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Transplante renal de donante vivo: un análisis crítico de estrategias quirúrgicas basado en 40 años de experiencia
Renal transplantation with living donors. a critical analysis of surgical procedures based on 40 years of experience
R. Vela Navarrete1
Autor para correspondencia
rvela@fjd.es

Correspondencia autor: Dr. R. Vela Navarrete Departamento de Urología y Unidad de Trasplante renal Fundación Jiménez Díaz Avda. de los Reyes Católicos, 2 - 28040 Madrid Tel.: 915 504 800
, J.L. Rodríguez Miñón Cifuentes, J. Calahorra Fernández, C. González Enguita, J. Cabrera, J.V. García Cardoso, I. Castillon Vela, J.J. Plaza
Departamento de Urología y Unidad de Trasplante Renal. Servicio de Nefrología. Fundación Jiménez Díaz. Universidad Autónoma de Madrid
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        "resumen" => "<span class="elsevierStyleSectionTitle">Introducci&#243;n</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">La prioridad inexcusable de un programa de trasplante renal de donante vivo &#40;TRDV&#41; es la seguridad vital del donante&#44; seguida de la preservaci&#243;n del &#243;rgano&#44; obtenido en las mejores condiciones anat&#243;micas y funcionales&#46; La reducci&#243;n de la morbilidad del donante&#44; inmediata y a largo t&#233;rmino&#44; debe ser otro objetivo&#46; Tanto en el TRDV como en el trasplante de cad&#225;ver el implante del &#243;rgano debe realizarse con las mayores garant&#237;as t&#233;cnicas&#46; Analizamos nuestra mortalidad&#44; morbilidad&#44; incidencias&#44; t&#233;cnica de la nefrectom&#237;a y otros datos relevantes observados en nuestro programa de TRDV iniciado en 1968&#44; con la intenci&#243;n de comparar nuestros resultados con los publicados utilizando t&#233;cnicas laparosc&#243;picas de nefrectom&#237;a&#44; y en consecuencia decidir si nuestro programa debe modificar&#44; o no&#44; sus estrategias quir&#250;rgicas actuales&#46;</p> <span class="elsevierStyleSectionTitle">Material y m&#233;todos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Nuestro programa de trasplante renal se inici&#243; en 1964&#44; con ri&#241;&#243;n de cad&#225;ver&#44; y en 1968 con ri&#241;&#243;n del donante vivo&#46; Desde junio de 1968 hasta junio del 2008 hemos realizado 243 TRDV&#59; un reducido n&#250;mero de trasplantes por a&#241;o&#46; La t&#233;cnica de nefrectom&#237;a empleada desde 1968-1972 fue el abordaje supracostal propuesto por Turner-Warrick y desde 1972 una miniincisi&#243;n subcostal&#44; anterior extraperitoneal&#46; La lumbotom&#237;a convencional con resecci&#243;n de la &#250;ltima costilla nunca ha sido practicada&#46; El ri&#241;&#243;n derecho fue utilizado en el 78&#37; y el implante en la fosa il&#237;aca derecha en el 85&#37; La cirug&#237;a del donante y el receptor se realizan simult&#225;neamente en dos quir&#243;fanos adyacentes&#44; por dos equipos distintos&#44; siendo un solo cirujano responsable de ambos procedimientos&#59; la nefrectom&#237;a y el implante&#46; Las complicaciones peroperatorias y postoperatorias&#44; potencialmente relacionadas con la nefrectom&#237;a&#44; o de otra naturaleza&#44; han sido evaluadas por los equipos urol&#243;gicos y nefrol&#243;gicos&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">No se han detectado en nuestra serie ning&#250;n caso de muerte del donante&#44; p&#233;rdida del &#243;rgano o complicaciones mayores tales como neumot&#243;rax&#44; hemorragias necesitando transfusi&#243;n&#44; infecciones graves&#44; reintervenciones&#46; Complicaciones menores tales como paresia intestinal&#44; fiebre&#44; infecci&#243;n de la herida operatoria&#44; fueron m&#225;s frecuentes con el abordaje supracostal que con el miniincisional&#46; Igualmente&#44; este abordaje ha reducido el dolor postoperatorio&#44; consumo de analg&#233;sicos y tiempo de recuperaci&#243;n&#46; En el seguimiento a largo plazo la incidencia de hernias incisionales&#44; o paresia de la pared abdominal&#44; no han sido detectadas&#46; La responsabilidad personal de un cirujano en ambos procedimientos soslaya reclamaciones sobre la calidad anat&#243;mica y funcional del &#243;rgano&#44; facilita la elecci&#243;n de vasos para la anastomosis y reduce el tiempo operatorio y de ocupaci&#243;n de quir&#243;fano&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">El an&#225;lisis de nuestros resultados cuestiona la conveniencia de sustituir nuestra estrategia quir&#250;rgica actual por los potenciales beneficios e inconvenientes de la nefrectom&#237;a laparosc&#243;pica&#44; especialmente en un programa de TRDV de reducido n&#250;mero anual&#46; Nuestra t&#233;cnica de nefrectom&#237;a ha ofrecido&#44; a lo largo de una experiencia de 40 a&#241;os&#44; m&#225;ximas garant&#237;as vitales para el donante y de calidad anat&#243;mica y funcional para el &#243;rgano&#44; con morbilidad postoperatoria similar a la conseguida con la incisi&#243;n final laparosc&#243;pica&#46;</p>"
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        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Absolute priority in an LDKT programme are donnor safety and kidney optimal anatomical and functional preservation&#46; Reduced donnor morbidities&#44;both at short and long term&#44;are important objectives&#46; Excellent technical grafting is a must as are the strategies employed for facilitatig it&#46; We revised the incidences of our whole LDKT programme &#40;40 years 243 donors&#41; to confirm if these exigences have been acomplished or a change to new surgical procedures is recommended&#46;</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Between 1968-2008 243 nephrectomies and grafting has been performed&#44;a reduced number per year &#40;A cadaver programme has been running simultaneously since 1964&#41;&#46; For the nephrectomies a Turner-Warrick apprach was inititialy used and since 1973 a miniincisional&#44; anterior&#44; extraperitoneal approach of approximately 10 cm in length&#46; The right kidney was removed in 75&#37; of the cases and the right iliac area for the implant in 85&#37; In adjacent opperating rooms&#44; one team performs the nephrectomy while the other prepares and dissects free the grafting vessels&#46; Most of the time the same senior surgeon performed both operatios&#58; the nephrectomy and the implant&#46; Peroperative and postoperative complications were evaluated by urologists and nephrologists in charge&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">No donors dead&#44;organs lost or major complications in the donors have been documented Minor complications such as intestinal paresia&#44; wound infection&#44;persistent incisional pain were common&#46; Miniincisional abdominal approach reduced postoperative pain and hospital stay &#40;4 days&#41;&#46; At long term no incisional hernia or abdominal paresia have been documented&#46; Simultaneous work reduces ischemia time &#40;30-45 s warm&#58; 30- 45 min cold&#41; and opperatig room occupation&#40;patient preparation plus anesthesia plus operation&#41;estimated in 90-120 min for the nephrectomy and 120-160 for the grafting&#46; The responsibility of the senior surgeon in both procedures facilitates vessel selection for the grafting&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">No reasons have been found to reconvert our current nephrectomy procedure to laparoscpic or modify current surgical strategy&#46; Superior safety of open surgery for donors and organs is confirmed&#46; Pain and recovery time are reduced in laparoscopic surgery but not as much when compared with miniincisional approach&#46; Open surgery permits optimal anatomical and functional organ extration facilitatig the quality of the implant&#46; As numbers matter in laparoscopic surgery open nephrectomy isrecommended for reduced LDKT programmes&#46;</p>"
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ISSN: 02104806
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