Viral Infection of Herpes simplex, Epstein-Barr, Varicela Zoster, Human Papilloma, Cytomegalovirus, or Adenovirus Are Not Related to Sinonasal Adenocarcinomas

Objective

Several types of virus have been implicated in the development of head and neck tumours. However, until now sinonasal adenocarcinomas (SNAC) have not been studied. The aim of this study is to screen a series of SNAC for the presence of a number of viruses known to play a role in cancer.

Material and method

Viral DNA sequences of Herpes simplex virus, Epstein-Barr, varicela zoster, human papilloma, cytomegalovirus, and adenovirus were analysed by PCR in 37 primary SNAC.

Results

Three tumours (8.1%) were positive for Epstein-Barr virus and 1 case (2.7%) for cytomegalovirus.

Conclusions

Viral infections do not seem to play a role in the aetiology of SNAC.

Objetivo

Se ha relacionado a diversos virus con el desarrollo de tumores epidermoides de cabeza y cuello. No obstante, no existen estudios previos que relacionen a los adenocarcinomas nasosinusales (ACN) con la presencia de virus. El objetivo de este estudio es determinar, en una serie de ACN, la presencia de virus que se sabe desempeñan un papel en el cáncer.

Material y método

Se estudió mediante PCR 37 ACN, para determinar la presencia de ADN de virus de papiloma humano, virus de Epstein-Barr (VEB), virus herpes simplex, virus de la varicela zoster, adenovirus y citomegalovirus.

Resultados

Se detectó ADN de VEB en 3 (8,1%) de las 37 muestras tumorales y ADN de citomegalovirus en 1 (2,7%) de los 37 casos analizados.

Conclusiones

Nuestros resultados indican que los virus estudiados no desempeñan papel alguno en la etiología de los ACN.