Factores predictivos de enfermedad localmente avanzada en pacientes con cáncer de próstata tratados con hormonoterapia neoadyuvante y prostatectomía radical
Servicio y Cátedra de Urología. Hospital del Mar. UAB. Barcelona
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Gil martínez, M.J. Gil Sanz, C. Allepuz Losa, A. Borque Fernando, P. Valdivia Navarro, L.A. Rioja sanz" "autores" => array:6 [ 0 => array:2 [ "nombre" => "P." "apellidos" => "Gil martínez" ] 1 => array:2 [ "nombre" => "M.J." "apellidos" => "Gil Sanz" ] 2 => array:2 [ "nombre" => "C." "apellidos" => "Allepuz Losa" ] 3 => array:2 [ "nombre" => "A." "apellidos" => "Borque Fernando" ] 4 => array:2 [ "nombre" => "P." "apellidos" => "Valdivia Navarro" ] 5 => array:2 [ "nombre" => "L.A." 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Granados loarca, E.A. Estrada barrondo" "autores" => array:2 [ 0 => array:2 [ "nombre" => "E.A." "apellidos" => "Granados loarca" ] 1 => array:2 [ "nombre" => "E.A." "apellidos" => "Estrada barrondo" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210480600724685?idApp=UINPBA00004N" "url" => "/02104806/0000002400000005/v1_201304251613/S0210480600724685/v1_201304251613/es/main.assets" ] "es" => array:12 [ "idiomaDefecto" => true "titulo" => "Factores predictivos de enfermedad localmente avanzada en pacientes con cáncer de próstata tratados con hormonoterapia neoadyuvante y prostatectomía radical" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "393" "paginaFinal" => "399" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "J.A. Lorente garin, O. Arango toro, O. Bielsa gali, R. Cortadellas angel, A. Gelabert-mas" "autores" => array:5 [ 0 => array:3 [ "nombre" => "J.A." "apellidos" => "Lorente garin" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "O." "apellidos" => "Arango toro" ] 2 => array:2 [ "nombre" => "O." "apellidos" => "Bielsa gali" ] 3 => array:2 [ "nombre" => "R." "apellidos" => "Cortadellas angel" ] 4 => array:2 [ "nombre" => "A." "apellidos" => "Gelabert-mas" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio y Cátedra de Urología. Hospital del Mar. UAB. Barcelona" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "1" "correspondencia" => "Dr. J.A. Lorente Garín Servicio de Urología Hospital del Mar Passeig Maritin, 25-29 08003 Barcelona" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "1999-07-20" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras Clave" "identificador" => "xpalclavsec86015" "palabras" => array:4 [ 0 => "Cáncer de próstata" 1 => "Neoadyuvancia" 2 => "Factores predictivos" 3 => "Estadio patológico" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key Words" "identificador" => "xpalclavsec86016" "palabras" => array:4 [ 0 => "Prostate cancer" 1 => "Neoadjuvant therapy" 2 => "Predictive factor" 3 => "Pathological stage" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Analizar los factores predictivos de la enfermedad localmente avanzada (márgenes positivos y afectación seminal) en pacientes con cáncer de próstata tratados con hormonoterapia neoadyuvante y prostatectomía radical</p> <span class="elsevierStyleSectionTitle">Pacientes Y Método</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se evalúan 78 pacientes tratados con bloqueo completo neoadyuvante y cirugía radical desde 1995 hasta 1998. Se analizan la edad, el PSA inicial, el volumen prostático determinado mediante ecografía transrectal y/o resonancia magnética, el estadio clínico, el grado de Gleason, el tiempo de bloqueo, el estadio patológico y el volumen tumoral</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">El 34,6% de los pacientes (27/78) presentaron márgenes positivos o afectación seminal (Odds: 0,53). No existieron diferencias significativas en la edad, el PSA inicial, el volumen prostático, el tiempo de bloqueo ni el grado de Gleason entre los pacientes con tumor órgano-confinado o localmente avanzado. Si existieron diferencias en el volumen tumoral (p = 0,0001). No obstante, el volumen tumoral no fue diferente en los pacientes con enfermedad palpable o no palpable (p = 0,5334). La eficacia para predecir los hallazgos patológicos adversos fue representada mediante curvas ROC (PSA: 0,628, estadio clínico: 0,612 y Gleason: 0,545). Se crearon tablas predictivas de la afectación extraprostática con diversos niveles de corte de PSA, estadio clínico y grado de Gleason. En el modelo de regresión logística ninguna de las variables analizadas demostró poder predecir de manera independiente la existencia de los márgenes positivos</p> <span class="elsevierStyleSectionTitle">Conclusión</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Las actuales variables clínicas no permiten predecir de manera fidedigna la existencia de enfermedad localmente avanzada en los pacientes tratados con neoadyuvancia. Esta se asocia, no obstante, a volúmenes tumorales grandes. La probabilidad de márgenes positivos o afectación seminal aumenta con la concentración de PSA y con el grado de Gleason</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Aim</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To analyze the predictors of local adverse pathological findings (positive surgical margins and seminal involvement) in prostate cancer patients treated with neoadjuvant hormonetherapy and radical prostatectomy</p> <span class="elsevierStyleSectionTitle">Patients And Methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">We studied seventy-eight patients treated with neoadjuvant androgen blockade prior to radical prostatectomy between 1995 and 1998. Age, PSA, prostate volume determined by transrectal ultrasound and/or magnetic resonance imaging, clinical stage, Gleason score, duration of blockade, pathological stage and tumoral volume were analyzed</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">34.6% of patients (27/78) had adverse pathology (odds: 0.53). No significant differences were found in age, PSA, prostate volume, duration of blockade and Gleason score between organ-confined and locally advanced patients. Differences were found in tumor volume (p = 0.0001) but this was not different in order to positive or negative digital rectal examination (p = 0.5334). The efficacy for predicting pathological adverse findings was represented by ROC curves (PSA: 0.628, clinical stage: 0.612 and Gleason score: 0.545). Predictive table of extracapsular disease for different PSA levels, clinical stage and Gleason score were developed. No variable predicted positive margins in logistic regression model</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Clinical variables do not predict locally advanced disease in prostate cancer patients treated with neoadjuvant androgen blockade. This is associated with higher tumor volumes. The probability of positive margins or seminal involvement increases with PSA level and Gleason score</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:23 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The clinical usefulness of prostate specific antigen: Update" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A.W. Partin" 1 => "J.E. 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| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Octubre | 0 | 6 | 6 |
| 2024 Septiembre | 0 | 19 | 19 |
| 2024 Agosto | 0 | 7 | 7 |
| 2024 Julio | 0 | 13 | 13 |
| 2024 Junio | 0 | 8 | 8 |
| 2024 Mayo | 0 | 6 | 6 |
| 2024 Abril | 0 | 18 | 18 |
| 2024 Marzo | 0 | 22 | 22 |
| 2024 Febrero | 0 | 14 | 14 |
| 2024 Enero | 0 | 10 | 10 |
| 2023 Diciembre | 0 | 42 | 42 |
| 2023 Noviembre | 0 | 41 | 41 |
| 2023 Octubre | 0 | 24 | 24 |
| 2023 Septiembre | 0 | 5 | 5 |
| 2023 Agosto | 0 | 2 | 2 |
| 2023 Julio | 0 | 24 | 24 |
| 2023 Junio | 0 | 5 | 5 |
| 2023 Mayo | 0 | 4 | 4 |
| 2023 Abril | 0 | 2 | 2 |
| 2023 Marzo | 0 | 1 | 1 |
| 2023 Febrero | 0 | 8 | 8 |
| 2023 Enero | 0 | 5 | 5 |
| 2022 Diciembre | 0 | 8 | 8 |
| 2022 Noviembre | 0 | 9 | 9 |
| 2022 Octubre | 0 | 8 | 8 |
| 2022 Septiembre | 0 | 1 | 1 |
| 2022 Agosto | 0 | 10 | 10 |
| 2022 Junio | 0 | 1 | 1 |
| 2022 Mayo | 0 | 4 | 4 |
| 2022 Abril | 0 | 10 | 10 |
| 2022 Marzo | 0 | 3 | 3 |
| 2022 Febrero | 0 | 2 | 2 |
| 2022 Enero | 0 | 2 | 2 |
| 2021 Diciembre | 0 | 6 | 6 |
| 2021 Noviembre | 0 | 4 | 4 |
| 2021 Octubre | 0 | 4 | 4 |
| 2021 Septiembre | 0 | 1 | 1 |
| 2021 Agosto | 0 | 7 | 7 |
| 2021 Julio | 0 | 5 | 5 |
| 2021 Junio | 0 | 1 | 1 |
| 2021 Mayo | 0 | 1 | 1 |
| 2021 Abril | 0 | 13 | 13 |
| 2021 Marzo | 0 | 3 | 3 |
| 2021 Febrero | 0 | 2 | 2 |
| 2021 Enero | 0 | 1 | 1 |
| 2020 Diciembre | 0 | 2 | 2 |
| 2020 Noviembre | 0 | 2 | 2 |
| 2020 Octubre | 0 | 3 | 3 |
| 2020 Septiembre | 0 | 3 | 3 |
| 2020 Agosto | 0 | 8 | 8 |
| 2020 Julio | 0 | 1 | 1 |
| 2020 Junio | 0 | 6 | 6 |
| 2020 Mayo | 0 | 2 | 2 |
| 2020 Abril | 0 | 3 | 3 |
| 2020 Marzo | 0 | 12 | 12 |
| 2020 Febrero | 0 | 9 | 9 |
| 2020 Enero | 0 | 5 | 5 |
| 2019 Diciembre | 0 | 17 | 17 |
| 2019 Noviembre | 0 | 3 | 3 |
| 2019 Octubre | 0 | 5 | 5 |
| 2019 Septiembre | 0 | 3 | 3 |
| 2019 Agosto | 0 | 5 | 5 |
| 2019 Julio | 0 | 3 | 3 |
| 2019 Junio | 0 | 28 | 28 |
| 2019 Mayo | 0 | 56 | 56 |
| 2018 Febrero | 3 | 0 | 3 |
| 2018 Enero | 1 | 0 | 1 |
| 2017 Diciembre | 0 | 1 | 1 |
| 2017 Noviembre | 2 | 1 | 3 |
| 2017 Octubre | 3 | 3 | 6 |
| 2017 Septiembre | 2 | 3 | 5 |
| 2017 Agosto | 0 | 1 | 1 |
| 2017 Julio | 5 | 0 | 5 |
| 2017 Junio | 4 | 12 | 16 |
| 2017 Mayo | 13 | 11 | 24 |
| 2017 Abril | 8 | 4 | 12 |
| 2017 Marzo | 6 | 18 | 24 |
| 2017 Febrero | 2 | 3 | 5 |
| 2017 Enero | 1 | 4 | 5 |
| 2016 Diciembre | 18 | 4 | 22 |
| 2016 Noviembre | 20 | 3 | 23 |
| 2016 Octubre | 21 | 2 | 23 |
| 2016 Septiembre | 10 | 6 | 16 |
| 2016 Agosto | 12 | 2 | 14 |
| 2016 Julio | 13 | 8 | 21 |
| 2016 Junio | 17 | 9 | 26 |
| 2016 Mayo | 12 | 9 | 21 |
| 2016 Abril | 19 | 12 | 31 |
| 2016 Marzo | 14 | 9 | 23 |
| 2016 Febrero | 15 | 11 | 26 |
| 2016 Enero | 10 | 17 | 27 |
| 2015 Diciembre | 6 | 12 | 18 |
| 2015 Noviembre | 15 | 14 | 29 |
| 2015 Octubre | 16 | 13 | 29 |
| 2015 Septiembre | 11 | 9 | 20 |
| 2015 Agosto | 20 | 9 | 29 |
| 2015 Julio | 7 | 0 | 7 |
| 2015 Junio | 1 | 1 | 2 |
| 2015 Mayo | 5 | 4 | 9 |
| 2015 Abril | 7 | 8 | 15 |
| 2015 Marzo | 1 | 0 | 1 |
| 2015 Febrero | 7 | 2 | 9 |
| 2015 Enero | 15 | 2 | 17 |
| 2014 Diciembre | 11 | 4 | 15 |
| 2014 Noviembre | 7 | 2 | 9 |
| 2014 Octubre | 24 | 4 | 28 |
| 2014 Septiembre | 11 | 2 | 13 |
| 2014 Agosto | 11 | 2 | 13 |
| 2014 Julio | 14 | 1 | 15 |
| 2014 Junio | 10 | 2 | 12 |
| 2014 Mayo | 8 | 2 | 10 |
| 2014 Abril | 11 | 3 | 14 |
| 2014 Marzo | 14 | 2 | 16 |
| 2014 Febrero | 7 | 0 | 7 |
| 2014 Enero | 9 | 3 | 12 |
| 2013 Diciembre | 5 | 3 | 8 |
| 2013 Noviembre | 8 | 2 | 10 |
| 2013 Octubre | 11 | 2 | 13 |
| 2013 Septiembre | 13 | 5 | 18 |
| 2013 Agosto | 7 | 2 | 9 |
| 2013 Julio | 5 | 0 | 5 |
| 2000 Abril | 204 | 0 | 204 |
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