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Gaya Sopena Servicio de Urología Fundació Puigvert - Cartagena 340-350. 08005 Barcelona. Tel.: 934 169 731" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Metastasic urethral squamous-cell a cancer" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2008-04-01" "fechaAceptado" => "2008-05-01" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec89004" "palabras" => array:4 [ 0 => "Cáncer uretra" 1 => "Carcinoma escamoso" 2 => "Metástasis" 3 => "Tratamiento" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec89003" "palabras" => array:4 [ 0 => "Urethral cancer" 1 => "Squamous-cell cancer" 2 => "Metastasis" 3 => "Treatment" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">El carcinoma primario de uretra es una neoplasia poco común, constituyendo menos del 1% de los tumores genitourinarios. Éste es más habitual en el sexo femenino, en una proporción 4:1, apareciendo en la sexta o séptima década de la vida, siendo el tipo histológico más frecuente el carcinoma de células escamosas. Los primeros signos y síntomas son más propios de estenosis benigna de uretra que de malignidad. El periodo entre los primeros síntomas y el diagnóstico suele ser de alrededor de tres años. Por consiguiente la mayoría de estos tumores son localmente avanzados en el momento del diagnóstico y a pesar de ser sometidos a tratamientos agresivos tiene mal pronóstico. El tratamiento depende del estadio y la localización de la lesión. Debido a la rareza de esta neoplasia no existe un consenso de tratamiento, pero parece ser que éste debe ser multimodal, con cirugía, radioterapia y quimioterapia.</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Presentamos el caso de un varón de 80 años afecto de un carcinoma escamoso de uretra, localmente avanzado en el momento del diagnóstico. Ante la imposibilidad de recibir tratamiento quirúrgico fue tratado con quimioterapia más radioterapia, presentando al poco tiempo progresión precoz de la enfermedad.</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Urethral cancer is an infrequent pathology, less than 1% of the genitourinary tumors. It is more frequent in women (4:1), in the sixth or seventh decade of life. The most frequent histology being squamous cell carcinoma. First signs and symptoms usually are more attributable to benign stricture disease, rather than malignicy. The interval between the onset of symptoms and diagnosis may be as long as three years. Therefore most of these tumors are locally advanced at the time of diagnosis with generally poor prognosis despite aggressive treatment. Therapeutic management varies with the stage and location of the lesion. Because of the rarity of this pathology, no consensus has been reached on treatment modalities, but seems to be that must be a multimodal one, including surgery, radiotherapy and chemotherapy.</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">We present the case of an 80 year-old male, with a diagnosis of urethral squamous-cell cancer, locally advanced at the time of diagnosis. Surgery was not feasible. The patient underwent chemotherapy and radiotherapy with evidence of quick progression thereafter.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:16 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Male urethral carcinoma: analysis of treatment outcome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "G. 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Carcinoma escamoso de uretra metastático
Metastasic urethral squamous-cell a cancer
Mª. Josep Gaya Sopena1
, A. Juan Peña González, M. Pascual Queralt, Juan Caparrós Sariol, Juan Palou Redorta, Humberto Villavicencio Mavrich
Autor para correspondencia
36178jgs@comb.es
Correspondencia autor: Dr. Josep M. Gaya Sopena Servicio de Urología Fundació Puigvert - Cartagena 340-350. 08005 Barcelona. Tel.: 934 169 731
Correspondencia autor: Dr. Josep M. Gaya Sopena Servicio de Urología Fundació Puigvert - Cartagena 340-350. 08005 Barcelona. Tel.: 934 169 731
Servicio de Urología. Fundació Puigvert. Barcelona, España