Características inmunofenotípicas y clínicas del carcinoma renal mucinoso tubular y de células fusiformes
Immunohistochemical profile and clinical features of mucinous tubular and spindle renal cell carcinoma
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Valor pronóstico de la clasificación TNM 1997" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "655" "paginaFinal" => "660" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Survival analysis for localized renal cell carcinoma.prognostic value of 1997 tnm classification." ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:2 [ 0 => array:2 [ "autoresLista" => "M. García Torrelles, M. Sánchez Sanchís, J.R. Beltrán Armada, J. Vidal Moreno, C. Sanjuán de Laorden" "autores" => array:5 [ 0 => array:2 [ "nombre" => "M." "apellidos" => "García Torrelles" ] 1 => array:2 [ "nombre" => "M." "apellidos" => "Sánchez Sanchís" ] 2 => array:2 [ "nombre" => "J.R." "apellidos" => "Beltrán Armada" ] 3 => array:2 [ "nombre" => "J." "apellidos" => "Vidal Moreno" ] 4 => array:2 [ "nombre" => "C." "apellidos" => "Sanjuán de Laorden" ] ] ] 1 => array:2 [ "autoresLista" => "D. Bautista Rentero" "autores" => array:1 [ 0 => array:2 [ "nombre" => "D." "apellidos" => "Bautista Rentero" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210480606735148?idApp=UINPBA00004N" "url" => "/02104806/0000003000000007/v1_201304251821/S0210480606735148/v1_201304251821/es/main.assets" ] "es" => array:13 [ "idiomaDefecto" => true "titulo" => "Características inmunofenotípicas y clínicas del carcinoma renal mucinoso tubular y de células fusiformes" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "649" "paginaFinal" => "654" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "L.F. Arias, j. Blanco, S. Hernández, G. Bocardo, L. González" "autores" => array:5 [ 0 => array:4 [ "nombre" => "L.F." "apellidos" => "Arias" "email" => array:1 [ 0 => "luisfer_uda@yahoo.com" ] "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">***</span>" "identificador" => "aff0015" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "j." "apellidos" => "Blanco" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "S." "apellidos" => "Hernández" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "G." "apellidos" => "Bocardo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">**a</span>" "identificador" => "aff0010" ] ] ] 4 => array:3 [ "nombre" => "L." "apellidos" => "González" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Departamento de Anatomía Patológica." "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Departamento de Urología, Hospital Clínico San Carlos, Madrid." "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Afiliación actual: Departamento de Patología, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia." "etiqueta" => "<span class="elsevierStyleSup">***</span>" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "1" "correspondencia" => "Dr. L.F. Arias Departamento de Patología. Facultad de Medicina Universidad de Antioquia, Carrera 51D, No. 62-29, Medellín, Colombia" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Immunohistochemical profile and clinical features of mucinous tubular and spindle renal cell carcinoma" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2006-02-28" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec87951" "palabras" => array:6 [ 0 => "Mucinoso" 1 => "Células fusiformes" 2 => "Carcinoma de células renales" 3 => "Riñón" 4 => "Neoplasias" 5 => "Inmunohistoquímica" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec87952" "palabras" => array:6 [ 0 => "Mucinous" 1 => "Spindle cell" 2 => "Renal cell carcinoma" 3 => "Kidney" 4 => "Neoplasms" 5 => "Immunohistochemistry" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Resumen</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Introducción: El carcinoma renal mucinoso y tubular de células fusiformes es una neoplasia recientemente incluida en la clasificación de tumores renales. Aún desconocemos aspectos moleculares y de su evolución. Nuestros objetivos son describir características inmunofenotípicas del tumor y aportar casos adicionales para un mejor conocimiento de la neoplasia.</p> <span class="elsevierStyleSectionTitle">Material y métodos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Realizamos inmunohistoquímica con un amplio panel de anticuerpos a 4 tumores (0,89% de carcinomas renales en nuestro centro). Correlacionamos con hallazgos clínicos y tratamos de determinar patrones de inmunotinción.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Todos los casos marcaron intensa y difusamente para citoqueratina (CK)7. La inmunotinción fue variable para antígeno de membrana epitelial, vimentina, S-100, antígeno Ulex europaeus, CK de alto peso molecular, CK8, CK18 y CK19. Los tumores fueron homogéneamente negativos para antígeno carcinoembriónico, CD15, CD10, CD34, desmina, actina, CK10, CK20 y HMB45. El índice proliferativo (Ki67) fue menor del 1% en todos los casos. La marcación fue similar en células cúbicas y fusiformes.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Este tumor presenta un inmunofenotipo variable de acuerdo con diferentes trabajos y no se conoce con precisión su histogénesis o la célula hacia la cual se diferencian. La similitud en la expresión de marcadores en células cúbicas y fusiformes confirma un mismo origen y diferenciación.</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">We present the immunohistochemical (IHC) analyses of a series of four kidney tumors currently classified as mucinous tubular and spindle renal cell carcinoma (WHO), a tumor with uncertain histogenesis and differentiation. Our aims were to determine an immunoprofile and to add clinical and morphological information about this rare renal carcinoma.</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">The four tumors were found between 415 renal carcinomas at our center (0.89%). IHC was carried out with a panel of antibodies in these four cases. Morphogical and clinical information was collected and analyzed.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">All tumors were well circumscribed and confined to the kidney. Immunoreactivity for cytokeratin (CK)7 was intense and diffuse. Immunostaining was variable for EMA, vimentin, S-100, Ulex europaeus antigen, high-molecular-weight CK, CK 8, CK18, and CK 19. The tumors were homogeneously negative for CEA, CD15, CD10, CD34, desmin, actin, CK10, CK20, and HMB45. Proliferative index (Ki67) was < 1% en all cases. The immunoreactivity was similar in cuboidal and spindle cells. Conclusions: The present tumor shows a variable immunophenotype and there is not a precise cell type differentiation. The immunostaining in cuboidal and spindle cells suggests a similar differentiation and histogenesis.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:13 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs. Lyon" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J.N. Eble" 1 => "G. Sauter" 2 => "J.I. Epstein" 3 => "I.A. Sesterhenn" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:3 [ "tituloSerie" => "IARC Press" "fecha" => "2004" "volumen" => "10" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2." 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| 2021 Febrero | 0 | 4 | 4 |
| 2021 Enero | 0 | 8 | 8 |
| 2020 Diciembre | 0 | 3 | 3 |
| 2020 Noviembre | 0 | 4 | 4 |
| 2020 Septiembre | 0 | 2 | 2 |
| 2020 Agosto | 0 | 5 | 5 |
| 2020 Julio | 0 | 2 | 2 |
| 2020 Junio | 0 | 6 | 6 |
| 2020 Mayo | 0 | 6 | 6 |
| 2020 Abril | 0 | 4 | 4 |
| 2020 Marzo | 0 | 2 | 2 |
| 2020 Febrero | 0 | 5 | 5 |
| 2020 Enero | 0 | 1 | 1 |
| 2019 Diciembre | 0 | 16 | 16 |
| 2019 Noviembre | 0 | 3 | 3 |
| 2019 Octubre | 0 | 3 | 3 |
| 2019 Septiembre | 0 | 1 | 1 |
| 2019 Agosto | 0 | 1 | 1 |
| 2019 Julio | 0 | 4 | 4 |
| 2019 Junio | 0 | 11 | 11 |
| 2019 Mayo | 0 | 34 | 34 |
| 2019 Abril | 0 | 20 | 20 |
| 2019 Febrero | 0 | 5 | 5 |
| 2019 Enero | 0 | 2 | 2 |
| 2018 Diciembre | 0 | 6 | 6 |
| 2018 Noviembre | 0 | 11 | 11 |
| 2018 Octubre | 0 | 8 | 8 |
| 2018 Febrero | 0 | 1 | 1 |
| 2018 Enero | 0 | 1 | 1 |
| 2017 Diciembre | 2 | 7 | 9 |
| 2017 Noviembre | 4 | 6 | 10 |
| 2017 Octubre | 3 | 8 | 11 |
| 2017 Septiembre | 3 | 6 | 9 |
| 2017 Agosto | 4 | 4 | 8 |
| 2017 Julio | 9 | 7 | 16 |
| 2017 Junio | 6 | 5 | 11 |
| 2017 Mayo | 2 | 7 | 9 |
| 2017 Abril | 6 | 3 | 9 |
| 2017 Marzo | 17 | 1 | 18 |
| 2017 Febrero | 25 | 2 | 27 |
| 2017 Enero | 3 | 2 | 5 |
| 2016 Diciembre | 17 | 5 | 22 |
| 2016 Noviembre | 16 | 7 | 23 |
| 2016 Octubre | 26 | 5 | 31 |
| 2016 Septiembre | 19 | 12 | 31 |
| 2016 Agosto | 12 | 9 | 21 |
| 2016 Julio | 11 | 3 | 14 |
| 2016 Junio | 6 | 10 | 16 |
| 2016 Mayo | 18 | 6 | 24 |
| 2016 Abril | 13 | 9 | 22 |
| 2016 Marzo | 17 | 17 | 34 |
| 2016 Febrero | 11 | 10 | 21 |
| 2016 Enero | 7 | 14 | 21 |
| 2015 Diciembre | 6 | 19 | 25 |
| 2015 Noviembre | 13 | 16 | 29 |
| 2015 Octubre | 19 | 12 | 31 |
| 2015 Septiembre | 14 | 15 | 29 |
| 2015 Agosto | 10 | 6 | 16 |
| 2015 Julio | 9 | 0 | 9 |
| 2015 Junio | 5 | 4 | 9 |
| 2015 Mayo | 10 | 6 | 16 |
| 2015 Abril | 17 | 15 | 32 |
| 2015 Marzo | 7 | 11 | 18 |
| 2015 Febrero | 6 | 5 | 11 |
| 2015 Enero | 9 | 4 | 13 |
| 2014 Diciembre | 17 | 6 | 23 |
| 2014 Noviembre | 8 | 6 | 14 |
| 2014 Octubre | 15 | 7 | 22 |
| 2014 Septiembre | 15 | 3 | 18 |
| 2014 Agosto | 11 | 2 | 13 |
| 2014 Julio | 12 | 1 | 13 |
| 2014 Junio | 13 | 4 | 17 |
| 2014 Mayo | 7 | 3 | 10 |
| 2014 Abril | 4 | 2 | 6 |
| 2014 Marzo | 10 | 0 | 10 |
| 2014 Febrero | 6 | 1 | 7 |
| 2014 Enero | 8 | 3 | 11 |
| 2013 Diciembre | 11 | 2 | 13 |
| 2013 Noviembre | 13 | 5 | 18 |
| 2013 Octubre | 5 | 8 | 13 |
| 2013 Septiembre | 8 | 5 | 13 |
| 2013 Agosto | 7 | 8 | 15 |
| 2013 Julio | 2 | 0 | 2 |
| 2006 Junio | 262 | 0 | 262 |
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