Correspondencia autor: Dra. M.P. Bahílo Mateu Servicio de Urología. Hospital Universitario La Fe Avda. Campanar, 21- 46009. Valencia. Tel.: 963 862 700
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Caballero Romeu, J. Palacios Ramos, J.G. Pereira Arias, M. Gamarra Quintanilla, A. Astobieta Odriozola, G. Ibarluzea González" "autores" => array:6 [ 0 => array:2 [ "nombre" => "J.P." "apellidos" => "Caballero Romeu" ] 1 => array:2 [ "nombre" => "J." "apellidos" => "Palacios Ramos" ] 2 => array:2 [ "nombre" => "J.G." "apellidos" => "Pereira Arias" ] 3 => array:2 [ "nombre" => "M." "apellidos" => "Gamarra Quintanilla" ] 4 => array:2 [ "nombre" => "A." "apellidos" => "Astobieta Odriozola" ] 5 => array:2 [ "nombre" => "G." "apellidos" => "Ibarluzea González" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210480608739743?idApp=UINPBA00004N" "url" => "/02104806/0000003200000010/v1_201304251917/S0210480608739743/v1_201304251917/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S021048060873972X" "issn" => "02104806" "doi" => "10.1016/S0210-4806(08)73972-X" "estado" => "S300" "fechaPublicacion" => "2008-01-01" "aid" => "73972" "copyright" => "Asociación Española de Urología (AEU)" "documento" => "article" "crossmark" => 0 "subdocumento" => "edi" "cita" => "Actas Urol Esp. 2008;32:957-60" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1380 "formatos" => array:3 [ "EPUB" => 6 "HTML" => 871 "PDF" => 503 ] ] "es" => array:7 [ "idiomaDefecto" => true "titulo" => "Uso de antimuscarínicos en pacientes con STUI-HBP y síntomas de VHA: maestría clínica y resistencia a perder el miedo al riesgo de retención urinaria" "tienePdf" => "es" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "957" "paginaFinal" => "960" ] ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J.L. Ruiz Cerdá" "autores" => array:1 [ 0 => array:2 [ "nombre" => "J.L." "apellidos" => "Ruiz Cerdá" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S021048060873972X?idApp=UINPBA00004N" "url" => "/02104806/0000003200000010/v1_201304251917/S021048060873972X/v1_201304251917/es/main.assets" ] "es" => array:14 [ "idiomaDefecto" => true "titulo" => "Características clínicas e histopatológicas del cáncer de próstata diagnosticado a partir de la tercera biopsia" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "961" "paginaFinal" => "967" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "M.P. Bahílo Mateu, M. Ramírez Backhaus, M. Trassierra Villa, C. Di Capua Sacoto, S. Arlandis Guzmán, J.F. Jiménez Cruz" "autores" => array:6 [ 0 => array:4 [ "nombre" => "M.P." "apellidos" => "Bahílo Mateu" "email" => array:1 [ 0 => "pilarbahilo@comv.es" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "M." "apellidos" => "Ramírez Backhaus" ] 2 => array:2 [ "nombre" => "M." "apellidos" => "Trassierra Villa" ] 3 => array:2 [ "nombre" => "C." "apellidos" => "Di Capua Sacoto" ] 4 => array:2 [ "nombre" => "S." "apellidos" => "Arlandis Guzmán" ] 5 => array:2 [ "nombre" => "J.F." "apellidos" => "Jiménez Cruz" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Urología. Hospital Universitario La Fe. Valencia" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "1" "correspondencia" => "Correspondencia autor: Dra. M.P. Bahílo Mateu Servicio de Urología. Hospital Universitario La Fe Avda. Campanar, 21- 46009. Valencia. Tel.: 963 862 700" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Clinical features and histopathology of prostate cancer diagnosed from the third biopsy" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2008-04-01" "fechaAceptado" => "2008-07-01" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec88742" "palabras" => array:2 [ 0 => "Biopsia prostática de repetición" 1 => "Cáncer de próstata" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec88741" "palabras" => array:2 [ 0 => "Repeated prostate biopsy" 1 => "Prostate cancer" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Estudiar las características histopatológicas y clínicas de los tumores diagnosticados a partir de terceras biopsias para valorar la relevancia clínica de éstos y descartar el sobrediagnóstico en el cáncer de próstata.</p> <span class="elsevierStyleSectionTitle">Material y método</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Revisamos las historias clínicas de 61 pacientes con al menos tres o más biopsias de próstata transrectales, sextantes o de saturación según el esquema preestablecido, desde el año 2000 al 2006. Las variables analizadas son: edad del paciente, PSA, cociente PSA libre/PSA total, PSA densidad, tacto rectal, volumen prostático, hallazgos ecográficos y lesión premaligna fuertemente asociadas a la presencia de tumor en biopsias previas. Y estudiamos la anatomía patológica de los tumores diagnosticados a partir de la tercera biopsia, abordaje terapéutico y su evolución con un seguimiento mínimo de 3 meses.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">De 61 pacientes con más de tres biopsias, a 15 pacientes se les diagnostica cáncer (24,6%) en la tercera biopsia. A 14 se les realiza nueva biopsia (cuarta), encontrando tumor en 5 de ellos (35,7%). Se realiza quinta biopsia en 2 pacientes siendo positiva en uno de ellos (50%). Según los resultados de la biopsia, 6 pacientes presentaban criterios de cáncer clínicamente no significativo (28,6%). En todos los pacientes se procedió a tratamiento curativo: 5 braquiterapia, 6 radioterapia externa y a 10 se les realizó una prostatectomía radical, que evidenció tumores clínicamente significativos: 2 tumores pT2b y 7 tumores pT2c sin invasión de los márgenes quirúrgicos y con un excelente control de la enfermedad tras un seguimiento mínimo de 13 meses y un pT4 por invasión del cuello vesical.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">En nuestro medio, la tercera, cuarta y quinta biopsia alcanza una positividad del 34,42% y se corresponde con tumores que se benefician de un tratamiento con intención curativa.</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To study of histological and clinical features of prostate cancer diagnosed after three or more prostate biopsies in order to assess its clinical relevance and to discard the overdiagnosis of prostate cancer.</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">We reviewed the clinical records of 61 patients who underwent three or more prostate biopsies between January 2000 and December 2006. The analyzed variables were: age, PSA level, free/total PSA ratio, PSA density, digital rectal examination, prostate volume, sonographic findings and previous malignant lesion strongly associated to the presence of tumor on previous biopsy. We studied the pathology of the tumors diagnosed from the third biopsy, therapeutical approach and its evolution with a minimum follow-up of 3 months.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Fifteen out of 61 patients with more than three biopsies had prostate cancer (24,59%) in the third biopsy, 5 out of 14 patients with 4 biopsies (35,71%) and 1 of the 2 cases (50%) who underwent a fifth biopsy. According to the results of biopsy, 6 patients met the criteria of clinically insignificant cancer (28,57%). Curative treatment was performed in all patients: brachytherapy in 5, external beam radiotherapy in 6 and radical prostatectomy in 10. Clinically significant tumors were found in all cases: 2 pT2b tumors and 7 pT2c tumors with negative surgical margins and with an excellent control of the cancer after a minimum follow up of 13 months, and one pT4 tumor with bladder neck infiltration.</p> <span class="elsevierStyleSectionTitle">Conclusion</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">In our practice, overall detection rate of the third, fourth and fifth biopsy is 34,42% corresponding with tumors that could benefit from curative treatment.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:22 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." 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2024 Noviembre | 0 | 1 | 1 |
2024 Octubre | 0 | 6 | 6 |
2024 Septiembre | 0 | 8 | 8 |
2024 Agosto | 0 | 2 | 2 |
2024 Julio | 0 | 8 | 8 |
2024 Junio | 0 | 12 | 12 |
2024 Mayo | 0 | 13 | 13 |
2024 Abril | 0 | 10 | 10 |
2024 Marzo | 0 | 35 | 35 |
2024 Febrero | 0 | 17 | 17 |
2024 Enero | 0 | 17 | 17 |
2023 Diciembre | 0 | 24 | 24 |
2023 Noviembre | 0 | 51 | 51 |
2023 Octubre | 0 | 33 | 33 |
2023 Septiembre | 0 | 3 | 3 |
2023 Agosto | 0 | 2 | 2 |
2023 Julio | 0 | 29 | 29 |
2023 Junio | 0 | 36 | 36 |
2023 Mayo | 0 | 8 | 8 |
2023 Abril | 0 | 3 | 3 |
2023 Marzo | 1 | 2 | 3 |
2023 Febrero | 0 | 4 | 4 |
2023 Enero | 0 | 4 | 4 |
2022 Noviembre | 0 | 13 | 13 |
2022 Octubre | 0 | 4 | 4 |
2022 Septiembre | 0 | 6 | 6 |
2022 Agosto | 0 | 14 | 14 |
2022 Julio | 0 | 3 | 3 |
2022 Junio | 0 | 8 | 8 |
2022 Mayo | 0 | 6 | 6 |
2022 Abril | 0 | 3 | 3 |
2022 Marzo | 0 | 5 | 5 |
2022 Febrero | 0 | 4 | 4 |
2022 Enero | 0 | 3 | 3 |
2021 Diciembre | 0 | 3 | 3 |
2021 Noviembre | 0 | 9 | 9 |
2021 Octubre | 0 | 2 | 2 |
2021 Septiembre | 0 | 1 | 1 |
2021 Agosto | 0 | 3 | 3 |
2021 Julio | 0 | 1 | 1 |
2021 Junio | 0 | 6 | 6 |
2021 Mayo | 0 | 1 | 1 |
2021 Abril | 0 | 8 | 8 |
2021 Marzo | 0 | 4 | 4 |
2021 Febrero | 0 | 1 | 1 |
2021 Enero | 0 | 2 | 2 |
2020 Diciembre | 0 | 1 | 1 |
2020 Noviembre | 0 | 4 | 4 |
2020 Octubre | 0 | 3 | 3 |
2020 Agosto | 0 | 13 | 13 |
2020 Julio | 0 | 3 | 3 |
2020 Junio | 0 | 2 | 2 |
2020 Mayo | 0 | 5 | 5 |
2020 Abril | 0 | 1 | 1 |
2020 Marzo | 0 | 10 | 10 |
2020 Febrero | 0 | 1 | 1 |
2020 Enero | 0 | 9 | 9 |
2019 Diciembre | 0 | 12 | 12 |
2019 Noviembre | 0 | 7 | 7 |
2019 Octubre | 0 | 5 | 5 |
2019 Septiembre | 0 | 9 | 9 |
2019 Agosto | 0 | 6 | 6 |
2019 Julio | 0 | 6 | 6 |
2019 Junio | 0 | 23 | 23 |
2019 Mayo | 0 | 43 | 43 |
2019 Abril | 0 | 40 | 40 |
2019 Febrero | 0 | 13 | 13 |
2018 Diciembre | 0 | 6 | 6 |
2018 Noviembre | 0 | 7 | 7 |
2018 Octubre | 0 | 15 | 15 |
2018 Mayo | 0 | 1 | 1 |
2018 Marzo | 1 | 0 | 1 |
2018 Febrero | 0 | 1 | 1 |
2017 Diciembre | 0 | 2 | 2 |
2017 Noviembre | 4 | 3 | 7 |
2017 Octubre | 2 | 1 | 3 |
2017 Septiembre | 1 | 2 | 3 |
2017 Agosto | 2 | 0 | 2 |
2017 Julio | 2 | 1 | 3 |
2017 Junio | 2 | 1 | 3 |
2017 Mayo | 10 | 3 | 13 |
2017 Abril | 7 | 1 | 8 |
2017 Marzo | 7 | 34 | 41 |
2017 Febrero | 1 | 3 | 4 |
2017 Enero | 3 | 3 | 6 |
2016 Diciembre | 17 | 5 | 22 |
2016 Noviembre | 15 | 4 | 19 |
2016 Octubre | 26 | 10 | 36 |
2016 Septiembre | 11 | 3 | 14 |
2016 Agosto | 11 | 3 | 14 |
2016 Julio | 7 | 6 | 13 |
2016 Junio | 5 | 10 | 15 |
2016 Mayo | 8 | 6 | 14 |
2016 Abril | 11 | 5 | 16 |
2016 Marzo | 5 | 5 | 10 |
2016 Febrero | 10 | 12 | 22 |
2016 Enero | 5 | 10 | 15 |
2015 Diciembre | 6 | 7 | 13 |
2015 Noviembre | 15 | 6 | 21 |
2015 Octubre | 9 | 3 | 12 |
2015 Septiembre | 9 | 3 | 12 |
2015 Agosto | 9 | 2 | 11 |
2015 Julio | 9 | 0 | 9 |
2015 Junio | 1 | 1 | 2 |
2015 Mayo | 5 | 1 | 6 |
2015 Abril | 7 | 3 | 10 |
2015 Marzo | 11 | 3 | 14 |
2015 Febrero | 2 | 3 | 5 |
2015 Enero | 13 | 4 | 17 |
2014 Diciembre | 15 | 5 | 20 |
2014 Noviembre | 4 | 2 | 6 |
2014 Octubre | 21 | 4 | 25 |
2014 Septiembre | 19 | 1 | 20 |
2014 Agosto | 18 | 4 | 22 |
2014 Julio | 22 | 2 | 24 |
2014 Junio | 10 | 3 | 13 |
2014 Mayo | 8 | 1 | 9 |
2014 Abril | 9 | 3 | 12 |
2014 Marzo | 14 | 1 | 15 |
2014 Febrero | 8 | 3 | 11 |
2014 Enero | 8 | 2 | 10 |
2013 Diciembre | 12 | 4 | 16 |
2013 Noviembre | 5 | 5 | 10 |
2013 Octubre | 3 | 3 | 6 |
2013 Septiembre | 6 | 3 | 9 |
2013 Agosto | 4 | 3 | 7 |
2013 Julio | 1 | 0 | 1 |
2008 Noviembre | 258 | 0 | 258 |