Análisis de microsatélites en células exfoliadas del sedimento urinario. su utilidad para la detección del cáncer vesical. estudio comparativo con citología urinaria
Microsatellite analysis in exfoliated cells from urine sediment. utility for bladder cancer detection. comparative study with urinary cytology
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Blanco díez, E. Fernández rosado, L. Álvarez castelo, J. Sánchez rodríguez-losada, V. Chantada abal, S. Novás castro, A. Barbagelata lópez, J. Serrano barrientos, M. González martín" "autores" => array:9 [ 0 => array:2 [ "nombre" => "A." "apellidos" => "Blanco díez" ] 1 => array:2 [ "nombre" => "E." "apellidos" => "Fernández rosado" ] 2 => array:2 [ "nombre" => "L." "apellidos" => "Álvarez castelo" ] 3 => array:2 [ "nombre" => "J." "apellidos" => "Sánchez rodríguez-losada" ] 4 => array:2 [ "nombre" => "V." "apellidos" => "Chantada abal" ] 5 => array:2 [ "nombre" => "S." "apellidos" => "Novás castro" ] 6 => array:2 [ "nombre" => "A." "apellidos" => "Barbagelata lópez" ] 7 => array:2 [ "nombre" => "J." "apellidos" => "Serrano barrientos" ] 8 => array:2 [ "nombre" => "M." "apellidos" => "González martín" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210480603729830?idApp=UINPBA00004N" "url" => "/02104806/0000002700000008/v1_201304251718/S0210480603729830/v1_201304251718/es/main.assets" ] "es" => array:13 [ "idiomaDefecto" => true "titulo" => "Análisis de microsatélites en células exfoliadas del sedimento urinario. su utilidad para la detección del cáncer vesical. estudio comparativo con citología urinaria" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "618" "paginaFinal" => "628" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "R. Molina burgos, J.M. Millán salvador, J.S. Oltra soler, J.F. Jiménez cruz" "autores" => array:4 [ 0 => array:3 [ "nombre" => "R." "apellidos" => "Molina burgos" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "J.M." "apellidos" => "Millán salvador" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "J.S." "apellidos" => "Oltra soler" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "J.F." "apellidos" => "Jiménez cruz" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Urología. Hospital Universitario La Fe. Valencia" "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Unidad de Genética. Hospital Universitario La Fe. Valencia" "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "1" "correspondencia" => "Dr. R. Molina Burgos C/ Sta. Cruz de la Zarza, 1 - 4º, p. 38 46021 Valencia" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Microsatellite analysis in exfoliated cells from urine sediment. utility for bladder cancer detection. comparative study with urinary cytology" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2003-04-21" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec86974" "palabras" => array:5 [ 0 => "Microsatélites" 1 => "Pérdida de hererocigosidad (LOH)" 2 => "Inestabilidad (MSI)" 3 => "Cáncer de vejiga" 4 => "Citología" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec86975" "palabras" => array:5 [ 0 => "Microsatellite" 1 => "Loss of heterozigosity (LOH)" 2 => "Inestability (MSI)" 3 => "Bladder cancer" 4 => "Cytology" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Introducción</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Teniendo en cuenta la precocidad de las alteraciones genéticas en la carcinogénesis de los tumores de vejiga, la valoración de estos cambios a nivel de 9p 21-22 por medio de marcadores microsatélites podrían ser útiles para el diagnóstico y seguimiento.</p> <span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Evaluar el uso de marcadores microsatélites y la utilidad de pérdida de heterocigosidad (LOH) e inestabilidad de microsatélites (MSI) en células exfoliadas del sedimento urinario para él diagnostico de tumores vesicales.</p> <span class="elsevierStyleSectionTitle">Material y método</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Amplificamos con PCR el DNA de muestras de orina y sangre de 160 pacientes con tumor vesical. Con 4 marcadores microsatélites de 9p 21-22 (D9S747-D9S171-D9S162-IFNA) y 1 de cromosoma 4 (D4S243) se analizó LOH/MSI en células del sedimento urinario. Utilizamos la citología urinaria como método comparativo y el análisis histológico del tejido obtenido por R.T.U, como diagnóstico de referencia. Calculamos la sensibilidad y especificidad del método y si existía alguna correlación con estadio y grado tumoral.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Se pudo utilizar correctamente 150 muestras. En 111 encontramos LOH/MSI (sensibilidad del 74%). La citología pudo descubrir solamente 60 pacientes (sensibilidad 40%). Encontramos mayor número de alteraciones microsatélites (AM) en tumores superficiales (sensibilidad 77,3% vs. 28,8% de la citología) y valores estadísticamente significativos (MSI p<0,001 - LOH p<0,004) cuando comparamos tumores GI-II vs. GIII. El marcador con mayor sensibilidad fue D4S243 con un 40%. Un paciente con AD. Carcinoma de próstata y otro con cistitis crónica dieron resultado falsos positivos.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">El estudio de LOH/MSI en tumores vesicales con 5 marcadores microsatélites, según nuestros datos presenta una sensibilidad del 74%.</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">El mayor números de LOH/MSI la encontramos en tumores superficiales y tumores GI-GII. Aunque no permite descartar la realización de cistoscopias en el diagnóstico y seguimiento, mejora la sensibilidad de la citología urinaria y seria una alternativa diagnostica como un procedimiento no invasivo. (Beca F.I.U).</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Taking into account the precocity of the genetic alterations in the carcinogénesis of the bladder tumors, the valuation of these changes at a level of 9p 21-22 by means of microsatellite markers could be useful for the diagnostic and follow-up.</p> <span class="elsevierStyleSectionTitle">Purpose</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">To evaluate the use of microsatellite markers and the utility of loss of heterozigosity (LOH) and microsatellite instability (MSI) in exfoliated cells from urine sediment. This observation offers the possibility of tumor detection by examining the DNA of urinary sediment.</p> <span class="elsevierStyleSectionTitle">Materials and methods</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">We amplified with PCR the DNA of urine and blood samples from 160 patients with bladder cancer. We analysed LOH/MSI in cells from urinary sediment using four microsatellite markers of 9p 21-22 (D9S747-D9S171-D9S162-IFNA) and one from chromosome 4 (D4S243). The urinary cytology was used as comparative method and histological examination of tissue obtained by transurethral resection (TUR) as reference diagnostic. We calculated the sensibility and specificity of this method and if there was some correlation between stage and grade tumoral.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">We could use 150 samples correctly. In 111 samples we found LOH/MSI (sensibility 74%). The cytology was positive only in 60 patients (sensibility 40%). We found a bigger number of microsatellite alterations (AM) in superficial tumors (sensibility 77,3% vs. 28,8% for the cytology) and these were significant when comparing tumors GI-II vs. GIII (MSI p <0,001 - LOH p <0,004). The marker with more sensibility was D4S243 with 40%. One patient with prostate carcinoma and another one with chronic cystitis gave false positive results.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">The study of LOH/MSI in bladder tumors with 5 microsatellites markers, according to our results showed a sensibility of 74%.</p><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">The biggest number in LOH/MSI was found in superficial tumors and GI-GII tumors. 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| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Octubre | 0 | 4 | 4 |
| 2024 Septiembre | 0 | 8 | 8 |
| 2024 Agosto | 0 | 8 | 8 |
| 2024 Julio | 0 | 4 | 4 |
| 2024 Junio | 0 | 8 | 8 |
| 2024 Mayo | 0 | 7 | 7 |
| 2024 Abril | 0 | 14 | 14 |
| 2024 Marzo | 0 | 31 | 31 |
| 2024 Febrero | 0 | 20 | 20 |
| 2024 Enero | 0 | 14 | 14 |
| 2023 Diciembre | 0 | 25 | 25 |
| 2023 Noviembre | 0 | 18 | 18 |
| 2023 Octubre | 0 | 34 | 34 |
| 2023 Septiembre | 0 | 16 | 16 |
| 2023 Agosto | 0 | 15 | 15 |
| 2023 Julio | 0 | 15 | 15 |
| 2023 Junio | 0 | 2 | 2 |
| 2023 Mayo | 0 | 1 | 1 |
| 2023 Abril | 0 | 1 | 1 |
| 2023 Marzo | 1 | 3 | 4 |
| 2023 Febrero | 2 | 7 | 9 |
| 2023 Enero | 0 | 7 | 7 |
| 2022 Diciembre | 0 | 2 | 2 |
| 2022 Noviembre | 0 | 13 | 13 |
| 2022 Octubre | 0 | 14 | 14 |
| 2022 Septiembre | 0 | 2 | 2 |
| 2022 Agosto | 0 | 12 | 12 |
| 2022 Julio | 0 | 4 | 4 |
| 2022 Junio | 0 | 8 | 8 |
| 2022 Mayo | 0 | 8 | 8 |
| 2022 Abril | 0 | 14 | 14 |
| 2022 Marzo | 0 | 3 | 3 |
| 2022 Febrero | 0 | 10 | 10 |
| 2022 Enero | 0 | 2 | 2 |
| 2021 Diciembre | 0 | 2 | 2 |
| 2021 Noviembre | 0 | 4 | 4 |
| 2021 Octubre | 0 | 4 | 4 |
| 2021 Septiembre | 0 | 1 | 1 |
| 2021 Agosto | 0 | 3 | 3 |
| 2021 Junio | 0 | 3 | 3 |
| 2021 Mayo | 0 | 1 | 1 |
| 2021 Abril | 0 | 3 | 3 |
| 2021 Marzo | 0 | 1 | 1 |
| 2021 Febrero | 0 | 11 | 11 |
| 2021 Enero | 0 | 4 | 4 |
| 2020 Diciembre | 0 | 4 | 4 |
| 2020 Noviembre | 0 | 1 | 1 |
| 2020 Octubre | 0 | 1 | 1 |
| 2020 Septiembre | 0 | 2 | 2 |
| 2020 Agosto | 0 | 8 | 8 |
| 2020 Julio | 0 | 2 | 2 |
| 2020 Junio | 0 | 4 | 4 |
| 2020 Mayo | 0 | 4 | 4 |
| 2020 Abril | 0 | 2 | 2 |
| 2020 Marzo | 0 | 3 | 3 |
| 2020 Febrero | 0 | 2 | 2 |
| 2020 Enero | 0 | 12 | 12 |
| 2019 Diciembre | 1 | 12 | 13 |
| 2019 Noviembre | 0 | 6 | 6 |
| 2019 Octubre | 0 | 8 | 8 |
| 2019 Septiembre | 0 | 8 | 8 |
| 2019 Agosto | 0 | 3 | 3 |
| 2019 Julio | 0 | 7 | 7 |
| 2019 Junio | 0 | 12 | 12 |
| 2019 Mayo | 0 | 42 | 42 |
| 2019 Abril | 0 | 7 | 7 |
| 2018 Mayo | 0 | 0 | 0 |
| 2018 Febrero | 0 | 0 | 0 |
| 2018 Enero | 2 | 0 | 2 |
| 2017 Diciembre | 1 | 1 | 2 |
| 2017 Noviembre | 4 | 3 | 7 |
| 2017 Octubre | 4 | 6 | 10 |
| 2017 Septiembre | 3 | 1 | 4 |
| 2017 Agosto | 5 | 3 | 8 |
| 2017 Julio | 1 | 3 | 4 |
| 2017 Junio | 9 | 10 | 19 |
| 2017 Mayo | 15 | 10 | 25 |
| 2017 Abril | 12 | 13 | 25 |
| 2017 Marzo | 15 | 26 | 41 |
| 2017 Febrero | 15 | 3 | 18 |
| 2017 Enero | 6 | 1 | 7 |
| 2016 Diciembre | 35 | 3 | 38 |
| 2016 Noviembre | 30 | 4 | 34 |
| 2016 Octubre | 28 | 3 | 31 |
| 2016 Septiembre | 10 | 2 | 12 |
| 2016 Agosto | 17 | 3 | 20 |
| 2016 Julio | 14 | 7 | 21 |
| 2016 Junio | 19 | 9 | 28 |
| 2016 Mayo | 15 | 6 | 21 |
| 2016 Abril | 12 | 7 | 19 |
| 2016 Marzo | 15 | 7 | 22 |
| 2016 Febrero | 14 | 6 | 20 |
| 2016 Enero | 10 | 11 | 21 |
| 2015 Diciembre | 6 | 4 | 10 |
| 2015 Noviembre | 19 | 2 | 21 |
| 2015 Octubre | 16 | 4 | 20 |
| 2015 Septiembre | 22 | 4 | 26 |
| 2015 Agosto | 24 | 1 | 25 |
| 2015 Julio | 26 | 5 | 31 |
| 2015 Junio | 15 | 2 | 17 |
| 2015 Mayo | 16 | 2 | 18 |
| 2015 Abril | 14 | 6 | 20 |
| 2015 Marzo | 8 | 0 | 8 |
| 2015 Febrero | 9 | 0 | 9 |
| 2015 Enero | 23 | 2 | 25 |
| 2014 Diciembre | 10 | 2 | 12 |
| 2014 Noviembre | 12 | 0 | 12 |
| 2014 Octubre | 9 | 2 | 11 |
| 2014 Septiembre | 7 | 0 | 7 |
| 2014 Agosto | 12 | 0 | 12 |
| 2014 Julio | 16 | 0 | 16 |
| 2014 Junio | 28 | 1 | 29 |
| 2014 Mayo | 6 | 0 | 6 |
| 2014 Abril | 3 | 1 | 4 |
| 2014 Marzo | 5 | 1 | 6 |
| 2014 Febrero | 6 | 0 | 6 |
| 2014 Enero | 10 | 1 | 11 |
| 2013 Diciembre | 10 | 2 | 12 |
| 2013 Noviembre | 13 | 2 | 15 |
| 2013 Octubre | 9 | 1 | 10 |
| 2013 Septiembre | 22 | 4 | 26 |
| 2013 Agosto | 8 | 1 | 9 |
| 2013 Julio | 3 | 0 | 3 |
| 2003 Agosto | 287 | 0 | 287 |
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