Efecto terapéutico de Mitomicina C en el postoperatorio inmediato de pacientes con tumores vesicales no músculo invasores de riesgo intermedio
Therapeutic Effect of Mitomycin C in the Immediate Postoperative Period in Patients with Intermediate-Risk Non-Muscle-Invasive Bladder Tumors.
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"apellidos" => "Vallejo Gil" ] 5 => array:2 [ "nombre" => "L.L." "apellidos" => "Cortadellas Angel" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210480608739561?idApp=UINPBA00004N" "url" => "/02104806/0000003200000009/v1_201304251914/S0210480608739561/v1_201304251914/es/main.assets" ] "es" => array:14 [ "idiomaDefecto" => true "titulo" => "Efecto terapéutico de Mitomicina C en el postoperatorio inmediato de pacientes con tumores vesicales no músculo invasores de riesgo intermedio" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "894" "paginaFinal" => "903" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "A. Jalón Monzón, J.M. Fernández Gómez, S. Escaf Barmadah, M. Álvarez Múgica, J.L. Martín Benito, F.J. Regadera Sejas" "autores" => array:6 [ 0 => array:4 [ "nombre" => "A." "apellidos" => "Jalón Monzón" "email" => array:1 [ 0 => "ajalonm@hotmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "cor0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0010" ] ] ] 1 => array:3 [ "nombre" => "J.M." "apellidos" => "Fernández Gómez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "S." "apellidos" => "Escaf Barmadah" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "M." "apellidos" => "Álvarez Múgica" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0010" ] ] ] 4 => array:3 [ "nombre" => "J.L." "apellidos" => "Martín Benito" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0010" ] ] ] 5 => array:3 [ "nombre" => "F.J." "apellidos" => "Regadera Sejas" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Urología. Hospital de Jove. Asturias. Actas Urol Esp. 2008;32(9):894-903" "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Urología-1. Hospital Universitario Central de Asturias. Servicio de Urología. Hospital de Jove. Asturias. Actas Urol Esp. 2008;32(9):894-903" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "1" "correspondencia" => "Correspondencia autor: Dr. A. Jalón Monzón Servicio de Urología-I. Hospital Universitario Central de Asturias Celestino Villamil, s/n - 33006 Oviedo (Asturias) Tel.: 985 108 004" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Therapeutic Effect of Mitomycin C in the Immediate Postoperative Period in Patients with Intermediate-Risk Non-Muscle-Invasive Bladder Tumors." ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2008-02-29" "fechaAceptado" => "2008-04-30" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec88722" "palabras" => array:5 [ 0 => "No músculo-invasor" 1 => "Cáncer vesical" 2 => "Terapia intravesical" 3 => "Quimioterapia" 4 => "Mitomicina C" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec88721" "palabras" => array:5 [ 0 => "Non muscle-invasive" 1 => "Bladder cancer" 2 => "Intravesical therapy" 3 => "Chemotherapy" 4 => "Mitomycin C" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Introducción</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Aproximadamente del 70-85% de los carcinomas de células transicionales de vejiga no invaden la muscular propia. La recidiva después de la cirugía se cifra en un 60-90% de pacientes, siendo el periodo de alto riesgo los dos primeros años. La causa fundamental de recidiva en tumores de riesgo intermedio podría ser la inestabilidad del urotelio, por lo que la instilación única de un quimioterápico después de la RTU podría considerarse insuficiente, recomendándose un tratamiento diferido asociado con mantenimiento en algunos casos.</p> <span class="elsevierStyleSectionTitle">Pacientes y Métodos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Estudio prospectivo, controlado y randomizado. Sólo se incluyeron pacientes con tumores vesicales no músculo-invasores de grado intermedio. Todos los pacientes fueron sometidos inicialmente a RTU y posteriormente randomizados para recibir Mitomicina C (MMC) postoperatoria en dosis única.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Se incluyeron 105 pacientes. La media de seguimiento fue de 22,70±8,15 meses. Se administró MMC en 53 pacientes, de los cuales el 66% no recidivó y el 34% lo hicieron como tumor vesical no invasor. De los 52 pacientes que no recibieron MMC, el 53,8% no recidivaron, el 44,2% recidivaron como tumor no invasor y sólo un caso recurrió como tumor invasor. En cuanto al tiempo libre de enfermedad, no se encontraron diferencias significativas en los que se empleó MMC postoperatoria o tratamiento diferido. Sólo existió un caso de mielosupresión.</p> <span class="elsevierStyleSectionTitle">Discusión</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">En tumores no músculo invasores de medio riesgo, diversos estudios sugieren que una instilación intravesical inmediata de un quimioterápico disminuye el riesgo de recidiva después de la RTU. No hemos logrado demostrar diferencias significativas al comparar la MMC postoperatoria frente a las instilaciones diferidas tradicionales.</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Approximately 70-85% of transitional bladder cell carcinomas are non-muscle-invasive. After an initial surgery, around 60-90% will have a recurrence, being the highest risk period the first two years. Urothelium instability could be the main reason for recurrence in mid grade tumours, reason why a single dose of a chemotherapy after transurethral resection of the bladder (TURB) might be insufficient. That is why a deferred therapy in occasions associated with maintenance is recommended.</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">A prospective, controlled and randomized study was performed. We included non-muscle-invasive mid risk bladder tumours. All patients had initially a TURB performed and were randomized to receive a single dose of mitomycin C (MMC), in the immediate postoperative period.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">A total of 105 patients were included. Mean follow-up was 22, 70±8, 15 months. MMC was administered to 53 patients. Of these 66, 0% had no recurrence and 34,0% had a non-muscle-invasive recurrence. Of the 52 patients in the non MMC group, 53,8% had no recurrence and 44,2% had a non-muscle-invasive recurrence and only 1 patient had a muscleinvasive progression. We did not find significantly differences in time to recurrence in mid risk tumours when using immediate postoperative single dose of MMC or deferred therapy. There was only one case of myelosuppression.</p> <span class="elsevierStyleSectionTitle">Discussion</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">In mid risk non-muscle-invasive tumors, some studies suggest that early intravesical instillation of chemotherapy reduces the risk of recurrence after TURB. 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| año/Mes | Html | Total | |
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| 2024 Noviembre | 0 | 4 | 4 |
| 2024 Octubre | 0 | 17 | 17 |
| 2024 Septiembre | 0 | 30 | 30 |
| 2024 Agosto | 0 | 22 | 22 |
| 2024 Julio | 0 | 20 | 20 |
| 2024 Junio | 0 | 23 | 23 |
| 2024 Mayo | 0 | 28 | 28 |
| 2024 Abril | 0 | 25 | 25 |
| 2024 Marzo | 0 | 36 | 36 |
| 2024 Febrero | 0 | 37 | 37 |
| 2024 Enero | 0 | 42 | 42 |
| 2023 Diciembre | 0 | 48 | 48 |
| 2023 Noviembre | 0 | 40 | 40 |
| 2023 Octubre | 0 | 59 | 59 |
| 2023 Septiembre | 0 | 21 | 21 |
| 2023 Agosto | 0 | 39 | 39 |
| 2023 Julio | 0 | 65 | 65 |
| 2023 Junio | 0 | 61 | 61 |
| 2023 Mayo | 0 | 24 | 24 |
| 2023 Abril | 0 | 40 | 40 |
| 2023 Marzo | 1 | 40 | 41 |
| 2023 Febrero | 0 | 28 | 28 |
| 2023 Enero | 0 | 30 | 30 |
| 2022 Diciembre | 0 | 34 | 34 |
| 2022 Noviembre | 0 | 21 | 21 |
| 2022 Octubre | 0 | 26 | 26 |
| 2022 Septiembre | 0 | 13 | 13 |
| 2022 Agosto | 0 | 50 | 50 |
| 2022 Julio | 0 | 18 | 18 |
| 2022 Junio | 0 | 17 | 17 |
| 2022 Mayo | 0 | 15 | 15 |
| 2022 Abril | 0 | 12 | 12 |
| 2022 Marzo | 0 | 17 | 17 |
| 2022 Febrero | 0 | 15 | 15 |
| 2022 Enero | 0 | 47 | 47 |
| 2021 Diciembre | 0 | 23 | 23 |
| 2021 Noviembre | 0 | 12 | 12 |
| 2021 Octubre | 0 | 8 | 8 |
| 2021 Septiembre | 0 | 14 | 14 |
| 2021 Agosto | 0 | 22 | 22 |
| 2021 Julio | 0 | 8 | 8 |
| 2021 Junio | 0 | 5 | 5 |
| 2021 Mayo | 0 | 21 | 21 |
| 2021 Abril | 0 | 38 | 38 |
| 2021 Marzo | 0 | 12 | 12 |
| 2021 Febrero | 0 | 19 | 19 |
| 2021 Enero | 0 | 23 | 23 |
| 2020 Diciembre | 0 | 20 | 20 |
| 2020 Noviembre | 0 | 16 | 16 |
| 2020 Octubre | 0 | 17 | 17 |
| 2020 Septiembre | 0 | 16 | 16 |
| 2020 Agosto | 0 | 17 | 17 |
| 2020 Julio | 0 | 6 | 6 |
| 2020 Junio | 0 | 9 | 9 |
| 2020 Mayo | 0 | 8 | 8 |
| 2020 Abril | 0 | 4 | 4 |
| 2020 Marzo | 0 | 4 | 4 |
| 2020 Febrero | 0 | 11 | 11 |
| 2020 Enero | 0 | 20 | 20 |
| 2019 Diciembre | 0 | 25 | 25 |
| 2019 Noviembre | 0 | 8 | 8 |
| 2019 Octubre | 0 | 6 | 6 |
| 2019 Septiembre | 0 | 10 | 10 |
| 2019 Agosto | 0 | 9 | 9 |
| 2019 Julio | 0 | 13 | 13 |
| 2019 Junio | 0 | 13 | 13 |
| 2019 Mayo | 0 | 54 | 54 |
| 2019 Abril | 0 | 33 | 33 |
| 2019 Marzo | 1 | 12 | 13 |
| 2019 Febrero | 0 | 12 | 12 |
| 2019 Enero | 0 | 2 | 2 |
| 2018 Diciembre | 0 | 6 | 6 |
| 2018 Noviembre | 0 | 14 | 14 |
| 2018 Octubre | 0 | 12 | 12 |
| 2018 Febrero | 4 | 8 | 12 |
| 2018 Enero | 0 | 7 | 7 |
| 2017 Diciembre | 0 | 5 | 5 |
| 2017 Noviembre | 2 | 7 | 9 |
| 2017 Octubre | 2 | 4 | 6 |
| 2017 Septiembre | 1 | 8 | 9 |
| 2017 Agosto | 3 | 4 | 7 |
| 2017 Julio | 4 | 5 | 9 |
| 2017 Junio | 2 | 21 | 23 |
| 2017 Mayo | 5 | 9 | 14 |
| 2017 Abril | 5 | 2 | 7 |
| 2017 Marzo | 6 | 24 | 30 |
| 2017 Febrero | 4 | 3 | 7 |
| 2017 Enero | 7 | 2 | 9 |
| 2016 Diciembre | 14 | 9 | 23 |
| 2016 Noviembre | 20 | 9 | 29 |
| 2016 Octubre | 36 | 8 | 44 |
| 2016 Septiembre | 13 | 6 | 19 |
| 2016 Agosto | 7 | 5 | 12 |
| 2016 Julio | 8 | 6 | 14 |
| 2016 Junio | 11 | 5 | 16 |
| 2016 Mayo | 16 | 9 | 25 |
| 2016 Abril | 7 | 6 | 13 |
| 2016 Marzo | 16 | 7 | 23 |
| 2016 Febrero | 10 | 6 | 16 |
| 2016 Enero | 10 | 12 | 22 |
| 2015 Diciembre | 3 | 7 | 10 |
| 2015 Noviembre | 11 | 5 | 16 |
| 2015 Octubre | 12 | 5 | 17 |
| 2015 Septiembre | 12 | 2 | 14 |
| 2015 Agosto | 6 | 0 | 6 |
| 2015 Julio | 11 | 5 | 16 |
| 2015 Junio | 4 | 2 | 6 |
| 2015 Mayo | 4 | 0 | 4 |
| 2015 Abril | 6 | 6 | 12 |
| 2015 Marzo | 4 | 2 | 6 |
| 2015 Febrero | 7 | 2 | 9 |
| 2015 Enero | 12 | 2 | 14 |
| 2014 Diciembre | 20 | 7 | 27 |
| 2014 Noviembre | 10 | 2 | 12 |
| 2014 Octubre | 20 | 3 | 23 |
| 2014 Septiembre | 21 | 1 | 22 |
| 2014 Agosto | 15 | 1 | 16 |
| 2014 Julio | 25 | 2 | 27 |
| 2014 Junio | 19 | 2 | 21 |
| 2014 Mayo | 15 | 1 | 16 |
| 2014 Abril | 3 | 3 | 6 |
| 2014 Marzo | 7 | 1 | 8 |
| 2014 Febrero | 2 | 0 | 2 |
| 2014 Enero | 5 | 2 | 7 |
| 2013 Diciembre | 13 | 3 | 16 |
| 2013 Noviembre | 13 | 9 | 22 |
| 2013 Octubre | 6 | 10 | 16 |
| 2013 Septiembre | 6 | 13 | 19 |
| 2013 Agosto | 4 | 17 | 21 |
| 2013 Julio | 2 | 0 | 2 |
| 2008 Septiembre | 275 | 0 | 275 |
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