Compartir
array:24 [ "pii" => "S0210480609741403" "issn" => "02104806" "doi" => "10.1016/S0210-4806(09)74140-3" "estado" => "S300" "fechaPublicacion" => "2009-01-01" "aid" => "74140" "copyright" => "Asociación Española de Urología (AEU)" "copyrightAnyo" => "2009" "documento" => "article" "crossmark" => 0 "subdocumento" => "rev" "cita" => "Actas Urol Esp. 2009;33:270-9" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1861 "formatos" => array:3 [ "EPUB" => 7 "HTML" => 1005 "PDF" => 849 ] ] "itemSiguiente" => array:18 [ "pii" => "S0210480609741415" "issn" => "02104806" "doi" => "10.1016/S0210-4806(09)74141-5" "estado" => "S300" "fechaPublicacion" => "2009-01-01" "aid" => "74141" "copyright" => "Asociación Española de Urología (AEU)" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Urol Esp. 2009;33:280-3" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1710 "formatos" => array:3 [ "EPUB" => 9 "HTML" => 1157 "PDF" => 544 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Primera nefrectomía transvaginal híbrida por cáncer renal" "tienePdf" => array:2 [ 0 => "es" 1 => "en" ] "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "280" "paginaFinal" => "283" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "First report on hybrid transvaginal nephrectomy for renal cancer" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:2 [ "es" => true "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "María J. Ribal Caparrós, Lluís Peri Cusí, Alejandro Molina Cabeza, Alexa García Larrosa, Francisco Carmona, Antonio Alcaraz Asensio" "autores" => array:6 [ 0 => array:2 [ "nombre" => "María J." "apellidos" => "Ribal Caparrós" ] 1 => array:2 [ "nombre" => "Lluís" "apellidos" => "Peri Cusí" ] 2 => array:2 [ "nombre" => "Alejandro" "apellidos" => "Molina Cabeza" ] 3 => array:2 [ "nombre" => "Alexa" "apellidos" => "García Larrosa" ] 4 => array:2 [ "nombre" => "Francisco" "apellidos" => "Carmona" ] 5 => array:2 [ "nombre" => "Antonio" "apellidos" => "Alcaraz Asensio" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210480609741415?idApp=UINPBA00004N" "url" => "/02104806/0000003300000003/v1_201304251925/S0210480609741415/v1_201304251925/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0210480609741397" "issn" => "02104806" "doi" => "10.1016/S0210-4806(09)74139-7" "estado" => "S300" "fechaPublicacion" => "2009-01-01" "aid" => "74139" "copyright" => "Asociación Española de Urología (AEU)" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Urol Esp. 2009;33:258-69" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1538 "formatos" => array:3 [ "EPUB" => 8 "HTML" => 889 "PDF" => 641 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Factores predictivos de neoplasia vesical metacrónica tras nefroureterectomía" "tienePdf" => array:2 [ 0 => "es" 1 => "en" ] "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "258" "paginaFinal" => "269" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Predictive factors of metachronous bladder neoplasm after nephroureterectomy" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:2 [ "es" => true "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Andres Rodriguez Alonso, Alfonso Gonzalez Blanco, Alfonso Barbagelata Lopez, Salvador Pita Fernandez, Carlos Bonelli Martin, Miguel A. Cuerpo Perez" "autores" => array:6 [ 0 => array:2 [ "nombre" => "Andres" "apellidos" => "Rodriguez Alonso" ] 1 => array:2 [ "nombre" => "Alfonso" "apellidos" => "Gonzalez Blanco" ] 2 => array:2 [ "nombre" => "Alfonso" "apellidos" => "Barbagelata Lopez" ] 3 => array:2 [ "nombre" => "Salvador" "apellidos" => "Pita Fernandez" ] 4 => array:2 [ "nombre" => "Carlos" "apellidos" => "Bonelli Martin" ] 5 => array:2 [ "nombre" => "Miguel A." "apellidos" => "Cuerpo Perez" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210480609741397?idApp=UINPBA00004N" "url" => "/02104806/0000003300000003/v1_201304251925/S0210480609741397/v1_201304251925/es/main.assets" ] "es" => array:12 [ "idiomaDefecto" => true "titulo" => "Guía del carcinoma de células renales" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "270" "paginaFinal" => "279" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Börje Ljungberg, C. Damian Hanbury, A. Marcus Kuczyk, S. Axel Merseburger, F.A. Peter Mulders, Jean-Jacques Patard, C. Ioanel Sinescuf" "autores" => array:8 [ 0 => array:1 [ "colaborador" => "Traducción del artículo european urology 51 (2007) 1502-1510: gonzalo garcía fadrique Servicio de Urología. Hospital Universitario La Fe. Valencia, España" ] 1 => array:4 [ "nombre" => "Börje" "apellidos" => "Ljungberg" "email" => array:1 [ 0 => "borje.ljungberg@urologi.umu.se" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "cor0005" ] ] ] 2 => array:3 [ "nombre" => "C." "apellidos" => "Damian Hanbury" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "A." "apellidos" => "Marcus Kuczyk" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 4 => array:3 [ "nombre" => "S." "apellidos" => "Axel Merseburger" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 5 => array:3 [ "nombre" => "F.A." "apellidos" => "Peter Mulders" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] ] ] 6 => array:3 [ "nombre" => "Jean-Jacques" "apellidos" => "Patard" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">e</span>" "identificador" => "aff0025" ] ] ] 7 => array:3 [ "nombre" => "C." "apellidos" => "Ioanel Sinescuf" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">f</span>" "identificador" => "aff0030" ] ] ] ] "afiliaciones" => array:6 [ 0 => array:3 [ "entidad" => "Servicio de Cirugía y Ciencias Perioperatorias, Urología y Andrología, Universidad de Umea, Umea, Suecia" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Urología, Hospital de Lister, Mill Lane, Stevenage, Reino Unido" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Servicio de Urología, Universidad de Tuebingen, Tuebingen, Alemania" "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Servicio de Urología, Centro Médico de la Universidad Radbound, Nijmegen, Holanda" "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] 4 => array:3 [ "entidad" => "Servicio de Urología, CHU Pontchaillou, Rennes, Francia" "etiqueta" => "<span class="elsevierStyleSup">e</span>" "identificador" => "aff0025" ] 5 => array:3 [ "entidad" => "Servicio de Urología y Trasplante Renal, Instituto Clínico Fundeni, Bucarest, Rumanía" "etiqueta" => "<span class="elsevierStyleSup">f</span>" "identificador" => "aff0030" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "1" "correspondencia" => "Autor para correspondencia: Börje Ljungberg Department of Surgical and Perioperative Sciences, Urology and Andrology, Umea° University, S-90 85 Umea°, Sweden. Tel. +46 90 785 330 Fax: +46 90 25396" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Renal cell carcinoma guideline" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras claves" "identificador" => "xpalclavsec88889" "palabras" => array:6 [ 0 => "Diagnóstico" 1 => "Seguimiento" 2 => "Recomendaciones" 3 => "Guías" 4 => "Carcinoma de células renales" 5 => "Tratamiento" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec88890" "palabras" => array:6 [ 0 => "Diagnosis" 1 => "Follow-up" 2 => "Recommendations" 3 => "Guidelines" 4 => "Renal cell carcinoma" 5 => "Treatment" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Objetivos</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">El Grupo de trabajo de la Asociación Europea de Urología (AEU) sobre el Carcinoma de Células Renales (CCR) ha preparado esta guía para ayudar a los urólogos a evaluar la evidencia sobre el manejo del CCR y a incorporar sus recomendaciones a su práctica clínica.</p> <span class="elsevierStyleSectionTitle">Material y métodos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Las recomendaciones proporcionadas en esta guía están basadas en una búsqueda sistemática de la literatura utilizando Medline, el Registro Central de Ensayos Controlados de la Cochrane, así como en publicaciones y artículos de revisión.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Hay un número limitado de estudios prospectivos aleatorizados con alto nivel de evidencia. La mayoría de las publicaciones acerca del CCR se basan en análisis retrospectivos, incluyendo algunos estudios multicéntricos más largos validados y estudios controlados bien diseñados.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">se debe remarcar que esta guía contiene información para el tratamiento individual de un paciente de acuerdo a un enfoque general estándar. El manejo clínico de los pacientes con CCR puede mejorarse con recomendaciones actualizadas sobre diagnóstico, tratamiento y seguimiento.</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Objectives</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">The European Association of Urology (EAU) Guideline Group for renal cell carcinoma (RCC) prepared this guideline to help urologists assess the evidence-based management of RCC and to incorporate the guideline recommendations into their clinical practice.</p> <span class="elsevierStyleSectionTitle">Methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">The re commendations provided in the current guideline are based on a systematic literature search using MedLine, the Cochrane Central Register of Controlled Trials, and publications and review articles.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">A Limited Number of prospective randomized studies are available with high-level evidence.Most publications concerning RCC are based on retrospective analyses, including some larger multicentre validation studies and well-designed controlled studies.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">It must be stressed that the current guideline contains information for the treatment of an individual patient according to a standardized general approach. Updated recommendations concerning diagnosis, treatment, and follow-up can improve the clinical handling of patients with RCC.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:64 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "titulo" => "European Network of Cancer Registries. Eurocim version 4.0" ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:3 [ "fecha" => "2001" "editorial" => "Lyon" "editorialLocalizacion" => "France" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epidemiology of renal cell carcinoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "P. Lindblad" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Scand J Surg" "fecha" => "2004" "volumen" => "93" "numero" => "2" "paginaInicial" => "88" "paginaFinal" => "96" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15285559" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The Heidelberg classification of renal cell tumours" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:19 [ 0 => "G. Kovacs" 1 => "M. Akhtar" 2 => "B.J. Beckwith" 3 => "P. Bugert" 4 => "C.S. Cooper" 5 => "B. Delahunt" 6 => "J.N. Eble" 7 => "S. Fleming" 8 => "B. Ljungberg" 9 => "L.J. Medeiros" 10 => "H. Moch" 11 => "V.E. Reuter" 12 => "E. Ritz" 13 => "G. Roos" 14 => "D. Schmidt" 15 => "J.R. Srigley" 16 => "S. Störkel" 17 => "E. van den Berg" 18 => "B. Zbar" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/(SICI)1096-9896(199710)183:2<131::AID-PATH931>3.0.CO;2-G" "Revista" => array:7 [ "tituloSerie" => "J Pathol" "fecha" => "1997" "volumen" => "183" "numero" => "2" "paginaInicial" => "131" "paginaFinal" => "133" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9390023" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Body size and risk of renal cell carcinoma in the European Prospective Investigation into Cancer and Nutrition (EPIC)" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "T. Pischon" 1 => "P.H. Lahmann" 2 => "H. Boeing" 3 => "A. Tjønneland" 4 => "J. Halkjaer" 5 => "K. Overvad" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/ijc.21398" "Revista" => array:7 [ "tituloSerie" => "Int J Cancer" "fecha" => "2006" "volumen" => "118" "numero" => "3" "paginaInicial" => "728" "paginaFinal" => "738" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16094628" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prognostic significance of the mode of detection in renal tumours" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J.J. Patard" 1 => "A. Rodriguez" 2 => "N. Rioux-Leclercq" 3 => "F. Guillé" 4 => "B. Lobel" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "BJU Int" "fecha" => "2002" "volumen" => "90" "numero" => "4" "paginaInicial" => "358" "paginaFinal" => "363" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12175389" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Natural history of small renal cell carcinoma: evaluation of growth rate, histological grade, cell proliferation and apoptosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M. Kato" 1 => "T. Suzuki" 2 => "Y. Suzuki" 3 => "Y. Terasawa" 4 => "H. Sasano" 5 => "Y. Arai" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/01.ju.0000136315.80057.99" "Revista" => array:7 [ "tituloSerie" => "J Urol" "fecha" => "2004" "volumen" => "172" "numero" => "3" "paginaInicial" => "863" "paginaFinal" => "866" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15310984" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Renal tumours" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A.C. Novick" 1 => "S.C. Campbell" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Campbell’s urology" "paginaInicial" => "2672" "paginaFinal" => "2731" "serieFecha" => "2002" ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mode of presentation of renal cell carcinoma provides prognostic information" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "C.T. Lee" 1 => "J. Katz" 2 => "P.A. Fearn" 3 => "P. Russo" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:8 [ "tituloSerie" => "Urol Oncol" "fecha" => "2002" "volumen" => "7" "numero" => "4" "paginaInicial" => "135" "paginaFinal" => "140" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12474528" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0091674910015666" "estado" => "S300" "issn" => "00916749" ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Correlation between symptom graduation, tumor characteristics and survival in renal cell carcinoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J.J. Patard" 1 => "E. Leray" 2 => "A. Rodriguez" 3 => "N. Rioux-Leclercq" 4 => "F. Guillé" 5 => "B. Lobel" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Eur Urol" "fecha" => "2003" "volumen" => "44" "numero" => "2" "paginaInicial" => "226" "paginaFinal" => "232" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12875943" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Paraneoplastic and serologic syndromes of renal adenocarcinoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "G. Sufrin" 1 => "S. Chasan" 2 => "A. Golio" 3 => "G.P. Murphy" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Semin Urol" "fecha" => "1989" "volumen" => "7" "numero" => "3" "paginaInicial" => "158" "paginaFinal" => "171" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2690260" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0055" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "European Society of Oncological Urology. Preoperative imaging in renal cell cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A. Heidenreich" 1 => "V. Ravery" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00345-004-0411-2" "Revista" => array:7 [ "tituloSerie" => "World J Urol" "fecha" => "2004" "volumen" => "22" "numero" => "5" "paginaInicial" => "307" "paginaFinal" => "315" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15290202" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0060" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Magnetic resonance imaging in the diagnosis and staging of renal and perirenal neoplasms" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "H. Hricak" 1 => "B.E. Demas" 2 => "R.D. Williams" 3 => "M.T. McNamara" 4 => "M.W. Hedgcock" 5 => "E.G. Amparo" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1148/radiology.154.3.3969475" "Revista" => array:7 [ "tituloSerie" => "Radiology" "fecha" => "1985" "volumen" => "154" "numero" => "3" "paginaInicial" => "709" "paginaFinal" => "715" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3969475" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0065" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Impact of imaging and thrombus level in management of renal cell carcinoma extending to veins" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "N.P. Gupta" 1 => "M.S. Ansari" 2 => "A. Khaitan" 3 => "M.S. Sivaramakrishna" 4 => "A.K. Hemal" 5 => "P.N. Dogra" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1159/000075966" "Revista" => array:7 [ "tituloSerie" => "Urol Int" "fecha" => "2004" "volumen" => "72" "numero" => "2" "paginaInicial" => "129" "paginaFinal" => "134" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14963353" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0070" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The WHO histological classification of urinary bladder tumours" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "L.H. Sobin" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Urol Res" "fecha" => "1978" "volumen" => "6" "numero" => "4" "paginaInicial" => "193" "paginaFinal" => "195" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/741530" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0075" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Multiinstitutional European validation of the 2002 TNM staging system in conventional and papillary localized renal cell carcinoma" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "V. Ficarra" 1 => "L. Schips" 2 => "F. Guillè" 3 => "G. Li" 4 => "A. De La Taille" 5 => "T. Prayer Galetti" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/cncr.21254" "Revista" => array:7 [ "tituloSerie" => "Cancer" "fecha" => "2005" "volumen" => "104" "numero" => "5" "paginaInicial" => "968" "paginaFinal" => "974" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16007683" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0080" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Is renal sinus fat invasion the same as perinephric fat invasion for pT3a renal cell carcinoma?" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R.H. Thompson" 1 => "B.C. Leibovich" 2 => "J.C. Cheville" 3 => "W.S. Webster" 4 => "C.M. Lohse" 5 => "E.D. Kwon" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "J Urol" "fecha" => "2005" "volumen" => "174" "numero" => "4 Pt 1" "paginaInicial" => "1218" "paginaFinal" => "1222" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16145373" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0085" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "TNM T3a renal cell carcinoma: adrenal gland involvement is not the same as renal fat invasion" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "K.R. Han" 1 => "M.H. Bui" 2 => "A.J. Pantuck" 3 => "D.G. Freitas" 4 => "B.C. Leibovich" 5 => "F.J. Dorey" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/01.ju.0000051480.62175.35" "Revista" => array:7 [ "tituloSerie" => "J Urol" "fecha" => "2003" "volumen" => "169" "numero" => "3" "paginaInicial" => "899" "paginaFinal" => "903" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12576809" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0090" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Reassessing the current TNM lymph node staging for renal cell carcinoma" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C. Terrone" 1 => "C. Cracco" 2 => "F. Porpiglia" 3 => "E. Bollito" 4 => "C. Scoffone" 5 => "M. Poggio" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.eururo.2005.11.014" "Revista" => array:7 [ "tituloSerie" => "Eur Urol" "fecha" => "2006" "volumen" => "49" "numero" => "2" "paginaInicial" => "324" "paginaFinal" => "331" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16386352" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0095" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pathology and genetics of tumours of the urinary system and male genital organs" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J.N. Eble" 1 => "G. Sauter" 2 => "J.I. Epstein" 3 => "I.A. Sesterhenn" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:3 [ "fecha" => "2004" "editorial" => "IARC Press" "editorialLocalizacion" => "France" ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0100" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Morphologic typing of papillary renal cell carcinoma: comparison of growth kinetics and patient survival in 66 cases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "B. Delahunt" 1 => "J.N. Eble" 2 => "M.R. McCredie" 3 => "P.B. Bethwaite" 4 => "J.H. Stewart" 5 => "A.M. Bilous" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1053/hupa.2001.24984" "Revista" => array:7 [ "tituloSerie" => "Hum Pathol" "fecha" => "2001" "volumen" => "32" "numero" => "6" "paginaInicial" => "590" "paginaFinal" => "595" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11431713" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib0105" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Gene expression profiling predicts survival in conventional renal cell carcinoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "H. Zhao" 1 => "B. Ljungberg" 2 => "K. Grankvist" 3 => "T. Rasmuson" 4 => "R. Tibshirani" 5 => "J.D. Brooks" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1371/journal.pmed.0030013" "Revista" => array:6 [ "tituloSerie" => "PLoS Med" "fecha" => "2006" "volumen" => "3" "numero" => "1" "paginaInicial" => "e13" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16318415" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib0110" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The results of radical nephrectomy for renal cell carcinoma. 1969" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "C.J. Robson" 1 => "B.M. Churchill" 2 => "W. Anderson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "J Urol" "fecha" => "2002" "volumen" => "67" "numero" => "2 Pt 2" "paginaInicial" => "873" "paginaFinal" => "875" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14939407" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib0115" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The need for routine adrenalectomy during surgical treatment for renal cell cancer: the Hannover experience" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Kuczyk" 1 => "T. Münch" 2 => "S. Machtens" 3 => "C. Bokemeyer" 4 => "A. Wefer" 5 => "J. Hartmann" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "BJU Int" "fecha" => "2002" "volumen" => "89" "numero" => "6" "paginaInicial" => "517" "paginaFinal" => "522" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11942955" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib0120" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The therapeutic value of adrenalectomy in case of solitary metastatic spread originating from primary renal cell cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M. Kuczyk" 1 => "G. Wegener" 2 => "U. Jonas" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.eururo.2005.04.004" "Revista" => array:7 [ "tituloSerie" => "Eur Urol" "fecha" => "2005" "volumen" => "48" "numero" => "2" "paginaInicial" => "252" "paginaFinal" => "257" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15936136" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib0125" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Long-term followup after surgical treatment for renal cell carcinoma extending into the right atrium" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A.A. Glazer" 1 => "A.C. Novick" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "J Urol" "fecha" => "1996" "volumen" => "155" "numero" => "2" "paginaInicial" => "448" "paginaFinal" => "450" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8558632" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib0130" "etiqueta" => "26." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The role of transarterial embolization in the treatment of renal cell carcinoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "N.P. Munro" 1 => "S. Woodhams" 2 => "J.D. Nawrocki" 3 => "M.S. Fletcher" 4 => "P.J. Thomas" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "BJU Int" "fecha" => "2003" "volumen" => "92" "numero" => "3" "paginaInicial" => "240" "paginaFinal" => "244" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12887475" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib0135" "etiqueta" => "27." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Nephron sparing surgery for localized renal cell carcinoma: impact of tumor size on patient survival, tumor recurrence and TNM staging" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "K.S. Hafez" 1 => "A.F. Fergany" 2 => "A.C. Novick" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:8 [ "tituloSerie" => "J Urol" "fecha" => "1999" "volumen" => "162" "numero" => "6" "paginaInicial" => "1930" "paginaFinal" => "1933" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10569540" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0213005X11003600" "estado" => "S300" "issn" => "0213005X" ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib0140" "etiqueta" => "28." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Partial nephrectomy for renal cortical tumors:pathologic findings and impact on outcome" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J. McKiernan" 1 => "O. Yossepowitch" 2 => "M.W. Kattan" 3 => "R. Simmons" 4 => "R.J. Motzer" 5 => "V.E. Reuter" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Urology" "fecha" => "2002" "volumen" => "60" "numero" => "6" "paginaInicial" => "1003" "paginaFinal" => "1009" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12475658" "web" => "Medline" ] ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib0145" "etiqueta" => "29." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Exploring the learning curve, pathological outcomes and perioperative morbidity of laparoscopic partial nephrectomy performed for renal mass" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R.E. Link" 1 => "S.B. Bhayani" 2 => "M.E. Allaf" 3 => "I. Varkarakis" 4 => "T. Inagaki" 5 => "C. Rogers" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/01.ju.0000154777.24753.1b" "Revista" => array:7 [ "tituloSerie" => "J Urol" "fecha" => "2005" "volumen" => "173" "numero" => "5" "paginaInicial" => "1690" "paginaFinal" => "1694" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15821559" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib0150" "etiqueta" => "30." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Laparoscopic and partial nephrectomy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "A.C. Novick" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1158/1078-0432.CCR-050003" "Revista" => array:7 [ "tituloSerie" => "Clin Cancer Res" "fecha" => "2004" "volumen" => "10" "numero" => "18 Pt 2" "paginaInicial" => "6322S" "paginaFinal" => "6327S" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15448025" "web" => "Medline" ] ] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib0155" "etiqueta" => "31." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Elective nephron sparing surgery should become standard treatment for small unilateral renal cell carcinoma: Long-term survival data of 216 patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "F. Becker" 1 => "S. Siemer" 2 => "U. Humke" 3 => "M. Hack" 4 => "M. Ziegler" 5 => "M. Stöckle" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.eururo.2005.10.020" "Revista" => array:7 [ "tituloSerie" => "Eur Urol" "fecha" => "2006" "volumen" => "49" "numero" => "2" "paginaInicial" => "308" "paginaFinal" => "313" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16359779" "web" => "Medline" ] ] ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib0160" "etiqueta" => "32." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Laparoscopic radical nephrectomy for renal cell carcinoma: the standard of care already?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "Y. Ono" 1 => "R. Hattori" 2 => "M. Gotoh" 3 => "Y. Yoshino" 4 => "Y. Yoshikawa" 5 => "O. Kamihira" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Curr Opin Urol" "fecha" => "2005" "volumen" => "15" "numero" => "2" "paginaInicial" => "75" "paginaFinal" => "78" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15725928" "web" => "Medline" ] ] ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bib0165" "etiqueta" => "33." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Outcome of laparoscopic radical and open partial nephrectomy for the sporadic 4 cm. or less renal tumor with a normal contralateral kidney" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "S.F. Matin" 1 => "I.S. Gill" 2 => "S. Worley" 3 => "A.C. Novick" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/01.ju.0000025392.88454.47" "Revista" => array:7 [ "tituloSerie" => "J Urol" "fecha" => "2002" "volumen" => "168" "numero" => "4 Pt 1" "paginaInicial" => "1356" "paginaFinal" => "1359" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12352392" "web" => "Medline" ] ] ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bib0170" "etiqueta" => "34." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Phase II clinical trial of interactive MR imaging-guided interstitial radiofrequency thermal ablation of primary kidney tumors: initial experience" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.S. Lewin" 1 => "S.G. Nour" 2 => "C.F. Connell" 3 => "A. Sulman" 4 => "J.L. Duerk" 5 => "M.I. Resnick" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1148/radiol.2323021351" "Revista" => array:7 [ "tituloSerie" => "Radiology" "fecha" => "2004" "volumen" => "232" "numero" => "3" "paginaInicial" => "835" "paginaFinal" => "845" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15333798" "web" => "Medline" ] ] ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bib0175" "etiqueta" => "35." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Renal cryoablation: outcome at 3 years" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "I.S. Gill" 1 => "E.M. Remer" 2 => "W.A. Hasan" 3 => "B. Strzempkowski" 4 => "M. Spaliviero" 5 => "A.P. Steinberg" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/01.ju.0000158154.28845.c9" "Revista" => array:7 [ "tituloSerie" => "J Urol" "fecha" => "2005" "volumen" => "173" "numero" => "6" "paginaInicial" => "1903" "paginaFinal" => "1907" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15879772" "web" => "Medline" ] ] ] ] ] ] ] ] 35 => array:3 [ "identificador" => "bib0180" "etiqueta" => "36." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Adjuvant autologous renal tumour cell vaccine and risk of tumour progression in patients with renalcell carcinoma after radical nephrectomy: phase III, randomised controlled trial" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "D. Jocham" 1 => "A. Richter" 2 => "L. Hoffmann" 3 => "K. Iwig" 4 => "D. Fahlenkamp" 5 => "G. Zakrzewski" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0140-6736(04)15590-6" "Revista" => array:7 [ "tituloSerie" => "Lancet" "fecha" => "2004" "volumen" => "363" "numero" => "9409" "paginaInicial" => "594" "paginaFinal" => "599" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14987883" "web" => "Medline" ] ] ] ] ] ] ] ] 36 => array:3 [ "identificador" => "bib0185" "etiqueta" => "37." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cytoreductive nephrectomy in patients with metastatic renal cancer: a combined analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "R.C. Flanigan" 1 => "G. Mickisch" 2 => "R. Sylvester" 3 => "C. Tangen" 4 => "H. Van Poppel" 5 => "E.D. Crawford" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/01.ju.0000110610.61545.ae" "Revista" => array:7 [ "tituloSerie" => "J Urol" "fecha" => "2004" "volumen" => "171" "numero" => "3" "paginaInicial" => "1071" "paginaFinal" => "1076" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14767273" "web" => "Medline" ] ] ] ] ] ] ] ] 37 => array:3 [ "identificador" => "bib0190" "etiqueta" => "38." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Factors of importance for prediction of survival in patients with metastatic renal cell carcinoma, treated with or without nephrectomy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "B. Ljungberg" 1 => "G. Landberg" 2 => "F.I. Alamdari" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Scand J Urol Nephrol" "fecha" => "2000" "volumen" => "34" "numero" => "4" "paginaInicial" => "246" "paginaFinal" => "251" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11095082" "web" => "Medline" ] ] ] ] ] ] ] ] 38 => array:3 [ "identificador" => "bib0195" "etiqueta" => "39." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Metastasectomy in renal cell carcinoma: A multicenter retrospective analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "H.G. Van der Poel" 1 => "J.A. Roukema" 2 => "S. Horenblas" 3 => "A.N. van Geel" 4 => "F.M. Debruyne" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "19849" "Revista" => array:7 [ "tituloSerie" => "Eur Urol" "fecha" => "1999" "volumen" => "35" "numero" => "3" "paginaInicial" => "197" "paginaFinal" => "203" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10072620" "web" => "Medline" ] ] ] ] ] ] ] ] 39 => array:3 [ "identificador" => "bib0200" "etiqueta" => "40." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Radiotherapy of metastases from renal cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "S.D. Fosså" 1 => "I. Kjølseth" 2 => "G. Lund" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Eur Urol" "fecha" => "1982" "volumen" => "8" "numero" => "6" "paginaInicial" => "340" "paginaFinal" => "342" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6183119" "web" => "Medline" ] ] ] ] ] ] ] ] 40 => array:3 [ "identificador" => "bib0205" "etiqueta" => "41." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: phase III results of the RTOG 9508 randomised trial" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "D.W. Andrews" 1 => "C.B. Scott" 2 => "P.W. Sperduto" 3 => "A.E. Flanders" 4 => "L.E. Gaspar" 5 => "M.C. Schell" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0140-6736(04)16250-8" "Revista" => array:7 [ "tituloSerie" => "Lancet" "fecha" => "2004" "volumen" => "363" "numero" => "9422" "paginaInicial" => "1665" "paginaFinal" => "1672" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15158627" "web" => "Medline" ] ] ] ] ] ] ] ] 41 => array:3 [ "identificador" => "bib0210" "etiqueta" => "42." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Resection of metastatic renal cell carcinoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J.P. Kavolius" 1 => "D.P. Mastorakos" 2 => "C. Pavlovich" 3 => "P. Russo" 4 => "M.E. Burt" 5 => "M.S. Brady" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Clin Oncol" "fecha" => "1998" "volumen" => "16" "numero" => "6" "paginaInicial" => "2226" "paginaFinal" => "2266" ] ] ] ] ] ] 42 => array:3 [ "identificador" => "bib0215" "etiqueta" => "43." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prognostic factors for survival with gemcitabine plus 5- fluorouracil based regimens for metastatic renal cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "W.M. Stadler" 1 => "D. Huo" 2 => "C. George" 3 => "X. Yang" 4 => "C.W. Ryan" 5 => "T. Karrison" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/01.ju.0000086829.74971.4a" "Revista" => array:7 [ "tituloSerie" => "J Urol" "fecha" => "2003" "volumen" => "170" "numero" => "4 Pt 1" "paginaInicial" => "1141" "paginaFinal" => "1145" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14501711" "web" => "Medline" ] ] ] ] ] ] ] ] 43 => array:3 [ "identificador" => "bib0220" "etiqueta" => "44." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "titulo" => "Interferon-alpha and survival in metastatic renal carcinoma: early results of a randomised controlled trial. Medical Research Council Renal Cancer Collaborators" ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "1999" "numero" => "353" "paginaInicial" => "14" "paginaFinal" => "17" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12853194" "web" => "Medline" ] ] ] ] ] ] ] ] 44 => array:3 [ "identificador" => "bib0225" "etiqueta" => "45." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prospective randomized trial of high-dose interleukin- 2 alone or in conjunction with lymphokine-activated killer cells for the treatment of patients with advanced cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:11 [ 0 => "S.A. Rosenberg" 1 => "M.T. Lotze" 2 => "J.C. Yang" 3 => "S.L. Topalian" 4 => "A.E. Chang" 5 => "D.J. Schwartzentruber" 6 => "P. Aebersold" 7 => "S. Leitman" 8 => "W.M. Linehan" 9 => "C.A. Seipp" 10 => "a.l. et" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "JNatl Cancer Inst" "fecha" => "1993" "volumen" => "85" "numero" => "8" "paginaInicial" => "622" "paginaFinal" => "632" ] ] ] ] ] ] 45 => array:3 [ "identificador" => "bib0230" "etiqueta" => "46." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Results of treatment of 255 patients with metastatic renal cell carcinoma who received high-dose recombinant interleukin- 2 therapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "G. Fyfe" 1 => "R.I. Fisher" 2 => "S.A. Rosenberg" 3 => "M. Sznol" 4 => "D.R. Parkinson" 5 => "A.C. Louie" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1200/jco.1995.13.3.688" "Revista" => array:7 [ "tituloSerie" => "J Clin Oncol" "fecha" => "1995" "volumen" => "13" "numero" => "3" "paginaInicial" => "688" "paginaFinal" => "696" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7884429" "web" => "Medline" ] ] ] ] ] ] ] ] 46 => array:3 [ "identificador" => "bib0235" "etiqueta" => "47." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Randomized phase III trial of highdose interleukin-2 versus subcutaneous interleukin-2 and interferon in patients with metastatic renal cell carcinoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:18 [ 0 => "D.F. McDermott" 1 => "M.M. Regan" 2 => "J.I. Clark" 3 => "L.E. Flaherty" 4 => "G.R. Weiss" 5 => "T.F. Logan" 6 => "J.M. Kirkwood" 7 => "M.S. Gordon" 8 => "J.A. Sosman" 9 => "M.S. Ernstoff" 10 => "C.P. Tretter" 11 => "W.J. Urba" 12 => "J.W. Smith" 13 => "K.A. Margolin" 14 => "J.W. Mier" 15 => "J.A. Gollob" 16 => "J.P. Dutcher" 17 => "M.B. Atkins" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1200/JCO.2005.03.206" "Revista" => array:7 [ "tituloSerie" => "J Clin Oncol" "fecha" => "2005" "volumen" => "23" "numero" => "1" "paginaInicial" => "133" "paginaFinal" => "141" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15625368" "web" => "Medline" ] ] ] ] ] ] ] ] 47 => array:3 [ "identificador" => "bib0240" "etiqueta" => "48." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Randomized study of high-dose and low-dose interleukin-2 in patients with metastatic renal cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:13 [ 0 => "J.C. Yang" 1 => "R.M. Sherry" 2 => "S.M. Steinberg" 3 => "S.L. Topalian" 4 => "D.J. Schwartzentruber" 5 => "P. Hwu" 6 => "C.A. Seipp" 7 => "L. Rogers-Freezer" 8 => "K.E. Morton" 9 => "D.E. White" 10 => "D.J. Liewehr" 11 => "M.J. Merino" 12 => "S.A. Rosenberg" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1200/JCO.2003.02.122" "Revista" => array:7 [ "tituloSerie" => "J Clin Oncol" "fecha" => "2003" "volumen" => "21" "numero" => "16" "paginaInicial" => "3127" "paginaFinal" => "3132" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12915604" "web" => "Medline" ] ] ] ] ] ] ] ] 48 => array:3 [ "identificador" => "bib0245" "etiqueta" => "49." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Recombinant human interleukin-2, recombinant human interferon alfa-2a, or both in metastatic renalcell carcinoma. Groupe Francais d’Immunotherapie" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:12 [ 0 => "S. Negrier" 1 => "B. Escudier" 2 => "C. Lasset" 3 => "J.Y. Douillard" 4 => "J. Savary" 5 => "C. Chevreau" 6 => "A. Ravaud" 7 => "A. Mercatello" 8 => "J. Peny" 9 => "M. Mousseau" 10 => "T. Philip" 11 => "T. Tursz" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM199804303381805" "Revista" => array:7 [ "tituloSerie" => "N Engl J Med" "fecha" => "1998" "volumen" => "338" "numero" => "18" "paginaInicial" => "1272" "paginaFinal" => "1278" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9562581" "web" => "Medline" ] ] ] ] ] ] ] ] 49 => array:3 [ "identificador" => "bib0250" "etiqueta" => "50." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Randomized phase II/III trial of interferon Alfa-2a with and without 3-cis-retinoic acid in patients with progressive metastatic renal cell Carcinoma: the European Organisation for Research and Treatment of Cancer Genito-Urinary Tract Cancer Group (EORTC 3095)" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:9 [ 0 => "N. Aass" 1 => "P.H. De Mulder" 2 => "G.H. Mickisch" 3 => "P. Mulders" 4 => "A.T. van Oosterom" 5 => "H. van Poppel" 6 => "S.D. Fossa" 7 => "L. de Prijck" 8 => "R.J. Sylvester" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1200/JCO.2005.07.114" "Revista" => array:7 [ "tituloSerie" => "J Clin Oncol" "fecha" => "2005" "volumen" => "23" "numero" => "18" "paginaInicial" => "4172" "paginaFinal" => "4178" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15961764" "web" => "Medline" ] ] ] ] ] ] ] ] 50 => array:3 [ "identificador" => "bib0255" "etiqueta" => "51." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "IL-2 in combination with IFN- alpha and 5-FU versus tamoxifen in metastatic renal cell carcinoma: long-term results of a controlled randomized clinical trial" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:12 [ 0 => "J. Atzpodien" 1 => "H. Kirchner" 2 => "H.J. Illiger" 3 => "B. Metzner" 4 => "D. Ukena" 5 => "H. Schott" 6 => "P.J. Funke" 7 => "M. Gramatzki" 8 => "S. Jürgenson" 9 => "T. Wandert" 10 => "T. Patzelt" 11 => "M. Reitz" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1054/bjoc.2001.2076" "Revista" => array:7 [ "tituloSerie" => "Br J Cancer" "fecha" => "2001" "volumen" => "85" "numero" => "8" "paginaInicial" => "1130" "paginaFinal" => "1136" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11710825" "web" => "Medline" ] ] ] ] ] ] ] ] 51 => array:3 [ "identificador" => "bib0260" "etiqueta" => "52." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Understanding the importance of smart drugs in renal cell carcinoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J.J. Patard" 1 => "N. Rioux-Leclercq" 2 => "P. Fergelot" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.eururo.2006.01.016" "Revista" => array:7 [ "tituloSerie" => "Eur Urol" "fecha" => "2006" "volumen" => "49" "numero" => "4" "paginaInicial" => "633" "paginaFinal" => "643" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16481093" "web" => "Medline" ] ] ] ] ] ] ] ] 52 => array:3 [ "identificador" => "bib0265" "etiqueta" => "53." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Targeting von Hippel-Lindau pathway in renal cell carcinoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "P.H. Patel" 1 => "R.S. Chadalavada" 2 => "R.S. Chaganti" 3 => "R.J. Motzer" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Cancer Res" "fecha" => "2006" "volumen" => "12" "numero" => "24" "paginaInicial" => "7120" "paginaFinal" => "7215" ] ] ] ] ] ] 53 => array:3 [ "identificador" => "bib0270" "etiqueta" => "54." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "TARGET Study Group. Sorafenib in advanced clear-cell renal-cell carcinoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:19 [ 0 => "B. Escudier" 1 => "T. Eisen" 2 => "W.M. Stadler" 3 => "C. Szczylik" 4 => "S. Oudard" 5 => "M. Siebels" 6 => "S. Negrier" 7 => "C. Chevreau" 8 => "E. Solska" 9 => "A.A. Desai" 10 => "F. Rolland" 11 => "T. Demkow" 12 => "T.E. Hutson" 13 => "M. Gore" 14 => "S. Freeman" 15 => "B. Schwartz" 16 => "M. Shan" 17 => "R. Simantov" 18 => "R.M. Bukowski" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMoa060655" "Revista" => array:7 [ "tituloSerie" => "N Engl J Med" "fecha" => "2007" "volumen" => "356" "numero" => "2" "paginaInicial" => "125" "paginaFinal" => "134" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17215530" "web" => "Medline" ] ] ] ] ] ] ] ] 54 => array:3 [ "identificador" => "bib0275" "etiqueta" => "55." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sunitinib in patients with metastatic renal cell carcinoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:15 [ 0 => "R.J. Motzer" 1 => "B.I. Rini" 2 => "R.M. Bukowski" 3 => "B.D. Curti" 4 => "D.J. George" 5 => "G.R. Hudes" 6 => "B.G. Redman" 7 => "K.A. Margolin" 8 => "J.R. Merchan" 9 => "G. Wilding" 10 => "M.S. Ginsberg" 11 => "J. Bacik" 12 => "S.T. Kim" 13 => "C.M. Baum" 14 => "M.D. Michaelson" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1001/jama.295.21.2516" "Revista" => array:7 [ "tituloSerie" => "JAMA" "fecha" => "2006" "volumen" => "295" "numero" => "21" "paginaInicial" => "2516" "paginaFinal" => "2524" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16757724" "web" => "Medline" ] ] ] ] ] ] ] ] 55 => array:3 [ "identificador" => "bib0280" "etiqueta" => "56." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:15 [ 0 => "R.J. Motzer" 1 => "M.D. Michaelson" 2 => "B.G. Redman" 3 => "G.R. Hudes" 4 => "G. Wilding" 5 => "R.A. Figlin" 6 => "M.S. Ginsberg" 7 => "S.T. Kim" 8 => "C.M. Baum" 9 => "S.E. DePrimo" 10 => "J.Z. Li" 11 => "C.L. Bello" 12 => "C.P. Theuer" 13 => "D.J. George" 14 => "B.I. Rini" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1200/JCO.2005.02.2574" "Revista" => array:7 [ "tituloSerie" => "J Clin Oncol" "fecha" => "2006" "volumen" => "24" "numero" => "1" "paginaInicial" => "16" "paginaFinal" => "24" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16330672" "web" => "Medline" ] ] ] ] ] ] ] ] 56 => array:3 [ "identificador" => "bib0285" "etiqueta" => "57." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sunitinib versus interferon alfa in metastatic renal-cell carcinoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:14 [ 0 => "R.J. Motzer" 1 => "T.E. Hutson" 2 => "P. Tomczak" 3 => "M.D. Michaelson" 4 => "R.M. Bukowski" 5 => "O. Rixe" 6 => "S. Oudard" 7 => "S. Negrier" 8 => "C. Szczylik" 9 => "S.T. Kim" 10 => "I. Chen" 11 => "P.W. Bycott" 12 => "C.M. Baum" 13 => "R.A. Figlin" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMoa065044" "Revista" => array:7 [ "tituloSerie" => "N Engl J Med" "fecha" => "2007" "volumen" => "356" "numero" => "2" "paginaInicial" => "115" "paginaFinal" => "124" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17215529" "web" => "Medline" ] ] ] ] ] ] ] ] 57 => array:3 [ "identificador" => "bib0290" "etiqueta" => "58." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A phase 3 randomized, 3-arm study of temsirolimus (TEMSR) or interferon-alpha (IFN) or the combination of TEMSR + IFN in the treatment of firstline, poor-risk patients with advanced renal cell carcinoma (adv RCC" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "G. Hudes" 1 => "M. Carducci" 2 => "P. Tomczak" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "J Clin Oncol (Meeting Abstracts)" "fecha" => "2006" "volumen" => "24" "paginaInicial" => "LBA4" ] ] ] ] ] ] 58 => array:3 [ "identificador" => "bib0295" "etiqueta" => "59." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Renal cell carcinoma 2005. new frontiers in staging, prognostication and targeted molecular therapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J.S. Lam" 1 => "O. Shvarts" 2 => "J.T. Leppert" 3 => "R.A. Figlin" 4 => "A.S. Belldegrun" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/01.ju.0000165693.68449.c3" "Revista" => array:7 [ "tituloSerie" => "J Urol" "fecha" => "2005" "volumen" => "173" "numero" => "6" "paginaInicial" => "1853" "paginaFinal" => "1862" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15879764" "web" => "Medline" ] ] ] ] ] ] ] ] 59 => array:3 [ "identificador" => "bib0300" "etiqueta" => "60." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Safety and efficacy of partial nephrectomy for all T tumors based on an international multicenter experience" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J.J. Patard" 1 => "O. Shvarts" 2 => "J.S. Lam" 3 => "A.J. Pantuck" 4 => "H.L. Kim" 5 => "V. Ficarra" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "J Urol" "fecha" => "2004" "volumen" => "171" "numero" => "6 Pt 1" "paginaInicial" => "2181" "paginaFinal" => "2435" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15126781" "web" => "Medline" ] ] ] ] ] ] ] ] 60 => array:3 [ "identificador" => "bib0305" "etiqueta" => "61." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Follow-up guidelines for nonmetastatic renal cell carcinoma based on the occurrence of metastases after radical nephrectomy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "B. Ljungberg" 1 => "F.I. Alamdari" 2 => "T. Rasmuson" 3 => "G. Roos" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:8 [ "tituloSerie" => "BJU Int" "fecha" => "1999" "volumen" => "84" "numero" => "4" "paginaInicial" => "405" "paginaFinal" => "411" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10468753" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0091674912002540" "estado" => "S300" "issn" => "00916749" ] ] ] ] ] ] ] 61 => array:3 [ "identificador" => "bib0310" "etiqueta" => "62." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A postoperative prognostic nomogram for renal cell carcinoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M.W. Kattan" 1 => "V. Reuter" 2 => "R.J. Motzer" 3 => "J. Katz" 4 => "P. Russo" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "J Urol" "fecha" => "2001" "volumen" => "166" "numero" => "1" "paginaInicial" => "63" "paginaFinal" => "67" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11435824" "web" => "Medline" ] ] ] ] ] ] ] ] 62 => array:3 [ "identificador" => "bib0315" "etiqueta" => "63." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Postoperative surveillance protocol for patients with localized and locally advanced renal cell carcinoma based on a validated prognostic nomogram and risk group stratification system" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.S. Lam" 1 => "O. Shvarts" 2 => "J.T. Leppert" 3 => "A.J. Pantuck" 4 => "R.A. Figlin" 5 => "A.S. Belldegrun" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/01.ju.0000165572.38887.da" "Revista" => array:7 [ "tituloSerie" => "J Urol" "fecha" => "2005" "volumen" => "174" "numero" => "2" "paginaInicial" => "466" "paginaFinal" => "472" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16006866" "web" => "Medline" ] ] ] ] ] ] ] ] 63 => array:3 [ "identificador" => "bib0320" "etiqueta" => "64." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prediction of progression after radical nephrectomy for patients with clear cell renal cell carcinoma: a stratification tool for prospective clinical trials" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "B.C. Leibovich" 1 => "M.L. Blute" 2 => "J.C. Cheville" 3 => "C.M. Lohse" 4 => "I. Frank" 5 => "E.D. Kwon" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/cncr.11234" "Revista" => array:7 [ "tituloSerie" => "Cancer" "fecha" => "2003" "volumen" => "97" "numero" => "7" "paginaInicial" => "1663" "paginaFinal" => "1671" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12655523" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/02104806/0000003300000003/v1_201304251925/S0210480609741403/v1_201304251925/es/main.assets" "Apartado" => array:4 [ "identificador" => "6502" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Revisión" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/02104806/0000003300000003/v1_201304251925/S0210480609741403/v1_201304251925/es/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210480609741403?idApp=UINPBA00004N" "pdfAlternativo" => array:1 [ 0 => array:3 [ "idioma" => "en" "documentoPdf" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/file/02104806/addon/S0210480609741403/S300/en/292v33n03a13143296pdf001_2.pdf" "portada" => "292v33n03a13143296pdf001_2.png" ] ] ]
