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Regojo Balboa, D. Sánchez Zalabardo, J. Rioja Zuazu, J.M. Fernández Montero, J. López Ferrandis, J.J. Zudaire Bergera, D. Rosell costa, J.E. Robles García, J.M. Berián Polo" "autores" => array:9 [ 0 => array:2 [ "nombre" => "J.M." "apellidos" => "Regojo Balboa" ] 1 => array:2 [ "nombre" => "D." "apellidos" => "Sánchez Zalabardo" ] 2 => array:2 [ "nombre" => "J." "apellidos" => "Rioja Zuazu" ] 3 => array:2 [ "nombre" => "J.M." "apellidos" => "Fernández Montero" ] 4 => array:2 [ "nombre" => "J." "apellidos" => "López Ferrandis" ] 5 => array:2 [ "nombre" => "J.J." "apellidos" => "Zudaire Bergera" ] 6 => array:2 [ "nombre" => "D." "apellidos" => "Rosell costa" ] 7 => array:2 [ "nombre" => "J.E." "apellidos" => "Robles García" ] 8 => array:2 [ "nombre" => "J.M." "apellidos" => "Berián Polo" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S021048060473079X?idApp=UINPBA00004N" "url" => "/02104806/0000002800000004/v1_201304251730/S021048060473079X/v1_201304251730/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0210480604730776" "issn" => "02104806" "doi" => "10.1016/S0210-4806(04)73077-6" "estado" => "S300" "fechaPublicacion" => "2004-01-01" "aid" => "73077" "copyright" => "Asociación Española de Urología (AEU)" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Urol Esp. 2004;28:290-7" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 984 "formatos" => array:3 [ "EPUB" => 6 "HTML" => 669 "PDF" => 309 ] ] "es" => array:9 [ "idiomaDefecto" => true "titulo" => "Tratamiento con doxazosina en 3.347 pacientes con síntomas del tracto urinario inferior. efecto sobre su función sexual. estudio impros" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "290" "paginaFinal" => "297" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "C. Hernández Fernández, I. Moncada Iribarren, J. Jara Rascón, I. Castaño González, M. Moralejo Gárate" "autores" => array:5 [ 0 => array:2 [ "nombre" => "C." "apellidos" => "Hernández Fernández" ] 1 => array:2 [ "nombre" => "I." "apellidos" => "Moncada Iribarren" ] 2 => array:2 [ "nombre" => "J." "apellidos" => "Jara Rascón" ] 3 => array:2 [ "nombre" => "I." "apellidos" => "Castaño González" ] 4 => array:2 [ "nombre" => "M." "apellidos" => "Moralejo Gárate" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210480604730776?idApp=UINPBA00004N" "url" => "/02104806/0000002800000004/v1_201304251730/S0210480604730776/v1_201304251730/es/main.assets" ] "es" => array:12 [ "idiomaDefecto" => true "titulo" => "Valor pronóstico de la ploidía del adn y la morfometría nuclear en el cáncer de próstata metastásico" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "298" "paginaFinal" => "307" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "J.M. Martínez jabaloyas, J.L. Ruiz cerdá, S. Sanz chinesta, J.F. Jiménez cruz, A. Jiménez sánchez, A. Sempere" "autores" => array:6 [ 0 => array:3 [ "nombre" => "J.M." "apellidos" => "Martínez jabaloyas" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "cor0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] ] ] 1 => array:3 [ "nombre" => "J.L." "apellidos" => "Ruiz cerdá" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "S." "apellidos" => "Sanz chinesta" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "J.F." "apellidos" => "Jiménez cruz" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] ] ] 4 => array:3 [ "nombre" => "A." "apellidos" => "Jiménez sánchez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "aff0010" ] ] ] 5 => array:3 [ "nombre" => "A." "apellidos" => "Sempere" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">***</span>" "identificador" => "aff0015" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Servicio de Urología" "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Anatomía Patológica" "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Servicio de Hematología. Hospital Universitario La Fe. Valencia" "etiqueta" => "<span class="elsevierStyleSup">***</span>" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "1." "correspondencia" => "Dr. J.M. Martínez Jabaloyas Servicio de Urología Hospital Clínico Universitario Avda. Blasco Ibáñez, 17 47010 Valencia" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2003-10-17" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec87126" "palabras" => array:6 [ 0 => "Cáncer de próstata" 1 => "Metástasis" 2 => "Ploidía del ADN" 3 => "Núcleo celular" 4 => "Factores pronósticos" 5 => "Análisis multivariante" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec87125" "palabras" => array:7 [ 0 => "Prostate cancer" 1 => "Metastasis" 2 => "Ploidies" 3 => "Cell nucleus" 4 => "Flow cytometry" 5 => "Prognosis" 6 => "Multivariate analysis" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Valor pronóstico de la ploidía del adn y la morfometría nuclear en el cáncer de próstata metastásico</p> <span class="elsevierStyleSectionTitle">Fundamento</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Conocer el valor pronóstico de la ploidía del ADN y la morfometría nuclear determinadas en el foco tumoral primario en pacientes afectos de cáncer de próstata con metástasis óseas.</p> <span class="elsevierStyleSectionTitle">Métodos</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Estudio retrospectivo sobre 54 pacientes con adenocarcinoma de próstata y metástasis óseas tratados con supresión androgénica. En todos ellos se realizó análisis de ADN (citometría de flujo) sobre tejido tumoral desparafinado y estudio de morfometría nuclear. También se analizó la edad, la puntuación de Gleason, la categoría T, el hematocrito, el nivel de albúmina sanguínea, las fosfatasas alcalinas, fosfatasas ácidas prostáticas, y el número de focos metastásicos que aparecían en el rastreo. Se realizaron estudios univariantes y multivariantes de supervivencia mediante el método de Kaplan-Meier y de riesgos proporcionales de Cox, respectivamente. Finalmente, realizamos un análisis de regresión logística multivariante para los factores pronósticos clásicos y otro en el que se añadieron los experimentales (ploidía de ADN y morfometría nuclear), con la intención de conocer qué factores pueden predecir el que un paciente alcance la mediana de supervivencia y en qué medida los factores experimentales mejoran dicha predicción.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">En el análisis univariante de supervivencia tuvieron carácter pronóstico la categoría T, el nivel de albúmina, las fosfatasas alcalinas, la puntuación de Gleason, el rastreo óseo, la ploidía del ADN y el área nuclear media. En el multivariante únicamente aportaron información pronóstica independiente la puntuación de Gleason, el rastreo óseo, el área nuclear media y la ploidía del ADN. En el estudio de regresión logística para factores pronósticos clásicos únicamente el Gleason tiene capacidad predictiva (sensibilidad 89,3%, especificidad 64%), mientras que al introducir los factores experimentales también el rastreo óseo y la ploidía del ADN son significativos (sensibilidad 90% y especificidad 72%).</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">El estudio de contenido de ADN y de morfometría nuclear del foco tumoral primitivo aporta información pronóstica independiente en el análisis de supervivencia para el cáncer de próstata metastásico. Sin embargo, la escasa mejora en la capacidad predictiva sobre los factores pronósticos clásicos cuestionan su utilidad en la práctica clínica.</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Prognostic value of dna ploidy and nuclear morphometry in metastatic prostate cancer</p> <span class="elsevierStyleSectionTitle">Purpose</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">To assess the prognostic value of DNA ploidy and nuclear morphometry in metastatic prostate cancer after androgenic deprivation treatment.</p> <span class="elsevierStyleSectionTitle">Methods</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Fifty four patients with prostate cancer and bone metastases who had undergone androgenic suppression treatment were retrospectively studied. The deoxyribonucleic acid (DNA) content was analysed by flow cytometry. Nuclear morphometry characterized 14 nuclear descriptors. The study also included age, Gleason score, T classification, haematocrite, serum albumin, serum alkaline phosphatase, serum prostatic acid phosphatase and the amount of metastatic foci detected during radioisotope bone scan. Univariate survival analyses were performed and Cox’s proportional hazards model was used to identify significant prognostic factors. To assess how the experimental factors improve the capacity of the classical factors for predicting the patients who reach median survival, logistic regression multivariate analysis was performed for the classical prognostic factors only and after added experimental variables (DNA content and Nuclear Area).</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">The univariate survival analyses assigned a prognostic value to T category, level of albumin, alkaline phosphatase, Gleason score, bone scan, DNA ploidy and mean nuclear area. In the case of the Cox regression model only Gleason score, bone scan, mean nuclear area and DNA ploidy provided independent prognostic information. In logistic regression for classic prognostic factors only Gleason score is significant (sensibility 89,3%, specificity 64%). However, when the experimental factors are added, in addition to Gleason score, radioisotope bone scan and DNA ploidy are of prognostic value (sensibility 90% and specificity 72%).</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">The study of DNA content and nuclear morphometry in the primitive tumor provides independent prognostic information in survival analysis for patients with metastatic prostate cancer. However, there is limited improvement with respect to the classical factors in predicting survival. This questions its utility in the daily clinical usage.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:34 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." 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