array:23 [ "pii" => "S2173573507703642" "issn" => "21735735" "doi" => "10.1016/S2173-5735(07)70364-2" "estado" => "S300" "fechaPublicacion" => "2007-01-01" "aid" => "70364" "copyright" => "Sociedad Española de Otorrinolaringología y Patología Cérvico-Facial" "copyrightAnyo" => "2007" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Acta Otorrinolaringol Esp. 2007;58:341-6" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 397 "formatos" => array:3 [ "EPUB" => 15 "HTML" => 100 "PDF" => 282 ] ] "itemSiguiente" => array:18 [ "pii" => "S2173573507703654" "issn" => "21735735" "doi" => "10.1016/S2173-5735(07)70365-4" "estado" => "S300" "fechaPublicacion" => "2007-01-01" "aid" => "70365" "copyright" => "Sociedad Española de Otorrinolaringología y Patología Cérvico-Facial" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Acta Otorrinolaringol Esp. 2007;58:347-51" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 436 "formatos" => array:3 [ "EPUB" => 23 "HTML" => 147 "PDF" => 266 ] ] "en" => array:10 [ "idiomaDefecto" => true "titulo" => "Relationship Between FAK and P53 Expression in Squamous Cell Carcinomas of the Larynx" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "347" "paginaFinal" => "351" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Relación entre la expresión de FAK y p53 en los carcinomas epidermoides de laringe" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Juan Pablo Rodrigo, Rubén Cabanillas, Pablo Secades, Marta Canel, María Dolores Chiara, Carlos Suárez" "autores" => array:6 [ 0 => array:2 [ "nombre" => "Juan Pablo" "apellidos" => "Rodrigo" ] 1 => array:2 [ "nombre" => "Rubén" "apellidos" => "Cabanillas" ] 2 => array:2 [ "nombre" => "Pablo" "apellidos" => "Secades" ] 3 => array:2 [ "nombre" => "Marta" "apellidos" => "Canel" ] 4 => array:2 [ "nombre" => "María Dolores" "apellidos" => "Chiara" ] 5 => array:2 [ "nombre" => "Carlos" "apellidos" => "Suárez" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173573507703654?idApp=UINPBA00004N" "url" => "/21735735/0000005800000008/v1_201304231400/S2173573507703654/v1_201304231400/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S2173573507703630" "issn" => "21735735" "doi" => "10.1016/S2173-5735(07)70363-0" "estado" => "S300" "fechaPublicacion" => "2007-01-01" "aid" => "70363" "copyright" => "Sociedad Española de Otorrinolaringología y Patología Cérvico-Facial" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Acta Otorrinolaringol Esp. 2007;58:336-40" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 438 "formatos" => array:3 [ "EPUB" => 29 "HTML" => 183 "PDF" => 226 ] ] "en" => array:10 [ "idiomaDefecto" => true "titulo" => "Analysis of Mortality Due to Laryngeal Cancer in Chile (1994–2004)" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "336" "paginaFinal" => "340" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Análisis de la mortalidad por cáncer laríngeo en Chile (1990–2004)" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Mariana Elisa Bogado, Felipe Sebastián Araya, Faustino Tomás Alonso" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Mariana" "apellidos" => "Elisa Bogado" ] 1 => array:2 [ "nombre" => "Felipe Sebastián" "apellidos" => "Araya" ] 2 => array:2 [ "nombre" => "Faustino Tomás" "apellidos" => "Alonso" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173573507703630?idApp=UINPBA00004N" "url" => "/21735735/0000005800000008/v1_201304231400/S2173573507703630/v1_201304231400/en/main.assets" ] "en" => array:14 [ "idiomaDefecto" => true "titulo" => "Is Microvascular Density an Independent Prognostic Factor in Squamous Cell Carcinoma of the Tongue?" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "341" "paginaFinal" => "346" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Mario M. Fernández, Álvaro García-Rozado, Pablo L. Parente" "autores" => array:3 [ 0 => array:4 [ "nombre" => "Mario M." "apellidos" => "Fernández" "email" => array:1 [ 0 => "mario_fernandez@canalejo.corg" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Álvaro" "apellidos" => "García-Rozado" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "Pablo L." "apellidos" => "Parente" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Otorrinolaringología. Complejo Hospitalario Universitario Juan Canalejo. ACoruña. Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Cirugía Máxilo-Facial. Complejo Hospitalario Universitario Juan Canalejo. ACoruña. Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Correspondence: Ventoeira, 24. 15179 Lians. Oleiros. A Coruña. Spain." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "¿La densidad microvascular es un factor pronóstico independiente en el carcinoma epidermoide de lengua?" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2007-05-31" "fechaAceptado" => "2007-06-21" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec80083" "palabras" => array:7 [ 0 => "Microvascular density" 1 => "Angiogenesis" 2 => "CD31" 3 => "Tongue" 4 => "Oral cavity" 5 => "Carcinoma" 6 => "Prognosis" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec80084" "palabras" => array:7 [ 0 => "Densidad microvascular" 1 => "Angiogénesis" 2 => "CD31" 3 => "Lengua" 4 => "Cavidad oral" 5 => "Carcinoma" 6 => "Pronóstico" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">The relationship between tumour angiogenesis and prognosis in head and neck squamous cell carcinomas remains controversial in the literature. This study was designed to determine the role of tumour vascularization in tongue squamous cell carcinoma behaviour.</p> <span class="elsevierStyleSectionTitle">Material and method</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Tumour vascularization was evaluated in 43 patients with primary squamous cell carcinomas of the tongue. Anti-endothelial cell antigen (CD31) was used to stain the specimens. The correlation between tumour vascularization and both survival rate and tumour recurrence was established to determine the prognostic value of microvessel density (Cox proportional-hazards survival regression).</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Adequate staining was achieved in all specimens with anti-CD31. Mean microvessel density was 30.6 (400× field), and the median was 27. After a 5-year follow-up, a local, regional, or distant recurrence of the tumour occurred in 29 patients (67.4%). Twenty patients (46.5%) were alive with or without tumour, while 23 patients (53.5%) had died due to tumour recurrence. Statistical analysis failed to demonstrate any correlation between microvessel density and 5-year survival (<span class="elsevierStyleItalic">P</span>=.59) and recurrence rate (<span class="elsevierStyleItalic">P</span>=.31).</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Despite the controversy, these results suggest that microvascular density is not a valid independent prognostic indicator in patients with squamous cell carcinoma of the tongue.</p>" ] "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objetivos</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">La relación entre angiogénesis tumoral y el pronóstico en carcinomas epidermoides de cabeza y cuello continúa en controversia. Se ha diseñado este estudio para determinar el papel de la vascularización tumoral en el comportamiento de los carcinomas epidermoides de lengua.</p> <span class="elsevierStyleSectionTitle">Material y método</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Se ha evaluado la vascularización tumoral en 43 pacientes con carcinoma epidermoide de lengua. Se emplearon anticuerpos antiendoteliales (CD31) para teñir las muestras. Para determinar el valor pronóstico de la microvascularización tumoral, se comparó la densidad icrovascular con el índice de recidiva y la supervivencia (test de regresión de Cox).</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Todas las muestras se tiñeron adecuadamente mediante anti-CD31. La densidad vascular media fue 30,6 (en campos 400x) y la mediana, 27. Tras un seguimiento de 5 años, en 29 (67,4%) pacientes se iniciaron recidivas local, regional o a distancia; 20 (46,5%) permanecían vivos con o sin tumor, mientras que 23 (53%) habían fallecido por una recidiva tumoral. El análisis estadístico no ha demostrado ninguna relación significativa de la densidad microvascular con la supervivencia a 5 años (p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,59) ni con el riesgo de recidiva a los 5 años (p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,31).</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Aunque hay controversias, estos resultados indican que la densidad microvascular no es un indicador pronóstico independiente y válido en pacientes con carcinoma epidermoide de lengua.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:26 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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