Cáncer de próstata estadio pt3 tras prostatectomía radical. resultados en progresión y supervivencia
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Queipo zaragozá, A. Budía alba, M. Pérez ebrí, C.D. Vera donoso, F. Vera sempere, J.F. Jiménez cruz" "autores" => array:6 [ 0 => array:2 [ "nombre" => "J.A." "apellidos" => "Queipo zaragozá" ] 1 => array:2 [ "nombre" => "A." "apellidos" => "Budía alba" ] 2 => array:2 [ "nombre" => "M." "apellidos" => "Pérez ebrí" ] 3 => array:2 [ "nombre" => "C.D." "apellidos" => "Vera donoso" ] 4 => array:2 [ "nombre" => "F." "apellidos" => "Vera sempere" ] 5 => array:2 [ "nombre" => "J.F." "apellidos" => "Jiménez cruz" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210480600724715?idApp=UINPBA00004N" "url" => "/02104806/0000002400000005/v1_201304251613/S0210480600724715/v1_201304251613/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0210480600724697" "issn" => "02104806" "doi" => "10.1016/S0210-4806(00)72469-7" "estado" => "S300" "fechaPublicacion" => "2000-01-01" "aid" => "72469" "copyright" => "Asociación Española de Urología (AEU)" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Urol Esp. 2000;24:393-9" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1140 "formatos" => array:3 [ "EPUB" => 7 "HTML" => 732 "PDF" => 401 ] ] "es" => array:9 [ "idiomaDefecto" => true "titulo" => "Factores predictivos de enfermedad localmente avanzada en pacientes con cáncer de próstata tratados con hormonoterapia neoadyuvante y prostatectomía radical" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "393" "paginaFinal" => "399" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J.A. Lorente garin, O. Arango toro, O. Bielsa gali, R. Cortadellas angel, A. Gelabert-mas" "autores" => array:5 [ 0 => array:2 [ "nombre" => "J.A." "apellidos" => "Lorente garin" ] 1 => array:2 [ "nombre" => "O." "apellidos" => "Arango toro" ] 2 => array:2 [ "nombre" => "O." "apellidos" => "Bielsa gali" ] 3 => array:2 [ "nombre" => "R." "apellidos" => "Cortadellas angel" ] 4 => array:2 [ "nombre" => "A." "apellidos" => "Gelabert-mas" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210480600724697?idApp=UINPBA00004N" "url" => "/02104806/0000002400000005/v1_201304251613/S0210480600724697/v1_201304251613/es/main.assets" ] "es" => array:12 [ "idiomaDefecto" => true "titulo" => "Cáncer de próstata estadio pt3 tras prostatectomía radical. resultados en progresión y supervivencia" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "400" "paginaFinal" => "405" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "P. Gil martínez, M.J. Gil Sanz, C. Allepuz Losa, A. Borque Fernando, P. Valdivia Navarro, L.A. Rioja sanz" "autores" => array:6 [ 0 => array:3 [ "nombre" => "P." "apellidos" => "Gil martínez" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "M.J." "apellidos" => "Gil Sanz" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "C." "apellidos" => "Allepuz Losa" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "A." "apellidos" => "Borque Fernando" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 4 => array:3 [ "nombre" => "P." "apellidos" => "Valdivia Navarro" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 5 => array:3 [ "nombre" => "L.A." "apellidos" => "Rioja sanz" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:3 [ "entidad" => "Servicio de Urología. Hospital “Miguel Servet”. Zaragoza" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "1" "correspondencia" => "Dr. P. Gil Martínez C/ Zurita, 4 - 5º A 50001 Zaragoza" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "1999-07-01" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec85994" "palabras" => array:3 [ 0 => "Prostatectomía radical" 1 => "pT3" 2 => "Progresión" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec85993" "palabras" => array:3 [ 0 => "Radical prostatectomy" 1 => "pT3" 2 => "Progression" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Objetivos</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Analizar los datos de progresión y supervivencia de los pacientes con cáncer de próstata estadío patológico pT3.</p> <span class="elsevierStyleSectionTitle">Material y métodos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">De las 372 prostatectomías radicales realizadas en nuestro Centro hasta noviembre de 1998, encontramos 74 pT3N0 (19,8%), 43 pT3a y 31 pT3b (TNM 97).</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Observamos hasta el final del seguimiento progresión biológica en 24 pacientes (32%), 8 en los pT3a, y 16 en los pT3b. En 10 de ellos la progresión fue clínica (local o a distancia). Respecto a los datos de supervivencia libre de progresión biológica, encontramos diferencias estadísticamente significativas entre los pacientes pT3a y pT3b (p < 0,0001). En los pT3a, no hubo diferencias entre los pacientes con PSA preoperatorio menor y mayor de 20 ng/ml (p = 0,415), y diferencias “marginales” según Gleason patológico de 7 o mayor respecto a menor de 7 (p = 0,048), diferencias que desaparecieron al combinar PSA mayor y menor de 20, con Gleason patológico mayor y menor de 6 (p = 0,195).</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Creemos apropiado administrar adyuvancia hormonal precoz en los pacientes pT3b, y en los pT3a, debe considerarse la posibilidad de administrar adyuvancia al aparecer progresión biológica, especialmente ante factores pronósticos desfavorables de Gleason patológico y PSA preoperatorio.</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Purpose</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To analyse progression and survival after radical prostatectomy in patients with stage pT3 carcinoma of the prostate.</p> <span class="elsevierStyleSectionTitle">Material And Methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Between 1986 and November 1998, we performed 372 radical prostatectomies, 74 of wich were pT3N0 (19,8%), 43 pT3a and 31 pT3b (TNM 97).</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">In patients with pathological stage pT3, we found any progression in 24 patients (32%), 8 in pT3a, and 16 in pT3b. In 10 of 24 pT3, there was local relapse or distant metastases. About the freedom from biochemical relapse survival rate, we found statistically differences between pT3a and pT3b (p < 0,0001). In pT3a patients, we found no differences between PSA levels > 20 ng/ml, versus < 20 (p = 0,415), and statistically differences between pathological Gleason 6 or greater, versus < 6 (p = 0,048). However, we found no differences when we used both criteria (PSA and Gleason) (p = 0,195).</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">We support for early adyuvant hormonal therapy in pT3b patients. In pT3a, the hormonotherapy may be used if appears biochemical failure, specially with adverse prognostic factors (PSA and Gleason).</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:20 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:1 [ "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:2 [ "titulo" => "TNM Classification of Malignant Tumours.Fifth Edition" "serieFecha" => "1997" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Positive surgical margins at radical prostatectomy: importance of the apical dissection" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "T.A. Stamey" 1 => "A. Villers" 2 => "J.E. Mcneal" 3 => "P.C. Link" 4 => "F.S. 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| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Octubre | 0 | 14 | 14 |
| 2024 Septiembre | 0 | 18 | 18 |
| 2024 Agosto | 0 | 12 | 12 |
| 2024 Julio | 1 | 24 | 25 |
| 2024 Junio | 0 | 15 | 15 |
| 2024 Mayo | 1 | 19 | 20 |
| 2024 Abril | 0 | 19 | 19 |
| 2024 Marzo | 1 | 36 | 37 |
| 2024 Febrero | 0 | 22 | 22 |
| 2024 Enero | 0 | 21 | 21 |
| 2023 Diciembre | 1 | 60 | 61 |
| 2023 Noviembre | 0 | 52 | 52 |
| 2023 Octubre | 0 | 46 | 46 |
| 2023 Septiembre | 5 | 6 | 11 |
| 2023 Julio | 0 | 14 | 14 |
| 2023 Junio | 0 | 17 | 17 |
| 2023 Mayo | 0 | 1 | 1 |
| 2023 Abril | 0 | 4 | 4 |
| 2023 Marzo | 7 | 9 | 16 |
| 2023 Febrero | 0 | 6 | 6 |
| 2023 Enero | 0 | 2 | 2 |
| 2022 Diciembre | 0 | 2 | 2 |
| 2022 Noviembre | 0 | 11 | 11 |
| 2022 Octubre | 0 | 1 | 1 |
| 2022 Septiembre | 2 | 3 | 5 |
| 2022 Agosto | 0 | 6 | 6 |
| 2022 Junio | 0 | 2 | 2 |
| 2022 Mayo | 1 | 5 | 6 |
| 2022 Abril | 0 | 3 | 3 |
| 2022 Marzo | 3 | 4 | 7 |
| 2022 Febrero | 1 | 3 | 4 |
| 2021 Diciembre | 0 | 1 | 1 |
| 2021 Noviembre | 0 | 1 | 1 |
| 2021 Octubre | 0 | 5 | 5 |
| 2021 Septiembre | 0 | 1 | 1 |
| 2021 Julio | 0 | 1 | 1 |
| 2021 Junio | 0 | 2 | 2 |
| 2021 Marzo | 0 | 3 | 3 |
| 2021 Enero | 0 | 3 | 3 |
| 2020 Diciembre | 0 | 1 | 1 |
| 2020 Noviembre | 0 | 2 | 2 |
| 2020 Octubre | 0 | 1 | 1 |
| 2020 Septiembre | 0 | 1 | 1 |
| 2020 Agosto | 0 | 8 | 8 |
| 2020 Julio | 0 | 5 | 5 |
| 2020 Junio | 0 | 3 | 3 |
| 2020 Mayo | 0 | 1 | 1 |
| 2020 Abril | 0 | 2 | 2 |
| 2020 Marzo | 0 | 2 | 2 |
| 2020 Febrero | 0 | 6 | 6 |
| 2020 Enero | 0 | 10 | 10 |
| 2019 Diciembre | 0 | 10 | 10 |
| 2019 Noviembre | 1 | 11 | 12 |
| 2019 Octubre | 0 | 19 | 19 |
| 2019 Septiembre | 0 | 19 | 19 |
| 2019 Agosto | 0 | 8 | 8 |
| 2019 Julio | 0 | 6 | 6 |
| 2019 Junio | 0 | 33 | 33 |
| 2019 Mayo | 0 | 71 | 71 |
| 2018 Febrero | 9 | 10 | 19 |
| 2018 Enero | 5 | 11 | 16 |
| 2017 Diciembre | 9 | 13 | 22 |
| 2017 Noviembre | 9 | 15 | 24 |
| 2017 Octubre | 13 | 14 | 27 |
| 2017 Septiembre | 11 | 11 | 22 |
| 2017 Agosto | 7 | 18 | 25 |
| 2017 Julio | 16 | 3 | 19 |
| 2017 Junio | 21 | 23 | 44 |
| 2017 Mayo | 30 | 10 | 40 |
| 2017 Abril | 29 | 5 | 34 |
| 2017 Marzo | 16 | 8 | 24 |
| 2017 Febrero | 10 | 3 | 13 |
| 2017 Enero | 14 | 3 | 17 |
| 2016 Diciembre | 28 | 8 | 36 |
| 2016 Noviembre | 22 | 2 | 24 |
| 2016 Octubre | 35 | 7 | 42 |
| 2016 Septiembre | 13 | 6 | 19 |
| 2016 Agosto | 11 | 3 | 14 |
| 2016 Julio | 20 | 2 | 22 |
| 2016 Junio | 29 | 11 | 40 |
| 2016 Mayo | 24 | 7 | 31 |
| 2016 Abril | 16 | 35 | 51 |
| 2016 Marzo | 18 | 8 | 26 |
| 2016 Febrero | 14 | 11 | 25 |
| 2016 Enero | 15 | 16 | 31 |
| 2015 Diciembre | 11 | 9 | 20 |
| 2015 Noviembre | 7 | 4 | 11 |
| 2015 Octubre | 15 | 5 | 20 |
| 2015 Septiembre | 22 | 3 | 25 |
| 2015 Agosto | 23 | 3 | 26 |
| 2015 Julio | 14 | 1 | 15 |
| 2015 Junio | 3 | 3 | 6 |
| 2015 Mayo | 3 | 2 | 5 |
| 2015 Abril | 9 | 7 | 16 |
| 2015 Marzo | 2 | 1 | 3 |
| 2015 Febrero | 2 | 4 | 6 |
| 2015 Enero | 15 | 6 | 21 |
| 2014 Diciembre | 20 | 13 | 33 |
| 2014 Noviembre | 17 | 2 | 19 |
| 2014 Octubre | 28 | 2 | 30 |
| 2014 Septiembre | 13 | 1 | 14 |
| 2014 Agosto | 19 | 3 | 22 |
| 2014 Julio | 10 | 3 | 13 |
| 2014 Junio | 15 | 2 | 17 |
| 2014 Mayo | 13 | 1 | 14 |
| 2014 Abril | 12 | 2 | 14 |
| 2014 Marzo | 12 | 2 | 14 |
| 2014 Febrero | 14 | 1 | 15 |
| 2014 Enero | 4 | 2 | 6 |
| 2013 Diciembre | 11 | 1 | 12 |
| 2013 Noviembre | 12 | 5 | 17 |
| 2013 Octubre | 10 | 7 | 17 |
| 2013 Septiembre | 7 | 4 | 11 |
| 2013 Agosto | 10 | 5 | 15 |
| 2013 Julio | 4 | 0 | 4 |
| 2000 Abril | 306 | 0 | 306 |
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