to detect epitopes and subsequent immune reactions.<a class="elsevierStyleCrossRef" href="#bb0200">40</a>,<a class="elsevierStyleCrossRef" href="#bb0205">41</a> Particularly, several vaccines are administered in three concentrations, 28 days apart. We have therefore agreed to prescribe three injections (concentration) with an interval of 4 weeks between the two concentrations. Each time-step in the C-ImmSim immune simulator is defined to be 8 h in real life; thus, three injections require 1, 84, and 170 time-steps. In addition, exposure to antigen in a typical endemic zone was measured as repeated exposure using a total of three injections.Results and discussionDetailed analysis of retrieved protein sequenceThe physicochemical properties of the EBOV GP, evaluated through Protparam, exhibited that 676 amino acids with 75,618.41 kDa molecular weight. GP were exposed to Vaxijen v2.0 server and it reflects an antigenic form. Theoretical isoelectric point (PI) of GP was found to be 6.27, suggesting its negative in nature. An isoelectric point below 7 specifies the positively charged protein and nearly 69 amino acid charges were reported to be positive as well as another 69 amino acid reported to be negative. The estimated instability index of Protparam was reported to be 36.61, which classifies the protein as stable. Aliphatic-index 78.43, dedicating a thought to the corresponding amount of aliphatic side chain holding and solubility shows −0.409, and it indicates the retrieved protein sequence was water soluble in nature. The half-life of GP showed in mammalian reticulocytes, and it takes around 30 h to disappear after the cell synthesis followed by yeast taking higher than 20 h. Moreover, Escherichia coli took around more than 10 h. The total numbers of Oxygen (O), Carbon (C), Hydrogen (H) Sulfur (S), and Nitrogen (N), were entitled by the formula: C3371H5243N929O1016S18<a class="elsevierStyleCrossRef" href="#t0005">Table 1</a>.<elsevierMultimedia ident="t0005"></elsevierMultimedia>Analysis and selection of CD4+, CD8+, and lineal B cell epitopeThe predicted epitopes of CD4+, CD8+, and lineal B-cell were subjected to appropriate server to validate the probable antigenicity, homologous, toxicity, and allergenicity property of epitopes. Five CD8+ epitope, eight CD4+ epitope, and six lineal B-cell epitope are antigenic, non-allergic, non-toxic, and non-homologous in nature (<a class="elsevierStyleCrossRefs" href="#t0010">Tables 2 and 3</a>).<elsevierMultimedia ident="t0010"></elsevierMultimedia><elsevierMultimedia ident="t0015"></elsevierMultimedia>Detailed analysis of adjuvant and constructed vaccineSelected 5CD4+, 8CD8+, and 6 lineal B cell epitope were used for constructing a vaccine with suitable linkers as previously described in Methods. In lieu to increase the efficacy of the vaccine adjuvant Mycobacterium tuberculosis lipoprotein was added. The physiochemical properties of the M. tuberculosis lipoprotein was evaluated through Protparam and identified that it consists of 236 amino acid with a molecular weight of 24,547.80 kDa. Theoretical isoelectric point (PI) of M. tuberculosis lipoprotein was found to be 7.78, suggesting its positive in nature. An isoelectric point >7 specifies the protein is charged positively. Nearly 20 amino acid charges were reported to be positive, whereas 19 amino acid reported to be negative. The estimated instability index of Protparam was reported to be 16.11, this classify the protein as stable. Aliphatic-index 86.86, dedicating a thought to the corresponding amount of aliphatic side chain holding and solubility shows −0.127, and it indicates the retrieved protein sequence found to be water soluble in nature. The half life of M. tuberculosis lipoprotein was showed, in mammalian reticulocytes and it took around 30 h to disappear after the cell synthesis followed by yeast which took more than 20 h. Moreover, E. coli takes more than 10 h. The total numbers of Oxygen (O), Carbon (C), Hydrogen (H) Sulfur (S), and Nitrogen (N), were entitled by the formula: C1076H1740N306O339S5<a class="elsevierStyleCrossRef" href="#t0005">Table 1</a>. Finally, the selected adjuvant was passed in all formats of physicochemical properties. So, the structural and functional analysis of the protein is very much suitable for acting as an adjuvant. So, we have selected M. tuberculosis lipoprotein as an adjuvant. Finally, our constructed vaccine also underwent evaluation of physicochemical properties using Protparam server, revealed that it consists of 598 aminoacid with a molecular weight of 63,546.58 kDa. The constructed vaccine reflects an antigenic nature when introduced to Vaxijen v2.0. Theoretical isoelectric point (PI) of constructed vaccine was reported to be 9.67, suggesting its positive in nature. An isoelectric point more than 7 specifies the protein is charged positively. Near to 54 amino acid charges were reported to be positive, whereas 34 aminoacid reported to be negative. The estimated instability index of Protparam was reported to be 19.16, this classifies the protein as stable. Aliphatic-index 92.12, dedicating a thought to the corresponding amount of aliphatic side chain holding and solubility shows 0.029 and it indicates the retrieved protein sequence was lipid soluble in nature. The half life of constructed vaccine was shown in E. coli and it takes more than 10 h to disappear after the cell synthesis followed by mammalian reticulocytes that takes 1 h. Moreover, yeast takes more than 30 min. The total numbers of Oxygen (O), Carbon (C), Hydrogen (H) Sulfur (S), and Nitrogen (N), were entitled by the formula: C2921H4575N773O800S7 (<a class="elsevierStyleCrossRef" href="#t0005">Table 1</a>). As per the detailed assessment, we strongly conclude that, our newly constructed vaccine reflects as a potential candidate vaccine.Assessment of protein structure perdition, refinement, and validation of constructed vaccineThe secondary structure of constructed vaccine was analyzed through PSIPRED server (<a class="elsevierStyleCrossRef" href="#f0005">Fig. 1</a>). The secondary structure elements estimated by SOPMA server are Alpha helix (18.23%), 310 helix (0.00%), Pi helix (0.00%), Beta Bridge (0.00%), extended strand (27.42%), Beta turns (0.00%), Bend region (0.00%), Random coil (54.35%), Ambiguous states (0.00%), and other states (0.00%). Furthermore, the constructed vaccine was subjected to the RaportX server for the prediction of tertiary structure. Five tertiary structure models were generated from the RaportX server (<a class="elsevierStyleCrossRef" href="#t0020">Table 4</a>). Based on the rank, we have selected the first rank of tertiary structure of the designed vaccine were subjected to the Galaxy web server for refinement, and it also generated five refined models. Quality assessment of the refined model are discussed below; firstly Global Distance Test (GDT-HA) - the correlation among two protein structures was calculated by a high precision score. The GDT-HA score achieves a high value of 0.900 between the five refined models and the initial model, suggesting that they have high similarity. The lower RMSD value implies greater stability and is generally appropriate for an RMSD score ranging from 0 to 1.2. The RMSD value of the five refined models shows <0.5 and it represents that the protein model have been stable. The refined models of crystallographic resolution is expressed by the Molprobity score. In our five refined protein models, the MolProbity score is <3, which is much lesser than the initial model, and also indicating the critical errors of refined models. Clash Score reflects the quantity of unfavorable steric all-atom lie on top and the refinement decreased the models' clash score from 328.5 to 45%, increasing the stability of the model to a high stage. Ramachandran plot score reflects the range of regions that are vigorously preferred, and typically a value higher than 85% is appropriate. However, based on the superiority score of all refined models passes in all parameters. So, the first model of the refined protein structure was retrieved in PDB format for further analysis (<a class="elsevierStyleCrossRef" href="#t0025">Table 5</a>). To validate the refined final vaccine model consistency using ProSA-web server which lies within the score range −6.84 was showed with good efficiency <a class="elsevierStyleCrossRef" href="#f0010">Fig. 2</a>A. Refined PDB model was subjected to Ramachandran plot check using PROCHEK server which showed that, in favored region 94.7% (450 amino acids) were located, in allowed region 4.6% (22 amino acids) were located, and in disallowed region 0.6% (3 amino acid) were located. The quality of the refined model was found to be more than 90% of residues positioned on suitable (favored and allowed) region (<a class="elsevierStyleCrossRef" href="#f0010">Fig. 2</a>B).<elsevierMultimedia ident="f0005"></elsevierMultimedia><elsevierMultimedia ident="t0020"></elsevierMultimedia><elsevierMultimedia ident="t0025"></elsevierMultimedia><elsevierMultimedia ident="f0010"></elsevierMultimedia>β-strand structure is denoted as yellow color amino acids, α-helix structure is denoted as pink color amino acids, and coil structure is denoted as ash color amino acids.Five models of 3D protein structure were predicted and categorized by the Rank and estimated RMSD(A°) value. Moreover, rank 1 shows the estimated RMSD(A°) value of 18.501, followed by Rank 2 showing the estimated RMSD (A°) value of 13.257, followed by Rank 3 showing the estimated RMSD (A°) value of 13.731, followed by Rank 4 showing the estimated RMSD(A°) value of 16.019. Finally, Rank 5 shows the estimated RMSD(A°) value of 13.681.There are five models of refined 3D protein structure that were predicted and it is also categorized by the model, GDT-HA, RMSD value, MolProbity, Clash score, Poor rotamers. The model 1 shows GDT-HA (0.8874), RMSD value (0.570), MolProbity (2.755), Clash score (45.7), Poor rotamers (1.6), Ramachandran plot (92.7), followed by model 2 showing the GDT-HA (0.8918), RMSD value (0.563), MolProbity (2.606), Clash score (47.2), Poor rotamers (1.0), Ramachandran plot (92.8), followed by Model 3 showing the GDT-HA (0.8898), RMSD value (0.565), MolProbity (2.855), Clash score (47.3), Poor rotamers (2.0), Ramachandran plot (92.4), followed by Model 4 showing the GDT-HA (0.8878), RMSD value (0.567), MolProbity (2.785), Clash score (44.8), Poor rotamers (1.8), Ramachandran plot (92.7). Final Model 5 shows the GDT-HA (0.8938), RMSD value (0.558), MolProbity (2.604), Clash score (47.7), Poor rotamers (1.0), Ramachandran plot (93.0).The Z-score of the refined model that falls within the score range is −6.84. Ramachandran plot study indicates 94.7%, 4.2%, and 1.0% of protein residues in favored, allowed and disallowed (foreign) regions, individually.Detailed assessment of B-cell epitope confirmationWe have utilized the ElliPro server to forecast the CBC epitopes with the help of refined vaccine model. Five new CBC epitopes were predicted by the ElliPro server involving 339 residues with scores ranging from 0.529 to 0.763. <a class="elsevierStyleCrossRef" href="#t0030">Table 6</a> demonstrates the comprehensive 3D model and the details for those five epitopes.<elsevierMultimedia ident="t0030"></elsevierMultimedia>The 3D model of the five predicted CBC epitopes in the refined vaccine model. The yellow parts represents the CBC epitopes and the gray parts represents the other residues. (I) 159 residues of CBC falls within a score of 0.763. (II) 129 residues of CBC falls within a score of 0.70. (III) 41 residues of CBC falls within a score of 0.556. (IV) Four residues of CBC falls within a score of 0.544. (V) Six residues of CBC falls within a score of 0.529.Molecular docking and dynamic stimulationMolecular docking studies were performed to verify the stability and binding interaction of the docked complex. TLR3, TLR4, and TLR7 were used to obtain essential human proteins for identification of EBOV and also triggers the immune response. Accordingly, we selected TLR3, TLR4, and TLR7 for molecular docking as the immune receptor. We use the Patchdock server to do the molecular docking between our final vaccine's refined 3D model and the immune receptors TLR3 (PDB ID: <a href="pdb:3ULU">3ULU</a>), <a href="pdb:TLR4">TLR4</a> (PDB ID: <a href="pdb:4G8A">4G8A</a>), and <a href="pdb:TLR7">TLR7</a> (PDB ID: <a href="pdb:7CYN">7CYN</a>). We selected the lowest energy score of −3.82 (<a class="elsevierStyleCrossRef" href="#f0015">Fig. 3</a>A), −9.00 (<a class="elsevierStyleCrossRef" href="#f0015">Fig. 3</a>B), −29.95 (<a class="elsevierStyleCrossRef" href="#f0015">Fig. 3</a>C), and (<a class="elsevierStyleCrossRef" href="#t0035">Table 7</a>) as the finest docked complex among the developed docking model, indicateing a good binding affinity. To assess the stability and physical movements of the vaccine, TLR3, TLR7, TLR9 docked complex were analyzed by employing iMOD server using MD simulation (<a class="elsevierStyleCrossRefs" href="#f0020">Figs. 4–6</a>). However, TLR4 showed higher stability and physical movements, when compared to TLR3 and TLR7.<elsevierMultimedia ident="f0015"></elsevierMultimedia><elsevierMultimedia ident="t0035"></elsevierMultimedia><elsevierMultimedia ident="f0020"></elsevierMultimedia><elsevierMultimedia ident="f0025"></elsevierMultimedia><elsevierMultimedia ident="f0030"></elsevierMultimedia>Binding affinity between our constructed vaccine and TLR3, TLR4, TLR7 was categorized by global energy. The lesser the global energy, the binding affinity will be higher. So, we retrieved the Rank 1 PDB format for molecular dynamics study. The Rank 1 of TLR3, TLR4, TLR7 shows −3.82, −900, −29.95 global energy.The vaccine protein indicates combination of red–gray color peptide and the TLR3, TLR4, TLR7 receptor indicates remaining residue. This complex model's lowest energy score is −3.82, −9.00, and −29.95 suggesting strong binding affinity.Detailed analysis of immune stimulationIn order to simulate the immune response generated by immunization, imaginary administration of three doses of designed vaccine was executed 4 weeks apart with 1050 units/dose. Antigenic recognition and subsequent response in terms of antibody production and active as well as memory B-cell and T-cell generation were indicated in-silico immune simulation plots in a population with a VL susceptible HLA profile after hypothetical immunization, a marked increase in vaccine-specific IgM production can characterize the primary response to the proposed vaccine. Secondary and tertiary response show rapid increase of IgM + IgG, followed by IgM and IgG1 + IgG2 antibodies. A corresponding decrease in antigen concentration after subsequent doses is shown in <a class="elsevierStyleCrossRef" href="#f0035">Fig. 7</a>A. The effector B-cell shows the consistency throughout 350 days is shown in <a class="elsevierStyleCrossRef" href="#f0035">Fig. 7</a>B. During secondary and tertiary dose–response, the plasma B-cells increases rapidly there and antibodies which includes IgM + IgG antibodies is shown in <a class="elsevierStyleCrossRef" href="#f0035">Fig. 7</a>C. From the significantly obtained results, we conclude that the effector B-cell and the plasma B-cells suggest a steady increase in persistent memory B-cell development. In addition, CD4+ T and CD8+ lymphocyte expansion with memory production following the initial dose was observed and shown in <a class="elsevierStyleCrossRef" href="#f0035">Fig. 7</a>D & E. After three subsequent dose of the vaccine, interferon gamma and interlukin-2 show the highest level in the blood plasma followed by interleukin-6, -23. However, compared to interleukin-10, interleukin-12 shows less immunogenic effect as shown in <a class="elsevierStyleCrossRef" href="#f0035">Fig. 7</a>E.<elsevierMultimedia ident="f0035"></elsevierMultimedia>ConclusionClinicians, researchers, and academicians have been continuously showing their effort to treat EBOV outbreaks in some of the countries due to lack of medication from the past few decades. In addition, the EBOV's mortality rate is also increasing during the time of epidemic. Even though most vaccines have been developed earlier based on B-cell immunity, due to long-lasting immunity, most of the researchers showed their interest to develop a T-cell epitope-based vaccine. We have developed a protein-based vaccine for immunization against the EVD using immunological information and knowledge of structural biology. In this present report, a vaccine mixture of both B-cell and T-cell epitopes was generated using a variety of immunoinformatic methods and interesting immunological properties were also evaluated. In addition, to determine the efficacy of the vaccine, molecular docking and molecular dynamics experiments were performed. The strong immune response against EBOV is demonstrated by engineered vaccine. We have predicted the secondary and tertiary structure of the constructed vaccine. The interactions between the vaccine and Toll-like receptors-3, -4, and -7, have been studied. The constructed vaccine demonstrates enhanced cellular immunity and also assesses the clearance of antigen from the body at various exposures. This method of research is time-consuming and often decreases the efforts in the laboratory trail and errors. It also offers a comprehensive idea for the potential design of protein-based vaccines.Consent for publicationNot applicable.FundingNone.Ethical approvalNot required." "textoCompletoSecciones" => array:1 [ "secciones" => array:13 [ 0 => array:3 [ "identificador" => "xres1851312" "titulo" => "Abstract" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "as0005" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec1609757" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres1851311" "titulo" => "Resumen" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "as1005" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec1609756" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "s0005" "titulo" => "Introduction" ] 5 => array:3 [ "identificador" => "s0010" "titulo" => "Materials and methods" "secciones" => array:7 [ 0 => array:2 [ "identificador" => "s0015" "titulo" => "Protein sequence retrieval, antigenicity and physicochemical properties evaluation" ] 1 => array:2 [ "identificador" => "s0020" "titulo" => "Retrieval of binding site of CD8, CD4, lineal B-cell from GP sequence" ] 2 => array:2 [ "identificador" => "s0025" "titulo" => "Adjuvant selection and vaccine construction" ] 3 => array:2 [ "identificador" => "s0030" "titulo" => "Protein structure prediction, refinement, and validation of constructed vaccine" ] 4 => array:2 [ "identificador" => "s0035" "titulo" => "Conformational B-cell epitope prediction" ] 5 => array:2 [ "identificador" => "s0040" "titulo" => "Molecular docking and dynamic stimulation" ] 6 => array:2 [ "identificador" => "s0045" "titulo" => "Evaluation of immune stimulation" ] ] ] 6 => array:3 [ "identificador" => "s0050" "titulo" => "Results and discussion" "secciones" => array:7 [ 0 => array:2 [ "identificador" => "s0055" "titulo" => "Detailed analysis of retrieved protein sequence" ] 1 => array:2 [ "identificador" => "s0060" "titulo" => "Analysis and selection of CD4, CD8, and lineal B cell epitope" ] 2 => array:2 [ "identificador" => "s0065" "titulo" => "Detailed analysis of adjuvant and constructed vaccine" ] 3 => array:2 [ "identificador" => "s0070" "titulo" => "Assessment of protein structure perdition, refinement, and validation of constructed vaccine" ] 4 => array:2 [ "identificador" => "s0075" "titulo" => "Detailed assessment of B-cell epitope confirmation" ] 5 => array:2 [ "identificador" => "s0080" "titulo" => "Molecular docking and dynamic stimulation" ] 6 => array:2 [ "identificador" => "s0085" "titulo" => "Detailed analysis of immune stimulation" ] ] ] 7 => array:2 [ "identificador" => "s0090" "titulo" => "Conclusion" ] 8 => array:2 [ "identificador" => "s0095" "titulo" => "Consent for publication" ] 9 => array:2 [ "identificador" => "s0100" "titulo" => "Funding" ] 10 => array:2 [ "identificador" => "s0105" "titulo" => "Ethical approval" ] 11 => array:2 [ "identificador" => "xack652596" "titulo" => "Acknowledgment" ] 12 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2021-08-01" "fechaAceptado" => "2021-10-18" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1609757" "palabras" => array:6 [ 0 => "Immunoinformatics" 1 => "Vaccine linkers" 2 => "In-silico biology" 3 => "Epitope" 4 => "Immunization" 5 => "Ebola virus" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec1609756" "palabras" => array:6 [ 0 => "Inmunoinformática" 1 => "Enlaces de la vacuna" 2 => "Biología in-silico" 3 => "Epítope" 4 => "Inmunización" 5 => "Virus del Ébola" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "The aim of this research is to develop a protein-based vaccine for immunization against the Ebola virus disease (EVD) using immunological information and knowledge of structural biology. According to WHO reports the fatality rate of the EVD is around 67% in the year 2019. Particularly, the Bundibugyo Ebolaviruses has the least pathogenic fatality rate approximately around 37%. Moreover, in past outbreaks, the fatality rate is different from 25 to 95% due to a shortage of powerful medication and vaccines. In this present work, immunological information tools and databases to retrieve the highest antigenicity of B-cell and T-cell epitopes from Ebola virus (EBOV) glycoprotein. Vaccine was constructed using 5CD8+, 8CD4+, and 6B-cell epitope with suitable linkers. Mycobacterium tuberculosis lipoprotein has been introduced into the vaccine as an adjuvant to strengthen the vaccine's efficacy. Physicochemical properties of the developed vaccine were assessed, which incorporates solubility, stability, and so forth. The interactions between the vaccine and Toll-like receptors 3, 4, and 7, have been studied. The constructed vaccine demonstrates enhanced cellular immunity and also assesses the clearance of antigen from the body at various exposures." ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "El objetivo de este estudio es desarrollar una vacuna a base de proteínas, para inmunización contra la enfermedad por el virus del Ébola (EVE) utilizando información inmunológica y conocimiento sobre biología estructural. En virtud de los informes de la OMS, la tasa de fatalidad de EVE se situó cerca del 67% en el año 2019. En particular, el virus Bundibugyo, tiene la menor tasa de fatalidad patogénica, de aproximadamente el 37%. Además, en los brotes pasados la tasa de fatalidad pasó del 25 al 95%, debido a la escasez de fármacos potentes y vacunas. En este trabajo se han utilizado herramientas de información y bases de datos inmunológicos para obtener la mayor antigenicidad de los epítopes de células B y células T de la glucoproteína del virus del Ébola (EBOV). La vacuna fue construida utilizando los epítopes celulares 5CD8+, 8CD4+, y 6B con los enlaces adecuados. Se introdujo en la vacuna lipoproteína de Mycobacterium tuberculosis como adyuvante para reforzar la eficacia de la misma. Se evaluaron las propiedades fisicoquímicas de la vacuna desarrollada, que incorporan solubilidad, estabilidad, etc. Se estudiaron las interacciones entre la vacuna y los receptores de tipo Toll 3, 4 y 7. La vacuna elaborada demuestra la mejora de la inmunidad celular, y evalúa también el aclaramiento del antígeno del cuerpo a diversas exposiciones." ] ] "multimedia" => array:29 [ 0 => array:8 [ "identificador" => "f0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 788 "Ancho" => 1890 "Tamanyo" => 278198 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "al0005" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "Secondary structure of the constructed vaccine." ] ] 1 => array:8 [ "identificador" => "f0010" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 2127 "Ancho" => 945 "Tamanyo" => 168426 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "al0010" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "(A, B) Vaccine 3D validation of structure by ProSA-web and PROCHECK." ] ] 2 => array:8 [ "identificador" => "f0015" "etiqueta" => "Fig. 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 1263 "Ancho" => 1654 "Tamanyo" => 204274 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "al0015" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "The docking complex of the TLR3, TLR4, TLR7, and the vaccine model." ] ] 3 => array:8 [ "identificador" => "f0020" "etiqueta" => "Fig. 4" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr4.jpeg" "Alto" => 760 "Ancho" => 1890 "Tamanyo" => 107620 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "al0020" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "The simulation of MD of vaccine-TLR3 docked complex structures. (A) The main-chain deformability simulation showed the hinges regions are average deformability. (B) B-factor values, determined by normal mode analysis, measure the volatility of each atom. (C) The eigenvalue of the docked complex's demonstrated that does not require energy to deform the structure. (D) Covariance matrix between residue pairs (white: uncorrelated, red: correlated, blue: anti-correlated). (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)" ] ] 4 => array:8 [ "identificador" => "f0025" "etiqueta" => "Fig. 5" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr5.jpeg" "Alto" => 315 "Ancho" => 1890 "Tamanyo" => 68134 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "al0025" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "The simulation of MD of vaccine-TLR4 docked complex structures. (A) The main-chain deformability simulation showed the hinges regions are strong deformability. (B) B-factor values, determined by normal mode analysis, measure the volatility of each atom. (C) The eigenvalue of the docked complex's showed the energy required to deform the structure. (D) Covariance matrix between residue pairs (red: correlated, white: uncorrelated, blue: anti-correlated). (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)" ] ] 5 => array:8 [ "identificador" => "f0030" "etiqueta" => "Fig. 6" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr6.jpeg" "Alto" => 359 "Ancho" => 1890 "Tamanyo" => 75352 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "al0030" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "The simulation of MD of vaccine-TLR3 docked complex structures. (A) The main-chain deformability simulation showed the hinges regions are weak deformability. (B) B-factor values were evaluated by normal mode analysis, measure the volatility of each atom. (C) The eigenvalue of the docked complex were illustrated that does not require the energy to deform the structure. (D) Covariance matrix between residue pairs (red: correlated, white: uncorrelated, blue: anti-correlated). (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)" ] ] 6 => array:8 [ "identificador" => "f0035" "etiqueta" => "Fig. 7" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr7.jpeg" "Alto" => 2204 "Ancho" => 1949 "Tamanyo" => 284763 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "al0035" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "Immune simulation caused by constructed vaccine. (A) Immune response patterns on exposure to antigens. (B) The effector B- cells consistency (C) Immune reaction of Plasma B-cell. (D) Cytotoxic CD4+ cell population. (E) Cytotoxic CD8+ cell population. (F) Cytokine generation." ] ] 7 => array:8 [ "identificador" => "t0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "al0040" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Features \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">EBOV glycoprotein \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Mycobacterium tuberculosis lipoprotein \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Vaccine candidate \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Number of amino acids \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">676 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">236 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">598 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Molecular weight \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">75,618.41 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">24,547.80 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">63,546.58 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Theoretical pI \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6.27 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7.78 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9.67 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Total number of negatively charged residues (Asp + Glu) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">69 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">19 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">34 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Total number of positively charged residues (Arg + Lys) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">62 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">20 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">54 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Total number of atoms \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">10,577 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3466 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9076 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Atomic composition formula \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">C3371H5243N929O1016S18 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">C1076H1740N306O339S5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">C2921H4575N773O800S7 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Instability index \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">36.61 (stable protein) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">16.11 (stable protein) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">19.16 (Stable protein) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Aliphatic index \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">78.43 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">86.86 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">92.12 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Hydropathicity \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−0.409 (water soluble) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−0.127 (water soluble) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.029 (lipid soluble) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Antigenicity \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.5218 (antigen) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.5980 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] ] "descripcion" => array:1 [ "en" => "Evaluation of physicochemical properties of EBOV GP, Mycobacterium tuberculosis lipoprotein and vaccine candidate." ] ] 8 => array:8 [ "identificador" => "t0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "al0045" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Allele \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Start \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">End \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Peptide \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Vaxijen score \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Allergencity \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Toxicity \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Human homology \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead rowgroup " rowspan="4" align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">CD8+ epitope</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">HLA-A*02:06 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">29 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">37 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">KVFPIPLGV \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.5020 Antigen \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Non-allergen \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Non-toxin \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">E-Value >23Non-homologous \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">HLA-A*02:01 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">29 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">37 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">KVFPIPLGV \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.5020 Antigen \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Non-allergen \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Non-toxin \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">E-Value >23Non-homologous \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">HLA-A*02:06 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">27 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">35 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">GITGVIIAV \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.7325 Antigen \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Non-allergen \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Non-toxin \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">E-Value >27Non-homologous \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">HLA-A*02:06 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">38 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">46 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">FTPQFLVQL \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.5875 Antigen \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Non-allergen \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Non-toxin \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">E-Value >0.57Non-homologous \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">HLA-A*02:01 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">20 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">28 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">TLSSEELSV \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">0.7753 Antigen \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Non-allergen \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Non-toxin \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">E-Value >6.6Non–homologous \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead rowgroup " rowspan="8" align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">CD4+ epitope</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">HLA-DRB1*01:01 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">24 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">38 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">IILFHKVFPIPLGVV \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.0161 Antigen \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Non-allergen \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Non-toxin \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">E-Value >7.4Non-homologous \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">HLA-DRB1*01:01 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">23 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">37 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">VIILFHKVFPIPLGV \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.9775 Antigen \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Non-allergen \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Non-toxin \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">E-Value >7.4Non-homologous \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">HLA-DRB1*01:01 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">25 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">39 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">ILFHKVFPIPLGVVH \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.9652 Antigen \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Non-allergen \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Non-toxin \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">E-Value >21Non-homologous \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">HLA-DRB1*01:01 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">22 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">36 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">WVIILFHKVFPIPLG \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.0023 Antigen \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Non-allergen \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Non-toxin \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">E-Value >5.2Non-homologous \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">HLA-DRB1*01:01 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">26 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">40 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">LFHKVFPIPLGVVHN \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.8038 Antigen \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Non-allergen \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Non-toxin \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">E-Value >3.7Non-homologous \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">HLA-DRB1*01:01 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">18 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">32 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">AFFLYDRLASTIIYR \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.4171 Antigen \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Non-allergen \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Non-toxin \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">E-Value >5.2Non-homologous \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">HLA-DRB1*01:01 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">21 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">35 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">VWVIILFHKVFPIPL \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.5147 Antigen \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Non-allergen \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Non-toxin \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">E-Value >3.7Non-homologous \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">HLA-DRB1*01:01 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">28 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">42 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">HLTYVQLEPRFTPQF \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.1594 Antigen \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Non-allergen \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Non-toxin \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">E-Value >7.4Non-homologous \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] ] "descripcion" => array:1 [ "en" => "Detailed analysis of CD8 + & CD4+ epitope." ] ] 9 => array:8 [ "identificador" => "t0015" "etiqueta" => "Table 3" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "al0050" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Position \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Epitope \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Vaxijen score \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Allergencity \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Toxicity \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Human homology \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead rowgroup " rowspan="6" align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Linear B-cell epitope</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">257 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">NETIYTNGRRSNTTGTLIWK \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.4557 Antigen \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Non-allergen \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Non-toxin \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">E-Value >3.9Non-homologous \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">311 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">VPRAQDPGSNQKTKVTPTSF \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.9762 Antigen \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Non-allergen \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Non-toxin \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">E-Value >7.9Non-homologous \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">509 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">AKCNPNLHYWTTQDEGAAIG \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.4132 Antigen \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Non-allergen \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Non-toxin \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">E-Value >2.9Non-homologous \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">388 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">ELPNISGNHQERNNTAHPET \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.5419 Antigen \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Non-allergen \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Non-toxin \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">E-Value >7.9Non-homologous \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">29 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">KVFPIPLGVVHNNTLQVSDI \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.0396 Antigen \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Non-allergen \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Non-toxin \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">E-Value >4.0Non-homologous \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">217 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">TLNYVADNFGTNMTNFLFQV \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.4002 Antigen \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Non-allergen \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Non-toxin \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">E-Value >5.5Non-homologous \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] ] "descripcion" => array:1 [ "en" => "Detailed analysis of lineal B-cell epitope." ] ] 10 => array:8 [ "identificador" => "t0020" "etiqueta" => "Table 4" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "al0055" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Rank of models \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Estimated RMSD(Å) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">3D structure \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">18.501 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><elsevierMultimedia ident="202302191853062911"></elsevierMultimedia> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">13.257 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><elsevierMultimedia ident="202302191853062912"></elsevierMultimedia> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">13.731 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><elsevierMultimedia ident="202302191853062913"></elsevierMultimedia> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">16.019 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><elsevierMultimedia ident="202302191853062914"></elsevierMultimedia> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">13.681 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><elsevierMultimedia ident="202302191853062915"></elsevierMultimedia> \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] ] "descripcion" => array:1 [ "en" => "Tertiary structure perdition of designed vaccine by RaptorX structure prediction server." ] ] 11 => array:8 [ "identificador" => "t0025" "etiqueta" => "Table 5" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "al0085" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Model \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">GDT-HA \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">RMSD \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">MolProbity \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Clash score \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Poorrotamers \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Rama favored \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Structure \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Initial \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.0000 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.000 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4.957 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">328.5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">81.2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">90.4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">MODEL 1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.8874 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.570 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.755 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">45.7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">92.7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><elsevierMultimedia ident="202302191853062916"></elsevierMultimedia> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">MODEL 2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.8918 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.563 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.606 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">47.2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">92.8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><elsevierMultimedia ident="202302191853062917"></elsevierMultimedia> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">MODEL 3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.8898 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.565 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.855 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">47.3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">92.4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><elsevierMultimedia ident="202302191853062918"></elsevierMultimedia> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">MODEL 4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.8878 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.567 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.785 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">44.8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">92.7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><elsevierMultimedia ident="202302191853062919"></elsevierMultimedia> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">MODEL 5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.8938 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.558 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.604 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">47.7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">93.0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><elsevierMultimedia ident="2023021918530629110"></elsevierMultimedia> \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab3110448.png" ] ] ] ] "descripcion" => array:1 [ "en" => "Refinement of constructed vaccine." ] ] 12 => array:8 [ "identificador" => "t0030" "etiqueta" => "Table 6" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "al0115" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">No \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Residues \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Number of Residues \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Score \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">3D Structure \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">I \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">A:E1, A:A2, A:A3, A:A4, A:K5, A:M6, A:R7, A:T8, A:P9, A:R10, A:R11, A:H12, A:C13, A:R14, A:R15, A:I16, A:A17, A:V18, A:L19, A:A20, A:A21, A:V22, A:S23, A:I24, A:A25, A:A26, A:T27, A:V28, A:V29, A:A30, A:G31, A:C32, A:S33, A:S34, A:G35, A:S36, A:K37, A:P38, A:S39, A:G40, A:G41, A:P42, A:L43, A:P44, A:D45, A:A46, A:K47, A:P48, A:L49, A:E51, A:E52, A:T68, A:V69, A:N70, A:G71, A:K72, A:I73, A:P74, A:G75, A:L76, A:S77, A:L78, A:K79, A:T80, A:L81, A:S82, A:G83, A:N95, A:V96, A:K97, A:L98, A:T99, A:L100, A:G101, A:G102, A:S103, A:D104, A:I105, A:D106, A:A107, A:D108, A:T119, A:L120, A:T121, A:P122, A:N123, A:Q124, A:W125, A:N153, A:F154, A:A155, A:D156, A:A157, A:K158, A:A159, A:E160, A:G161, A:R162, A:D163, A:T164, A:I165, A:N166, A:G167, A:Q168, A:N169, A:T170, A:I171, A:R172, A:I173, A:S174, A:G175, A:K176, A:V177, A:S178, A:A179, A:Q180, A:V182, A:N183, A:A186, A:P188, A:F189, A:N190, A:A191, A:T192, A:Q193, A:P194, A:V195, A:P196, A:A197, A:T198, A:V199, A:W200, A:I201, A:Q202, A:E203, A:T204, A:G205, A:D206, A:H207, A:Q208, A:Q211, A:Q213, A:L214, A:D215, A:R216, A:G217, A:S218, A:G219, A:N220, A:S221, A:V222, A:Q223, A:P238, A:P239, A:V240, A:S241, A:A242, A:A243, A:Y244 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">159 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.763 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><elsevierMultimedia ident="2023021918530629111"></elsevierMultimedia> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">II \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">A:F457, A:I480, A:Y481, A:K482, A:K483, A:N484, A:E485, A:T486, A:I487, A:Y488, A:T489, A:N490, A:G491, A:R492, A:R493, A:S494, A:N495, A:T496, A:T497, A:G498, A:T499, A:L500, A:W502, A:K505, A:V506, A:P507, A:R508, A:A509, A:Q510, A:D511, A:P512, A:G513, A:S514, A:N515, A:Q516, A:K517, A:T518, A:K519, A:V520, A:P522, A:S524, A:F525, A:K526, A:N531, A:P532, A:N533, A:L534, A:H535, A:Y536, A:W537, A:T538, A:T539, A:D541, A:E542, A:G543, A:A544, A:A545, A:I546, A:G547, A:K548, A:K549, A:E550, A:L551, A:P552, A:N553, A:I554, A:S555, A:G556, A:N557, A:H558, A:Q559, A:E560, A:R561, A:N562, A:N563, A:T564, A:A565, A:H566, A:P567, A:E568, A:T569, A:K570, A:K571, A:K572, A:V573, A:F574, A:P575, A:I576, A:P577, A:L578, A:G579, A:V580, A:V581, A:H582, A:N583, A:N584, A:T585, A:L586, A:Q587, A:V588, A:S589, A:D590, A:I591, A:K592, A:K593, A:T594, A:L595, A:N596, A:Y597, A:V598, A:A599, A:D600, A:N601, A:F602, A:G603, A:T604, A:N605, A:M606, A:T607, A:N608, A:F609, A:L610, A:F611, A:Q612, A:V613, A:E614, A:A615, A:A616, A:K617 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">129 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.70 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><elsevierMultimedia ident="2023021918530629112"></elsevierMultimedia> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">III \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">A:F281, A:T282, A:P283, A:Q284, A:Q288, A:E298, A:L299, A:S300, A:V301, A:G302, A:P303, A:G304, A:P305, A:G306, A:I307, A:I308, A:V334, A:F335, A:P336, A:I337, A:P338, A:L339, A:G340, A:V341, A:G342, A:P343, A:G344, A:P345, A:G346, A:P377, A:I378, A:L380, A:G381, A:G382, A:P383, A:G384, A:P385, A:G386, A:L387, A:F388, A:H389 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">41 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.556 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><elsevierMultimedia ident="2023021918530629113"></elsevierMultimedia> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">IV \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">A:S227, A:K228, A:G230, A:E231 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.544 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><elsevierMultimedia ident="2023021918530629114"></elsevierMultimedia> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">V \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">A:G442, A:P443, A:G444, A:P445, A:G446, A:H447 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.529 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><elsevierMultimedia ident="2023021918530629115"></elsevierMultimedia> \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] ] "descripcion" => array:1 [ "en" => "linear B- cell epitope confirmation." ] ] 13 => array:8 [ "identificador" => "t0035" "etiqueta" => "Table 7" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "al0145" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Rank \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Solution number \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Global energy \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Attractive VdW \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Repulsive VdW \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">ACE \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">HB \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_colgroup " colspan="7" align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">TLR3(PDB ID:3ULU)</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−3.82 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−32.61 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">47.26 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−15.50 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−0.27 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−1.33 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−6.99 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6.02 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−0.70 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−2.01 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.52 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−14.91 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">11.53 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8.49 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−2.08 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5.32 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−10.79 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.62 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7.97 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−1.21 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6.42 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−4.88 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.00 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.45 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.00 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">10 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">15.50 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−19.56 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">22.11 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7.40 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−1.43 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">15.80 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−6.60 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.11 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6.34 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.00 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">633.71 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−46.15 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">937.19 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−19.58 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−9.81 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3469.23 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−30.79 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4439.76 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−11.43 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−5.18 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">10 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4918.74 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−43.32 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6225.50 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.43 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−8.85 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_colgroup " colspan="7" align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"></td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_colgroup " colspan="7" align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">TLR4(PDB ID:4G8A)</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−9.00 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−15.09 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4.05 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.91 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−0.53 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">10 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−1.26 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−3.62 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.46 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−2.16 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.00 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.00 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−5.74 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5.12 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−2.96 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.00 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7.54 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−29.89 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">20.36 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">24.60 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−4.21 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8.28 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−33.29 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">29.32 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">16.10 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−3.19 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">24.90 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−37.54 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">38.94 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">21.33 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−5.79 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">26.10 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−10.53 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">15.49 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6.73 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−0.82 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">34.78 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−30.63 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">43.65 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">20.90 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−3.02 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">938.33 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−14.65 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1192.97 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5.91 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−2.35 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">10 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3313.17 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−59.89 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4262.53 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−8.05 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−10.16 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_colgroup " colspan="7" align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"></td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_colgroup " colspan="7" align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">TLR7(PDB ID:7CYN)</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−29.95 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−23.62 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">11.51 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−3.74 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−2.81 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−12.32 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−9.10 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.32 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−5.28 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.00 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6.40 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−2.84 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.00 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4.39 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−0.55 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9.75 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−1.68 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.18 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.77 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−1.84 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">11.05 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−4.38 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6.05 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.34 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−0.91 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">13.70 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−5.32 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.95 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−2.42 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.00 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">15.47 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−3.04 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.00 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.24 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−0.95 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">10 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">20.55 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−36.45 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">56.42 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">11.80 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−7.42 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">539.25 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−30.24 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">674.57 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">15.18 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−6.01 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">10 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">600.31 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−33.20 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">817.93 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.02 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−4.90 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] ] "descripcion" => array:1 [ "en" => "Representation of binding affinity between constructed vaccine and TLR3, TLR4, TLR7." ] ] 14 => array:6 [ "identificador" => "202302191853062911" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => false "mostrarDisplay" => true "figura" => array:1 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In silico designed novel multi epitope vaccine construct towards Bundibugyo Ebolavirus

Rajaguru Arivuselvama, A. Mohamed Sheik Tharikb, S.B. Santhoshc, S.N. Meyyanathanb, Raman Rajeshkumara,

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ramanrajeshkumarbiotech@gmail.com
bathmic@jssuni.edu.in

Corresponding author.

a Department of Pharmaceutical Biotechnology, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Ooty, Tamilnadu, India

b Department of Pharmaceutical Analysis, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Ooty, Tamilnadu, India

c Department of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Ooty, Tamilnadu, India

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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="s0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0015">Introduction</span><p id="p0005" class="elsevierStylePara elsevierViewall">Ebola virus &#40;EBOV&#41; a deadly virus belonging to the <span class="elsevierStyleItalic">Filoviridae</span> family&#44; within the order of <span class="elsevierStyleItalic">Mononegavirales&#46;</span><a class="elsevierStyleCrossRef" href="#bb0005"><span class="elsevierStyleSup">1</span></a> EBOV have been reported most commonly with the size of 19&#8239;k and consists of undifferentiated RNA negative-strand&#46;<a class="elsevierStyleCrossRef" href="#bb0010"><span class="elsevierStyleSup">2</span></a> The genome of EBOV contains eight monocistronic genes that encode eight viral proteins namely nucleoprotein &#40;N&#41;&#44; glycoprotein &#40;GP&#41;&#44; Transcription factor Vp30&#44; polymerase cofactor Vp35&#44; VP24&#44; polymerase L&#44; Glycoprotein &#40;GP&#41;&#44;<a class="elsevierStyleCrossRef" href="#bb0005"><span class="elsevierStyleSup">1</span></a> non-structural glycoprotein&#46;<a class="elsevierStyleCrossRef" href="#bb0010"><span class="elsevierStyleSup">2</span></a> The outermost layer of the EBOVconsists of GP&#44; which helps the virus to bind its target site and it also acts as a mediator of virus in order to deliver their genetic pattern to the host cells&#46; However&#44; the three forms of protein&#44; namely attachment protein &#40;GP1&#41;&#44; entry&#47;fusion protein &#40;GP2&#41;&#44; and soluble GP &#40;sGP&#41; were expressed by the GP&#46; Further&#44; GP1 and GP2 are synthesized from non-template adenosine-containing messenger RNA&#46; Except in the case of sGP&#44; the transcript is synthesized from unedited RNA&#46;<a class="elsevierStyleCrossRef" href="#bb0015"><span class="elsevierStyleSup">3</span></a> In addition&#44; GP also acts as a target for immune cells to produce their immunogenic effect against the EBOV&#46; As a result&#44; GP is considered a crucial factor in the proposal of vaccines&#46;<a class="elsevierStyleCrossRefs" href="#bb0020"><span class="elsevierStyleSup">4&#8211;6</span></a> However&#44; Ellen et al&#46; recently published a review article related to the topic of the clinical trial of the Ebola vaccine&#46; In the review article&#44; it is mentioned that among the EBOV strains&#44; the vaccine did not become effective against <span class="elsevierStyleItalic">Bundibugyo Ebolaviruses</span> strains&#46; So&#44; due to the fatality rate of <span class="elsevierStyleItalic">Bundibugyo Ebolaviruses</span> strains&#44; now it is of very much priority to make a vaccine against these virus strains&#46;<a class="elsevierStyleCrossRef" href="#bb0035"><span class="elsevierStyleSup">7</span></a></p><p id="p0010" class="elsevierStylePara elsevierViewall">Nowadays&#44; multi-epitope-based vaccine design is considered to be a promising approach due to the long-lasting capability&#46;<a class="elsevierStyleCrossRef" href="#bb0040"><span class="elsevierStyleSup">8</span></a> Epitope is the tiny immunogenic portion of a protein sequence that precisely generates precise immune responses&#46;<a class="elsevierStyleCrossRef" href="#bb0045"><span class="elsevierStyleSup">9</span></a> Several studies have recently confirmed that the epitope-based vaccination mechanism effectively produces protective immune responses against various pathogens&#46;<a class="elsevierStyleCrossRefs" href="#bb0050"><span class="elsevierStyleSup">10&#8211;13</span></a> In this regard&#44; vaccine design process&#44; forecasting of epitopes through <span class="elsevierStyleItalic">in-silico</span> techniques may greatly reduce the time and expense for the vaccine production&#46; Thus&#44; in this present study we tried to develop a successful epitope-related protein-vaccines &#40;T-cell and B-cell epitope&#41; by utilizing several <span class="elsevierStyleItalic">in-silico</span> tools based on the available EBOV GP sequences&#46; These findings have given new candidates for epitope vaccines for EBOV vaccine development&#46;<a class="elsevierStyleCrossRef" href="#bb0070"><span class="elsevierStyleSup">14</span></a></p><p id="p0015" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Selection of adjuvant</span>&#58; we have selected the adjuvant <span class="elsevierStyleItalic">Mycobacterium tuberculosis</span> as this adjuvant gives further efficacy to the constructed vaccine&#46; Moreover&#44; Toll-like receptor-4&#44; which is present in the antigen-presenting cells recognizes <span class="elsevierStyleItalic">M&#46; tuberculosis</span> and stimulates the immune cells against <span class="elsevierStyleItalic">M&#46; tuberculosis</span>&#46;<a class="elsevierStyleCrossRef" href="#bb0075"><span class="elsevierStyleSup">15</span></a> Importantly&#44; Toll-like receptors-3&#44; -4&#44; and -7 detects the EBOV antigen or genetic pattern&#44; which further stimulates the immune cells against them&#46; Particularly&#44; Toll-like receptor-4&#44; first detects the genetic pattern of EBOV antigen of EBOV compared to other Toll-like receptors-3&#44; -7&#46;<a class="elsevierStyleCrossRef" href="#bb0080"><span class="elsevierStyleSup">16</span></a></p></span><span id="s0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0020">Materials and methods</span><span id="s0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0025">Protein sequence retrieval&#44; antigenicity and physicochemical properties evaluation</span><p id="p0020" class="elsevierStylePara elsevierViewall">Complete amino acid sequence of EBOV Glycoprotein &#40;GP&#41; &#40;Accession No&#58; AGL73474&#41; was taken in FASTA format from the NCBI &#40;<a href="https://www.ncbi.nlm.nih.gov/protein/AGL73474.1">https&#58;&#47;&#47;www&#46;ncbi&#46;nlm&#46;nih&#46;gov&#47;protein&#47;AGL73474&#46;1</a>&#41; server&#46; The functional and structural features of a protein reflect physicochemical properties&#46; However&#44; in the next step&#44; predicted GP sequence was further submitted to the ProtParamtool of ExPASy Proteomics Server &#40;<a href="https://web.expasy.org/protparam/">https&#58;&#47;&#47;web&#46;expasy&#46;org&#47;protparam&#47;</a>&#41; for the evaluation of physicochemical properties&#46; Different physicochemical parameters of the GP were evaluated which includes&#44; total amino acid length&#44; molecular weight&#44; theoretical PI&#44; negative and positive residues&#44; solubility&#44; instability index&#44; and half-life&#46;<a class="elsevierStyleCrossRef" href="#bb0085"><span class="elsevierStyleSup">17</span></a> Furthermore&#44; GP sequence were analyzed with vaxiJen v2&#46;0 server &#40;<a href="http://www.ddg-pharmfac.net/vaxijen/VaxiJen/VaxiJen.html">http&#58;&#47;&#47;www&#46;ddg-pharmfac&#46;net&#47;vaxijen&#47;VaxiJen&#47;VaxiJen&#46;html</a>&#41;&#46;<a class="elsevierStyleCrossRef" href="#bb0090"><span class="elsevierStyleSup">18</span></a> The threshold value of 0&#46;4 was used for the accuracy rate to validate the antigenicity of the full-length sequence&#46; It shows GP amino acid sequences with an antigenic score of &#62;<span class="elsevierStyleHsp" style=""></span>0&#46;5&#46; These GP sequences were selected for further study&#46;</p></span><span id="s0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0030">Retrieval of binding site of CD8<span class="elsevierStyleSup">&#43;</span>&#44; CD4<span class="elsevierStyleSup">&#43;</span>&#44; lineal B-cell from GP sequence</span><p id="p0025" class="elsevierStylePara elsevierViewall">The selected GP protein sequence was introduced to BCpreds &#40;<a href="http://ailab-projects1.ist.psu.edu:8080/bcpred/predict.html">http&#58;&#47;&#47;ailab-projects1&#46;ist&#46;psu&#46;edu&#58;8080&#47;bcpred&#47;predict&#46;html</a>&#41; for the detection of lineal B-cell epitopes&#46; Predicted lineal B-cell epitopes with appropriate length of 20 amino acid with a cut-off score &#62;<span class="elsevierStyleHsp" style=""></span>0&#46;9 were selected&#46;<a class="elsevierStyleCrossRef" href="#bb0095"><span class="elsevierStyleSup">19</span></a> The Immune Epitope Database &#40;IEDB&#41; &#40;<a href="https://www.iedb.org/">https&#58;&#47;&#47;www&#46;iedb&#46;org&#47;</a>&#41; is an immunoinformatic tool used to identify the T-cell epitope&#46; The selected GP sequence was introduced to MHC-I binding predictions server &#40;<a href="http://tools.iedb.org/mhci/">http&#58;&#47;&#47;tools&#46;iedb&#46;org&#47;mhci&#47;</a>&#41; for the analysis using NetMHCPan 4&#46;1 EL &#40;2020&#46;09 &#40;current&#41;&#41; method&#46; Moreover&#44; we have selected the common allele with appropriate amino acid length &#40;9&#41;&#46;<a class="elsevierStyleCrossRef" href="#bb0100"><span class="elsevierStyleSup">20</span></a> Alleles which includes HLA-A&#42;02&#58;01&#44; HLA-A&#42;02&#58;02&#44; HLA-A&#42;02&#58;06 are commonly found on the 90&#37; of the human population in the world&#46; Finally&#44; we retrieved the CD8<span class="elsevierStyleSup">&#43;</span> epitope sequence which is commonly interacting with above-mentioned allele&#46;<a class="elsevierStyleCrossRefs" href="#bb0105"><span class="elsevierStyleSup">21&#8211;24</span></a> The retrieved GP sequence was subjected to MHC-II binding predictions server &#40;<a href="http://tools.iedb.org/mhcii/">http&#58;&#47;&#47;tools&#46;iedb&#46;org&#47;mhcii&#47;</a>&#41; for the analysis using Consensus method&#46; Apparently&#44; we have selected the common allele with appropriate amino acid length &#40;15&#41;&#46;<a class="elsevierStyleCrossRef" href="#bb0125"><span class="elsevierStyleSup">25</span></a> HLA-DRB1&#42;01&#58;01 allele are commonly found on 90&#37; of the human population in the world&#46;<a class="elsevierStyleCrossRef" href="#bb0130"><span class="elsevierStyleSup">26</span></a><span class="elsevierStyleSup">&#44;</span><a class="elsevierStyleCrossRef" href="#bb0135"><span class="elsevierStyleSup">27</span></a> Further&#44; we retrieved the CD4<span class="elsevierStyleSup">&#43;</span> epitope sequence which is commonly interacting with above-mentioned allele&#46; Using VaxiJenv2&#46;0 <a href="http://www.ddg-pharmfac.net/vaxijen/VaxiJen/VaxiJen.html">http&#58;&#47;&#47;www&#46;ddg-pharmfac&#46;net&#47;vaxijen&#47;VaxiJen&#47;VaxiJen&#46;html</a>&#41; at threshold 0&#46;4 to check the antigenicity of predicted T-cell and lineal B-cell epitopes were analyzed&#46;<a class="elsevierStyleCrossRef" href="#bb0090"><span class="elsevierStyleSup">18</span></a> Furthermore&#44; predicted T-cell and lineal B-cell epitopes protein sequence was then subjected to allergen and toxicity analysis using AllerTOP v&#46; 2&#46;0 &#40;<a href="https://www.ddg-pharmfac.net/AllerTOP/">https&#58;&#47;&#47;www&#46;ddg-pharmfac&#46;net&#47;AllerTOP&#47;</a>&#41;<a class="elsevierStyleCrossRef" href="#bb0140"><span class="elsevierStyleSup">28</span></a> &#38; TOXINPRED &#40;<a href="http://crdd.osdd.net/raghava/toxinpred/">http&#58;&#47;&#47;crdd&#46;osdd&#46;net&#47;raghava&#47;toxinpred&#47;</a>&#41;&#46;<a class="elsevierStyleCrossRef" href="#bb0145"><span class="elsevierStyleSup">29</span></a> Finally&#44; predicted T-cell and lineal B-cell epitope was submitted to the protein BLAST server &#40;<a href="https://blast.ncbi.nlm.nih.gov/Blast.cgi?PAGE=Proteins">https&#58;&#47;&#47;blast&#46;ncbi&#46;nlm&#46;nih&#46;gov&#47;Blast&#46;cgi&#63;PAGE&#61;Proteins</a>&#41; against the non-radiant protein sequence within the organism &#40;<span class="elsevierStyleItalic">Homo sapiens</span> &#40;taxid&#58; 9606&#41;&#41;&#46; T-cell and lineal B-cell epitope amino acid sequence cut-off score&#8239;&#62;&#8239;0&#46;05 was selected and represents non-homologous&#46; However&#44; the selected T-cell and lineal B-cell epitope was antigen&#44; non-allergen&#44; non-toxic&#44; and non-homologous sequence and was selected for vaccine construction&#46;</p></span><span id="s0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0035">Adjuvant selection and vaccine construction</span><p id="p0030" class="elsevierStylePara elsevierViewall">Complete protein sequence of <span class="elsevierStyleItalic">Mycobacterium tuberculosis</span> lipoprotein LprG &#40;Accession no&#58; KBJ35626&#41; was taken in FASTA format from the NCBI &#40;<a href="https://www.ncbi.nlm.nih.gov/protein/KBJ35626.1">https&#58;&#47;&#47;www&#46;ncbi&#46;nlm&#46;nih&#46;gov&#47;protein&#47;KBJ35626&#46;1</a>&#41; website&#46; Predicted <span class="elsevierStyleItalic">M&#46; tuberculosis</span> lipoprotein sequence was further submitted to the ProtParam tool of ExPASy Proteomics Server &#40;<a href="https://web.expasy.org/protparam/">https&#58;&#47;&#47;web&#46;expasy&#46;org&#47;protparam&#47;</a>&#41; for the evaluation of physicochemical properties as discussed earlier&#46;<a class="elsevierStyleCrossRef" href="#bb0085"><span class="elsevierStyleSup">17</span></a><span class="elsevierStyleItalic">M&#46; tuberculosis</span> lipoprotein was introduced as an adjuvant to strengthen the vaccines immunogenicity ahead of the first EAAAK linkers epitope&#46; Followed by the powerful T-cell &#40;CD8<span class="elsevierStyleSup">&#43;</span>&#44; CD4<span class="elsevierStyleSup">&#43;</span>&#41; and lineal B-cell epitopes with suitable adjuvants and linkers&#44; a multi-epitope vaccine was constructed&#46; While doing so&#44; epitopes of CD8<span class="elsevierStyleSup">&#43;</span> were connected to AAY linkers&#44; although GPGPG linkers were used to connect CD4<span class="elsevierStyleSup">&#43;</span> epitopes&#46; In addition&#44; to fuse lineal B-cell epitopes&#44; KK linkers were used&#46; Finally&#44; our construct was submitted to the ProtParam tool of ExPASy Proteomics Server &#40;<a href="https://web.expasy.org/protparam/">https&#58;&#47;&#47;web&#46;expasy&#46;org&#47;protparam&#47;</a>&#41; for the evaluation of physicochemical properties as discussed earlier&#46;<a class="elsevierStyleCrossRef" href="#bb0085"><span class="elsevierStyleSup">17</span></a> Antigen assessment was conducted out using VaxiJenv2&#46;0 &#40;<a href="http://www.ddg-pharmfac.net/vaxijen/VaxiJen/VaxiJen.html">http&#58;&#47;&#47;www&#46;ddg-pharmfac&#46;net&#47;vaxijen&#47;VaxiJen&#47;VaxiJen&#46;html</a>&#41; at threshold 0&#46;4 to validate the antigenicity of the constructed vaccine&#46;<a class="elsevierStyleCrossRef" href="#bb0095"><span class="elsevierStyleSup">19</span></a> AlgPred &#40;<a href="https://webs.iiitd.edu.in/raghava/algpred/submission.html">https&#58;&#47;&#47;webs&#46;iiitd&#46;edu&#46;in&#47;raghava&#47;algpred&#47;submission&#46;html</a>&#41; with the MEME&#47;MAST motif approach was used to investigate the allergenicity of the constructed vaccine&#46;<a class="elsevierStyleCrossRef" href="#bb0150"><span class="elsevierStyleSup">30</span></a></p></span><span id="s0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0040">Protein structure prediction&#44; refinement&#44; and validation of constructed vaccine</span><p id="p0035" class="elsevierStylePara elsevierViewall">PSIPRED 4&#46;0 &#40;<a href="http://bioinf.cs.ucl.ac.uk/psipred/">http&#58;&#47;&#47;bioinf&#46;cs&#46;ucl&#46;ac&#46;uk&#47;psipred&#47;</a>&#41; and SOPMA &#40;<a href="https://npsa-prabi.ibcp.fr/cgi-bin/npsa_automat.pl?page=/NPSA/npsa_sopma.html">https&#58;&#47;&#47;npsa-prabi&#46;ibcp&#46;fr&#47;cgi-bin&#47;npsa&#95;automat&#46;pl&#63;page&#61;&#47;NPSA&#47;npsa&#95;sopma&#46;html</a>&#41; is the most commonly used server to forecast the constructed vaccine secondary structure&#46;<a class="elsevierStyleCrossRef" href="#bb0155"><span class="elsevierStyleSup">31</span></a><span class="elsevierStyleSup">&#44;</span><a class="elsevierStyleCrossRef" href="#bb0160"><span class="elsevierStyleSup">32</span></a> The 3D structure of the constructed vaccine was forecasted by RaptorX web server &#40;<a href="http://raptorx.uchicago.edu/ContactMap/">http&#58;&#47;&#47;raptorx&#46;uchicago&#46;edu&#47;ContactMap&#47;</a>&#41;&#46; It uses various template stitching iterative to select the optimum template on the basis of which the protein is constructed by arranging iterative template pieces and offers a rank for each projected 3D model&#46;<a class="elsevierStyleCrossRef" href="#bb0165"><span class="elsevierStyleSup">33</span></a> The rudimentary structure of the 3D vaccine was quite well with Galaxy Refine tool &#40;<a href="http://galaxy.seoklab.org/cgi-bin/submit.cgi?type=REFINE">http&#58;&#47;&#47;galaxy&#46;seoklab&#46;org&#47;cgi-bin&#47;submit&#46;cgi&#63;type&#61;REFINE</a>&#41;&#46;<a class="elsevierStyleCrossRef" href="#bb0155"><span class="elsevierStyleSup">31</span></a> This database uses systemic dynamic analysis which repacks the side chain&#44; replaces inaccurate loops&#44; and soothes the framework&#46; Further&#44; we have sent the structure of the refined vaccine for validation purposes to the ProSA-web server &#40;<a href="https://prosa.services.came.sbg.ac.at/prosa.php">https&#58;&#47;&#47;prosa&#46;services&#46;came&#46;sbg&#46;ac&#46;at&#47;prosa&#46;php</a>&#41;<a class="elsevierStyleCrossRef" href="#bb0170"><span class="elsevierStyleSup">34</span></a> and the PROCHEK web-server &#40;<a href="https://saves.mbi.ucla.edu/">https&#58;&#47;&#47;saves&#46;mbi&#46;ucla&#46;edu&#47;</a>&#41; to confirm the structure was refined&#46;<a class="elsevierStyleCrossRef" href="#bb0175"><span class="elsevierStyleSup">35</span></a> By comparing the protein structure with the X-ray and NMR crystallography derived evaluated structures&#59; the ProSA-web server assesses the protein structure and gave a score as an appropriate performance variable&#46;<a class="elsevierStyleCrossRef" href="#bb0170"><span class="elsevierStyleSup">34</span></a> A Ramachandran plot was generated by the PROCHECK server and the number of residues energetically preferred&#44; permitted&#44; and disallowed region was observed with significant values&#46;<a class="elsevierStyleCrossRef" href="#bb0175"><span class="elsevierStyleSup">35</span></a></p></span><span id="s0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0045">Conformational B-cell epitope prediction</span><p id="p0040" class="elsevierStylePara elsevierViewall">The unique portion of refined protein structure is the conformational &#40;discrete&#41; B-cell epitope &#40;CBE&#41; that was able to promote the production of antibody&#46; The occurrence of CBE in the vaccine is&#44; therefore&#44; important&#46; To calculate the CBE&#44; the ElliPro &#40;<a href="http://tools.iedb.org/ellipro/">http&#58;&#47;&#47;tools&#46;iedb&#46;org&#47;ellipro&#47;</a>&#41; framework accessible on the IEDB sever is to be used&#46;<a class="elsevierStyleCrossRef" href="#bb0180"><span class="elsevierStyleSup">36</span></a></p></span><span id="s0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0050">Molecular docking and dynamic stimulation</span><p id="p0045" class="elsevierStylePara elsevierViewall">Molecular docking is an online assessment analytical tool to assess the binding energy and interlinkage between the ligand and receptor&#46; As we all know&#44; toll-like receptor recognizes the viral cells and it gives activation to the monocyte gate&#46; So&#44; in this computer-based molecular docking studies&#44; we have used a common toll-like receptor&#44; which always recognizes the EBOV&#46; We therefore considered TLR3&#44; TLR4&#44; and TLR7 as the receptor&#44; while the ligand was the vaccine protein&#46; The TLR3 &#40;PDB ID&#58; <a href="pdb:3ULU">3ULU</a>&#41;&#44; <a href="pdb:TLR4">TLR4</a> &#40;PDB ID&#58; <a href="pdb:4G8A">4G8A</a>&#41;&#44; <a href="pdb:TLR7">TLR7</a> &#40;PDB ID&#58; <a href="pdb:7CYN">7CYN</a>&#41; molecule was acquired from the RCSB PDB server&#46;<a class="elsevierStyleCrossRef" href="#bb0185"><span class="elsevierStyleSup">37</span></a> Finally&#44; the binding affinity and interlinkage among the vaccine and the TLR3&#44; TLR4&#44; TLR7 receptor was anticipated using the web-based Patchdock docking server &#40;<a href="https://bioinfo3d.cs.tau.ac.il/PatchDock/">https&#58;&#47;&#47;bioinfo3d&#46;cs&#46;tau&#46;ac&#46;il&#47;PatchDock&#47;</a>&#41;&#46; The finest-docked complex with an acceptable pose was calculated based on the global energy ranking&#46;<a class="elsevierStyleCrossRef" href="#bb0190"><span class="elsevierStyleSup">38</span></a> We have simulated molecular dynamics &#40;MD&#41; to evaluate the structural integrity and stability of the docked multiplex andthe highest TLR3&#44; TLR4&#44; TLR7 global energy complex has been introduced into the iMODS server &#40;&#40;<a href="http://imods.chaconlab.org/">http&#58;&#47;&#47;imods&#46;chaconlab&#46;org&#47;</a>&#41;&#41;&#46; Depending upon the NMA &#40;normal mode analysis&#41; method&#44; it offers deformability&#44; Eigenvalues&#44; to evaluate deformation and fluctuations in protein movement&#46;<a class="elsevierStyleCrossRef" href="#bb0195"><span class="elsevierStyleSup">39</span></a></p></span><span id="s0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0055">Evaluation of immune stimulation</span><p id="p0050" class="elsevierStylePara elsevierViewall">The selected GP protein sequence &#40;<a href="http://150.146.2.1/C-IMMSIM/">http&#58;&#47;&#47;150&#46;146&#46;2&#46;1&#47;C-IMMSIM&#47;</a>&#41; was introduced to the C-ImmSim server to authenticate the vaccine&#39;s feasibility in exacerbating an immune response&#46; For agent-based dynamics simulation&#44; the C-ImmSim server uses ML techniques and PSSM &#40;position-specific scoring matrix&#41; to detect epitopes and subsequent immune reactions&#46;<a class="elsevierStyleCrossRef" href="#bb0200"><span class="elsevierStyleSup">40</span></a><span class="elsevierStyleSup">&#44;</span><a class="elsevierStyleCrossRef" href="#bb0205"><span class="elsevierStyleSup">41</span></a> Particularly&#44; several vaccines are administered in three concentrations&#44; 28&#8239;days apart&#46; We have therefore agreed to prescribe three injections &#40;concentration&#41; with an interval of 4&#8239;weeks between the two concentrations&#46; Each time-step in the C-ImmSim immune simulator is defined to be 8&#8239;h in real life&#59; thus&#44; three injections require 1&#44; 84&#44; and 170 time-steps&#46; In addition&#44; exposure to antigen in a typical endemic zone was measured as repeated exposure using a total of three injections&#46;</p></span></span><span id="s0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0060">Results and discussion</span><span id="s0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0065">Detailed analysis of retrieved protein sequence</span><p id="p0055" class="elsevierStylePara elsevierViewall">The physicochemical properties of the EBOV GP&#44; evaluated through Protparam&#44; exhibited that 676 amino acids with 75&#44;618&#46;41&#8239;kDa molecular weight&#46; GP were exposed to Vaxijen v2&#46;0 server and it reflects an antigenic form&#46; Theoretical isoelectric point &#40;PI&#41; of GP was found to be 6&#46;27&#44; suggesting its negative in nature&#46; An isoelectric point below 7 specifies the positively charged protein and nearly 69 amino acid charges were reported to be positive as well as another 69 amino acid reported to be negative&#46; The estimated instability index of Protparam was reported to be 36&#46;61&#44; which classifies the protein as stable&#46; Aliphatic-index 78&#46;43&#44; dedicating a thought to the corresponding amount of aliphatic side chain holding and solubility shows &#8722;<span class="elsevierStyleHsp" style=""></span>0&#46;409&#44; and it indicates the retrieved protein sequence was water soluble in nature&#46; The half-life of GP showed in mammalian reticulocytes&#44; and it takes around 30&#8239;h to disappear after the cell synthesis followed by yeast taking higher than 20&#8239;h&#46; Moreover&#44; <span class="elsevierStyleItalic">Escherichia coli</span> took around more than 10&#8239;h&#46; The total numbers of Oxygen &#40;O&#41;&#44; Carbon &#40;C&#41;&#44; Hydrogen &#40;H&#41; Sulfur &#40;S&#41;&#44; and Nitrogen &#40;N&#41;&#44; were entitled by the formula&#58; C<span class="elsevierStyleInf">3371</span>H<span class="elsevierStyleInf">5243</span>N<span class="elsevierStyleInf">929</span>O<span class="elsevierStyleInf">1016</span>S<span class="elsevierStyleInf">18</span><a class="elsevierStyleCrossRef" href="#t0005">Table 1</a>&#46;</p><elsevierMultimedia ident="t0005"></elsevierMultimedia></span><span id="s0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0070">Analysis and selection of CD4<span class="elsevierStyleSup">&#43;</span>&#44; CD8<span class="elsevierStyleSup">&#43;</span>&#44; and lineal B cell epitope</span><p id="p0060" class="elsevierStylePara elsevierViewall">The predicted epitopes of CD4<span class="elsevierStyleSup">&#43;</span>&#44; CD8<span class="elsevierStyleSup">&#43;</span>&#44; and lineal B-cell were subjected to appropriate server to validate the probable antigenicity&#44; homologous&#44; toxicity&#44; and allergenicity property of epitopes&#46; Five CD8<span class="elsevierStyleSup">&#43;</span> epitope&#44; eight CD4<span class="elsevierStyleSup">&#43;</span> epitope&#44; and six lineal B-cell epitope are antigenic&#44; non-allergic&#44; non-toxic&#44; and non-homologous in nature &#40;<a class="elsevierStyleCrossRefs" href="#t0010">Tables 2 and 3</a>&#41;&#46;</p><elsevierMultimedia ident="t0010"></elsevierMultimedia><elsevierMultimedia ident="t0015"></elsevierMultimedia></span><span id="s0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0075">Detailed analysis of adjuvant and constructed vaccine</span><p id="p0065" class="elsevierStylePara elsevierViewall">Selected 5CD4<span class="elsevierStyleHsp" style=""></span>&#43;&#44; 8CD8<span class="elsevierStyleHsp" style=""></span>&#43;&#44; and 6 lineal B cell epitope were used for constructing a vaccine with suitable linkers as previously described in Methods&#46; In lieu to increase the efficacy of the vaccine adjuvant <span class="elsevierStyleItalic">Mycobacterium tuberculosis</span> lipoprotein was added&#46; The physiochemical properties of the <span class="elsevierStyleItalic">M&#46; tuberculosis</span> lipoprotein was evaluated through Protparam and identified that it consists of 236 amino acid with a molecular weight of 24&#44;547&#46;80&#8239;kDa&#46; Theoretical isoelectric point &#40;PI&#41; of <span class="elsevierStyleItalic">M&#46; tuberculosis</span> lipoprotein was found to be 7&#46;78&#44; suggesting its positive in nature&#46; An isoelectric point &#62;<span class="elsevierStyleHsp" style=""></span>7 specifies the protein is charged positively&#46; Nearly 20 amino acid charges were reported to be positive&#44; whereas 19 amino acid reported to be negative&#46; The estimated instability index of Protparam was reported to be 16&#46;11&#44; this classify the protein as stable&#46; Aliphatic-index 86&#46;86&#44; dedicating a thought to the corresponding amount of aliphatic side chain holding and solubility shows &#8722;<span class="elsevierStyleHsp" style=""></span>0&#46;127&#44; and it indicates the retrieved protein sequence found to be water soluble in nature&#46; The half life of <span class="elsevierStyleItalic">M&#46; tuberculosis</span> lipoprotein was showed&#44; in mammalian reticulocytes and it took around 30&#8239;h to disappear after the cell synthesis followed by yeast which took more than 20&#8239;h&#46; Moreover&#44; <span class="elsevierStyleItalic">E&#46; coli</span> takes more than 10&#8239;h&#46; The total numbers of Oxygen &#40;O&#41;&#44; Carbon &#40;C&#41;&#44; Hydrogen &#40;H&#41; Sulfur &#40;S&#41;&#44; and Nitrogen &#40;N&#41;&#44; were entitled by the formula&#58; C<span class="elsevierStyleInf">1076</span>H<span class="elsevierStyleInf">1740</span>N<span class="elsevierStyleInf">306</span>O<span class="elsevierStyleInf">339</span>S<span class="elsevierStyleInf">5</span><a class="elsevierStyleCrossRef" href="#t0005">Table 1</a>&#46; Finally&#44; the selected adjuvant was passed in all formats of physicochemical properties&#46; So&#44; the structural and functional analysis of the protein is very much suitable for acting as an adjuvant&#46; So&#44; we have selected <span class="elsevierStyleItalic">M&#46; tuberculosis</span> lipoprotein as an adjuvant&#46; Finally&#44; our constructed vaccine also underwent evaluation of physicochemical properties using Protparam server&#44; revealed that it consists of 598 aminoacid with a molecular weight of 63&#44;546&#46;58&#8239;kDa&#46; The constructed vaccine reflects an antigenic nature when introduced to Vaxijen v2&#46;0&#46; Theoretical isoelectric point &#40;PI&#41; of constructed vaccine was reported to be 9&#46;67&#44; suggesting its positive in nature&#46; An isoelectric point more than 7 specifies the protein is charged positively&#46; Near to 54 amino acid charges were reported to be positive&#44; whereas 34 aminoacid reported to be negative&#46; The estimated instability index of Protparam was reported to be 19&#46;16&#44; this classifies the protein as stable&#46; Aliphatic-index 92&#46;12&#44; dedicating a thought to the corresponding amount of aliphatic side chain holding and solubility shows 0&#46;029 and it indicates the retrieved protein sequence was lipid soluble in nature&#46; The half life of constructed vaccine was shown in <span class="elsevierStyleItalic">E&#46; coli</span> and it takes more than 10&#8239;h to disappear after the cell synthesis followed by mammalian reticulocytes that takes 1&#8239;h&#46; Moreover&#44; yeast takes more than 30&#8239;min&#46; The total numbers of Oxygen &#40;O&#41;&#44; Carbon &#40;C&#41;&#44; Hydrogen &#40;H&#41; Sulfur &#40;S&#41;&#44; and Nitrogen &#40;N&#41;&#44; were entitled by the formula&#58; C<span class="elsevierStyleInf">2921</span>H<span class="elsevierStyleInf">4575</span>N<span class="elsevierStyleInf">773</span>O<span class="elsevierStyleInf">800</span>S<span class="elsevierStyleInf">7</span> &#40;<a class="elsevierStyleCrossRef" href="#t0005">Table 1</a>&#41;&#46; As per the detailed assessment&#44; we strongly conclude that&#44; our newly constructed vaccine reflects as a potential candidate vaccine&#46;</p></span><span id="s0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0080">Assessment of protein structure perdition&#44; refinement&#44; and validation of constructed vaccine</span><p id="p0070" class="elsevierStylePara elsevierViewall">The secondary structure of constructed vaccine was analyzed through PSIPRED server &#40;<a class="elsevierStyleCrossRef" href="#f0005">Fig&#46; 1</a>&#41;&#46; The secondary structure elements estimated by SOPMA server are Alpha helix &#40;18&#46;23&#37;&#41;&#44; 310 helix &#40;0&#46;00&#37;&#41;&#44; Pi helix &#40;0&#46;00&#37;&#41;&#44; Beta Bridge &#40;0&#46;00&#37;&#41;&#44; extended strand &#40;27&#46;42&#37;&#41;&#44; Beta turns &#40;0&#46;00&#37;&#41;&#44; Bend region &#40;0&#46;00&#37;&#41;&#44; Random coil &#40;54&#46;35&#37;&#41;&#44; Ambiguous states &#40;0&#46;00&#37;&#41;&#44; and other states &#40;0&#46;00&#37;&#41;&#46; Furthermore&#44; the constructed vaccine was subjected to the RaportX server for the prediction of tertiary structure&#46; Five tertiary structure models were generated from the RaportX server &#40;<a class="elsevierStyleCrossRef" href="#t0020">Table 4</a>&#41;&#46; Based on the rank&#44; we have selected the first rank of tertiary structure of the designed vaccine were subjected to the Galaxy web server for refinement&#44; and it also generated five refined models&#46; Quality assessment of the refined model are discussed below&#59; firstly Global Distance Test &#40;GDT-HA&#41; - the correlation among two protein structures was calculated by a high precision score&#46; The GDT-HA score achieves a high value of 0&#46;900 between the five refined models and the initial model&#44; suggesting that they have high similarity&#46; The lower RMSD value implies greater stability and is generally appropriate for an RMSD score ranging from 0 to 1&#46;2&#46; The RMSD value of the five refined models shows &#60;<span class="elsevierStyleHsp" style=""></span>0&#46;5 and it represents that the protein model have been stable&#46; The refined models of crystallographic resolution is expressed by the Molprobity score&#46; In our five refined protein models&#44; the MolProbity score is &#60;<span class="elsevierStyleHsp" style=""></span>3&#44; which is much lesser than the initial model&#44; and also indicating the critical errors of refined models&#46; Clash Score reflects the quantity of unfavorable steric all-atom lie on top and the refinement decreased the models&#39; clash score from 328&#46;5 to 45&#37;&#44; increasing the stability of the model to a high stage&#46; Ramachandran plot score reflects the range of regions that are vigorously preferred&#44; and typically a value higher than 85&#37; is appropriate&#46; However&#44; based on the superiority score of all refined models passes in all parameters&#46; So&#44; the first model of the refined protein structure was retrieved in PDB format for further analysis &#40;<a class="elsevierStyleCrossRef" href="#t0025">Table 5</a>&#41;&#46; To validate the refined final vaccine model consistency using ProSA-web server which lies within the score range &#8722;<span class="elsevierStyleHsp" style=""></span>6&#46;84 was showed with good efficiency <a class="elsevierStyleCrossRef" href="#f0010">Fig&#46; 2</a>A&#46; Refined PDB model was subjected to Ramachandran plot check using PROCHEK server which showed that&#44; in favored region 94&#46;7&#37; &#40;450 amino acids&#41; were located&#44; in allowed region 4&#46;6&#37; &#40;22 amino acids&#41; were located&#44; and in disallowed region 0&#46;6&#37; &#40;3 amino acid&#41; were located&#46; The quality of the refined model was found to be more than 90&#37; of residues positioned on suitable &#40;favored and allowed&#41; region &#40;<a class="elsevierStyleCrossRef" href="#f0010">Fig&#46; 2</a>B&#41;&#46;</p><elsevierMultimedia ident="f0005"></elsevierMultimedia><elsevierMultimedia ident="t0020"></elsevierMultimedia><elsevierMultimedia ident="t0025"></elsevierMultimedia><elsevierMultimedia ident="f0010"></elsevierMultimedia><p id="p0075" class="elsevierStylePara elsevierViewall">&#946;-strand structure is denoted as yellow color amino acids&#44; &#945;-helix structure is denoted as pink color amino acids&#44; and coil structure is denoted as ash color amino acids&#46;</p><p id="p0080" class="elsevierStylePara elsevierViewall">Five models of 3D protein structure were predicted and categorized by the Rank and estimated RMSD&#40;A&#176;&#41; value&#46; Moreover&#44; rank 1 shows the estimated RMSD&#40;A&#176;&#41; value of 18&#46;501&#44; followed by Rank 2 showing the estimated RMSD &#40;A&#176;&#41; value of 13&#46;257&#44; followed by Rank 3 showing the estimated RMSD &#40;A&#176;&#41; value of 13&#46;731&#44; followed by Rank 4 showing the estimated RMSD&#40;A&#176;&#41; value of 16&#46;019&#46; Finally&#44; Rank 5 shows the estimated RMSD&#40;A&#176;&#41; value of 13&#46;681&#46;</p><p id="p0085" class="elsevierStylePara elsevierViewall">There are five models of refined 3D protein structure that were predicted and it is also categorized by the model&#44; GDT-HA&#44; RMSD value&#44; MolProbity&#44; Clash score&#44; Poor rotamers&#46; The model 1 shows GDT-HA &#40;0&#46;8874&#41;&#44; RMSD value &#40;0&#46;570&#41;&#44; MolProbity &#40;2&#46;755&#41;&#44; Clash score &#40;45&#46;7&#41;&#44; Poor rotamers &#40;1&#46;6&#41;&#44; Ramachandran plot &#40;92&#46;7&#41;&#44; followed by model 2 showing the GDT-HA &#40;0&#46;8918&#41;&#44; RMSD value &#40;0&#46;563&#41;&#44; MolProbity &#40;2&#46;606&#41;&#44; Clash score &#40;47&#46;2&#41;&#44; Poor rotamers &#40;1&#46;0&#41;&#44; Ramachandran plot &#40;92&#46;8&#41;&#44; followed by Model 3 showing the GDT-HA &#40;0&#46;8898&#41;&#44; RMSD value &#40;0&#46;565&#41;&#44; MolProbity &#40;2&#46;855&#41;&#44; Clash score &#40;47&#46;3&#41;&#44; Poor rotamers &#40;2&#46;0&#41;&#44; Ramachandran plot &#40;92&#46;4&#41;&#44; followed by Model 4 showing the GDT-HA &#40;0&#46;8878&#41;&#44; RMSD value &#40;0&#46;567&#41;&#44; MolProbity &#40;2&#46;785&#41;&#44; Clash score &#40;44&#46;8&#41;&#44; Poor rotamers &#40;1&#46;8&#41;&#44; Ramachandran plot &#40;92&#46;7&#41;&#46; Final Model 5 shows the GDT-HA &#40;0&#46;8938&#41;&#44; RMSD value &#40;0&#46;558&#41;&#44; MolProbity &#40;2&#46;604&#41;&#44; Clash score &#40;47&#46;7&#41;&#44; Poor rotamers &#40;1&#46;0&#41;&#44; Ramachandran plot &#40;93&#46;0&#41;&#46;</p><p id="p0090" class="elsevierStylePara elsevierViewall">The Z-score of the refined model that falls within the score range is &#8722;<span class="elsevierStyleHsp" style=""></span>6&#46;84&#46; Ramachandran plot study indicates 94&#46;7&#37;&#44; 4&#46;2&#37;&#44; and 1&#46;0&#37; of protein residues in favored&#44; allowed and disallowed &#40;foreign&#41; regions&#44; individually&#46;</p></span><span id="s0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0085">Detailed assessment of B-cell epitope confirmation</span><p id="p0095" class="elsevierStylePara elsevierViewall">We have utilized the ElliPro server to forecast the CBC epitopes with the help of refined vaccine model&#46; Five new CBC epitopes were predicted by the ElliPro server involving 339 residues with scores ranging from 0&#46;529 to 0&#46;763&#46; <a class="elsevierStyleCrossRef" href="#t0030">Table 6</a> demonstrates the comprehensive 3D model and the details for those five epitopes&#46;</p><elsevierMultimedia ident="t0030"></elsevierMultimedia><p id="p0100" class="elsevierStylePara elsevierViewall">The 3D model of the five predicted CBC epitopes in the refined vaccine model&#46; The yellow parts represents the CBC epitopes and the gray parts represents the other residues&#46; &#40;I&#41; 159 residues of CBC falls within a score of 0&#46;763&#46; &#40;II&#41; 129 residues of CBC falls within a score of 0&#46;70&#46; &#40;III&#41; 41 residues of CBC falls within a score of 0&#46;556&#46; &#40;IV&#41; Four residues of CBC falls within a score of 0&#46;544&#46; &#40;V&#41; Six residues of CBC falls within a score of 0&#46;529&#46;</p></span><span id="s0080" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0090">Molecular docking and dynamic stimulation</span><p id="p0105" class="elsevierStylePara elsevierViewall">Molecular docking studies were performed to verify the stability and binding interaction of the docked complex&#46; TLR3&#44; TLR4&#44; and TLR7 were used to obtain essential human proteins for identification of EBOV and also triggers the immune response&#46; Accordingly&#44; we selected TLR3&#44; TLR4&#44; and TLR7 for molecular docking as the immune receptor&#46; We use the Patchdock server to do the molecular docking between our final vaccine&#39;s refined 3D model and the immune receptors TLR3 &#40;PDB ID&#58; <a href="pdb:3ULU">3ULU</a>&#41;&#44; <a href="pdb:TLR4">TLR4</a> &#40;PDB ID&#58; <a href="pdb:4G8A">4G8A</a>&#41;&#44; and <a href="pdb:TLR7">TLR7</a> &#40;PDB ID&#58; <a href="pdb:7CYN">7CYN</a>&#41;&#46; We selected the lowest energy score of &#8722;<span class="elsevierStyleHsp" style=""></span>3&#46;82 &#40;<a class="elsevierStyleCrossRef" href="#f0015">Fig&#46; 3</a>A&#41;&#44; &#8722;<span class="elsevierStyleHsp" style=""></span>9&#46;00 &#40;<a class="elsevierStyleCrossRef" href="#f0015">Fig&#46; 3</a>B&#41;&#44; &#8722;<span class="elsevierStyleHsp" style=""></span>29&#46;95 &#40;<a class="elsevierStyleCrossRef" href="#f0015">Fig&#46; 3</a>C&#41;&#44; and &#40;<a class="elsevierStyleCrossRef" href="#t0035">Table 7</a>&#41; as the finest docked complex among the developed docking model&#44; indicateing a good binding affinity&#46; To assess the stability and physical movements of the vaccine&#44; TLR3&#44; TLR7&#44; TLR9 docked complex were analyzed by employing iMOD server using MD simulation &#40;<a class="elsevierStyleCrossRefs" href="#f0020">Figs&#46; 4&#8211;6</a>&#41;&#46; However&#44; TLR4 showed higher stability and physical movements&#44; when compared to TLR3 and TLR7&#46;</p><elsevierMultimedia ident="f0015"></elsevierMultimedia><elsevierMultimedia ident="t0035"></elsevierMultimedia><elsevierMultimedia ident="f0020"></elsevierMultimedia><elsevierMultimedia ident="f0025"></elsevierMultimedia><elsevierMultimedia ident="f0030"></elsevierMultimedia><p id="p0110" class="elsevierStylePara elsevierViewall">Binding affinity between our constructed vaccine and TLR3&#44; TLR4&#44; TLR7 was categorized by global energy&#46; The lesser the global energy&#44; the binding affinity will be higher&#46; So&#44; we retrieved the Rank 1 PDB format for molecular dynamics study&#46; The Rank 1 of TLR3&#44; TLR4&#44; TLR7 shows &#8722;<span class="elsevierStyleHsp" style=""></span>3&#46;82&#44; &#8722;<span class="elsevierStyleHsp" style=""></span>900&#44; &#8722;<span class="elsevierStyleHsp" style=""></span>29&#46;95 global energy&#46;</p><p id="p0115" class="elsevierStylePara elsevierViewall">The vaccine protein indicates combination of red&#8211;gray color peptide and the TLR3&#44; TLR4&#44; TLR7 receptor indicates remaining residue&#46; This complex model&#39;s lowest energy score is &#8722;<span class="elsevierStyleHsp" style=""></span>3&#46;82&#44; &#8722;<span class="elsevierStyleHsp" style=""></span>9&#46;00&#44; and &#8722;<span class="elsevierStyleHsp" style=""></span>29&#46;95 suggesting strong binding affinity&#46;</p></span><span id="s0085" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0095">Detailed analysis of immune stimulation</span><p id="p0120" class="elsevierStylePara elsevierViewall">In order to simulate the immune response generated by immunization&#44; imaginary administration of three doses of designed vaccine was executed 4&#8239;weeks apart with 1050&#8239;units&#47;dose&#46; Antigenic recognition and subsequent response in terms of antibody production and active as well as memory B-cell and T-cell generation were indicated <span class="elsevierStyleItalic">in-silico</span> immune simulation plots in a population with a VL susceptible HLA profile after hypothetical immunization&#44; a marked increase in vaccine-specific IgM production can characterize the primary response to the proposed vaccine&#46; Secondary and tertiary response show rapid increase of IgM&#8239;&#43;&#8239;IgG&#44; followed by IgM and IgG1&#8239;&#43;&#8239;IgG2 antibodies&#46; A corresponding decrease in antigen concentration after subsequent doses is shown in <a class="elsevierStyleCrossRef" href="#f0035">Fig&#46; 7</a>A&#46; The effector B-cell shows the consistency throughout 350&#8239;days is shown in <a class="elsevierStyleCrossRef" href="#f0035">Fig&#46; 7</a>B&#46; During secondary and tertiary dose&#8211;response&#44; the plasma B-cells increases rapidly there and antibodies which includes IgM&#8239;&#43;&#8239;IgG antibodies is shown in <a class="elsevierStyleCrossRef" href="#f0035">Fig&#46; 7</a>C&#46; From the significantly obtained results&#44; we conclude that the effector B-cell and the plasma B-cells suggest a steady increase in persistent memory B-cell development&#46; In addition&#44; CD4<span class="elsevierStyleSup">&#43;</span> T and CD8<span class="elsevierStyleSup">&#43;</span> lymphocyte expansion with memory production following the initial dose was observed and shown in <a class="elsevierStyleCrossRef" href="#f0035">Fig&#46; 7</a>D &#38; E&#46; After three subsequent dose of the vaccine&#44; interferon gamma and interlukin-2 show the highest level in the blood plasma followed by interleukin-6&#44; -23&#46; However&#44; compared to interleukin-10&#44; interleukin-12 shows less immunogenic effect as shown in <a class="elsevierStyleCrossRef" href="#f0035">Fig&#46; 7</a>E&#46;</p><elsevierMultimedia ident="f0035"></elsevierMultimedia></span></span><span id="s0090" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0100">Conclusion</span><p id="p0125" class="elsevierStylePara elsevierViewall">Clinicians&#44; researchers&#44; and academicians have been continuously showing their effort to treat EBOV outbreaks in some of the countries due to lack of medication from the past few decades&#46; In addition&#44; the EBOV&#39;s mortality rate is also increasing during the time of epidemic&#46; Even though most vaccines have been developed earlier based on B-cell immunity&#44; due to long-lasting immunity&#44; most of the researchers showed their interest to develop a T-cell epitope-based vaccine&#46; We have developed a protein-based vaccine for immunization against the EVD using immunological information and knowledge of structural biology&#46; In this present report&#44; a vaccine mixture of both B-cell and T-cell epitopes was generated using a variety of immunoinformatic methods and interesting immunological properties were also evaluated&#46; In addition&#44; to determine the efficacy of the vaccine&#44; molecular docking and molecular dynamics experiments were performed&#46; The strong immune response against EBOV is demonstrated by engineered vaccine&#46; We have predicted the secondary and tertiary structure of the constructed vaccine&#46; The interactions between the vaccine and Toll-like receptors-3&#44; -4&#44; and -7&#44; have been studied&#46; The constructed vaccine demonstrates enhanced cellular immunity and also assesses the clearance of antigen from the body at various exposures&#46; This method of research is time-consuming and often decreases the efforts in the laboratory trail and errors&#46; It also offers a comprehensive idea for the potential design of protein-based vaccines&#46;</p></span><span id="s0095" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0105">Consent for publication</span><p id="p0130" class="elsevierStylePara elsevierViewall">Not applicable&#46;</p></span><span id="s0100" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0110">Funding</span><p id="p0135" class="elsevierStylePara elsevierViewall">None&#46;</p></span><span id="s0105" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0115">Ethical approval</span><p id="p0140" class="elsevierStylePara elsevierViewall">Not required&#46;</p></span></span>"
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          "titulo" => "Introduction"
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          "titulo" => "Materials and methods"
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              "titulo" => "Protein sequence retrieval&#44; antigenicity and physicochemical properties evaluation"
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              "titulo" => "Retrieval of binding site of CD8&#44; CD4&#44; lineal B-cell from GP sequence"
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              "identificador" => "s0025"
              "titulo" => "Adjuvant selection and vaccine construction"
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              "titulo" => "Protein structure prediction&#44; refinement&#44; and validation of constructed vaccine"
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              "titulo" => "Conformational B-cell epitope prediction"
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              "titulo" => "Analysis and selection of CD4&#44; CD8&#44; and lineal B cell epitope"
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              "titulo" => "Detailed analysis of adjuvant and constructed vaccine"
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              "titulo" => "Assessment of protein structure perdition&#44; refinement&#44; and validation of constructed vaccine"
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              "titulo" => "Detailed assessment of B-cell epitope confirmation"
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              "titulo" => "Molecular docking and dynamic stimulation"
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          "titulo" => "Acknowledgment"
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            1 => "Vaccine linkers"
            2 => "<span class="elsevierStyleItalic">In-silico</span> biology"
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            0 => "Inmunoinform&#225;tica"
            1 => "Enlaces de la vacuna"
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        "resumen" => "<span id="as0005" class="elsevierStyleSection elsevierViewall"><p id="sp0075" class="elsevierStyleSimplePara elsevierViewall">The aim of this research is to develop a protein-based vaccine for immunization against the Ebola virus disease &#40;EVD&#41; using immunological information and knowledge of structural biology&#46; According to WHO reports the fatality rate of the EVD is around 67&#37; in the year 2019&#46; Particularly&#44; the <span class="elsevierStyleItalic">Bundibugyo Ebolaviruses</span> has the least pathogenic fatality rate approximately around 37&#37;&#46; Moreover&#44; in past outbreaks&#44; the fatality rate is different from 25 to 95&#37; due to a shortage of powerful medication and vaccines&#46; In this present work&#44; immunological information tools and databases to retrieve the highest antigenicity of B-cell and T-cell epitopes from Ebola virus &#40;EBOV&#41; glycoprotein&#46; Vaccine was constructed using 5CD8<span class="elsevierStyleSup">&#43;</span>&#44; 8CD4<span class="elsevierStyleSup">&#43;</span>&#44; and 6B-cell epitope with suitable linkers&#46; <span class="elsevierStyleItalic">Mycobacterium tuberculosis</span> lipoprotein has been introduced into the vaccine as an adjuvant to strengthen the vaccine&#39;s efficacy&#46; Physicochemical properties of the developed vaccine were assessed&#44; which incorporates solubility&#44; stability&#44; and so forth&#46; The interactions between the vaccine and Toll-like receptors 3&#44; 4&#44; and 7&#44; have been studied&#46; The constructed vaccine demonstrates enhanced cellular immunity and also assesses the clearance of antigen from the body at various exposures&#46;</p></span>"
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        "resumen" => "<span id="as1005" class="elsevierStyleSection elsevierViewall"><p id="sp1075" class="elsevierStyleSimplePara elsevierViewall">El objetivo de este estudio es desarrollar una vacuna a base de prote&#237;nas&#44; para inmunizaci&#243;n contra la enfermedad por el virus del &#201;bola &#40;EVE&#41; utilizando informaci&#243;n inmunol&#243;gica y conocimiento sobre biolog&#237;a estructural&#46; En virtud de los informes de la OMS&#44; la tasa de fatalidad de EVE se situ&#243; cerca del 67&#37; en el a&#241;o 2019&#46; En particular&#44; el virus Bundibugyo&#44; tiene la menor tasa de fatalidad patog&#233;nica&#44; de aproximadamente el 37&#37;&#46; Adem&#225;s&#44; en los brotes pasados la tasa de fatalidad pas&#243; del 25 al 95&#37;&#44; debido a la escasez de f&#225;rmacos potentes y vacunas&#46; En este trabajo se han utilizado herramientas de informaci&#243;n y bases de datos inmunol&#243;gicos para obtener la mayor antigenicidad de los ep&#237;topes de c&#233;lulas B y c&#233;lulas T de la glucoprote&#237;na del virus del &#201;bola &#40;EBOV&#41;&#46; La vacuna fue construida utilizando los ep&#237;topes celulares 5CD8<span class="elsevierStyleSup">&#43;</span>&#44; 8CD4<span class="elsevierStyleSup">&#43;</span>&#44; y 6B con los enlaces adecuados&#46; Se introdujo en la vacuna lipoprote&#237;na de Mycobacterium tuberculosis como adyuvante para reforzar la eficacia de la misma&#46; Se evaluaron las propiedades fisicoqu&#237;micas de la vacuna desarrollada&#44; que incorporan solubilidad&#44; estabilidad&#44; etc&#46; Se estudiaron las interacciones entre la vacuna y los receptores de tipo Toll 3&#44; 4 y 7&#46; La vacuna elaborada demuestra la mejora de la inmunidad celular&#44; y eval&#250;a tambi&#233;n el aclaramiento del ant&#237;geno del cuerpo a diversas exposiciones&#46;</p></span>"
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        "identificador" => "f0030"
        "etiqueta" => "Fig&#46; 6"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
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          "en" => "<p id="sp0030" class="elsevierStyleSimplePara elsevierViewall">The simulation of MD of vaccine-TLR3 docked complex structures&#46; &#40;A&#41; The main-chain deformability simulation showed the hinges regions are weak deformability&#46; &#40;B&#41; B-factor values were evaluated by normal mode analysis&#44; measure the volatility of each atom&#46; &#40;C&#41; The eigenvalue of the docked complex were illustrated that does not require the energy to deform the structure&#46; &#40;D&#41; Covariance matrix between residue pairs &#40;red&#58; correlated&#44; white&#58; uncorrelated&#44; blue&#58; anti-correlated&#41;&#46; &#40;For interpretation of the references to color in this figure legend&#44; the reader is referred to the web version of this article&#46;&#41;</p>"
        ]
      ]
      6 => array:8 [
        "identificador" => "f0035"
        "etiqueta" => "Fig&#46; 7"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
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        "figura" => array:1 [
          0 => array:4 [
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          "en" => "<p id="sp0035" class="elsevierStyleSimplePara elsevierViewall">Immune simulation caused by constructed vaccine&#46; &#40;A&#41; Immune response patterns on exposure to antigens&#46; &#40;B&#41; The effector B- cells consistency &#40;C&#41; Immune reaction of Plasma B-cell&#46; &#40;D&#41; Cytotoxic CD4<span class="elsevierStyleSup">&#43;</span> cell population&#46; &#40;E&#41; Cytotoxic CD8<span class="elsevierStyleSup">&#43;</span> cell population&#46; &#40;F&#41; Cytokine generation&#46;</p>"
        ]
      ]
      7 => array:8 [
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Features&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">EBOV glycoprotein&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">Mycobacterium tuberculosis</span> lipoprotein&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Vaccine candidate&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Number of amino acids&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">676&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">236&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">598&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Molecular weight&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">75&#44;618&#46;41&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">24&#44;547&#46;80&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">63&#44;546&#46;58&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Theoretical pI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#46;27&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#46;78&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&#46;67&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Total number of negatively charged residues &#40;Asp &#43; Glu&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">69&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">19&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">34&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Total number of positively charged residues &#40;Arg&#8239;&#43;&#8239;Lys&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">62&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">54&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Total number of atoms&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&#44;577&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3466&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9076&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Atomic composition formula&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">C<span class="elsevierStyleInf">3371</span>H<span class="elsevierStyleInf">5243</span>N<span class="elsevierStyleInf">929</span>O<span class="elsevierStyleInf">1016</span>S<span class="elsevierStyleInf">18</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">C<span class="elsevierStyleInf">1076</span>H<span class="elsevierStyleInf">1740</span>N<span class="elsevierStyleInf">306</span>O<span class="elsevierStyleInf">339</span>S<span class="elsevierStyleInf">5</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">C<span class="elsevierStyleInf">2921</span>H<span class="elsevierStyleInf">4575</span>N<span class="elsevierStyleInf">773</span>O<span class="elsevierStyleInf">800</span>S<span class="elsevierStyleInf">7</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Instability index&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">36&#46;61 &#40;stable protein&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#46;11 &#40;stable protein&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">19&#46;16 &#40;Stable protein&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Aliphatic index&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">78&#46;43&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">86&#46;86&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">92&#46;12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hydropathicity&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;<span class="elsevierStyleHsp" style=""></span>0&#46;409 &#40;water soluble&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;<span class="elsevierStyleHsp" style=""></span>0&#46;127 &#40;water soluble&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;029 &#40;lipid soluble&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Antigenicity&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;5218 &#40;antigen&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;5980&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
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        "descripcion" => array:1 [
          "en" => "<p id="sp0040" class="elsevierStyleSimplePara elsevierViewall">Evaluation of physicochemical properties of EBOV GP&#44; <span class="elsevierStyleItalic">Mycobacterium tuberculosis</span> lipoprotein and vaccine candidate&#46;</p>"
        ]
      ]
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Allele&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Start&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">End&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Peptide&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Vaxijen score&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Allergencity&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Toxicity&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Human homology&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead rowgroup " rowspan="4" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CD8<span class="elsevierStyleSup">&#43;</span> epitope</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">HLA-A&#42;02&#58;06&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">29&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">37&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">KVFPIPLGV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;5020 Antigen&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Non-allergen&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Non-toxin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">E-Value &#62;<span class="elsevierStyleHsp" style=""></span>23Non-homologous&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">HLA-A&#42;02&#58;01&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">29&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">37&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">KVFPIPLGV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;5020 Antigen&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Non-allergen&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Non-toxin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">E-Value &#62;<span class="elsevierStyleHsp" style=""></span>23Non-homologous&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">HLA-A&#42;02&#58;06&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">27&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">35&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">GITGVIIAV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;7325 Antigen&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Non-allergen&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Non-toxin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">E-Value &#62;<span class="elsevierStyleHsp" style=""></span>27Non-homologous&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">HLA-A&#42;02&#58;06&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">38&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">46&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">FTPQFLVQL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;5875 Antigen&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Non-allergen&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Non-toxin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">E-Value &#62;<span class="elsevierStyleHsp" style=""></span>0&#46;57Non-homologous&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">HLA-A&#42;02&#58;01&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">28&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">TLSSEELSV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">0&#46;7753 Antigen&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Non-allergen&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Non-toxin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">E-Value &#62;<span class="elsevierStyleHsp" style=""></span>6&#46;6Non&#8211;homologous&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead rowgroup " rowspan="8" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CD4<span class="elsevierStyleSup">&#43;</span> epitope</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">HLA-DRB1&#42;01&#58;01&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">24&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">38&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IILFHKVFPIPLGVV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;0161 Antigen&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Non-allergen&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Non-toxin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">E-Value &#62;<span class="elsevierStyleHsp" style=""></span>7&#46;4Non-homologous&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">HLA-DRB1&#42;01&#58;01&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">23&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">37&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">VIILFHKVFPIPLGV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;9775 Antigen&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Non-allergen&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Non-toxin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">E-Value &#62;<span class="elsevierStyleHsp" style=""></span>7&#46;4Non-homologous&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">HLA-DRB1&#42;01&#58;01&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">39&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ILFHKVFPIPLGVVH&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;9652 Antigen&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Non-allergen&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Non-toxin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">E-Value &#62;<span class="elsevierStyleHsp" style=""></span>21Non-homologous&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">HLA-DRB1&#42;01&#58;01&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">22&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">36&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">WVIILFHKVFPIPLG&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;0023 Antigen&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Non-allergen&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Non-toxin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">E-Value &#62;<span class="elsevierStyleHsp" style=""></span>5&#46;2Non-homologous&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">HLA-DRB1&#42;01&#58;01&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">26&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">40&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">LFHKVFPIPLGVVHN&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;8038 Antigen&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Non-allergen&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Non-toxin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">E-Value &#62;<span class="elsevierStyleHsp" style=""></span>3&#46;7Non-homologous&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">HLA-DRB1&#42;01&#58;01&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">32&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">AFFLYDRLASTIIYR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;4171 Antigen&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Non-allergen&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Non-toxin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">E-Value &#62;<span class="elsevierStyleHsp" style=""></span>5&#46;2Non-homologous&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">HLA-DRB1&#42;01&#58;01&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">35&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">VWVIILFHKVFPIPL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;5147 Antigen&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Non-allergen&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Non-toxin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">E-Value &#62;<span class="elsevierStyleHsp" style=""></span>3&#46;7Non-homologous&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">HLA-DRB1&#42;01&#58;01&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">28&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">42&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">HLTYVQLEPRFTPQF&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;1594 Antigen&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Non-allergen&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Non-toxin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">E-Value &#62;<span class="elsevierStyleHsp" style=""></span>7&#46;4Non-homologous&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="sp0045" class="elsevierStyleSimplePara elsevierViewall">Detailed analysis of CD8&#8239;&#43;&#8239;&#38; CD4<span class="elsevierStyleHsp" style=""></span>&#43; epitope&#46;</p>"
        ]
      ]
      9 => array:8 [
        "identificador" => "t0015"
        "etiqueta" => "Table 3"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "al0050"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:1 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Position&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Epitope&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Vaxijen score&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Allergencity&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Toxicity&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Human homology&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead rowgroup " rowspan="6" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Linear B-cell epitope</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">257&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NETIYTNGRRSNTTGTLIWK&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;4557 Antigen&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Non-allergen&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Non-toxin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">E-Value &#62;<span class="elsevierStyleHsp" style=""></span>3&#46;9Non-homologous&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">311&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">VPRAQDPGSNQKTKVTPTSF&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;9762 Antigen&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Non-allergen&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Non-toxin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">E-Value &#62;<span class="elsevierStyleHsp" style=""></span>7&#46;9Non-homologous&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">509&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">AKCNPNLHYWTTQDEGAAIG&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;4132 Antigen&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Non-allergen&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Non-toxin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">E-Value &#62;<span class="elsevierStyleHsp" style=""></span>2&#46;9Non-homologous&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">388&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ELPNISGNHQERNNTAHPET&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;5419 Antigen&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Non-allergen&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Non-toxin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">E-Value &#62;<span class="elsevierStyleHsp" style=""></span>7&#46;9Non-homologous&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">29&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">KVFPIPLGVVHNNTLQVSDI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;0396 Antigen&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Non-allergen&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Non-toxin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">E-Value &#62;<span class="elsevierStyleHsp" style=""></span>4&#46;0Non-homologous&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">217&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">TLNYVADNFGTNMTNFLFQV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;4002 Antigen&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Non-allergen&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Non-toxin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">E-Value &#62;<span class="elsevierStyleHsp" style=""></span>5&#46;5Non-homologous&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
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                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Rank of models&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Estimated RMSD&#40;&#197;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">3D structure&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">18&#46;501&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="center" valign="\n
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                  \t\t\t\t">2&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13&#46;257&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><elsevierMultimedia ident="202302191853062912"></elsevierMultimedia>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">3&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="center" valign="\n
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                  \t\t\t\t">13&#46;731&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#46;019&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><elsevierMultimedia ident="202302191853062914"></elsevierMultimedia>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13&#46;681&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><elsevierMultimedia ident="202302191853062915"></elsevierMultimedia>&nbsp;\t\t\t\t\t\t\n
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          "en" => "<p id="sp0055" class="elsevierStyleSimplePara elsevierViewall">Tertiary structure perdition of designed vaccine by RaptorX structure prediction server&#46;</p>"
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              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">GDT-HA&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">MolProbity&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Clash score&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Poorrotamers&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Rama favored&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Structure&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Initial&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;0000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#46;957&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">328&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">81&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">90&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">MODEL 1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;8874&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
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                  \t\t\t\t">0&#46;570&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
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                  \t\t\t\t">2&#46;755&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="center" valign="\n
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                  \t\t\t\t">45&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
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                  \t\t\t\t">1&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
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                  \t\t\t\t">92&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t"><elsevierMultimedia ident="202302191853062916"></elsevierMultimedia>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">MODEL 2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
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                  \t\t\t\t">0&#46;8918&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
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                  \t\t\t\t">0&#46;563&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
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                  \t\t\t\t">2&#46;606&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
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                  \t\t\t\t">47&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">92&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><elsevierMultimedia ident="202302191853062917"></elsevierMultimedia>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">MODEL 3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;8898&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;565&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;855&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
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                  \t\t\t\t">47&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
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                  \t\t\t\t">92&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t"><elsevierMultimedia ident="202302191853062918"></elsevierMultimedia>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">MODEL 4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
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                  \t\t\t\t">0&#46;8878&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
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                  \t\t\t\t">0&#46;567&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">2&#46;785&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
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                  \t\t\t\t">44&#46;8&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">1&#46;8&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">92&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><elsevierMultimedia ident="202302191853062919"></elsevierMultimedia>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">MODEL 5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
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                  \t\t\t\t">0&#46;8938&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
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                  \t\t\t\t">0&#46;558&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
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                  \t\t\t\t">2&#46;604&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
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                  \t\t\t\t">47&#46;7&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">1&#46;0&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">93&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t"><elsevierMultimedia ident="2023021918530629110"></elsevierMultimedia>&nbsp;\t\t\t\t\t\t\n
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                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Residues&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Number of Residues&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Score&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">3D Structure&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">I&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">A&#58;E1&#44; A&#58;A2&#44; A&#58;A3&#44; A&#58;A4&#44; A&#58;K5&#44; A&#58;M6&#44; A&#58;R7&#44; A&#58;T8&#44; A&#58;P9&#44; A&#58;R10&#44; A&#58;R11&#44; A&#58;H12&#44; A&#58;C13&#44; A&#58;R14&#44; A&#58;R15&#44; A&#58;I16&#44; A&#58;A17&#44; A&#58;V18&#44; A&#58;L19&#44; A&#58;A20&#44; A&#58;A21&#44; A&#58;V22&#44; A&#58;S23&#44; A&#58;I24&#44; A&#58;A25&#44; A&#58;A26&#44; A&#58;T27&#44; A&#58;V28&#44; A&#58;V29&#44; A&#58;A30&#44; A&#58;G31&#44; A&#58;C32&#44; A&#58;S33&#44; A&#58;S34&#44; A&#58;G35&#44; A&#58;S36&#44; A&#58;K37&#44; A&#58;P38&#44; A&#58;S39&#44; A&#58;G40&#44; A&#58;G41&#44; A&#58;P42&#44; A&#58;L43&#44; A&#58;P44&#44; A&#58;D45&#44; A&#58;A46&#44; A&#58;K47&#44; A&#58;P48&#44; A&#58;L49&#44; A&#58;E51&#44; A&#58;E52&#44; A&#58;T68&#44; A&#58;V69&#44; A&#58;N70&#44; A&#58;G71&#44; A&#58;K72&#44; A&#58;I73&#44; A&#58;P74&#44; A&#58;G75&#44; A&#58;L76&#44; A&#58;S77&#44; A&#58;L78&#44; A&#58;K79&#44; A&#58;T80&#44; A&#58;L81&#44; A&#58;S82&#44; A&#58;G83&#44; A&#58;N95&#44; A&#58;V96&#44; A&#58;K97&#44; A&#58;L98&#44; A&#58;T99&#44; A&#58;L100&#44; A&#58;G101&#44; A&#58;G102&#44; A&#58;S103&#44; A&#58;D104&#44; A&#58;I105&#44; A&#58;D106&#44; A&#58;A107&#44; A&#58;D108&#44; A&#58;T119&#44; A&#58;L120&#44; A&#58;T121&#44; A&#58;P122&#44; A&#58;N123&#44; A&#58;Q124&#44; A&#58;W125&#44; A&#58;N153&#44; A&#58;F154&#44; A&#58;A155&#44; A&#58;D156&#44; A&#58;A157&#44; A&#58;K158&#44; A&#58;A159&#44; A&#58;E160&#44; A&#58;G161&#44; A&#58;R162&#44; A&#58;D163&#44; A&#58;T164&#44; A&#58;I165&#44; A&#58;N166&#44; A&#58;G167&#44; A&#58;Q168&#44; A&#58;N169&#44; A&#58;T170&#44; A&#58;I171&#44; A&#58;R172&#44; A&#58;I173&#44; A&#58;S174&#44; A&#58;G175&#44; A&#58;K176&#44; A&#58;V177&#44; A&#58;S178&#44; A&#58;A179&#44; A&#58;Q180&#44; A&#58;V182&#44; A&#58;N183&#44; A&#58;A186&#44; A&#58;P188&#44; A&#58;F189&#44; A&#58;N190&#44; A&#58;A191&#44; A&#58;T192&#44; A&#58;Q193&#44; A&#58;P194&#44; A&#58;V195&#44; A&#58;P196&#44; A&#58;A197&#44; A&#58;T198&#44; A&#58;V199&#44; A&#58;W200&#44; A&#58;I201&#44; A&#58;Q202&#44; A&#58;E203&#44; A&#58;T204&#44; A&#58;G205&#44; A&#58;D206&#44; A&#58;H207&#44; A&#58;Q208&#44; A&#58;Q211&#44; A&#58;Q213&#44; A&#58;L214&#44; A&#58;D215&#44; A&#58;R216&#44; A&#58;G217&#44; A&#58;S218&#44; A&#58;G219&#44; A&#58;N220&#44; A&#58;S221&#44; A&#58;V222&#44; A&#58;Q223&#44; A&#58;P238&#44; A&#58;P239&#44; A&#58;V240&#44; A&#58;S241&#44; A&#58;A242&#44; A&#58;A243&#44; A&#58;Y244&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">159&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;763&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><elsevierMultimedia ident="2023021918530629111"></elsevierMultimedia>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">II&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">A&#58;F457&#44; A&#58;I480&#44; A&#58;Y481&#44; A&#58;K482&#44; A&#58;K483&#44; A&#58;N484&#44; A&#58;E485&#44; A&#58;T486&#44; A&#58;I487&#44; A&#58;Y488&#44; A&#58;T489&#44; A&#58;N490&#44; A&#58;G491&#44; A&#58;R492&#44; A&#58;R493&#44; A&#58;S494&#44; A&#58;N495&#44; A&#58;T496&#44; A&#58;T497&#44; A&#58;G498&#44; A&#58;T499&#44; A&#58;L500&#44; A&#58;W502&#44; A&#58;K505&#44; A&#58;V506&#44; A&#58;P507&#44; A&#58;R508&#44; A&#58;A509&#44; A&#58;Q510&#44; A&#58;D511&#44; A&#58;P512&#44; A&#58;G513&#44; A&#58;S514&#44; A&#58;N515&#44; A&#58;Q516&#44; A&#58;K517&#44; A&#58;T518&#44; A&#58;K519&#44; A&#58;V520&#44; A&#58;P522&#44; A&#58;S524&#44; A&#58;F525&#44; A&#58;K526&#44; A&#58;N531&#44; A&#58;P532&#44; A&#58;N533&#44; A&#58;L534&#44; A&#58;H535&#44; A&#58;Y536&#44; A&#58;W537&#44; A&#58;T538&#44; A&#58;T539&#44; A&#58;D541&#44; A&#58;E542&#44; A&#58;G543&#44; A&#58;A544&#44; A&#58;A545&#44; A&#58;I546&#44; A&#58;G547&#44; A&#58;K548&#44; A&#58;K549&#44; A&#58;E550&#44; A&#58;L551&#44; A&#58;P552&#44; A&#58;N553&#44; A&#58;I554&#44; A&#58;S555&#44; A&#58;G556&#44; A&#58;N557&#44; A&#58;H558&#44; A&#58;Q559&#44; A&#58;E560&#44; A&#58;R561&#44; A&#58;N562&#44; A&#58;N563&#44; A&#58;T564&#44; A&#58;A565&#44; A&#58;H566&#44; A&#58;P567&#44; A&#58;E568&#44; A&#58;T569&#44; A&#58;K570&#44; A&#58;K571&#44; A&#58;K572&#44; A&#58;V573&#44; A&#58;F574&#44; A&#58;P575&#44; A&#58;I576&#44; A&#58;P577&#44; A&#58;L578&#44; A&#58;G579&#44; A&#58;V580&#44; A&#58;V581&#44; A&#58;H582&#44; A&#58;N583&#44; A&#58;N584&#44; A&#58;T585&#44; A&#58;L586&#44; A&#58;Q587&#44; A&#58;V588&#44; A&#58;S589&#44; A&#58;D590&#44; A&#58;I591&#44; A&#58;K592&#44; A&#58;K593&#44; A&#58;T594&#44; A&#58;L595&#44; A&#58;N596&#44; A&#58;Y597&#44; A&#58;V598&#44; A&#58;A599&#44; A&#58;D600&#44; A&#58;N601&#44; A&#58;F602&#44; A&#58;G603&#44; A&#58;T604&#44; A&#58;N605&#44; A&#58;M606&#44; A&#58;T607&#44; A&#58;N608&#44; A&#58;F609&#44; A&#58;L610&#44; A&#58;F611&#44; A&#58;Q612&#44; A&#58;V613&#44; A&#58;E614&#44; A&#58;A615&#44; A&#58;A616&#44; A&#58;K617&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">129&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;70&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><elsevierMultimedia ident="2023021918530629112"></elsevierMultimedia>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">III&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">A&#58;F281&#44; A&#58;T282&#44; A&#58;P283&#44; A&#58;Q284&#44; A&#58;Q288&#44; A&#58;E298&#44; A&#58;L299&#44; A&#58;S300&#44; A&#58;V301&#44; A&#58;G302&#44; A&#58;P303&#44; A&#58;G304&#44; A&#58;P305&#44; A&#58;G306&#44; A&#58;I307&#44; A&#58;I308&#44; A&#58;V334&#44; A&#58;F335&#44; A&#58;P336&#44; A&#58;I337&#44; A&#58;P338&#44; A&#58;L339&#44; A&#58;G340&#44; A&#58;V341&#44; A&#58;G342&#44; A&#58;P343&#44; A&#58;G344&#44; A&#58;P345&#44; A&#58;G346&#44; A&#58;P377&#44; A&#58;I378&#44; A&#58;L380&#44; A&#58;G381&#44; A&#58;G382&#44; A&#58;P383&#44; A&#58;G384&#44; A&#58;P385&#44; A&#58;G386&#44; A&#58;L387&#44; A&#58;F388&#44; A&#58;H389&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">41&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;556&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><elsevierMultimedia ident="2023021918530629113"></elsevierMultimedia>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
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Article information

ISSN: 24451460
Original language: English

DOI:10.1016/j.vacune.2022.11.004

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