Metástasis cutáneas de un carcinoma transicional vesical productor de β-HCG
Cutaneous metastases from transitional cell carcinoma of the bladder producing β-HCG
Leído
2403
Vecesse ha leído el artículo
1640
Total PDF
763
Total HTML
Compartir estadísticas
array:24 [ "pii" => "S0210480609741269" "issn" => "02104806" "doi" => "10.1016/S0210-4806(09)74126-9" "estado" => "S300" "fechaPublicacion" => "2009-01-01" "aid" => "74126" "copyright" => "Asociación Española de Urología (AEU)" "copyrightAnyo" => "2009" "documento" => "article" "crossmark" => 0 "subdocumento" => "sco" "cita" => "Actas Urol Esp. 2009;33:209-13" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1653 "formatos" => array:3 [ "EPUB" => 7 "HTML" => 763 "PDF" => 883 ] ] "itemSiguiente" => array:18 [ "pii" => "S0210480609741270" "issn" => "02104806" "doi" => "10.1016/S0210-4806(09)74127-0" "estado" => "S300" "fechaPublicacion" => "2009-01-01" "aid" => "74127" "copyright" => "Asociación Española de Urología (AEU)" "documento" => "article" "crossmark" => 0 "subdocumento" => "sco" "cita" => "Actas Urol Esp. 2009;33:214" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1120 "formatos" => array:3 [ "EPUB" => 9 "HTML" => 544 "PDF" => 567 ] ] "es" => array:7 [ "idiomaDefecto" => true "titulo" => "Ruptura renal tras caída accidental" "tienePdf" => array:2 [ 0 => "es" 1 => "en" ] "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "214" ] ] "contienePdf" => array:2 [ "es" => true "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Rosa M. García Fanjul" "autores" => array:1 [ 0 => array:2 [ "nombre" => "Rosa M." "apellidos" => "García Fanjul" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210480609741270?idApp=UINPBA00004N" "url" => "/02104806/0000003300000002/v1_201304251922/S0210480609741270/v1_201304251922/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0210480609741257" "issn" => "02104806" "doi" => "10.1016/S0210-4806(09)74125-7" "estado" => "S300" "fechaPublicacion" => "2009-01-01" "aid" => "74125" "copyright" => "Asociación Española de Urología (AEU)" "documento" => "article" "crossmark" => 0 "subdocumento" => "sco" "cita" => "Actas Urol Esp. 2009;33:205-8" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1905 "formatos" => array:3 [ "EPUB" => 8 "HTML" => 1041 "PDF" => 856 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Mucocele apendicular confundido con quiste de uraco infectado: un diagnóstico diferencial a tener en cuenta" "tienePdf" => array:2 [ 0 => "es" 1 => "en" ] "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "205" "paginaFinal" => "208" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Appendiceal mucocele misdiagnosed with infected urachal cyst: a differential diagnosis to keep in mind" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:2 [ "es" => true "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "A. Daniel Pérez Fentes, Melissa Cortegoso González, Ana Puñal Pereira, Antonio Cimadevila García, Serafín Novás Castro, Miguel Blanco Parra" "autores" => array:6 [ 0 => array:2 [ "nombre" => "A." "apellidos" => "Daniel Pérez Fentes" ] 1 => array:2 [ "nombre" => "Melissa" "apellidos" => "Cortegoso González" ] 2 => array:2 [ "nombre" => "Ana" "apellidos" => "Puñal Pereira" ] 3 => array:2 [ "nombre" => "Antonio" "apellidos" => "Cimadevila García" ] 4 => array:2 [ "nombre" => "Serafín" "apellidos" => "Novás Castro" ] 5 => array:2 [ "nombre" => "Miguel" "apellidos" => "Blanco Parra" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210480609741257?idApp=UINPBA00004N" "url" => "/02104806/0000003300000002/v1_201304251922/S0210480609741257/v1_201304251922/es/main.assets" ] "es" => array:14 [ "idiomaDefecto" => true "titulo" => "Metástasis cutáneas de un carcinoma transicional vesical productor de β-HCG" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "209" "paginaFinal" => "213" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Miguel Pascual Samaniego, Manuel A. Ruiz Serrano, Mª Ángeles González Núñez, Inmaculada Bravo Fernández, Juan A. Ramos Martín, Antonio García González" "autores" => array:6 [ 0 => array:4 [ "nombre" => "Miguel" "apellidos" => "Pascual Samaniego" "email" => array:1 [ 0 => "mpaski10@yahoo.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "cor0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0010" ] ] ] 1 => array:3 [ "nombre" => "Manuel A." "apellidos" => "Ruiz Serrano" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "Mª" "apellidos" => "Ángeles González Núñez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "Inmaculada" "apellidos" => "Bravo Fernández" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0010" ] ] ] 4 => array:3 [ "nombre" => "Juan A." "apellidos" => "Ramos Martín" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0010" ] ] ] 5 => array:3 [ "nombre" => "Antonio" "apellidos" => "García González" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Anatomía Patológica. Hospital San Pedro de Alcántara. Cáceres, España" "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Urología. Servicio de Anatomía Patológica. Hospital San Pedro de Alcántara. Cáceres, España" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "1" "correspondencia" => "Correspondencia autor: Dr. Miguel Pascual Samaniego Servicio de Urología. Hospital Universitario de Valladolid Avda. Ramón y Cajal, 3 - 47005 Valladolid Tel.: 983 420 000 Extensión 226" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Cutaneous metastases from transitional cell carcinoma of the bladder producing β-HCG" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2007-05-31" "fechaAceptado" => "2007-06-30" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec88856" "palabras" => array:3 [ 0 => "Metástasis cutánea" 1 => "Carcinoma transicional vesical" 2 => "Beta-gonadotropina coriónica humana" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec88855" "palabras" => array:3 [ 0 => "Cutaneous metastases" 1 => "Transitional bladder cancer" 2 => "Beta-human chorionic gonadotropin" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A pesar de la alta incidencia de carcinoma transicional vesical, la aparición de metástasis cutáneas es infrecuente, más aún como primera manifestación de diseminación metastásica, asociándose a una pobre supervivencia.</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">La producción ectópica de beta-gonadotropina coriónica humana (β-HCG) ocurre en un 35% de los carcinomas transicionales vesicales y se ha correlacionado con tumores de alto grado, estadios avanzados, enfermedad metastásica, falta de respuesta a la radioterapia y pobre supervivencia, en virtud de su efecto regulador del crecimiento tumoral por un probable efecto antagonista sobre receptores de la cascada apoptótica. Presentamos el caso de una paciente de 36 años con carcinoma transicional de vejiga productor de β-HCG que presentó dos metástasis cutáneas como primer signo de enfermedad a distancia. Ambas circunstancias asociadas de forma excepcional identificaron un comportamiento muy agresivo del tumor y su mal pronóstico, desarrollando a corto plazo un estallido metastático a múltiples niveles incluyendo una metástasis pericárdica.</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">In spite of the high incidence of transitional cell carcinoma, cutaneous metastases are infrequent, especially when they are the first sign of metastatic spread, with a low survival rate.</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Thirty five per cent of transitional cell carcinoma of the bladder have ectopic beta- human chorionic gonadotropin (β-HCG) production. It has been related with high grade tumors, advanced stage, metastatic disease, radioresistent tumors and low survival rate because of its effect as a growth modulator with a probably antagonist action in the apoptotic cascade. We present a thirty six years old woman affected by a transitional cell carcinoma of the bladder producing β-HCG that showed two cutaneous metastases as first sign of metastatic disease. The exceptional coincidence of these two circumstances announced a very aggressive tumor behaviour and bad prognostic, with a quickly multiple metastatic dissemination including a pericardic metastases.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:15 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Carcinomas with trophoblastic differentiation and secretion of chorionic gonadotrophins" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "F. Civantos" 1 => "A.M. Rywlin" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Cancer" "fecha" => "1972" "volumen" => "29" "numero" => "3" "paginaInicial" => "789" "paginaFinal" => "798" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4334242" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Human chorionic gonadotropin expression by bladder cancers: biology and clinical potential" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "R.K. Iles" 1 => "T. Chard" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "J Urol" "fecha" => "1991" "volumen" => "145" "numero" => "3" "paginaInicial" => "453" "paginaFinal" => "458" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1705292" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Beta human chorionic gonadotrophin in serum and urine. A marker for metastatic urothelial cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "R.K. Iles" 1 => "B.J. Jenkins" 2 => "R.T. Oliver" 3 => "J.P. Blandy" 4 => "T. Chard" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Br J Urol" "fecha" => "1989" "volumen" => "64" "numero" => "3" "paginaInicial" => "241" "paginaFinal" => "244" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2478247" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The effects of β-human chorionic gonadotrophin on the in vitro growth of bladder cancer cell lines" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D.J. Guillot" 1 => "R.K. Iles" 2 => "T. Chard" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Br J Cancer" "fecha" => "1996" "volumen" => "73" "numero" => "3" "paginaInicial" => "323" "paginaFinal" => "326" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8562337" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The increase in bladder carcinoma cell population induced by the free beta subunit of human chorionic gonadotrophin is a result of an anti-apoptosis effect and not cell proliferation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "S.A. Butler" 1 => "M.S. Ikram" 2 => "S. Mathieu" 3 => "R.K. Iles" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1054/bjoc.2000.1177" "Revista" => array:7 [ "tituloSerie" => "Br J Cancer" "fecha" => "2000" "volumen" => "82" "numero" => "9" "paginaInicial" => "1553" "paginaFinal" => "1556" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10789723" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Human chorionic gonadotropin, neuron specific enolase and deoxyribonucleic acid flow cytometry in patients with high grade bladder carcinoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A.B. Jacobsen" 1 => "J.M. Nesland" 2 => "S.D. Fosså" 3 => "E.O. Pettersen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "J Urol" "fecha" => "1990" "volumen" => "143" "numero" => "4" "paginaInicial" => "706" "paginaFinal" => "709" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2313795" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Ectopic hCGbeta expression by epithelial cancer: malignant behaviour, metastasis and inhibition of tumor cell apoptosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "R.K. Iles" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Mol Cell Endocrinol" "fecha" => "2007" "volumen" => "2" "numero" => "260-262" "paginaInicial" => "264" "paginaFinal" => "270" ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Urinary concentration of human chorionic gona - dotrophin and its fragments as a prognostic marker in bladder cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R.K. Iles" 1 => "R. Persad" 2 => "M. Trivedi" 3 => "K.B. Sharma" 4 => "A. Dickinson" 5 => "P. Smith" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Br J Urol" "fecha" => "1996" "volumen" => "77" "numero" => "1" "paginaInicial" => "61" "paginaFinal" => "69" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8653319" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Production of trophoblastic hormones by transitional cell carcinoma of the bladder: association to tumor stage and grade" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "S. Dirnhofer" 1 => "P. Koessler" 2 => "C. Ensinger" 3 => "H. Feichtinger" 4 => "S. Maders- bacher" 5 => "P. Berger" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Hum Pathol" "fecha" => "1998" "volumen" => "29" "numero" => "4" "paginaInicial" => "377" "paginaFinal" => "382" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9563788" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Glycoprotein hormones: structure and function" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J.G. Pierce" 1 => "T.F. Parsons" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1146/annurev.bi.50.070181.002341" "Revista" => array:6 [ "tituloSerie" => "Annu Rev Biochem" "fecha" => "1981" "volumen" => "50" "paginaInicial" => "465" "paginaFinal" => "495" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6267989" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0055" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Crystal structure of human chorionic gonadotropin" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A.J. Lapthorn" 1 => "D.C. Harris" 2 => "A. Littlejohn" 3 => "J.W. Lustbader" 4 => "R.E. Canfield" 5 => "K.J. Machin" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Nature" "fecha" => "1994" "volumen" => "9" "numero" => "369(6480" "paginaInicial" => "455" "paginaFinal" => "461" ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0060" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The probable origin of an anemone cell tumor: metastatic transitional cell carcinoma producing HCG" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "D.P. Wirt" 1 => "R.B. Nagle" 2 => "H.M. Gustafson" 3 => "P.J. Philpott" 4 => "N.A. Kuivinen" 5 => "M. Schuchardt" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Ultrastruct Pathol" "fecha" => "1984" "volumen" => "7" "numero" => "4" "paginaInicial" => "277" "paginaFinal" => "288" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6537094" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0065" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cutaneous metastases from genitourinary malignancies" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "T.J. Mueller" 1 => "H. Wu" 2 => "R.E. Greenberg" 3 => "G. Hudes" 4 => "N. Topham" 5 => "S.R. Lessin" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.urology.2004.01.014" "Revista" => array:7 [ "tituloSerie" => "Urology" "fecha" => "2004" "volumen" => "63" "numero" => "6" "paginaInicial" => "1021" "paginaFinal" => "1026" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15183939" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0070" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cystic cutaneous metastases from transitional cell carcinoma of the bladder" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "I. Eardley" 1 => "J. Abercrombie" 2 => "B.J. Wright" 3 => "W.F. Hendry" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "J R Soc Med" "fecha" => "1987" "volumen" => "80" "numero" => "5" "paginaInicial" => "314" "paginaFinal" => "315" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3612665" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0075" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Impact of surgical resection of bladder cancer metastases refractory to systemic therapy on performance score: a phase II trial" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "T. Otto" 1 => "S. Krege" 2 => "J. Suhr" 3 => "H. Rubben" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Urology" "fecha" => "2001" "volumen" => "57" "numero" => "1" "paginaInicial" => "55" "paginaFinal" => "59" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11164143" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/02104806/0000003300000002/v1_201304251922/S0210480609741269/v1_201304251922/es/main.assets" "Apartado" => array:4 [ "identificador" => "6431" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Nota clínica" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/02104806/0000003300000002/v1_201304251922/S0210480609741269/v1_201304251922/es/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210480609741269?idApp=UINPBA00004N" "pdfAlternativo" => array:1 [ 0 => array:3 [ "idioma" => "en" "documentoPdf" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/file/02104806/addon/S0210480609741269/S300/en/292v33n02a13143333pdf001_2.pdf" "portada" => "292v33n02a13143333pdf001_2.png" ] ] ]
| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Octubre | 0 | 7 | 7 |
| 2024 Septiembre | 0 | 8 | 8 |
| 2024 Agosto | 0 | 25 | 25 |
| 2024 Julio | 0 | 15 | 15 |
| 2024 Junio | 0 | 14 | 14 |
| 2024 Mayo | 0 | 13 | 13 |
| 2024 Abril | 0 | 23 | 23 |
| 2024 Marzo | 0 | 46 | 46 |
| 2024 Febrero | 0 | 52 | 52 |
| 2024 Enero | 0 | 48 | 48 |
| 2023 Diciembre | 0 | 49 | 49 |
| 2023 Noviembre | 0 | 40 | 40 |
| 2023 Octubre | 0 | 22 | 22 |
| 2023 Septiembre | 0 | 10 | 10 |
| 2023 Agosto | 0 | 25 | 25 |
| 2023 Julio | 0 | 34 | 34 |
| 2023 Junio | 0 | 10 | 10 |
| 2023 Mayo | 0 | 8 | 8 |
| 2023 Abril | 0 | 7 | 7 |
| 2023 Marzo | 0 | 16 | 16 |
| 2023 Febrero | 0 | 14 | 14 |
| 2023 Enero | 0 | 5 | 5 |
| 2022 Diciembre | 0 | 14 | 14 |
| 2022 Noviembre | 0 | 12 | 12 |
| 2022 Octubre | 0 | 8 | 8 |
| 2022 Septiembre | 0 | 16 | 16 |
| 2022 Agosto | 0 | 21 | 21 |
| 2022 Julio | 0 | 3 | 3 |
| 2022 Junio | 0 | 10 | 10 |
| 2022 Mayo | 0 | 10 | 10 |
| 2022 Abril | 0 | 6 | 6 |
| 2022 Marzo | 0 | 9 | 9 |
| 2022 Febrero | 0 | 2 | 2 |
| 2022 Enero | 0 | 2 | 2 |
| 2021 Diciembre | 0 | 7 | 7 |
| 2021 Noviembre | 0 | 6 | 6 |
| 2021 Octubre | 0 | 6 | 6 |
| 2021 Septiembre | 0 | 6 | 6 |
| 2021 Agosto | 0 | 9 | 9 |
| 2021 Julio | 0 | 16 | 16 |
| 2021 Junio | 0 | 12 | 12 |
| 2021 Mayo | 0 | 5 | 5 |
| 2021 Abril | 0 | 6 | 6 |
| 2021 Marzo | 0 | 9 | 9 |
| 2021 Febrero | 0 | 12 | 12 |
| 2021 Enero | 0 | 3 | 3 |
| 2020 Diciembre | 0 | 3 | 3 |
| 2020 Noviembre | 0 | 4 | 4 |
| 2020 Octubre | 0 | 5 | 5 |
| 2020 Septiembre | 0 | 8 | 8 |
| 2020 Agosto | 0 | 6 | 6 |
| 2020 Julio | 0 | 4 | 4 |
| 2020 Junio | 0 | 2 | 2 |
| 2020 Mayo | 0 | 5 | 5 |
| 2020 Abril | 0 | 7 | 7 |
| 2020 Marzo | 0 | 9 | 9 |
| 2020 Febrero | 0 | 5 | 5 |
| 2020 Enero | 0 | 21 | 21 |
| 2019 Diciembre | 0 | 13 | 13 |
| 2019 Noviembre | 0 | 6 | 6 |
| 2019 Octubre | 0 | 4 | 4 |
| 2019 Septiembre | 0 | 7 | 7 |
| 2019 Agosto | 0 | 18 | 18 |
| 2019 Julio | 0 | 11 | 11 |
| 2019 Junio | 0 | 16 | 16 |
| 2019 Mayo | 0 | 62 | 62 |
| 2019 Abril | 0 | 27 | 27 |
| 2019 Marzo | 0 | 2 | 2 |
| 2019 Febrero | 0 | 15 | 15 |
| 2019 Enero | 0 | 1 | 1 |
| 2018 Diciembre | 0 | 10 | 10 |
| 2018 Noviembre | 0 | 12 | 12 |
| 2018 Octubre | 0 | 31 | 31 |
| 2018 Septiembre | 0 | 2 | 2 |
| 2018 Agosto | 0 | 1 | 1 |
| 2018 Julio | 0 | 1 | 1 |
| 2018 Mayo | 0 | 1 | 1 |
| 2018 Abril | 0 | 1 | 1 |
| 2018 Marzo | 0 | 2 | 2 |
| 2018 Febrero | 1 | 3 | 4 |
| 2018 Enero | 0 | 8 | 8 |
| 2017 Diciembre | 0 | 6 | 6 |
| 2017 Noviembre | 5 | 12 | 17 |
| 2017 Octubre | 3 | 9 | 12 |
| 2017 Septiembre | 5 | 8 | 13 |
| 2017 Agosto | 5 | 7 | 12 |
| 2017 Julio | 7 | 7 | 14 |
| 2017 Junio | 3 | 19 | 22 |
| 2017 Mayo | 9 | 14 | 23 |
| 2017 Abril | 9 | 4 | 13 |
| 2017 Marzo | 9 | 27 | 36 |
| 2017 Febrero | 11 | 5 | 16 |
| 2017 Enero | 6 | 7 | 13 |
| 2016 Diciembre | 15 | 18 | 33 |
| 2016 Noviembre | 27 | 20 | 47 |
| 2016 Octubre | 31 | 25 | 56 |
| 2016 Septiembre | 13 | 8 | 21 |
| 2016 Agosto | 11 | 2 | 13 |
| 2016 Julio | 11 | 5 | 16 |
| 2016 Junio | 14 | 17 | 31 |
| 2016 Mayo | 14 | 28 | 42 |
| 2016 Abril | 10 | 24 | 34 |
| 2016 Marzo | 10 | 16 | 26 |
| 2016 Febrero | 10 | 17 | 27 |
| 2016 Enero | 4 | 23 | 27 |
| 2015 Diciembre | 14 | 30 | 44 |
| 2015 Noviembre | 8 | 26 | 34 |
| 2015 Octubre | 22 | 32 | 54 |
| 2015 Septiembre | 7 | 23 | 30 |
| 2015 Agosto | 7 | 14 | 21 |
| 2015 Julio | 9 | 22 | 31 |
| 2015 Junio | 2 | 6 | 8 |
| 2015 Mayo | 2 | 14 | 16 |
| 2015 Abril | 4 | 18 | 22 |
| 2015 Marzo | 2 | 17 | 19 |
| 2015 Febrero | 2 | 22 | 24 |
| 2015 Enero | 10 | 0 | 10 |
| 2014 Diciembre | 9 | 8 | 17 |
| 2014 Noviembre | 8 | 3 | 11 |
| 2014 Octubre | 17 | 1 | 18 |
| 2014 Septiembre | 12 | 0 | 12 |
| 2014 Agosto | 5 | 1 | 6 |
| 2014 Julio | 12 | 0 | 12 |
| 2014 Junio | 11 | 3 | 14 |
| 2014 Mayo | 9 | 0 | 9 |
| 2014 Abril | 1 | 2 | 3 |
| 2014 Marzo | 4 | 1 | 5 |
| 2014 Febrero | 2 | 3 | 5 |
| 2014 Enero | 5 | 2 | 7 |
| 2013 Diciembre | 7 | 2 | 9 |
| 2013 Noviembre | 11 | 2 | 13 |
| 2013 Octubre | 3 | 7 | 10 |
| 2013 Septiembre | 4 | 7 | 11 |
| 2013 Agosto | 4 | 12 | 16 |
| 2013 Julio | 3 | 0 | 3 |
| 2009 Febrero | 304 | 0 | 304 |
Mostrar todo
