array:23 [ "pii" => "S0210480600724004" "issn" => "02104806" "doi" => "10.1016/S0210-4806(00)72400-4" "estado" => "S300" "fechaPublicacion" => "2000-01-01" "aid" => "72400" "copyright" => "Asociación Española de Urología (AEU)" "copyrightAnyo" => "2000" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Urol Esp. 2000;24:24-30" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 18391 "formatos" => array:3 [ "EPUB" => 13 "HTML" => 17014 "PDF" => 1364 ] ] "itemSiguiente" => array:18 [ "pii" => "S0210480600724016" "issn" => "02104806" "doi" => "10.1016/S0210-4806(00)72401-6" "estado" => "S300" "fechaPublicacion" => "2000-01-01" "aid" => "72401" "copyright" => "Asociación Española de Urología (AEU)" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Urol Esp. 2000;24:31-4" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1223 "formatos" => array:3 [ "EPUB" => 9 "HTML" => 822 "PDF" => 392 ] ] "es" => array:9 [ "idiomaDefecto" => true "titulo" => "Tumores del tracto urinario superior metacrónicos subsiguientes a tumores superficiales primarios de vejiga" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "31" "paginaFinal" => "34" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "A. Ojea calvo, A. Rodríguez alonso, D. Pérez garcía, A. Alonso rodrigo, B. Rodríguez iglesias, J. Benavente delgado, J.M. Barros rodríguez, J.L. Nogueira march" "autores" => array:8 [ 0 => array:2 [ "nombre" => "A." "apellidos" => "Ojea calvo" ] 1 => array:2 [ "nombre" => "A." "apellidos" => "Rodríguez alonso" ] 2 => array:2 [ "nombre" => "D." "apellidos" => "Pérez garcía" ] 3 => array:2 [ "nombre" => "A." "apellidos" => "Alonso rodrigo" ] 4 => array:2 [ "nombre" => "B." "apellidos" => "Rodríguez iglesias" ] 5 => array:2 [ "nombre" => "J." "apellidos" => "Benavente delgado" ] 6 => array:2 [ "nombre" => "J.M." "apellidos" => "Barros rodríguez" ] 7 => array:2 [ "nombre" => "J.L." "apellidos" => "Nogueira march" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210480600724016?idApp=UINPBA00004N" "url" => "/02104806/0000002400000001/v1_201304251601/S0210480600724016/v1_201304251601/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0210480600723990" "issn" => "02104806" "doi" => "10.1016/S0210-4806(00)72399-0" "estado" => "S300" "fechaPublicacion" => "2000-01-01" "aid" => "72399" "copyright" => "Asociación Española de Urología (AEU)" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Urol Esp. 2000;24:19-23" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1585 "formatos" => array:3 [ "EPUB" => 9 "HTML" => 1099 "PDF" => 477 ] ] "es" => array:9 [ "idiomaDefecto" => true "titulo" => "Hematomas renales tras litotricia extracorpórea con el litotriptor “lithostar multiline de siemens”" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "19" "paginaFinal" => "23" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J.A. Gallego sánchez, G. Ibarlucea gonzález, M. Gamarra quintanilla, J. Guisasola, C. Bernuy malfaz" "autores" => array:5 [ 0 => array:2 [ "nombre" => "J.A." "apellidos" => "Gallego sánchez" ] 1 => array:2 [ "nombre" => "G." "apellidos" => "Ibarlucea gonzález" ] 2 => array:2 [ "nombre" => "M." "apellidos" => "Gamarra quintanilla" ] 3 => array:2 [ "nombre" => "J." "apellidos" => "Guisasola" ] 4 => array:2 [ "nombre" => "C." "apellidos" => "Bernuy malfaz" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210480600723990?idApp=UINPBA00004N" "url" => "/02104806/0000002400000001/v1_201304251601/S0210480600723990/v1_201304251601/es/main.assets" ] "es" => array:12 [ "idiomaDefecto" => true "titulo" => "Utilidad del cociente psa libre/psa total en el diagnóstico del cáncer de próstata en pacientes sintomáticos con niveles de psa entre 2,5 y 20 ng/ml" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "24" "paginaFinal" => "30" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "F. Herranz Amo, F. Verdú Tartajo, J.M. Díez Cordero, F. Leal Hernández, A. Bielsa Carrillo, J. García Burgos, D. Subirá Ríos" "autores" => array:7 [ 0 => array:3 [ "nombre" => "F." "apellidos" => "Herranz Amo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "F." "apellidos" => "Verdú Tartajo" ] 2 => array:2 [ "nombre" => "J.M." "apellidos" => "Díez Cordero" ] 3 => array:2 [ "nombre" => "F." "apellidos" => "Leal Hernández" ] 4 => array:2 [ "nombre" => "A." "apellidos" => "Bielsa Carrillo" ] 5 => array:2 [ "nombre" => "J." "apellidos" => "García Burgos" ] 6 => array:2 [ "nombre" => "D." "apellidos" => "Subirá Ríos" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Urología. H.G.U. Gregorio Marañón. Madrid" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "1" "correspondencia" => "Dr. F.Herranz Amo c/ Doctor Esquerdo 155<span class="elsevierStyleSup">a</span>, 7°, 3 28007-Madrid" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "1999-05-13" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec85820" "palabras" => array:4 [ 0 => "Cáncer de próstata" 1 => "Hiperplasia benigna de próstata" 2 => "PSA" 3 => "Cociente PSA libre / PSA total" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec85819" "palabras" => array:4 [ 0 => "Prostate cancer" 1 => "Prostate benign hyperplasia" 2 => "PSA" 3 => "Free PSA/total PSA ratio" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Evaluación de la utilidad del cociente PSA libre / PSA total (PSAl/PSAt) para incrementar la especificidad del PSA total (PSAt), en el diagnóstico del cáncer de próstata en una serie de pacientes sintomáticos.</p> <span class="elsevierStyleSectionTitle">Material Y Método</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Estudio prospectivo sobre 334 pacientes con síntomas compatibles con HBP y PSAt (ProStatusTM, Wallace Oy, Turku, Finland) entre 2,5 y 20 ng/ml, con una edad media de 67,2 ± 7 (49-87). Se dividieron en 3 grupos: Grupo I (tacto rectal normal y PSAt entre 2,5 y 10 ng/ml) - 189 pacientes. Grupo II (tacto rectal normal y PSAt entre 10 y 20 ng/ml) - 78 pacientes. Grupo III (tacto rectal sospechoso y PSAt entre 2,5 y 20 ng/ml) - 67 pacientes. Se calculó la sensibilidad, especificidad y curvas ROC para diferentes puntos de corte del cociente PSAl/PSAt en cada grupo.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Grupo I - En el 11% (20/189) de los pacientes se diagnosticó cáncer de próstata. Sólo se encontraron diferencias significativas en el cociente de PSAl/PSAt (p = 0,01). Utilizando el 27% como punto de corte, habríamos diagnosticado el 95% (19 de 20) de los pacientes con cáncer, disminuyendo en un 21% (39 de 189) el total de las biopsias, y en un 23% (39 de 169) el número de biopsias negativas. Grupo II - En el 19% (15/78) de los pacientes se detectó cáncer de próstata. Sólo se encontraron diferencias significativas en el volumen prostático (p = 0,02). Utilizando el 30% como punto de corte habríamos diagnosticado el 93% (14 de 15) de los pacientes con cáncer, disminuyendo en un 6,5% (5 de 78) el total de las biopsias y en un 8% (5 de 63) el número de biopsias negativas. Grupo III - En el 72% (48/67) de los pacientes se detectó cáncer de próstata. Se encontraron diferencias significativas en el cociente de PSAl/PSAt (p = 0,003), el volumen prostático (p = 0,02) y la existencia de nódulos ecográficos (p = 0,004). Utilizando el 25% como punto de corte habríamos diagnosticado el 96% (46 de 48) de los pacientes con cáncer, disminuyendo en un 13% (9 de 67) el total de las biopsias, y en un 47% (9 de 19) el número de biopsias negativas.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Aconsejamos la utilización del índice de PSAl/PSAt sólo en los pacientes con tacto rectal normal y PSAt entre 2,5 y 10 ng/ml. La biopsia de los pacientes con un porcentaje de PSAl menor o igual al 27%, habría evitado el 23% de las biopsias negativas manteniendo una sensibilidad diagnóstica del 95%.</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To evaluate the value of free PSA/total PSA ratio (fPSA/tPSA) to boost total PSA (tPSA) specificity in the diagnosis of prostate cancer in a series of symptomatic patients.</p> <span class="elsevierStyleSectionTitle">Material And Method</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Prospective study on 334 patients presenting symptoms compatible with PBH and tPSA (ProStatusTM, Wallace Oy, Turku, Finland) between 2.5 and 20 ng/ml, and mean age 67.2 ± 7 (49-87). Patients were divided into 3 groups: Group I (normal DRE and tPSA between 2.5 and 10 ng/ml) - 189 patients. Group II (normal DRE and tPSA between 10 and 20 ng/ml) - 78 patients. Group III (suspicion DRE and sPSA between 2.5 and 20 ng/ml) - 67 patients. For each group, the sensitivity, specificity and ROC curves were calculated for several cut-off values of the lPSA/tPSA ratio.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Group I - Prostate cancer was diagnosed in 11% (20/189) patients. Significant differences were found only in the lPSA/tPSA ratio (p = 0.01). Using 27% as the cut-off value, cancer would have been diagnosed in 95% (19 of 20) patients, decreasing the total number of negative biopsies by 21% (39 of 189). Group II - Prostate cancer was diagnosed in 19% (15/78) patients. The only significant differences found were in prostate volume (p = 0.02). Using 30% as the cut-off value, 93% (14 of 15) patients with cancer would have been diagnosed, decreasing the total number of biopsies by 6.5% (5 of 78) and the number of negative biopsies by 8% (5 of 63). Group III - Prostate cancer was detected in 72% (48/67) patients. Significant differences were found in lPSA/tPSA ratio (p = 0.003), prostate volume (p = 0.02) and presence of ultrasound nodes (p = 0.004). Using 25% as the cut-off value, 96% (46 of 48) of patients with cancer would have been diagnosed, decreasing the total number of biopsies by 13% (9 of 67) and the number of negative biopsies by 47% (9 of 19).</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">We advise use of lPSA/tPSA ratio only in patients with normal DRE and tPSA between 2.5 and 10 ng/ml. Biopsing patients with lPSA percent equal to or lower than 27% would have prevented 23% of negative biopsies while still maintaining a diagnostic sensitivity of 95%.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:20 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Comparison of digital rectal examination and serum prostate specific antigen in the early detection of prostate cancer: results of a multicenter clinical trial of 6.630 men" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "W.J. Catalona" 1 => "J.P. Richie" 2 => "F.R. Ahmann" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Urol" "fecha" => "1994" "volumen" => "151" "paginaInicial" => "1.283" "paginaFinal" => "1.290" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8189604" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cols.Prostate specific antigen density: a men of distinguishing between bening prostatic hypertrophy and prostate cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M.C. Benson" 1 => "I.S. Whang" 2 => "A. Pantuck" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Urol" "fecha" => "1992" "volumen" => "147" "paginaInicial" => "815" "paginaFinal" => "816" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1371554" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cols.Estimation of prostatic growht using serial prostate- specific antigen measurements in men with and without prostate disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "H.B. Carter" 1 => "C.H. Morrell" 2 => "J.D. Persons" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer Res" "fecha" => "1992" "volumen" => "52" "paginaInicial" => "3.323" "paginaFinal" => "3.328" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1458489" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cols.Serum prostate-specific antigen in a community- based population of healthy men: establishment of age-specific reference ranges" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J. Oesterling" 1 => "W.H. Cooner" 2 => "S.J. Jacobson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "JAMA" "fecha" => "1993" "volumen" => "270" "paginaInicial" => "860" "paginaFinal" => "864" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7688054" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cols.Age and race-specfic reference ranges for prostate-specific antigen from a large communitybased study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "E.P. De Antoni" 1 => "E.D. Crawford" 2 => "J.E. Oesterling" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Urology" "fecha" => "1996" "volumen" => "48" "paginaInicial" => "234" "paginaFinal" => "239" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8753735" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Systematic prostatic biopsies in 100 men with no suspicion of cancer on digital rectal examination" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "G. Vallancien" 1 => "D. Prapotnich" 2 => "B. Veillon" 3 => "J.M. Brisset" 4 => "J. Andre-Bougeran" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Urol" "fecha" => "1991" "volumen" => "146" "paginaInicial" => "1.308" "paginaFinal" => "1.312" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1942345" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Free-to-total prostate-specific antigen (PSA) ratio improves the specificity for detecting prostate cancer in patients with prostatism and intermediate PSA levels" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "F. Recker" 1 => "M.K. Kwiatkowski" 2 => "T. Piironen" 3 => "K. Petterson" 4 => "M. Goepel" 5 => "R. Tscholl" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J Urol" "fecha" => "1998" "volumen" => "81" "paginaInicial" => "532" "paginaFinal" => "538" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9598623" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Rendimiento de la biopsia transrectal ecodirigida en el diagnóstico del carcinoma de próstata" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "I. Fernández González" 1 => "J. Ruiz Rubio" 2 => "C. Llorente Abarca" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Esp Urol" "fecha" => "1995" "volumen" => "48" "paginaInicial" => "587" "paginaFinal" => "594" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7544968" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Rendimiento de la ecografía transrectal en el diagnóstico del cáncer de próstata en los pacientes sintomáticos con tacto rectal normal" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "F. Herranz Amo" 1 => "F. Verdú Tartajo" 2 => "J.M<span class="elsevierStyleSup">a</span>. Díez Cordero" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Actas Urol Esp" "fecha" => "1997" "volumen" => "21" "paginaInicial" => "565" "paginaFinal" => "571" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9412190" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prostate cancer detection in a clinical urological practice by ultrasonography, digital rectal examination and prostate specific antigen" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "W.H. Cooner" 1 => "B.R. Mosley" 2 => "C.L. Rutherford" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Urol" "fecha" => "1990" "volumen" => "143" "paginaInicial" => "1.146" "paginaFinal" => "1.154" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1692885" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0055" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prostate specific antigen: its role in the diagnosis and staging of prostate cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J.E. Oesterling" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer" "fecha" => "1995" "volumen" => "75" "paginaInicial" => "1.795" "paginaFinal" => "1.804" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7773949" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0060" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Characteristics of prostatic infarcts and their effect on serum prostate-specific antigen and prostatic acid phosphatase" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "P.N. Brawn" 1 => "D.M. Foster" 2 => "D.W. Jay" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Urology" "fecha" => "1994" "volumen" => "44" "paginaInicial" => "71" "paginaFinal" => "75" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7518984" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0065" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cols.Serum concentrations of prostate specific antigen and its complex with alpha-1-antichymotrypsin before diagnosis of prostate cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "U.H. Stenman" 1 => "M. Hakama" 2 => "P. Knekt" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Lancet" "fecha" => "1994" "volumen" => "344" "paginaInicial" => "1594" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7527116" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0070" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Molecular forms of serum prostate-specific antigen. The clinical value of percent free prostatespecific antigen" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "P-A. Abrahamsson" 1 => "H. Lilja" 2 => "J.E. Oesterling" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Urol Clin North Am" "fecha" => "1997" "volumen" => "24" "paginaInicial" => "353" "paginaFinal" => "365" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9126233" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0075" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Interpretation of free prostate specific antigen clinical research studies for the detection of prostate cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "D.L. Woodrum" 1 => "M.K. Brawer" 2 => "A.W. Partin" 3 => "W.J. Catalona" 4 => "P.C. Southwic" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Urol" "fecha" => "1998" "volumen" => "159" "paginaInicial" => "5" "paginaFinal" => "12" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9400426" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0080" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Comparison of 3 investigational assays for the free form of prostate specific antigen" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "R.G. Nixon" 1 => "G.E. Meyer" 2 => "A.B. Blase" 3 => "M.H. Gold" 4 => "M.K. Brawer" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Urol" "fecha" => "1998" "volumen" => "160" "paginaInicial" => "420" "paginaFinal" => "425" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9679890" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0085" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cols.Comparison of percent free prostate specific antigen and prostate specific antigen density as methods to enhance prostate specific antigen specificity in early prostate cancer detection in men with normal rectal examination and prostate specific antigen between 4.1 and 10 ng/ml" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J. Morote" 1 => "C.X. Raventos" 2 => "J.A. Lorente" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Urol" "fecha" => "1997" "volumen" => "158" "paginaInicial" => "502" "paginaFinal" => "504" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9224333" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0090" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Serum free prostate-specific antigen in the diagnosis of prostate cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "H.Y. Leung" 1 => "L.C. Lai" 2 => "J. Day" 3 => "J. Thomson" 4 => "D.E. Neal" 5 => "F.C. Hamdy" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J Urol" "fecha" => "1997" "volumen" => "80" "paginaInicial" => "256" "paginaFinal" => "259" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9284198" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0095" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Free/total serum prostate-specific antigen ratio: how helpful is it in detecting prostata cancer?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J.G. Masters" 1 => "P.E. Keegan" 2 => "A.J. Hildreth" 3 => "D.R.J. Greene" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J Urol" "fecha" => "1998" "volumen" => "81" "paginaInicial" => "419" "paginaFinal" => "423" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9523663" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0100" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cols.Free to total prostate-specific antigen (PSA) ratio improves the discrimination between prostate cancer and benign prostatic hyperplasia (BPH) in the diagnosis gray zone of 1.8 to 10 ng/ml. total PSA" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "P.J. Van Cangh" 1 => "P. De Nayer" 2 => "L. De Vischer" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Urology" "fecha" => "1996" "volumen" => "48" "numero" => "6A Suppl" "paginaInicial" => "67" "paginaFinal" => "70" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8973703" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/02104806/0000002400000001/v1_201304251601/S0210480600724004/v1_201304251601/es/main.assets" "Apartado" => array:4 [ "identificador" => "6429" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Original" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/02104806/0000002400000001/v1_201304251601/S0210480600724004/v1_201304251601/es/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210480600724004?idApp=UINPBA00004N" ]
Información de la revista
Compartir
Descargar PDF
Más opciones de artículo
Utilidad del cociente psa libre/psa total en el diagnóstico del cáncer de próstata en pacientes sintomáticos con niveles de psa entre 2,5 y 20 ng/ml
F. Herranz Amo1, F. Verdú Tartajo, J.M. Díez Cordero, F. Leal Hernández, A. Bielsa Carrillo, J. García Burgos, D. Subirá Ríos
Servicio de Urología. H.G.U. Gregorio Marañón. Madrid