Estadísticas

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      "titulo" => "Tratamiento quirúrgico de las metástasis del cáncer renal"
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          "autoresLista" => "José L. Ruiz-Cerdá, Fernando Jiménez Cruz"
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              "nombre" => "José L."
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      "titulo" => "Factores pronósticos del carcinoma de células renales"
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        "resumen" => "Objetivo&#58; Evaluar la importancia y efectos de la inmunoterapia cl&#225;sica en el tratamiento del c&#225;ncer renal diseminado&#46;Material y m&#233;todos&#46; Se revisan los datos hist&#243;ricos de los estudios realizados con citocinas&#44; interferon e interleukina&#44; evaluandosus combinaciones&#44; y comparando los diferentes estudios relevantes existentes&#46; <br />Comentarios&#58; Aunque diversos&#44; los resultados son pobres en cuanto a respuesta objetivable y en cuanto a duraci&#243;n de lamisma&#44; observando series ya hist&#243;ricas que empleando interleukina2 lograron&#44; pesar de graves efectos secundarios&#44; remisionesincluso completas de la enfermedad&#46; <br />Conclusiones&#58; En la actualidad y tras el advenimiento de los nuevos f&#225;rmacos&#44; el empleo de la inmunoterapia cl&#225;sica puedeencontrar indicaci&#243;n en pacientes concretos&#44; con buen estado general&#44; con nefrectom&#237;a previa por carcinoma de c&#233;lulas claras&#44;al menos 12 meses antes de la aparici&#243;n de met&#225;stasis en un solo &#243;rgano&#44; preferentemente pulm&#243;n&#44; y con niveles normales dehemoglobina&#44; calcio y lactodehidrogenasa&#44; buscando ese peque&#241;o porcentaje de respuestas estables y mantenidas&#46;"
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        "resumen" => "Objective&#58; To assess the significance and effects of conventional immunotherapy for management of disseminated renalcancer&#46; <br />Materials and methods&#58; Historical data from studies conducted with cytokines&#44; interferon&#44; and interleukin are reviewed&#44;their combinations are evaluated&#44; and the different relevant studies available are compared&#46; <br />Discussion&#58; While diverse&#44; results are poor in terms of objective response and its duration&#46; Historical series usinginterleukin-2 achieved&#44; despite severe side effects&#44; disease remissions&#44; some of them complete&#46; <br />Conclusions&#58; Currently&#44; after the advent of new drugs&#44; use of conventional immunotherapy may be indicated for specificpatients with a good general condition undergoing previous nephrectomy for a clear cell carcinoma at least 12 monthsbefore occurrence of metastasis in a single organ&#44; preferably the lung&#44; and with normal levels of hemoglobin&#44; calcium&#44; andlactate dehydrogenase&#44; looking for that small percentage of stable and sustained responses&#46;"
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