Cistectomía radical como tratamiento del cáncer vesical infiltrante en el paciente de edad avanzada
Radical cystectomy as a muscle-invasive bladder cancer treatment in elderly patients
J.A. March Villalba1
, J.M. Martinez Jabaloyas, F. Pastor Hernandez, F.J. Gunthner Stefan, R. Rodriguez Navarro, P. Chuan Nuez
Autor para correspondencia
joseantoniomarch@hotmail.com
Correspondencia autor: Dr. J.A. March Villalba Servicio de Urologia. Hospital Clinico Universitario de Valencia Avda. Blasco Ibanez, 17 - 46010 Valencia Tel.: 963 862 600
Correspondencia autor: Dr. J.A. March Villalba Servicio de Urologia. Hospital Clinico Universitario de Valencia Avda. Blasco Ibanez, 17 - 46010 Valencia Tel.: 963 862 600
Servicio de Urología del Hospital Clínico Universitario de Valencia. Valencia
Leído
1769
Vecesse ha leído el artículo
1048
Total PDF
721
Total HTML
Compartir estadísticas
array:23 [ "pii" => "S0210480608739172" "issn" => "02104806" "doi" => "10.1016/S0210-4806(08)73917-2" "estado" => "S300" "fechaPublicacion" => "2008-01-01" "aid" => "73917" "copyright" => "Asociación Española de Urología (AEU)" "copyrightAnyo" => "2008" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Urol Esp. 2008;32:696-704" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1138 "formatos" => array:3 [ "EPUB" => 8 "HTML" => 717 "PDF" => 413 ] ] "itemSiguiente" => array:18 [ "pii" => "S0210480608739184" "issn" => "02104806" "doi" => "10.1016/S0210-4806(08)73918-4" "estado" => "S300" "fechaPublicacion" => "2008-01-01" "aid" => "73918" "copyright" => "Asociación Española de Urología (AEU)" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Urol Esp. 2008;32:705-12" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1264 "formatos" => array:3 [ "EPUB" => 10 "HTML" => 760 "PDF" => 494 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Prevalencia de disfunción eyaculatoria secundaria al tratamiento con alfa-bloqueantes en pacientes con hiperplasia benigna de próstata" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "705" "paginaFinal" => "712" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Prevalence of ejaculatory dysfunction secondary to alpha-blocker therapy in patients with benign prostatic hyperplasia" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "A. Martín-Morales, G. Meyer, E. Ramírez" "autores" => array:3 [ 0 => array:2 [ "nombre" => "A." "apellidos" => "Martín-Morales" ] 1 => array:2 [ "nombre" => "G." "apellidos" => "Meyer" ] 2 => array:2 [ "nombre" => "E." "apellidos" => "Ramírez" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210480608739184?idApp=UINPBA00004N" "url" => "/02104806/0000003200000007/v1_201304251911/S0210480608739184/v1_201304251911/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0210480608739160" "issn" => "02104806" "doi" => "10.1016/S0210-4806(08)73916-0" "estado" => "S300" "fechaPublicacion" => "2008-01-01" "aid" => "73916" "copyright" => "Asociación Española de Urología (AEU)" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Urol Esp. 2008;32:691-5" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1023 "formatos" => array:3 [ "EPUB" => 8 "HTML" => 595 "PDF" => 420 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Tendencia en la incidencia del cáncer testicular de células germinales en un área sanitaria española de 300.000 habitantes (1991-2005)" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "691" "paginaFinal" => "695" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Trends in the incidence of testicular germ cell cancer in a 300.000 inhabitants spanish population (1991-2005)" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "L. Llanes González, M. Luján Galán, N. Rodríguez García, A. García Tello, A. Berenguer Sánchez" "autores" => array:5 [ 0 => array:2 [ "nombre" => "L." "apellidos" => "Llanes González" ] 1 => array:2 [ "nombre" => "M." "apellidos" => "Luján Galán" ] 2 => array:2 [ "nombre" => "N." "apellidos" => "Rodríguez García" ] 3 => array:2 [ "nombre" => "A." "apellidos" => "García Tello" ] 4 => array:2 [ "nombre" => "A." "apellidos" => "Berenguer Sánchez" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210480608739160?idApp=UINPBA00004N" "url" => "/02104806/0000003200000007/v1_201304251911/S0210480608739160/v1_201304251911/es/main.assets" ] "es" => array:12 [ "idiomaDefecto" => true "titulo" => "Cistectomía radical como tratamiento del cáncer vesical infiltrante en el paciente de edad avanzada" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "696" "paginaFinal" => "704" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "J.A. March Villalba, J.M. Martinez Jabaloyas, F. Pastor Hernandez, F.J. Gunthner Stefan, R. Rodriguez Navarro, P. Chuan Nuez" "autores" => array:6 [ 0 => array:4 [ "nombre" => "J.A." "apellidos" => "March Villalba" "email" => array:1 [ 0 => "joseantoniomarch@hotmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "J.M." "apellidos" => "Martinez Jabaloyas" ] 2 => array:2 [ "nombre" => "F." "apellidos" => "Pastor Hernandez" ] 3 => array:2 [ "nombre" => "F.J." "apellidos" => "Gunthner Stefan" ] 4 => array:2 [ "nombre" => "R." "apellidos" => "Rodriguez Navarro" ] 5 => array:2 [ "nombre" => "P." "apellidos" => "Chuan Nuez" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Urología del Hospital Clínico Universitario de Valencia. Valencia" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "1" "correspondencia" => "Correspondencia autor: Dr. J.A. March Villalba Servicio de Urologia. Hospital Clinico Universitario de Valencia Avda. Blasco Ibanez, 17 - 46010 Valencia Tel.: 963 862 600" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Radical cystectomy as a muscle-invasive bladder cancer treatment in elderly patients" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec88682" "palabras" => array:3 [ 0 => "Anciano" 1 => "Cistectomía" 2 => "Cáncer vesical infiltrante" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec88681" "palabras" => array:3 [ 0 => "Elderly" 1 => "Cystectomy" 2 => "Bladder neoplasm" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Introducción</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Realizar una cistectomía radical en ancianos con cáncer vesical infiltrante es un tema controvertido</p> <span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">El objetivo de nuestro trabajo ha sido determinar si existen diferencias significativas en cuanto a la morbimortalidad perioperatoria, complicaciones tardías, tiempo libre de enfermedad y supervivencia cáncer-específica en un grupo de pacientes ancianos con cáncer vesical infiltrante tratados mediante cistectomía radical, comparado al resto de pacientes de menor edad y analizar qué variables pudieron predecir la morbi-mortalidad perioperatoria</p> <span class="elsevierStyleSectionTitle">Material y métodos</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Estudio retrospectivo de pacientes con cáncer vesical infiltrante tratados mediante cistectomía radical y derivación ileal. Se compararon 2 grupos: <70 años en el momento de la realización de la cistectomía (n=55) y ≥=70 años (n=57)</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">No hubo diferencias entre ambos grupos con respecto a: tiempo quirúrgico, complicaciones intraoperatorias (<70=21,8%, ≥=70=31,6%), mortalidad postoperatoria (<70=3,6%, ≥=70=8,8%), complicaciones postoperatorias menores (<70=18,2%, ≥=70=26,3%) y médicas (<70=7,3%, ≥=70=8,8%), eventos tardíos, periodo libre de enfermedad y supervivencia cáncer-específica. El porcentaje de complicaciones mayores (<70=23,6%, ≥=70=43,9%) y la estancia hospitalaria (<70=10,2, =70=15,2 días) difieren significativamente entre ambos grupos. La edad y los factores de riesgo cardiacos predicen de manera independiente la aparición de complicaciones postoperatorias mayores</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">La cistectomía radical puede ser realizada en pacientes ancianos seleccionados adecuadamente</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Radical cystectomy in elderly is a controversial issue that increases importance overtime because average life span is growing</p> <span class="elsevierStyleSectionTitle">Objetive</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">The porpouse of our work was to analize the differences about perioperative and later outcomes between ages of patients with muscle-invasive bladder neoplasm treated with radical cystectomy</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">We retrospectively reviewed the records of patients who underwent radical cystectomy for muscle-invasive bladder cancer. Two age groups were compared: <70 years old at time of cystectomy (n=55) and ≥=70 years (n=57)</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">There was no difference between both age groups about: time of surgery, intraoperative complications (<70=21,8%,≥=70=31,6%), postoperative mortality (<70=3,6%, ≥=70=8,8%), minor (<70=18,2%, ≥=70=26,3%) and major medical postoperative complications (<70=7,3%, ≥=70=8,8%), late outcomes as cancer-specific morby-mortality and actuarial overall survival stratified by patient age. The rate of major postoperative complications (<70=23,6%, ≥=70=43,9%) as well as the mean length of hospital stay (<70=10,2, ≥=70=15,2 days) differed significantly between the two age groups. Age and cardiovascular risk factors were independient predictive factors of mayor postoperative complications</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Radical cystectomy could be performed in carefully selected elderly patients</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:26 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Anuario estadistíco de España 1998-2005. Instituto Nacional de Estadística. Ministerio de Economía y Hacienda.<a class="elsevierStyleInterRef" href="http://www.ine.es">http://www.ine.es</span> (fecha de consulta 20/08/2007). Disponible en<span class="elsevierStyleInterRef" href="http://www.ine.es">http://www.ine.es/prodyser/pubweb/espcif/pobl07.pdf.</a>" ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Situación del cáncer en España: Incidencia" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "G. López-Abente" 1 => "M. Pollán" 2 => "N. Aragonés" 3 => "B. Pérez Gómez" 4 => "V. Hernández Barrera" 5 => "V. Lope" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "An Sist Sanit Navar" "fecha" => "2004" "volumen" => "27" "numero" => "2" "paginaInicial" => "165" "paginaFinal" => "173" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15381948" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Otero Mauricio G., Ferná ndez A., Gil Fabra J. Epidemiologí a descriptiva y analí tica en Urologí a, oncoló gica. Tema monográ fico del LXIII Congreso Nacional de Urologí a. Asociacion Españ ola de Urologí a. Jun 1998" ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Bladder cancer. Epidemiology, diagnosis and management" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "C.L. Pashos" 1 => "M.F. Botteman" 2 => "B.L. Laskin" 3 => "A. Redaelli" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Cancer pract" "fecha" => "2002" "volumen" => "10" "numero" => "6" "paginaInicial" => "311" "paginaFinal" => "322" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12406054" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Radical cystectomy in patients aged >75 years: an updated review of patients treated with curative and palliative intent" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "N. Zebic" 1 => "S. Weinknecht" 2 => "D. Kroepfl" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1464-410X.2005.05507.x" "Revista" => array:7 [ "tituloSerie" => "BJU int" "fecha" => "2005" "volumen" => "95" "numero" => "9" "paginaInicial" => "1211" "paginaFinal" => "1214" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15892803" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Surgical management of infiltrating bladder cancer in elderly patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M. Peyromaure" 1 => "F. Guerin" 2 => "B. Debre" 3 => "M. Zerbib" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Eur Urol" "fecha" => "2004" "volumen" => "45" "numero" => "2" "paginaInicial" => "147" "paginaFinal" => "153" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14733998" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Management of muscle-invasive bladder cancer in the elderly" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "U. Basso" 1 => "P. Bassi" 2 => "T. Sava" 3 => "S. Monfardini" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1586/14737140.4.6.1017" "Revista" => array:7 [ "tituloSerie" => "Expert Rev Anticancer Ther" "fecha" => "2004" "volumen" => "4" "numero" => "6" "paginaInicial" => "1017" "paginaFinal" => "1035" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15606330" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clinical outcome in patients with locally advanced bladder carcinoma treated with conservative multimodality therapy" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "L. George" 1 => "F. Bladou" 2 => "V.J. Bardou" 3 => "G. Gravis" 4 => "A. Tallet" 5 => "C. Alzieu" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.urology.2004.04.088" "Revista" => array:7 [ "tituloSerie" => "Urology" "fecha" => "2004" "volumen" => "64" "numero" => "3" "paginaInicial" => "488" "paginaFinal" => "493" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15351577" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Chemoradiotherapy for muscle invading bladder carcinoma. Final report of a single institutional organ-sparing program" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "F. Arias" 1 => "M.A. Dominguez" 2 => "E. Martinez" 3 => "J.J. Illarramendi" 4 => "S. Miquelez" 5 => "I. Pascual" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Int J Radiat Oncol Biol Phys" "fecha" => "2000" "volumen" => "47" "numero" => "2" "paginaInicial" => "373" "paginaFinal" => "378" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10802362" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Conservative treatment of invasive bladder carcinoma by transurethral resection, protracted intravenous infusion chemmotherapy, and hyperfractionated radiotherapy: long term results" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "D.T. Danesi" 1 => "G. Arcangeli" 2 => "E. Cruciani" 3 => "P. Altavista" 4 => "A. Mecozzi" 5 => "B. Saracino" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/cncr.20654" "Revista" => array:7 [ "tituloSerie" => "Cancer" "fecha" => "2004" "volumen" => "101" "numero" => "11" "paginaInicial" => "2540" "paginaFinal" => "2548" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15481058" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0055" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Radical cystectomy in the elderly. Comparison of survival between younger and older patients" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "P.E. Clark" 1 => "J.P. Stein" 2 => "S.G. Groshen" 3 => "J. Cai" 4 => "G. Miranda" 5 => "G. Lieskovsky" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/cncr.20805" "Revista" => array:7 [ "tituloSerie" => "Cancer" "fecha" => "2005" "volumen" => "103" "numero" => "3" "paginaInicial" => "546" "paginaFinal" => "552" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15630702" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0060" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Advanced age is associated with poorer bladder cancer-specific survival in patients treated with radical cystectomy" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M.E. Nielsen" 1 => "S.F. Shariat" 2 => "P.I. Karakiewicz" 3 => "Y. Lotan" 4 => "C.G. Rogers" 5 => "G.E. Amiel" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.eururo.2006.11.004" "Revista" => array:7 [ "tituloSerie" => "Eur Urol" "fecha" => "2007" "volumen" => "51" "numero" => "3" "paginaInicial" => "699" "paginaFinal" => "706" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17113703" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0065" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Radical cystectomy in the elderly. Comparison of clinical outcomes between younger and older patients" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "P.E. Clark" 1 => "J.P. Stein" 2 => "S.G. Groshen" 3 => "J. Cai" 4 => "G. Miranda" 5 => "G. Lieskovsky" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/cncr.21126" "Revista" => array:7 [ "tituloSerie" => "Cancer" "fecha" => "2005" "volumen" => "104" "numero" => "1" "paginaInicial" => "36" "paginaFinal" => "43" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15912515" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0070" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Analysis of early complications after radical cystectomy:Results of a collaborative care pathway" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "S. Chang" 1 => "M.S. Cookson" 2 => "R.G. Baumgartner" 3 => "N. Wells" 4 => "J.A. Jr. Smith" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "J Urol" "fecha" => "2002" "volumen" => "167" "numero" => "5" "paginaInicial" => "2012" "paginaFinal" => "2016" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11956429" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0075" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Radical cystectomy is safe in elderly patients at high risk" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "S. Chang" 1 => "G. Alberts" 2 => "M.S. Cookson" 3 => "J.A. Jr. Smith" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "J Urol" "fecha" => "2001" "volumen" => "166" "numero" => "3" "paginaInicial" => "938" "paginaFinal" => "941" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11490250" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0080" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Identifying risk factors for potentially avoidable complications following radical cystectomy" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "B.K. Hollenbeck" 1 => "D.C. Miller" 2 => "D. Taub" 3 => "R.L. Dunn" 4 => "S.F. Khuri" 5 => "W.G. Henderson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "J Urol" "fecha" => "2005" "volumen" => "174" "numero" => "4 Pt 1" "paginaInicial" => "1231" "paginaFinal" => "1237" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16145376" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0085" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epidemiology in aging research" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "H. Brenner" 1 => "V. Arndt" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Exp.Geront" "fecha" => "2004" "numero" => "39" "paginaInicial" => "679" "paginaFinal" => "686" ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0090" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Gastroenterologí a geriá trica: Introducció n" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M. Bixquert Jimenez" 1 => "R. Gil Lita" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:3 [ "paginaInicial" => "3" "paginaFinal" => "6" "serieFecha" => "2004" ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0095" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A multicenter study of the morbidity of radical cystectomy in select elderly patients with bladder cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Soulií" 1 => "M. Straub" 2 => "X. Gamé" 3 => "P. Seguin" 4 => "R. De Petriconi" 5 => "P. Plante" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "J Urol" "fecha" => "2002" "volumen" => "167" "numero" => "3" "paginaInicial" => "1325" "paginaFinal" => "1328" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11832724" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0100" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Causes of increased hospital stay after radical cystectomy in a clinical pathway setting" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "S. Chang" 1 => "R.G. Baumgartner" 2 => "N. Wells" 3 => "M.S. Cookson" 4 => "J.A. Jr. Smith" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "J Urol" "fecha" => "2002" "volumen" => "167" "numero" => "1" "paginaInicial" => "208" "paginaFinal" => "211" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11743307" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib0105" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "titulo" => "Editorial.The surgical risk of elderly patients with cancer" ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.suronc.2004.09.012" "Revista" => array:6 [ "tituloSerie" => "Surgical Oncology" "fecha" => "2004" "volumen" => "13" "paginaInicial" => "169" "paginaFinal" => "173" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15615652" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib0110" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Age and comorbidity impact surgical therapy in older bladder carcinoma patients. A population study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "G.R. Prout" 1 => "M.N. Wesley" 2 => "R. Yancik" 3 => "L.A. Ries" 4 => "R.J. Havlik" 5 => "B.K. Edwards" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/cncr.21354" "Revista" => array:7 [ "tituloSerie" => "Cancer" "fecha" => "2005" "volumen" => "104" "numero" => "8" "paginaInicial" => "1638" "paginaFinal" => "1647" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16130136" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib0115" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Factors influencing aggresive therapy for bladder cancer:an analysis of data from the SEER program" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "B.R. Konety" 1 => "S.A. Joslyn" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/01.ju.0000091620.86778.2e" "Revista" => array:7 [ "tituloSerie" => "J. Urol" "fecha" => "2003" "volumen" => "170" "paginaInicial" => "1765" "paginaFinal" => "1771" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14532772" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0140673601056276" "estado" => "S300" "issn" => "01406736" ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib0120" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Gender diferences in radical cystectomy: complications and blood loss" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "K.L. Lee" 1 => "F. Freiha" 2 => "J.C. Presti" 3 => "H.S. Gill" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.urology.2004.01.029" "Revista" => array:7 [ "tituloSerie" => "Urology" "fecha" => "2004" "volumen" => "63" "numero" => "6" "paginaInicial" => "1095" "paginaFinal" => "1099" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15183957" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib0125" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Radical cystectomy for elderly patients with bladder carcinoma. An updated experience with 404 patients" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A.J. Figueroa" 1 => "J.P. Stein" 2 => "M. Dickinson" 3 => "E.C. Skinner" 4 => "D. Thangathurai" 5 => "M.S. Mikhail" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Cancer" "fecha" => "1997" "volumen" => "83" "numero" => "1" "paginaInicial" => "141" "paginaFinal" => "147" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9655304" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib0130" "etiqueta" => "26." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Performance status is a predictor of overall survival of elderly patients with muscle invasive bladder cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A.Z. Weizer" 1 => "D. Joshi" 2 => "S. Daignault" 3 => "M. Kinnaman" 4 => "M. Hussain" 5 => "J.E. Montie" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.juro.2006.11.060" "Revista" => array:7 [ "tituloSerie" => "J Urol" "fecha" => "2007" "volumen" => "177" "numero" => "4" "paginaInicial" => "1287" "paginaFinal" => "1293" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17382715" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/02104806/0000003200000007/v1_201304251911/S0210480608739172/v1_201304251911/es/main.assets" "Apartado" => array:4 [ "identificador" => "6429" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Original" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/02104806/0000003200000007/v1_201304251911/S0210480608739172/v1_201304251911/es/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210480608739172?idApp=UINPBA00004N" ]
| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 0 | 2 | 2 |
| 2024 Octubre | 0 | 14 | 14 |
| 2024 Septiembre | 0 | 14 | 14 |
| 2024 Agosto | 0 | 10 | 10 |
| 2024 Julio | 0 | 17 | 17 |
| 2024 Junio | 0 | 14 | 14 |
| 2024 Mayo | 0 | 7 | 7 |
| 2024 Abril | 0 | 65 | 65 |
| 2024 Marzo | 0 | 80 | 80 |
| 2024 Febrero | 0 | 105 | 105 |
| 2024 Enero | 0 | 19 | 19 |
| 2023 Diciembre | 0 | 5 | 5 |
| 2023 Noviembre | 0 | 38 | 38 |
| 2023 Octubre | 0 | 49 | 49 |
| 2023 Septiembre | 0 | 17 | 17 |
| 2023 Agosto | 0 | 1 | 1 |
| 2023 Julio | 0 | 45 | 45 |
| 2023 Junio | 0 | 12 | 12 |
| 2023 Mayo | 0 | 1 | 1 |
| 2023 Marzo | 4 | 3 | 7 |
| 2023 Febrero | 0 | 6 | 6 |
| 2023 Enero | 0 | 4 | 4 |
| 2022 Diciembre | 0 | 3 | 3 |
| 2022 Noviembre | 0 | 11 | 11 |
| 2022 Octubre | 0 | 11 | 11 |
| 2022 Septiembre | 0 | 9 | 9 |
| 2022 Agosto | 0 | 3 | 3 |
| 2022 Junio | 0 | 4 | 4 |
| 2022 Mayo | 0 | 1 | 1 |
| 2022 Abril | 0 | 3 | 3 |
| 2022 Marzo | 0 | 5 | 5 |
| 2022 Febrero | 0 | 2 | 2 |
| 2022 Enero | 0 | 1 | 1 |
| 2021 Diciembre | 0 | 2 | 2 |
| 2021 Noviembre | 0 | 4 | 4 |
| 2021 Agosto | 0 | 2 | 2 |
| 2021 Julio | 0 | 2 | 2 |
| 2021 Junio | 0 | 1 | 1 |
| 2021 Mayo | 0 | 3 | 3 |
| 2021 Marzo | 0 | 6 | 6 |
| 2021 Febrero | 0 | 1 | 1 |
| 2021 Enero | 0 | 3 | 3 |
| 2020 Diciembre | 0 | 1 | 1 |
| 2020 Noviembre | 0 | 1 | 1 |
| 2020 Octubre | 0 | 3 | 3 |
| 2020 Septiembre | 0 | 3 | 3 |
| 2020 Agosto | 0 | 10 | 10 |
| 2020 Julio | 0 | 2 | 2 |
| 2020 Junio | 0 | 2 | 2 |
| 2020 Mayo | 0 | 3 | 3 |
| 2020 Abril | 0 | 1 | 1 |
| 2020 Marzo | 0 | 4 | 4 |
| 2020 Febrero | 0 | 2 | 2 |
| 2020 Enero | 0 | 5 | 5 |
| 2019 Diciembre | 0 | 13 | 13 |
| 2019 Noviembre | 0 | 4 | 4 |
| 2019 Octubre | 0 | 5 | 5 |
| 2019 Septiembre | 0 | 5 | 5 |
| 2019 Julio | 0 | 12 | 12 |
| 2019 Junio | 0 | 21 | 21 |
| 2019 Mayo | 0 | 44 | 44 |
| 2019 Abril | 0 | 21 | 21 |
| 2019 Marzo | 0 | 10 | 10 |
| 2019 Febrero | 0 | 3 | 3 |
| 2019 Enero | 0 | 8 | 8 |
| 2018 Diciembre | 0 | 7 | 7 |
| 2018 Noviembre | 0 | 17 | 17 |
| 2018 Octubre | 0 | 7 | 7 |
| 2018 Septiembre | 1 | 2 | 3 |
| 2018 Febrero | 0 | 3 | 3 |
| 2018 Enero | 1 | 0 | 1 |
| 2017 Diciembre | 3 | 0 | 3 |
| 2017 Noviembre | 2 | 2 | 4 |
| 2017 Octubre | 5 | 4 | 9 |
| 2017 Septiembre | 3 | 2 | 5 |
| 2017 Agosto | 7 | 0 | 7 |
| 2017 Julio | 2 | 9 | 11 |
| 2017 Junio | 8 | 6 | 14 |
| 2017 Mayo | 9 | 3 | 12 |
| 2017 Abril | 7 | 1 | 8 |
| 2017 Marzo | 8 | 6 | 14 |
| 2017 Febrero | 5 | 4 | 9 |
| 2017 Enero | 1 | 0 | 1 |
| 2016 Diciembre | 18 | 3 | 21 |
| 2016 Noviembre | 22 | 1 | 23 |
| 2016 Octubre | 35 | 2 | 37 |
| 2016 Septiembre | 10 | 2 | 12 |
| 2016 Agosto | 12 | 3 | 15 |
| 2016 Julio | 8 | 4 | 12 |
| 2016 Junio | 9 | 6 | 15 |
| 2016 Mayo | 16 | 14 | 30 |
| 2016 Abril | 16 | 13 | 29 |
| 2016 Marzo | 12 | 6 | 18 |
| 2016 Febrero | 12 | 10 | 22 |
| 2016 Enero | 10 | 9 | 19 |
| 2015 Diciembre | 2 | 7 | 9 |
| 2015 Noviembre | 12 | 3 | 15 |
| 2015 Octubre | 10 | 3 | 13 |
| 2015 Septiembre | 7 | 5 | 12 |
| 2015 Agosto | 8 | 0 | 8 |
| 2015 Julio | 3 | 4 | 7 |
| 2015 Junio | 1 | 1 | 2 |
| 2015 Mayo | 5 | 2 | 7 |
| 2015 Abril | 11 | 6 | 17 |
| 2015 Marzo | 4 | 3 | 7 |
| 2015 Febrero | 0 | 5 | 5 |
| 2015 Enero | 1 | 3 | 4 |
| 2014 Diciembre | 8 | 4 | 12 |
| 2014 Noviembre | 6 | 4 | 10 |
| 2014 Octubre | 3 | 2 | 5 |
| 2014 Septiembre | 15 | 1 | 16 |
| 2014 Agosto | 7 | 2 | 9 |
| 2014 Julio | 14 | 1 | 15 |
| 2014 Junio | 3 | 2 | 5 |
| 2014 Mayo | 3 | 2 | 5 |
| 2014 Abril | 2 | 3 | 5 |
| 2014 Marzo | 3 | 0 | 3 |
| 2014 Febrero | 4 | 4 | 8 |
| 2014 Enero | 2 | 1 | 3 |
| 2013 Diciembre | 8 | 5 | 13 |
| 2013 Noviembre | 13 | 8 | 21 |
| 2013 Octubre | 5 | 16 | 21 |
| 2013 Septiembre | 5 | 7 | 12 |
| 2013 Agosto | 4 | 9 | 13 |
| 2013 Julio | 1 | 1 | 2 |
| 2008 Junio | 305 | 0 | 305 |
Mostrar todo
