Nuevas dianas terapéuticas para el carcinoma de células renales metastásico. Resultados del tratamiento con bevacizumab en monoterapia en un único centro hospitalario
Novel therapeutic targets in metastatic renal cell carcinoma. Results of the treatment with single-agent bevacizumab in a single institution
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Resultados del tratamiento con bevacizumab en monoterapia en un único centro hospitalario" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "138" "paginaFinal" => "142" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Verónica Calderero Aragón, Roberto Pazo Cid, Teresa Puértolas Hernández, Angel Artal Cortés, Angel Borque Fernando, Mª Jesús Gil Sanz" "autores" => array:6 [ 0 => array:4 [ "nombre" => "Verónica" "apellidos" => "Calderero Aragón" "email" => array:1 [ 0 => "dracalde@hotmail.com" ] "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "cor0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0015" ] ] ] 1 => array:3 [ "nombre" => "Roberto" "apellidos" => "Pazo Cid" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0015" ] ] ] 2 => array:3 [ "nombre" => "Teresa" "apellidos" => "Puértolas Hernández" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0015" ] ] ] 3 => array:3 [ "nombre" => "Angel" "apellidos" => "Artal Cortés" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0015" ] ] ] 4 => array:3 [ "nombre" => "Angel" "apellidos" => "Borque Fernando" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "aff0010" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0015" ] ] ] 5 => array:3 [ "nombre" => "Mª" "apellidos" => "Jesús Gil Sanz" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "aff0010" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0015" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Servicio de Oncología Médica. Hospital Universitario Miguel Servet. Zaragoza, España" "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Urología. Hospital Universitario Miguel Servet. Zaragoza, España" "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Servicio de Oncología Médica. Servicio de Urología. Hospital Universitario Miguel Servet. Zaragoza, España" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "1" "correspondencia" => "Correspondencia autor: Dra. Verónica Calderero Aragón Servicio de Oncología Médica. Hospital Universitario Miguel Servet Pº Isabel La Católica, 1-3 - 50009 Zaragoza Tel.: 976 765 500" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Novel therapeutic targets in metastatic renal cell carcinoma. Results of the treatment with single-agent bevacizumab in a single institution" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2008-08-31" "fechaAceptado" => "2008-10-31" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec88851" "palabras" => array:3 [ 0 => "Bevacizumab" 1 => "Carcinoma renal" 2 => "Nuevos agentes" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec88852" "palabras" => array:3 [ 0 => "Bevacizumab" 1 => "Renal cell carcinoma" 2 => "Novel agents" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Objetivos</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">En la última década se están desarrollando multitud de nuevas moléculas que ofrecen resultados esperanzadores para el tratamiento del CCR metastásico. Este estudio describe nuestra experiencia en 25 pacientes tratados con bevacizumab en monoterapia.</p> <span class="elsevierStyleSectionTitle">Material y métodos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se analizan los resultados obtenidos en 25 pacientes con CCR metastásico tratados con Bevacizumab (10 mg/Kg quincenal) entre enero del 2006 y enero del 2008. Se recogieron datos acerca del tipo de cirugía practicada, tipo histológico, estadio tumoral, grupo de riesgo de Motzer, localizaciones metastásicas, número de ciclos administrados, tiempo hasta la progresión y supervivencia global.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Se analizaron 25 pacientes (16 varones y 9 mujeres), con una mediana de edad de 59 años. Más de la mitad de ellos (19) se había sometido a algún tipo de intervención quirúrgica (14 nefrectomía radical, 4 citorreductora y 1 tumorectomía). La mayor parte de los enfermos presentaban histología de células claras (22). 14 pacientes pertenecían al grupo de buen pronóstico de Motzer, 8 al grupo de pronóstico intermedio y 3 al de mal pronóstico. La mediana de tiempo hasta la progresión fue de 19 semanas, con una mediana de supervivencia global desde el inicio de tratamiento de 8,7 meses.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">El bevacizumab en monoterapia ofrece unos resultados modestos para el tratamiento del CCR metastásico. Su reciente aprobación en combinación con Interferon, y la aparición progresiva de distintas dianas terapéuticas, permitirá optimizar los resultados en los próximos años.</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Aim</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Along the past decade a number of new agents have been developed showing promising results in the treatment of metastatic renal cell carcinoma. We describe our experience with the use of bevacizumab in monotherapy in the Urology and Medical Oncology departments of our institution.</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">A consecutive series of patients treated with Bevacizumab 10 mg/Kg every 14 days between January 2006 and January 2008 has been assessed. Data concerning the type of surgery, histological subtype, tumor stage, Motzer’s risk group, metastatic sites number of bevacizumab courses given, time to progression and overall survival were collected.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">25 patients (16 male, 9 female) were analyzed. Median age was 59 years. Nineteen of them (75%) had prior surgery: radical nephrectomy 14, cytoreductive 4 y tumorectomy 1). Clear cell carcinoma was the most frequent subtype (22 patients). According to Motzer’s prognostic index 14 had good prognosis, 8 intermediate and 3 poor prognosis. Median time to progression was 19 weeks. Overall median survival since metastatic disease was diagnosed 8,7 months.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Bevacizumab offers, as single agent, modest activity in the metastatic renal cell carcinoma. 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| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Octubre | 0 | 9 | 9 |
| 2024 Septiembre | 0 | 2 | 2 |
| 2024 Agosto | 0 | 5 | 5 |
| 2024 Julio | 0 | 2 | 2 |
| 2024 Junio | 0 | 4 | 4 |
| 2024 Mayo | 0 | 4 | 4 |
| 2024 Abril | 0 | 9 | 9 |
| 2024 Marzo | 0 | 32 | 32 |
| 2024 Febrero | 0 | 13 | 13 |
| 2024 Enero | 0 | 23 | 23 |
| 2023 Diciembre | 0 | 18 | 18 |
| 2023 Noviembre | 0 | 30 | 30 |
| 2023 Octubre | 0 | 13 | 13 |
| 2023 Septiembre | 0 | 23 | 23 |
| 2023 Agosto | 0 | 20 | 20 |
| 2023 Julio | 0 | 15 | 15 |
| 2023 Junio | 0 | 3 | 3 |
| 2023 Mayo | 0 | 2 | 2 |
| 2023 Abril | 0 | 2 | 2 |
| 2023 Marzo | 0 | 2 | 2 |
| 2023 Febrero | 0 | 7 | 7 |
| 2022 Diciembre | 0 | 5 | 5 |
| 2022 Noviembre | 0 | 6 | 6 |
| 2022 Octubre | 0 | 11 | 11 |
| 2022 Septiembre | 0 | 7 | 7 |
| 2022 Agosto | 0 | 5 | 5 |
| 2022 Julio | 0 | 5 | 5 |
| 2022 Junio | 0 | 4 | 4 |
| 2022 Mayo | 0 | 8 | 8 |
| 2022 Abril | 0 | 8 | 8 |
| 2022 Marzo | 0 | 3 | 3 |
| 2022 Febrero | 0 | 2 | 2 |
| 2022 Enero | 0 | 2 | 2 |
| 2021 Diciembre | 0 | 1 | 1 |
| 2021 Noviembre | 0 | 4 | 4 |
| 2021 Octubre | 0 | 2 | 2 |
| 2021 Julio | 0 | 3 | 3 |
| 2021 Junio | 0 | 1 | 1 |
| 2021 Mayo | 0 | 16 | 16 |
| 2021 Abril | 0 | 16 | 16 |
| 2021 Marzo | 0 | 13 | 13 |
| 2021 Febrero | 0 | 6 | 6 |
| 2021 Enero | 0 | 6 | 6 |
| 2020 Diciembre | 0 | 4 | 4 |
| 2020 Noviembre | 0 | 2 | 2 |
| 2020 Octubre | 0 | 6 | 6 |
| 2020 Septiembre | 0 | 5 | 5 |
| 2020 Agosto | 0 | 11 | 11 |
| 2020 Julio | 0 | 9 | 9 |
| 2020 Junio | 0 | 5 | 5 |
| 2020 Mayo | 0 | 2 | 2 |
| 2020 Abril | 0 | 1 | 1 |
| 2020 Marzo | 0 | 3 | 3 |
| 2020 Febrero | 0 | 2 | 2 |
| 2020 Enero | 0 | 12 | 12 |
| 2019 Diciembre | 0 | 17 | 17 |
| 2019 Noviembre | 0 | 9 | 9 |
| 2019 Octubre | 0 | 5 | 5 |
| 2019 Septiembre | 0 | 9 | 9 |
| 2019 Agosto | 0 | 6 | 6 |
| 2019 Julio | 0 | 6 | 6 |
| 2019 Junio | 0 | 13 | 13 |
| 2019 Mayo | 0 | 26 | 26 |
| 2019 Abril | 0 | 30 | 30 |
| 2019 Marzo | 0 | 5 | 5 |
| 2019 Febrero | 0 | 14 | 14 |
| 2019 Enero | 0 | 2 | 2 |
| 2018 Diciembre | 0 | 13 | 13 |
| 2018 Noviembre | 0 | 12 | 12 |
| 2018 Octubre | 0 | 25 | 25 |
| 2018 Septiembre | 0 | 3 | 3 |
| 2018 Agosto | 0 | 1 | 1 |
| 2018 Abril | 0 | 2 | 2 |
| 2018 Marzo | 0 | 1 | 1 |
| 2018 Febrero | 3 | 3 | 6 |
| 2018 Enero | 0 | 2 | 2 |
| 2017 Diciembre | 1 | 4 | 5 |
| 2017 Noviembre | 0 | 5 | 5 |
| 2017 Octubre | 5 | 4 | 9 |
| 2017 Septiembre | 2 | 3 | 5 |
| 2017 Agosto | 5 | 3 | 8 |
| 2017 Julio | 7 | 3 | 10 |
| 2017 Junio | 2 | 8 | 10 |
| 2017 Mayo | 4 | 2 | 6 |
| 2017 Abril | 7 | 2 | 9 |
| 2017 Marzo | 10 | 20 | 30 |
| 2017 Febrero | 8 | 10 | 18 |
| 2017 Enero | 1 | 3 | 4 |
| 2016 Diciembre | 14 | 15 | 29 |
| 2016 Noviembre | 61 | 18 | 79 |
| 2016 Octubre | 29 | 29 | 58 |
| 2016 Septiembre | 15 | 6 | 21 |
| 2016 Agosto | 11 | 3 | 14 |
| 2016 Julio | 13 | 1 | 14 |
| 2016 Junio | 21 | 20 | 41 |
| 2016 Mayo | 23 | 23 | 46 |
| 2016 Abril | 10 | 17 | 27 |
| 2016 Marzo | 15 | 22 | 37 |
| 2016 Febrero | 11 | 22 | 33 |
| 2016 Enero | 10 | 32 | 42 |
| 2015 Diciembre | 17 | 21 | 38 |
| 2015 Noviembre | 20 | 15 | 35 |
| 2015 Octubre | 15 | 18 | 33 |
| 2015 Septiembre | 17 | 13 | 30 |
| 2015 Agosto | 8 | 1 | 9 |
| 2015 Julio | 20 | 8 | 28 |
| 2015 Junio | 11 | 2 | 13 |
| 2015 Mayo | 5 | 5 | 10 |
| 2015 Abril | 7 | 10 | 17 |
| 2015 Marzo | 11 | 2 | 13 |
| 2015 Febrero | 6 | 3 | 9 |
| 2015 Enero | 11 | 1 | 12 |
| 2014 Diciembre | 24 | 12 | 36 |
| 2014 Noviembre | 22 | 1 | 23 |
| 2014 Octubre | 27 | 6 | 33 |
| 2014 Septiembre | 21 | 2 | 23 |
| 2014 Agosto | 25 | 2 | 27 |
| 2014 Julio | 25 | 3 | 28 |
| 2014 Junio | 17 | 4 | 21 |
| 2014 Mayo | 12 | 4 | 16 |
| 2014 Abril | 7 | 5 | 12 |
| 2014 Marzo | 6 | 5 | 11 |
| 2014 Febrero | 12 | 4 | 16 |
| 2014 Enero | 9 | 3 | 12 |
| 2013 Diciembre | 14 | 2 | 16 |
| 2013 Noviembre | 10 | 3 | 13 |
| 2013 Octubre | 7 | 2 | 9 |
| 2013 Septiembre | 5 | 2 | 7 |
| 2013 Agosto | 3 | 3 | 6 |
| 2013 Julio | 4 | 1 | 5 |
| 2009 Febrero | 347 | 0 | 347 |
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