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Características clínicas e histopatológicas del cáncer de próstata diagnosticado a partir de la tercera biopsia
Clinical features and histopathology of prostate cancer diagnosed from the third biopsy
M.P. Bahílo Mateu1
Autor para correspondencia
pilarbahilo@comv.es

Correspondencia autor: Dra. M.P. Bahílo Mateu Servicio de Urología. Hospital Universitario La Fe Avda. Campanar, 21- 46009. Valencia. Tel.: 963 862 700
, M. Ramírez Backhaus, M. Trassierra Villa, C. Di Capua Sacoto, S. Arlandis Guzmán, J.F. Jiménez Cruz
Servicio de Urología. Hospital Universitario La Fe. Valencia
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Estudiar las caracter&#237;sticas histopatol&#243;gicas y cl&#237;nicas de los tumores diagnosticados a partir de terceras biopsias para valorar la relevancia cl&#237;nica de &#233;stos y descartar el sobrediagn&#243;stico en el c&#225;ncer de pr&#243;stata&#46;</p> <span class="elsevierStyleSectionTitle">Material y m&#233;todo</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Revisamos las historias cl&#237;nicas de 61 pacientes con al menos tres o m&#225;s biopsias de pr&#243;stata transrectales&#44; sextantes o de saturaci&#243;n seg&#250;n el esquema preestablecido&#44; desde el a&#241;o 2000 al 2006&#46; Las variables analizadas son&#58; edad del paciente&#44; PSA&#44; cociente PSA libre&#47;PSA total&#44; PSA densidad&#44; tacto rectal&#44; volumen prost&#225;tico&#44; hallazgos ecogr&#225;ficos y lesi&#243;n premaligna fuertemente asociadas a la presencia de tumor en biopsias previas&#46; Y estudiamos la anatom&#237;a patol&#243;gica de los tumores diagnosticados a partir de la tercera biopsia&#44; abordaje terap&#233;utico y su evoluci&#243;n con un seguimiento m&#237;nimo de 3 meses&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">De 61 pacientes con m&#225;s de tres biopsias&#44; a 15 pacientes se les diagnostica c&#225;ncer &#40;24&#44;6&#37;&#41; en la tercera biopsia&#46; A 14 se les realiza nueva biopsia &#40;cuarta&#41;&#44; encontrando tumor en 5 de ellos &#40;35&#44;7&#37;&#41;&#46; Se realiza quinta biopsia en 2 pacientes siendo positiva en uno de ellos &#40;50&#37;&#41;&#46; Seg&#250;n los resultados de la biopsia&#44; 6 pacientes presentaban criterios de c&#225;ncer cl&#237;nicamente no significativo &#40;28&#44;6&#37;&#41;&#46; En todos los pacientes se procedi&#243; a tratamiento curativo&#58; 5 braquiterapia&#44; 6 radioterapia externa y a 10 se les realiz&#243; una prostatectom&#237;a radical&#44; que evidenci&#243; tumores cl&#237;nicamente significativos&#58; 2 tumores pT2b y 7 tumores pT2c sin invasi&#243;n de los m&#225;rgenes quir&#250;rgicos y con un excelente control de la enfermedad tras un seguimiento m&#237;nimo de 13 meses y un pT4 por invasi&#243;n del cuello vesical&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">En nuestro medio&#44; la tercera&#44; cuarta y quinta biopsia alcanza una positividad del 34&#44;42&#37; y se corresponde con tumores que se benefician de un tratamiento con intenci&#243;n curativa&#46;</p>"
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        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To study of histological and clinical features of prostate cancer diagnosed after three or more prostate biopsies in order to assess its clinical relevance and to discard the overdiagnosis of prostate cancer&#46;</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">We reviewed the clinical records of 61 patients who underwent three or more prostate biopsies between January 2000 and December 2006&#46; The analyzed variables were&#58; age&#44; PSA level&#44; free&#47;total PSA ratio&#44; PSA density&#44; digital rectal examination&#44; prostate volume&#44; sonographic findings and previous malignant lesion strongly associated to the presence of tumor on previous biopsy&#46; We studied the pathology of the tumors diagnosed from the third biopsy&#44; therapeutical approach and its evolution with a minimum follow-up of 3 months&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Fifteen out of 61 patients with more than three biopsies had prostate cancer &#40;24&#44;59&#37;&#41; in the third biopsy&#44; 5 out of 14 patients with 4 biopsies &#40;35&#44;71&#37;&#41; and 1 of the 2 cases &#40;50&#37;&#41; who underwent a fifth biopsy&#46; According to the results of biopsy&#44; 6 patients met the criteria of clinically insignificant cancer &#40;28&#44;57&#37;&#41;&#46; Curative treatment was performed in all patients&#58; brachytherapy in 5&#44; external beam radiotherapy in 6 and radical prostatectomy in 10&#46; Clinically significant tumors were found in all cases&#58; 2 pT2b tumors and 7 pT2c tumors with negative surgical margins and with an excellent control of the cancer after a minimum follow up of 13 months&#44; and one pT4 tumor with bladder neck infiltration&#46;</p> <span class="elsevierStyleSectionTitle">Conclusion</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">In our practice&#44; overall detection rate of the third&#44; fourth and fifth biopsy is 34&#44;42&#37; corresponding with tumors that could benefit from curative treatment&#46;</p>"
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Información del artículo
ISSN: 02104806
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2014 Diciembre 15 5 20
2014 Noviembre 4 2 6
2014 Octubre 21 4 25
2014 Septiembre 19 1 20
2014 Agosto 18 4 22
2014 Julio 22 2 24
2014 Junio 10 3 13
2014 Mayo 8 1 9
2014 Abril 9 3 12
2014 Marzo 14 1 15
2014 Febrero 8 3 11
2014 Enero 8 2 10
2013 Diciembre 12 4 16
2013 Noviembre 5 5 10
2013 Octubre 3 3 6
2013 Septiembre 6 3 9
2013 Agosto 4 3 7
2013 Julio 1 0 1
2008 Noviembre 258 0 258
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es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos