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"correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Melanoma maligno metastásico de laringe" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1212 "Ancho" => 2341 "Tamanyo" => 193096 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Figure " "rol" => "short" ] ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">A 61-year-old woman with a stage-B cutaneous melanoma (CM), superficial spreading in the left parietal region with BRAF V600K mutation, treated by extended local excision. The patient progressed favourably for the first 9 years, until she presented thyroid gland enlargement with FNA findings compatible with melanoma metastasis. A thyroidectomy with VI level neck dissection was performed. Months after the thyroidectomy the patient started persistent dysphonia. Nasofibrolaryngoscopy revealed submucosal nodules in the left aryepiglottic fold, with preserved mobility in both folds and unaltered vascular pattern with NBI light (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). The initial biopsy gave a non-specific anatomopathological result; however, based on the patient’s history, we performed another direct laryngoscopy and biopsy, which confirmed the diagnosis of melanoma metastasis, Melan-A and SOX-10 positive. Restaging PET/CT (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>) showed a metastatic pancreatic lesion with no changes with respect to previous studies, and therefore total laryngectomy and bilateral functional neck dissection were indicated.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">From 10% to 25% of CM develop in the head and neck region. CM metastases to the upper aerodigestive tract are extremely rare. It is estimated that more than 73% of metastases in this location suggest disseminated disease, with a gloomy prognosis despite locoregional or systemic treatment. Long-term follow-up of these patients is essential, and the ENT specialist is involved in the diagnosis, follow-up, and treatment of patients with cutaneous or mucosal melanoma of the head and neck.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Funding</span><p id="par0015" class="elsevierStylePara elsevierViewall">This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Conflict of interests</span><p id="par0020" class="elsevierStylePara elsevierViewall">The authors have no conflict of interests to declare.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Funding" ] 1 => array:2 [ "identificador" => "sec0010" "titulo" => "Conflict of interests" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "multimedia" => array:2 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 405 "Ancho" => 1005 "Tamanyo" => 69456 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1212 "Ancho" => 2341 "Tamanyo" => 193096 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Figure " "rol" => "short" ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/21735735/0000007400000003/v1_202305272013/S2173573523000418/v1_202305272013/en/main.assets" "Apartado" => array:4 [ "identificador" => "5869" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Images in otorhinolaryngology" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/21735735/0000007400000003/v1_202305272013/S2173573523000418/v1_202305272013/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173573523000418?idApp=UINPBA00004N" ]
Journal Information
Vol. 74. Issue 3.
Pages 198-199 (May - June 2023)
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Vol. 74. Issue 3.
Pages 198-199 (May - June 2023)
Images in Otorhinolaryngology
Metastatic malignant melanoma of the larynx
Melanoma maligno metastásico de laringe
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6
Daniel-Iván Martín-Jiménez
, José Palacios-García, Serafín Sánchez-Gómez
Corresponding author
Unidad de Gestión Clínica de Otorrinolaringología, Hospital Universitario Virgen Macarena, Sevilla, Spain
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