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array:24 [ "pii" => "S0210480609742263" "issn" => "02104806" "doi" => "10.1016/S0210-4806(09)74226-3" "estado" => "S300" "fechaPublicacion" => "2009-01-01" "aid" => "74226" "copyright" => "Asociación Española de Urología (AEU)" "copyrightAnyo" => "2009" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Urol Esp. 2009;33:747-54" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1818 "formatos" => array:3 [ "EPUB" => 7 "HTML" => 962 "PDF" => 849 ] ] "itemSiguiente" => array:18 [ "pii" => "S0210480609742275" "issn" => "02104806" "doi" => "10.1016/S0210-4806(09)74227-5" "estado" => "S300" "fechaPublicacion" => "2009-01-01" "aid" => "74227" "copyright" => "Asociación Española de Urología (AEU)" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Urol Esp. 2009;33:755-8" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1521 "formatos" => array:3 [ "EPUB" => 6 "HTML" => 738 "PDF" => 777 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Nefrectomía radical laparoscópica en piezas quirúrgicas de gran tamaño" "tienePdf" => array:2 [ 0 => "es" 1 => "en" ] "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "755" "paginaFinal" => "758" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Laparoscopic radial nephrectomy in big surgical specimens" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:2 [ "es" => true "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Sergio Alonso, Gregorio, S. Sánchez, C. Soler, A. Rando, M. Girón, J. Ángel Tabernero Gómez, A. Aguilera, Jesús Cisneros Ledo, Javier de la Peña Barthel" "autores" => array:10 [ 0 => array:2 [ "nombre" => "Sergio" "apellidos" => "Alonso" ] 1 => array:1 [ "apellidos" => "Gregorio" ] 2 => array:2 [ "nombre" => "S." "apellidos" => "Sánchez" ] 3 => array:2 [ "nombre" => "C." "apellidos" => "Soler" ] 4 => array:2 [ "nombre" => "A." "apellidos" => "Rando" ] 5 => array:2 [ "nombre" => "M." "apellidos" => "Girón" ] 6 => array:2 [ "nombre" => "J." "apellidos" => "Ángel Tabernero Gómez" ] 7 => array:2 [ "nombre" => "A." "apellidos" => "Aguilera" ] 8 => array:2 [ "nombre" => "Jesús" "apellidos" => "Cisneros Ledo" ] 9 => array:2 [ "nombre" => "Javier" "apellidos" => "de la Peña Barthel" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210480609742275?idApp=UINPBA00004N" "url" => "/02104806/0000003300000007/v1_201304251940/S0210480609742275/v1_201304251940/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0210480609742251" "issn" => "02104806" "doi" => "10.1016/S0210-4806(09)74225-1" "estado" => "S300" "fechaPublicacion" => "2009-01-01" "aid" => "74225" "copyright" => "Asociación Española de Urología (AEU)" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Urol Esp. 2009;33:741-6" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1819 "formatos" => array:3 [ "EPUB" => 8 "HTML" => 903 "PDF" => 908 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "El índice de masa corporal y la dieta afectan el desarrollo del cáncer de próstata" "tienePdf" => array:2 [ 0 => "es" 1 => "en" ] "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "741" "paginaFinal" => "746" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Body mass index and diet affect prostate cancer development" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:2 [ "es" => true "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Constanza M. López Fontana, Gabriela M. Recalde Rincón, Diego. Messina Lombino, Ana L. Uvilla Recupero, Rafael F. Pérez Elizalde, José D. López Laur" "autores" => array:6 [ 0 => array:2 [ "nombre" => "Constanza M." "apellidos" => "López Fontana" ] 1 => array:2 [ "nombre" => "Gabriela M." "apellidos" => "Recalde Rincón" ] 2 => array:2 [ "nombre" => "Diego." "apellidos" => "Messina Lombino" ] 3 => array:2 [ "nombre" => "Ana L." "apellidos" => "Uvilla Recupero" ] 4 => array:2 [ "nombre" => "Rafael F." "apellidos" => "Pérez Elizalde" ] 5 => array:2 [ "nombre" => "José D." "apellidos" => "López Laur" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210480609742251?idApp=UINPBA00004N" "url" => "/02104806/0000003300000007/v1_201304251940/S0210480609742251/v1_201304251940/es/main.assets" ] "es" => array:12 [ "idiomaDefecto" => true "titulo" => "Hipogonadismo prolongado tras la suspensión de tratamiento hormonal en pacientes con cáncer de próstata" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "747" "paginaFinal" => "754" ] ] "autores" => array:2 [ 0 => array:4 [ "autoresLista" => "I. Federico Rodríguez-Rubio Cortadellas, Miguel E. Jiménez Romero, Delfín González Moreno, Sofía Garrido Insúa" "autores" => array:4 [ 0 => array:4 [ "nombre" => "I." "apellidos" => "Federico Rodríguez-Rubio Cortadellas" "email" => array:1 [ 0 => "frubio@pulso.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "Miguel E." "apellidos" => "Jiménez Romero" ] 2 => array:2 [ "nombre" => "Delfín" "apellidos" => "González Moreno" ] 3 => array:2 [ "nombre" => "Sofía" "apellidos" => "Garrido Insúa" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Área de Medicina Preventiva. Facultad de Medicina. Universidad de Cádiz, España" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "**" "correspondencia" => "Correspondencia autor: Dr. Federico I. Rodríguez-Rubio Cortadellas Servicio de Urología. Hospital Universitario Puerto Real Carretera Nacional IV, Km 665 - 11510 Puerto Real, Cádiz Tel.: 956 005 000" ] ] ] 1 => array:3 [ "autoresLista" => "José P. Novalbos Ruiz" "autores" => array:1 [ 0 => array:3 [ "nombre" => "José P." "apellidos" => "Novalbos Ruiz" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:3 [ "entidad" => "Servicio de Urología. Hospital Universitario Puerto Real. Departamento de Cirugía. Universidad de Cádiz, España" "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Prolonged hypogonadism after cessation of androgen deprivation therapy for prostate cancer" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec89062" "palabras" => array:5 [ 0 => "Cáncer de próstata" 1 => "Supresión androgénica intermitente" 2 => "Testosterona" 3 => "Antígeno prostático específico" 4 => "Estudio prospectivo" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec89063" "palabras" => array:5 [ 0 => "Prostate cancer" 1 => "Intermittent androgen supression" 2 => "Testosterone" 3 => "Prostate-specific antigen" 4 => "Prospective studies" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Objetivos</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Estudiar los niveles de LH, testosterona y PSA tras suspender el tratamiento prolongado con análogos LH-RH</p> <span class="elsevierStyleSectionTitle">Material y Método</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se estudió la evolución hormonal de 29 pacientes a los que se les retiró el tratamiento. Los pacientes previamente habían seguido tratamiento con análogo LH-RH por más de un año y con LH<2 mUI/mL y testosterona <2,8 ng/mL. Se determinó mensualmente la LH, testosterona y PSA junto con valoración clínica. Se reinicia el tratamiento y el tiempo de seguimiento finaliza ante la presencia de progresión clínica y/o PSA ? 10 ng/mL. Se realizó descripción de la cohorte, el cálculo de supervivencia mediante Kaplan-Meier y regresión de Cox.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">El tiempo medio sin tratamiento de la serie fue de 35 meses (IC 95% 15,7-54,2 meses). El 17% de los pacientes presentaron hipogonadismo prolongado (>24 meses). La recuperación del eje LH-T-PSA, cuando se produjo, siguió la secuencia esperada. Las variables que influyeron en el tiempo de recuperación del PSA fueron el PSA pretratamiento y la asociación de antiandrógeno.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Tras retirar el tratamiento prolongado con análogos LH-RH la mayoría de los pacientes recuperan los niveles de LH-T-PSA si bien un subgrupo se mantienen hipogonádicos más de 24 meses. Palabras clave: Cáncer de próstata. Supresión androgénica intermitente. Testosterona. Antígeno prostático específico. Estudio prospectivo.</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Objectives</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To study the levels of LH, testosterone and PSA after suspending prolonged treatment with LH-RH analogs.</p> <span class="elsevierStyleSectionTitle">Materials and Method</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Hormonal evolution was studied in 29 patients from whom treatment had been withdrawn. The patients had previously been receiving treatment with LH-RH analog for more than one year, and with LH< 2 mUI/mL and testosterone <2.8 ng/mL. LH, testosterone and PSA were determined monthly, together with clinical assessment. The treatment was re-initiated and the period of monitoring ended before the presence of clinical progression and/or PSA ? 10 ng/mL. The cohort was described and survival was calculated using Kaplan-Meier and Cox regression.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">The mean period of time without treatment for the series was 35 months (CI 95%, 15.7-54.2 months). Prolonged hypogonadism (> 24 months) was presented by 17% of the patients. The recovery of the LH-T-PSA axis, when it occurred, followed the expected sequence. The variables that influenced the period of recovery of the PSA were the PSA pretreatment and the association of an antiandrogen.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">After withdrawing the prolonged treatment with LH-RH analogs, most of the patients recovered the levels of LH-T-PSA, although a subgroup remained hypogonadic for more than 24 months.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:30 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." 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