Influencia de la impronta genómica masculina en la reproducción
Influence of the Male Genomic Imprinting on the Reproduction
G.C. Vasco1
, A.M. Gil Villa, C. Piedrahita Ochoa, W. Cardona Maya, A. Cadavid Jaramillo
Autor para correspondencia
cadavida@une.net.co
reproduccion@medicina.udea.edu.co
Correspondencia autor: Dra. A. Cadavid Jaramillo Grupo Reproducción Sede de Investigación Universitaria (SIU) Universidad de Antioquia Medellín, Colombia, Sur América, A.A.1226. Tel: (57-4)-2196685 Fax: (57-4)-2196470
reproduccion@medicina.udea.edu.co
Correspondencia autor: Dra. A. Cadavid Jaramillo Grupo Reproducción Sede de Investigación Universitaria (SIU) Universidad de Antioquia Medellín, Colombia, Sur América, A.A.1226. Tel: (57-4)-2196685 Fax: (57-4)-2196470
Grupo Reproducción. Sede de Investigación Universitaria (SIU). Universidad de Antioquia. Medellín, Colombia
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Cadavid Jaramillo" "autores" => array:5 [ 0 => array:4 [ "nombre" => "G.C." "apellidos" => "Vasco" "email" => array:2 [ 0 => "cadavida@une.net.co" 1 => "reproduccion@medicina.udea.edu.co" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "A.M." "apellidos" => "Gil Villa" ] 2 => array:2 [ "nombre" => "C." "apellidos" => "Piedrahita Ochoa" ] 3 => array:2 [ "nombre" => "W." "apellidos" => "Cardona Maya" ] 4 => array:2 [ "nombre" => "A." "apellidos" => "Cadavid Jaramillo" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Grupo Reproducción. Sede de Investigación Universitaria (SIU). Universidad de Antioquia. Medellín, Colombia" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "1" "correspondencia" => "Correspondencia autor: Dra. A. Cadavid Jaramillo Grupo Reproducción Sede de Investigación Universitaria (SIU) Universidad de Antioquia Medellín, Colombia, Sur América, A.A.1226. Tel: (57-4)-2196685 Fax: (57-4)-2196470" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Influence of the Male Genomic Imprinting on the Reproduction" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2008-01-05" "fechaAceptado" => "2008-07-01" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec88744" "palabras" => array:5 [ 0 => "Espermatozoide" 1 => "Impronta" 2 => "Fertilidad" 3 => "Desarrollo embrionario" 4 => "Placenta" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec88743" "palabras" => array:5 [ 0 => "Spermatozoa" 1 => "Genomic imprinting" 2 => "Fertility" 3 => "Embryo development" 4 => "Placenta" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">La impronta genómica es la modificación epigenética que ocurre de manera diferencial tanto en genes específicos del oocito como del espermatozoide de acuerdo con su origen paterno o materno, permitiendo así una expresión monoalélica. En esta revisión se realiza un análisis crítico de la información relacionada con el papel que tiene la impronta masculina sobre el éxito reproductivo.</p> <span class="elsevierStyleSectionTitle">Metodología</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se hizo una búsqueda bibliográfica sobre algunos de los componentes que regulan la impronta geonómica masculina y el posible papel sobre los eventos reproductivos como la espermatogénesis y el desarrollo placentario y embrionario.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Este análisis de la literatura permitió valorar que los cambios estructurales, genéticos y epigenéticos que ocurren durante la formación del gameto masculino, pueden tener repercusiones en el desarrollo embrionario, principalmente en la formación de tejidos extraembrionarios como la placenta.</p> <span class="elsevierStyleSectionTitle">Conclusión</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Las alteraciones en los mecanismos moleculares implicados en el proceso de metilación del ADN durante la espermatogénesis, pueden generar errores en el patrón normal de expresión requerido para el adecuado desarrollo de los componentes feto-placentarios.</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Genomic imprinting is the epigenetic change that occurred differentially in the specific genes in spermatozoa and oocyte according to their paternal or maternal origin, thus allowing a monoallelic expression. This review is a critical analysis of the published information relating to the role of the male imprinting on the successful reproduction.</p> <span class="elsevierStyleSectionTitle">Methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">We performed a literature search on some of the components that regulate the male genomic imprinting and the possible role on reproductive events such as spermatogenesis, and placental and embryo development.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">The literature analysis allowed us to appreciate structural, genetic and epigenetic changes occurring during the formation of the male gamete that could have an impact on embryo development, mainly in the formation of extraembryonic tissues as the placenta.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Alterations in the molecular mechanisms involved in the sperm DNA methylation during the spermatogenesis, could induce alterations in the normal pattern of expression required in the fetal-placental components development.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:59 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Genomic imprinting: a chromatin connection" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "R. Feil" 1 => "G. Kelsey" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1086/301655" "Revista" => array:7 [ "tituloSerie" => "Am J Hum Genet" "fecha" => "1997" "volumen" => "61" "numero" => "6" "paginaInicial" => "1213" "paginaFinal" => "1219" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9399913" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "DNA methylation density influences the stability of an epigenetic imprint and Dnmt3a/b-independent de novo methylation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M.C. Lorincz" 1 => "D. Schubeler" 2 => "S.R. Hutchinson" 3 => "D.R. Dickerson" 4 => "M. Groudine" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Mol Cell Biol" "fecha" => "2002" "volumen" => "22" "numero" => "21" "paginaInicial" => "7572" "paginaFinal" => "7580" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12370304" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Chromatin-based silencing mechanisms" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J. Bender" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.pbi.2004.07.003" "Revista" => array:7 [ "tituloSerie" => "Curr Opin Plant Biol" "fecha" => "2004" "volumen" => "7" "numero" => "5" "paginaInicial" => "521" "paginaFinal" => "526" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15337094" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Establishment of male-specific epigenetic information" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "S. Rousseaux" 1 => "C. Caron" 2 => "J. Govin" 3 => "C. Lestrat" 4 => "A.K. Faure" 5 => "S. Khochbin" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.gene.2004.12.004" "Revista" => array:8 [ "tituloSerie" => "Gene" "fecha" => "2005" "volumen" => "345" "numero" => "2" "paginaInicial" => "139" "paginaFinal" => "153" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15716030" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0140673610611981" "estado" => "S300" "issn" => "01406736" ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epigenética: una explicación de las enfermedades hereditarias" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "R. García" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Perinatol Reprod Hum" "fecha" => "2003" "volumen" => "17" "paginaInicial" => "57" "paginaFinal" => "60" ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Genomic imprinting and reproduction" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "A.K. Swales" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1530/rep.1.00395" "Revista" => array:7 [ "tituloSerie" => "Reproduction" "fecha" => "2005" "volumen" => "130" "numero" => "4" "paginaInicial" => "389" "paginaFinal" => "399" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16183857" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Genomic imprinting in the placenta" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "A. Wagschal" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cytogenet Genome Res" "fecha" => "2006" "volumen" => "113" "numero" => "1-4" "paginaInicial" => "89" "paginaFinal" => "90" ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Preimplantation expression of the somatic form of Dnmt1 suggests a role in the inheritance of genomic imprints" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M.C. Cirio" 1 => "S. Ratnam" 2 => "F. Ding" 3 => "B. Reinhart" 4 => "C. Navara" 5 => "J.R. Chaillet" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/1471-213X-8-9" "Revista" => array:5 [ "tituloSerie" => "BMC Dev Biol" "fecha" => "2008" "volumen" => "8" "paginaInicial" => "9" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18221528" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Recognition of native DNA methylation by the PvuII restriction endonuclease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M.R. Rice" 1 => "R.M. Blumenthal" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Nucleic Acids Res" "fecha" => "2000" "volumen" => "28" "numero" => "16" "paginaInicial" => "3143" "paginaFinal" => "3150" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10931930" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Chromatin modification and remodeling during early seed development" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "C. Baroux" 1 => "S. Pien" 2 => "U. Grossniklaus" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.gde.2007.09.004" "Revista" => array:7 [ "tituloSerie" => "Curr Opin Genet Dev" "fecha" => "2007" "volumen" => "17" "numero" => "6" "paginaInicial" => "473" "paginaFinal" => "479" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18029170" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0055" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The role of imprinted genes in fetal growth" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M. Miozzo" 1 => "G. Simoni" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "56752" "Revista" => array:7 [ "tituloSerie" => "Biol Neonate" "fecha" => "2002" "volumen" => "81" "numero" => "4" "paginaInicial" => "217" "paginaFinal" => "228" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12011565" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0060" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Endogenous assays of DNA methyltransferases: Evidence for differential activities of DNMT1, DNMT2, and DNMT3 in mammalian cells in vivo" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "K. Liu" 1 => "Y.F. Wang" 2 => "C. Cantemir" 3 => "M.T. Muller" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Mol Cell Biol" "fecha" => "2003" "volumen" => "23" "numero" => "8" "paginaInicial" => "2709" "paginaFinal" => "2719" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12665573" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0065" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Developmental profile of H19 differentially methylated domain (DMD) deletion alleles reveals multiple roles of the DMD in regulating allelic expression and DNA methylation at the imprinted H19/Igf2 locus" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J.L. Thorvaldsen" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1128/MCB.26.4.1245-1258.2006" "Revista" => array:8 [ "tituloSerie" => "Mol Cell Biol" "fecha" => "2006" "volumen" => "26" "numero" => "4" "paginaInicial" => "1245" "paginaFinal" => "1258" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16449639" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0735109706015324" "estado" => "S300" "issn" => "07351097" ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0070" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Genetic imprinting during impaired spermatogenesis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "S. Hartmann" 1 => "M. Bergmann" 2 => "R.M. Bohle" 3 => "W. Weidner" 4 => "K. Steger" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/molehr/gal040" "Revista" => array:7 [ "tituloSerie" => "Mol Hum Reprod" "fecha" => "2006" "volumen" => "12" "numero" => "6" "paginaInicial" => "407" "paginaFinal" => "411" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16608903" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0075" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "CTCF elements direct allele-specific undermethylation at the imprinted H19 locus" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "E. Rand" 1 => "I. Ben-Porath" 2 => "I. Keshet" 3 => "H. Cedar" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.cub.2004.05.041" "Revista" => array:8 [ "tituloSerie" => "Curr Biol" "fecha" => "2004" "volumen" => "14" "numero" => "11" "paginaInicial" => "1007" "paginaFinal" => "1012" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15182675" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0300893211005239" "estado" => "S300" "issn" => "03008932" ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0080" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mechanisms of genomic imprinting" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "K. Pfeifer" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1086/303101" "Revista" => array:8 [ "tituloSerie" => "Am J Hum Genet" "fecha" => "2000" "volumen" => "67" "numero" => "4" "paginaInicial" => "777" "paginaFinal" => "787" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10986038" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S014067360861171X" "estado" => "S300" "issn" => "01406736" ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0085" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Genomic imprinting in disruptive spermatogenesis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "C.J. Marques" 1 => "F. Carvalho" 2 => "M. Sousa" 3 => "A. Barros" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0140-6736(04)16256-9" "Revista" => array:7 [ "tituloSerie" => "Lancet" "fecha" => "2004" "volumen" => "363" "numero" => "9422" "paginaInicial" => "1700" "paginaFinal" => "1702" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15158633" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0090" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epigenetic events in mammalian germ-cell development: reprogramming and beyond" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "H. Sasaki" 1 => "Y. Matsui" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/nrg2295" "Revista" => array:7 [ "tituloSerie" => "Nat Rev Genet" "fecha" => "2008" "volumen" => "9" "numero" => "2" "paginaInicial" => "129" "paginaFinal" => "140" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18197165" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0095" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Genomic imprinting of the insulin-like growth factor 2 gene in sheep" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "R.J. McLaren" 1 => "G.W. Montgomery" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Mamm Genome" "fecha" => "1999" "volumen" => "10" "numero" => "6" "paginaInicial" => "588" "paginaFinal" => "591" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10341091" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0100" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Demethylation of the zygotic paternal genome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "W. Mayer" 1 => "A. Niveleau" 2 => "J. Walter" 3 => "R. Fundele" 4 => "T. Haaf" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/35000654" "Revista" => array:7 [ "tituloSerie" => "Nature" "fecha" => "2000" "volumen" => "403" "numero" => "6769" "paginaInicial" => "501" "paginaFinal" => "502" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10676950" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib0105" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M. Okano" 1 => "D.W. Bell" 2 => "D.A. Haber" 3 => "E. Li" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Cell" "fecha" => "1999" "volumen" => "99" "numero" => "3" "paginaInicial" => "247" "paginaFinal" => "257" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10555141" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib0110" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Parental effect of DNA (Cytosine-5) methyltransferase 1 on grandparental-origin-dependent transmission ratio distortion in mouse crosses and human families" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "L. Yang" 1 => "M.F. Andrade" 2 => "S. Labialle" 3 => "S. Moussette" 4 => "G. Geneau" 5 => "D. Sinnett" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1534/genetics.107.081562" "Revista" => array:7 [ "tituloSerie" => "Genetics" "fecha" => "2008" "volumen" => "178" "numero" => "1" "paginaInicial" => "35" "paginaFinal" => "45" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18202356" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib0115" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "R. Jaenisch" 1 => "A. Bird" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/ng1089" "Revista" => array:7 [ "tituloSerie" => "Nat Genet" "fecha" => "2003" "volumen" => "33" "numero" => "Suppl" "paginaInicial" => "245" "paginaFinal" => "254" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12610534" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib0120" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dnmt3L cooperates with the Dnmt3 family of de novo DNA methyltransferases to establish maternal imprints in mice" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "K. Hata" 1 => "M. Okano" 2 => "H. Lei" 3 => "E. Li" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Development" "fecha" => "2002" "volumen" => "129" "numero" => "8" "paginaInicial" => "1983" "paginaFinal" => "1993" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11934864" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib0125" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Interactions within the mammalian DNA methyltransferase family" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J.B. Margot" 1 => "A.E. Ehrenhofer-Murray" 2 => "H. Leonhardt" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/1471-2199-4-7" "Revista" => array:6 [ "tituloSerie" => "BMC Molecular Biology" "fecha" => "2003" "volumen" => "4" "numero" => "1" "paginaInicial" => "7" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12777184" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib0130" "etiqueta" => "26." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "DNMT3L stimulates the DNA methylation activity of Dnmt3a and Dnmt3b through a direct interaction" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "I. Suetake" 1 => "F. Shinozaki" 2 => "J. Miyagawa" 3 => "H. Takeshima" 4 => "S. Tajima" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1074/jbc.M400181200" "Revista" => array:7 [ "tituloSerie" => "J Biol Chem" "fecha" => "2004" "volumen" => "279" "numero" => "26" "paginaInicial" => "27816" "paginaFinal" => "27823" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15105426" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib0135" "etiqueta" => "27." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The role of mammalian DNA methyltransferases in the regulation of gene expression" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J. Turek-Plewa" 1 => "P.P. Jagodzinski" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Cell Mol Biol Lett" "fecha" => "2005" "volumen" => "10" "numero" => "4" "paginaInicial" => "631" "paginaFinal" => "647" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16341272" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib0140" "etiqueta" => "28." "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Yanagimachi R. “Fertilization in Mammalian”. Knobil E NJ. ed. New York; 1994" ] ] ] 28 => array:3 [ "identificador" => "bib0145" "etiqueta" => "29." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Role of sperm chromatin abnormalities and DNA damage in male infertility" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A. Agarwal" 1 => "T.M. Said" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Hum Reprod Update" "fecha" => "2003" "volumen" => "9" "numero" => "4" "paginaInicial" => "331" "paginaFinal" => "345" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12926527" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib0150" "etiqueta" => "30." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "R.P. Martins" 1 => "S.A. Krawetz" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Nuclear organization of the protamine locus Soc Reprod Fertil Suppl" "fecha" => "2007" "volumen" => "64" "paginaInicial" => "1" "paginaFinal" => "12" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17491138" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S073510970301550X" "estado" => "S300" "issn" => "07351097" ] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib0155" "etiqueta" => "31." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "DNA organization in human spermatozoa" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J.G. Barone" 1 => "J. De Lara" 2 => "K.B. Cummings" 3 => "W.S. Ward" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "J Androl" "fecha" => "1994" "volumen" => "15" "numero" => "2" "paginaInicial" => "139" "paginaFinal" => "144" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8056637" "web" => "Medline" ] ] ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib0160" "etiqueta" => "32." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sperm chromatin structure and male fertility: biological and clinical aspects" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J. Erenpreiss" 1 => "M. Spano" 2 => "J. Erenpreisa" 3 => "M. Bungum" 4 => "A. Giwercman" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1745-7262.2006.00112.x" "Revista" => array:7 [ "tituloSerie" => "Asian J Androl" "fecha" => "2006" "volumen" => "8" "numero" => "1" "paginaInicial" => "11" "paginaFinal" => "29" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16372115" "web" => "Medline" ] ] ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bib0165" "etiqueta" => "33." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Imprinting in the germ line" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J.R. Mann" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1634/stemcells.19-4-287" "Revista" => array:7 [ "tituloSerie" => "Stem Cells" "fecha" => "2001" "volumen" => "19" "numero" => "4" "paginaInicial" => "287" "paginaFinal" => "294" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11463948" "web" => "Medline" ] ] ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bib0170" "etiqueta" => "34." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Establishment of the paternal methylation imprint of the human H19 and MEST/PEG1 genes during spermatogenesis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Kerjean" 1 => "J.M. Dupont" 2 => "C. Vasseur" 3 => "D. Le Tessier" 4 => "L. Cuisset" 5 => "A. Paldi" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Hum Mol Genet" "fecha" => "2000" "volumen" => "9" "numero" => "14" "paginaInicial" => "2183" "paginaFinal" => "2187" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10958657" "web" => "Medline" ] ] ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bib0175" "etiqueta" => "35." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Gene-specific timing and epigenetic memory in oocyte imprinting" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "D. Lucifero" 1 => "M.R. Mann" 2 => "M.S. Bartolomei" 3 => "J.M. Trasler" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/hmg/ddh104" "Revista" => array:7 [ "tituloSerie" => "Hum Mol Genet" "fecha" => "2004" "volumen" => "13" "numero" => "8" "paginaInicial" => "839" "paginaFinal" => "849" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14998934" "web" => "Medline" ] ] ] ] ] ] ] ] 35 => array:3 [ "identificador" => "bib0180" "etiqueta" => "36." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Factors affecting meiotic and developmental competence of primary spermatocyte nuclei injected into mouse oocytes" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "Y. Kimura" 1 => "H. Tateno" 2 => "M.A. Handel" 3 => "R. Yanagimachi" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Biol Reprod" "fecha" => "1998" "volumen" => "59" "numero" => "4" "paginaInicial" => "871" "paginaFinal" => "877" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9746737" "web" => "Medline" ] ] ] ] ] ] ] ] 36 => array:3 [ "identificador" => "bib0185" "etiqueta" => "37." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Genetic and epigenetic risks of intracytoplasmic sperm injection method" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "I. Georgiou" 1 => "M. Syrrou" 2 => "N. Pardalidis" 3 => "K. Karakitsios" 4 => "T. Mantzavinos" 5 => "N. Giotitsas" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1745-7262.2006.00231.x" "Revista" => array:7 [ "tituloSerie" => "Asian J Androl" "fecha" => "2006" "volumen" => "8" "numero" => "6" "paginaInicial" => "643" "paginaFinal" => "673" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17111067" "web" => "Medline" ] ] ] ] ] ] ] ] 37 => array:3 [ "identificador" => "bib0190" "etiqueta" => "38." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Functional characterization of a testis-specific DNA binding activity at the H19/Igf2 imprinting control region" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A.B. Bowman" 1 => "J.M. Levorse" 2 => "R.S. Ingram" 3 => "S.M. Tilghman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Mol Cell Biol" "fecha" => "2003" "volumen" => "23" "numero" => "22" "paginaInicial" => "8345" "paginaFinal" => "8351" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14585991" "web" => "Medline" ] ] ] ] ] ] ] ] 38 => array:3 [ "identificador" => "bib0195" "etiqueta" => "39." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The novel BORIS + CTCF gene family is uniquely involved in the epigenetics of normal biology and cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "E.M. Klenova" 1 => "H.C. Morse 3rd" 2 => "R. Ohlsson" 3 => "V.V. Lobanenkov" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Semin Cancer Biol" "fecha" => "2002" "volumen" => "12" "numero" => "5" "paginaInicial" => "399" "paginaFinal" => "414" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12191639" "web" => "Medline" ] ] ] ] ] ] ] ] 39 => array:3 [ "identificador" => "bib0200" "etiqueta" => "40." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "BORIS, a novel male germ-line-specific protein associated with epigenetic reprogramming events, shares the same 11-zinc-finger domain with CTCF, the insulator protein involved in reading imprinting marks in the soma" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "D.I. Loukinov" 1 => "E. Pugacheva" 2 => "S. Vatolin" 3 => "S.D. Pack" 4 => "H. Moon" 5 => "I. Chernukhin" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1073/pnas.092123699" "Revista" => array:7 [ "tituloSerie" => "Proc Natl Acad Sci U S A" "fecha" => "2002" "volumen" => "99" "numero" => "10" "paginaInicial" => "6806" "paginaFinal" => "6811" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12011441" "web" => "Medline" ] ] ] ] ] ] ] ] 40 => array:3 [ "identificador" => "bib0205" "etiqueta" => "41." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Developmental regulation of genomic imprinting during gametogenesis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A.J. Villar" 1 => "E.M. Eddy" 2 => "R.A. Pedersen" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1006/dbio.1995.0021" "Revista" => array:7 [ "tituloSerie" => "Dev Biol" "fecha" => "1995" "volumen" => "172" "numero" => "1" "paginaInicial" => "264" "paginaFinal" => "271" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7589806" "web" => "Medline" ] ] ] ] ] ] ] ] 41 => array:3 [ "identificador" => "bib0210" "etiqueta" => "42." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dnmt3a binds deacetylases and is recruited by a sequence-specific repressor to silence transcription" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "F. Fuks" 1 => "W.A. Burgers" 2 => "N. Godin" 3 => "M. Kasai" 4 => "T. Kouzarides" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/emboj/20.10.2536" "Revista" => array:7 [ "tituloSerie" => "Embo J" "fecha" => "2001" "volumen" => "20" "numero" => "10" "paginaInicial" => "2536" "paginaFinal" => "2544" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11350943" "web" => "Medline" ] ] ] ] ] ] ] ] 42 => array:3 [ "identificador" => "bib0215" "etiqueta" => "43." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dnmt3L is a transcriptional repressor that recruits histone deacetylase" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R. Deplus" 1 => "C. Brenner" 2 => "W.A. Burgers" 3 => "P. Putmans" 4 => "T. Kouzarides" 5 => "Y. de Launoit" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Nucleic Acids Res" "fecha" => "2002" "volumen" => "30" "numero" => "17" "paginaInicial" => "3831" "paginaFinal" => "3838" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12202768" "web" => "Medline" ] ] ] ] ] ] ] ] 43 => array:3 [ "identificador" => "bib0220" "etiqueta" => "44." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Imprinting regulator DNMT3L is a transcriptional repressor associated with histone deacetylase activity" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "U.L.I. Aapola" 1 => "P. Peterson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Nucleic Acids Res" "fecha" => "2002" "volumen" => "30" "numero" => "16" "paginaInicial" => "3602" "paginaFinal" => "3608" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12177302" "web" => "Medline" ] ] ] ] ] ] ] ] 44 => array:3 [ "identificador" => "bib0225" "etiqueta" => "45." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Modification of de novo DNA methyltransferase 3a (Dnmt3a) by SUMO-1 modulates its interaction with histone deacetylases (HDACs) and its capacity to repress transcription" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "Y. Ling" 1 => "U.T. Sankpal" 2 => "A.K. Robertson" 3 => "J.G. McNally" 4 => "T. Karpova" 5 => "K.D. Robertson" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/nar/gkh195" "Revista" => array:7 [ "tituloSerie" => "Nucleic Acids Res" "fecha" => "2004" "volumen" => "32" "numero" => "2" "paginaInicial" => "598" "paginaFinal" => "610" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14752048" "web" => "Medline" ] ] ] ] ] ] ] ] 45 => array:3 [ "identificador" => "bib0230" "etiqueta" => "46." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Aberrant DNA methylation of imprinted loci in sperm from oligospermic patients" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "H. Kobayashi" 1 => "A. Sato" 2 => "E. Otsu" 3 => "H. Hiura" 4 => "C. Tomatsu" 5 => "T. Utsunomiya" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/hmg/ddm187" "Revista" => array:7 [ "tituloSerie" => "Hum Mol Genet" "fecha" => "2007" "volumen" => "16" "numero" => "21" "paginaInicial" => "2542" "paginaFinal" => "2551" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17636251" "web" => "Medline" ] ] ] ] ] ] ] ] 46 => array:3 [ "identificador" => "bib0235" "etiqueta" => "47." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epigenetics and imprinting of the trophoblast - a workshop report" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A.C. Ferguson-Smith" 1 => "T. Moore" 2 => "J. Detmar" 3 => "A. Lewis" 4 => "M. Hemberger" 5 => "H. Jammes" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Placenta" "fecha" => "2006" "volumen" => "27" "numero" => "9-10" "paginaInicial" => "1036" "itemHostRev" => array:3 [ "pii" => "S0300893211006373" "estado" => "S300" "issn" => "03008932" ] ] ] ] ] ] ] 47 => array:3 [ "identificador" => "bib0240" "etiqueta" => "48." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Genomic imprinting in mammalian development: a parental tug-of-war" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "T. Moore" 1 => "D. Haig" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/0168-9525(91)90230-N" "Revista" => array:8 [ "tituloSerie" => "Trends Genet" "fecha" => "1991" "volumen" => "7" "numero" => "2" "paginaInicial" => "45" "paginaFinal" => "49" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2035190" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0735109704001925" "estado" => "S300" "issn" => "07351097" ] ] ] ] ] ] ] 48 => array:3 [ "identificador" => "bib0245" "etiqueta" => "49." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epigenetics in development" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J.C. Kiefer" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/dvdy.21094" "Revista" => array:7 [ "tituloSerie" => "Dev Dyn" "fecha" => "2007 Apr" "volumen" => "236" "numero" => "4" "paginaInicial" => "1144" "paginaFinal" => "1156" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17304537" "web" => "Medline" ] ] ] ] ] ] ] ] 49 => array:3 [ "identificador" => "bib0250" "etiqueta" => "50." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Assisted reproduction: the epigenetic perspective" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "B. Horsthemke" 1 => "M. Ludwig" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/humupd/dmi022" "Revista" => array:8 [ "tituloSerie" => "Hum Reprod Update" "fecha" => "2005" "volumen" => "11" "numero" => "5" "paginaInicial" => "473" "paginaFinal" => "482" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15994847" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0300893211005239" "estado" => "S300" "issn" => "03008932" ] ] ] ] ] ] ] 50 => array:3 [ "identificador" => "bib0255" "etiqueta" => "51." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Maternal insulin-like growth factors-I and -II act via different pathways to promote fetal growth" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "A.N. Sferruzzi-Perri" 1 => "J.A. Owens" 2 => "K.G. Pringle" 3 => "J.S. Robinson" 4 => "C.T. Roberts" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1210/en.2005-1328" "Revista" => array:7 [ "tituloSerie" => "Endocrinology" "fecha" => "2006" "volumen" => "147" "numero" => "7" "paginaInicial" => "3344" "paginaFinal" => "3355" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16556757" "web" => "Medline" ] ] ] ] ] ] ] ] 51 => array:3 [ "identificador" => "bib0260" "etiqueta" => "52." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "New light on early post-implantation pregnancy in the mouse: roles for insulin-like growth factor-II (IGF-II)?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "K.G. Pringle" 1 => "C.T. Roberts" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.placenta.2006.04.006" "Revista" => array:7 [ "tituloSerie" => "Placenta" "fecha" => "2007" "volumen" => "28" "numero" => "4" "paginaInicial" => "286" "paginaFinal" => "297" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16824595" "web" => "Medline" ] ] ] ] ] ] ] ] 52 => array:3 [ "identificador" => "bib0265" "etiqueta" => "53." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Stimulation of human extravillous trophoblast migration by IGF-II is mediated by IGF type 2 receptor involving inhibitory G protein(s) and phosphorylation of MAPK" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "T. McKinnon" 1 => "C. Chakraborty" 2 => "L.M. Gleeson" 3 => "P. Chidiac" 4 => "P.K. Lala" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Clin Endocrinol Metab" "fecha" => "2001" "volumen" => "86" "numero" => "8" "paginaInicial" => "3374" "paginaFinal" => "3665" ] ] ] ] ] ] 53 => array:3 [ "identificador" => "bib0270" "etiqueta" => "54." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Endovascular trophoblast invasion: implications for the pathogenesis of intrauterine growth retardation and preeclampsia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "P. Kaufmann" 1 => "S. Black" 2 => "B. Huppertz" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1095/biolreprod.102.014977" "Revista" => array:7 [ "tituloSerie" => "Biol Reprod" "fecha" => "2003" "volumen" => "69" "numero" => "1" "paginaInicial" => "1" "paginaFinal" => "7" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12620937" "web" => "Medline" ] ] ] ] ] ] ] ] 54 => array:3 [ "identificador" => "bib0275" "etiqueta" => "55." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Differential imprinting and expression of maternal and paternal genomes" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "D. Solter" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1146/annurev.ge.22.120188.001015" "Revista" => array:6 [ "tituloSerie" => "Annu Rev Genet" "fecha" => "1988" "volumen" => "22" "paginaInicial" => "127" "paginaFinal" => "146" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3071246" "web" => "Medline" ] ] ] ] ] ] ] ] 55 => array:3 [ "identificador" => "bib0280" "etiqueta" => "56." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Role of paternal and maternal genomes in mouse development" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "S.C. Barton" 1 => "M.A. Surani" 2 => "M.L. Norris" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Nature" "fecha" => "1984" "volumen" => "311" "numero" => "5984" "paginaInicial" => "374" "paginaFinal" => "376" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6482961" "web" => "Medline" ] ] ] ] ] ] ] ] 56 => array:3 [ "identificador" => "bib0285" "etiqueta" => "57." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Inability of mouse blastomere nuclei transferred to enucleated zygotes to support development in vitro" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J. McGrath" 1 => "D. Solter" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Science" "fecha" => "1984" "volumen" => "226" "numero" => "4680" "paginaInicial" => "1317" "paginaFinal" => "1319" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6542249" "web" => "Medline" ] ] ] ] ] ] ] ] 57 => array:3 [ "identificador" => "bib0290" "etiqueta" => "58." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epigenetic risks related to assisted reproductive technologies: epigenetics, imprinting, ART and icebergs?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "E.R. Maher" 1 => "M. Afnan" 2 => "C.L. Barratt" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Hum Reprod" "fecha" => "2003" "volumen" => "18" "numero" => "12" "paginaInicial" => "2508" "paginaFinal" => "2511" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14645164" "web" => "Medline" ] ] ] ] ] ] ] ] 58 => array:3 [ "identificador" => "bib0295" "etiqueta" => "59." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Imprinting and assisted reproductive technology" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "E.R. Maher" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/hmg/ddi107" "Revista" => array:7 [ "tituloSerie" => "Hum Mol Genet" "fecha" => "2005" "volumen" => "14" "numero" => "Spec No 1" "paginaInicial" => "R133" "paginaFinal" => "R138" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15809265" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/02104806/0000003200000010/v1_201304251917/S0210480608739792/v1_201304251917/es/main.assets" "Apartado" => array:4 [ "identificador" => "6429" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Original" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/02104806/0000003200000010/v1_201304251917/S0210480608739792/v1_201304251917/es/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210480608739792?idApp=UINPBA00004N" ]
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| 2017 Octubre | 8 | 4 | 12 |
| 2017 Septiembre | 8 | 3 | 11 |
| 2017 Agosto | 4 | 3 | 7 |
| 2017 Julio | 6 | 0 | 6 |
| 2017 Junio | 9 | 11 | 20 |
| 2017 Mayo | 12 | 15 | 27 |
| 2017 Abril | 9 | 9 | 18 |
| 2017 Marzo | 11 | 25 | 36 |
| 2017 Febrero | 15 | 5 | 20 |
| 2017 Enero | 7 | 2 | 9 |
| 2016 Diciembre | 19 | 9 | 28 |
| 2016 Noviembre | 16 | 1 | 17 |
| 2016 Octubre | 30 | 3 | 33 |
| 2016 Septiembre | 10 | 5 | 15 |
| 2016 Agosto | 9 | 3 | 12 |
| 2016 Julio | 9 | 2 | 11 |
| 2016 Junio | 19 | 10 | 29 |
| 2016 Mayo | 13 | 21 | 34 |
| 2016 Abril | 4 | 11 | 15 |
| 2016 Marzo | 15 | 14 | 29 |
| 2016 Febrero | 8 | 15 | 23 |
| 2016 Enero | 8 | 13 | 21 |
| 2015 Diciembre | 5 | 7 | 12 |
| 2015 Noviembre | 11 | 10 | 21 |
| 2015 Octubre | 17 | 5 | 22 |
| 2015 Septiembre | 8 | 5 | 13 |
| 2015 Agosto | 9 | 3 | 12 |
| 2015 Julio | 2 | 3 | 5 |
| 2015 Junio | 4 | 1 | 5 |
| 2015 Mayo | 5 | 0 | 5 |
| 2015 Abril | 13 | 6 | 19 |
| 2015 Marzo | 6 | 2 | 8 |
| 2015 Febrero | 4 | 3 | 7 |
| 2015 Enero | 16 | 3 | 19 |
| 2014 Diciembre | 4 | 16 | 20 |
| 2014 Noviembre | 9 | 5 | 14 |
| 2014 Octubre | 13 | 4 | 17 |
| 2014 Septiembre | 19 | 2 | 21 |
| 2014 Agosto | 9 | 1 | 10 |
| 2014 Julio | 11 | 3 | 14 |
| 2014 Junio | 6 | 3 | 9 |
| 2014 Mayo | 4 | 2 | 6 |
| 2014 Abril | 3 | 3 | 6 |
| 2014 Marzo | 9 | 0 | 9 |
| 2014 Febrero | 3 | 5 | 8 |
| 2014 Enero | 0 | 1 | 1 |
| 2013 Diciembre | 1 | 2 | 3 |
| 2013 Noviembre | 4 | 3 | 7 |
| 2013 Octubre | 4 | 12 | 16 |
| 2013 Septiembre | 5 | 8 | 13 |
| 2013 Agosto | 3 | 9 | 12 |
| 2013 Julio | 0 | 1 | 1 |
| 2008 Noviembre | 355 | 0 | 355 |
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