Mecanismo fisiopatológico de los sofocos-sudores inducidos por deprivación androgénica en el carcinoma prostático

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Sabater Martí" "autores" => array:6 [ 0 => array:4 [ "nombre" => "Santiago" "apellidos" => "Vilar Gónzalez" "email" => array:1 [ 0 => "santiagov06@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "1" "identificador" => "cor0005" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "aff0005" ] ] ] 1 => array:3 [ "nombre" => "Francesc" "apellidos" => "Montañá Puig" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "**" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "Mª" "apellidos" => "Victoria Villas Sánchez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "*" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "Mª" "apellidos" => "del Mar Sevillano Capellán" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "*" "identificador" => "aff0005" ] ] ] 4 => array:3 [ "nombre" => "Manuel" "apellidos" => "Martos Aguayo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "*" "identificador" => "aff0005" ] ] ] 5 => array:3 [ "nombre" => "Sebastiá." 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Tel.: 0034 96 75 97 523" ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Physiopathological mechanism of hot flushes-perspiration induced by androgen deprivation in prostate carcinoma" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2008-10-01" "fechaAceptado" => "2008-11-01" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec88894" "palabras" => array:3 [ 0 => "Carcinoma prostático" 1 => "Sofocos" 2 => "Deprivación hormonal" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec88893" "palabras" => array:3 [ 0 => "Prostate carcinoma" 1 => "Hot flushes" 2 => "Hormone deprivation" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "Los sofocos-sudores son problemas frecuentes durante el tratamiento con deprivación androgénica en pacientes afectos de carcinoma prostático. Estos efectos secundarios contribuyen en gran medida al deterioro de la calidad de vida.Se han postulado diferentes hipótesis sobre los mecanismos fisiopatogénicos implicados, todos ellos de una alta complejidad debida básicamente a su multicausalidad.El objetivo de esta revisión es aportar una visión meditada y actualizada de su génesis.La retroalimentación negativa de las hormonas sexuales plasmáticas sobre la secreción hipotalámica de noradrenalina y serotonina serían la causa principal.Asimismo la acción directa de estos mecanismos sobre el centro hipotalámico productor de LH-RH cercano al centro termorregulador, junto al acortamiento del intervalo termoneutral también estarían implicados.La mejor comprensión de su mecanismo de producción nos puede hacer enfocar mas correctamente su tratamiento." ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "Hot flushes and perspiration are common problems during androgen deprivation therapy for prostate carcinoma, and largely contribute to worsen patient quality of life.Different hypotheses have been proposed to explain the underlying physiopathological mechanisms, though all are very complex, basically because of the multiple causal factors involved.The present review offers a pondered and updated perspective of the origin of hot flushes-perspiration in such patients.Negative feedback of the plasma sexual hormones upon the hypothalamic secretion of noradrenalin and serotonin appears to be the main cause. Likewise, the direct action of such mechanisms upon the LH-RH producing hypothalamic center located close to the thermoregulatory center, together with shortening of the thermoneutral interval, would also play a role.Improved understanding of the causal mechanism may help improve the treatment of such symptoms." ] ] "bibliografia" => array:2 [ "titulo" => "Referencias" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:65 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "G. López-Abente" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:3 [ "fecha" => "2005" "editorial" => "Ministerio de Sanidad y Consumo" "editorialLocalizacion" => "Madrid" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2." 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Mecanismo fisiopatológico de los sofocos-sudores inducidos por deprivación androgénica en el carcinoma prostático

Physiopathological mechanism of hot flushes-perspiration induced by androgen deprivation in prostate carcinoma

Santiago Vilar Gónzalez1,

, Francesc Montañá Puig**, Mª Victoria Villas Sánchez*, Mª del Mar Sevillano Capellán*, Manuel Martos Aguayo*, Sebastiá. Sabater Martí*

* Complejo Hospitalario Universitario de Albacete (CHUA)

** Angelini-Farmacéutica. Barcelona, España

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Información del artículo

ISSN: 02104806
Idioma original: Español

DOI:10.1016/S0210-4806(09)74136-1

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2022 Diciembre	0	15	15
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2022 Mayo	0	17	17
2022 Abril	0	12	12
2022 Marzo	0	8	8
2022 Febrero	0	2	2
2022 Enero	0	5	5
2021 Diciembre	0	5	5
2021 Noviembre	0	5	5
2021 Octubre	0	7	7
2021 Septiembre	0	2	2
2021 Agosto	0	7	7
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2021 Mayo	0	4	4
2021 Abril	0	5	5
2021 Marzo	0	9	9
2021 Febrero	0	3	3
2021 Enero	0	6	6
2020 Diciembre	0	9	9
2020 Noviembre	0	2	2
2020 Octubre	0	2	2
2020 Septiembre	0	7	7
2020 Agosto	0	3	3
2020 Julio	0	6	6
2020 Junio	0	9	9
2020 Mayo	0	13	13
2020 Abril	0	5	5
2020 Marzo	0	5	5
2020 Febrero	0	3	3
2020 Enero	0	15	15
2019 Diciembre	0	15	15
2019 Noviembre	0	6	6
2019 Octubre	0	4	4
2019 Septiembre	0	3	3
2019 Agosto	0	10	10
2019 Julio	0	11	11
2019 Junio	0	21	21
2019 Mayo	0	62	62
2019 Abril	0	23	23
2019 Marzo	0	6	6
2019 Febrero	0	12	12
2019 Enero	0	5	5
2018 Diciembre	0	11	11
2018 Noviembre	0	9	9
2018 Octubre	0	25	25
2018 Agosto	0	1	1
2018 Julio	0	3	3
2018 Febrero	1	4	5
2018 Enero	4	3	7
2017 Diciembre	4	2	6
2017 Noviembre	8	6	14
2017 Octubre	12	5	17
2017 Septiembre	5	11	16
2017 Agosto	8	6	14
2017 Julio	10	5	15
2017 Junio	17	9	26
2017 Mayo	9	6	15
2017 Abril	7	6	13
2017 Marzo	14	41	55
2017 Febrero	14	9	23
2017 Enero	4	4	8
2016 Diciembre	23	5	28
2016 Noviembre	27	6	33
2016 Octubre	29	5	34
2016 Septiembre	14	10	24
2016 Agosto	11	12	23
2016 Julio	12	11	23
2016 Junio	26	13	39
2016 Mayo	14	17	31
2016 Abril	7	25	32
2016 Marzo	9	21	30
2016 Febrero	7	23	30
2016 Enero	22	24	46
2015 Diciembre	19	26	45
2015 Noviembre	21	15	36
2015 Octubre	15	17	32
2015 Septiembre	25	6	31
2015 Agosto	13	3	16
2015 Julio	14	3	17
2015 Junio	6	1	7
2015 Mayo	6	2	8
2015 Abril	12	14	26
2015 Marzo	10	2	12
2015 Febrero	4	5	9
2015 Enero	8	7	15
2014 Diciembre	7	9	16
2014 Noviembre	7	3	10
2014 Octubre	13	4	17
2014 Septiembre	4	3	7
2014 Agosto	7	4	11
2014 Julio	9	3	12
2014 Junio	3	7	10
2014 Mayo	8	4	12
2014 Abril	2	3	5
2014 Marzo	2	3	5
2014 Febrero	1	4	5
2014 Enero	3	0	3
2013 Diciembre	4	2	6
2013 Noviembre	12	7	19
2013 Octubre	5	6	11
2013 Septiembre	6	10	16
2013 Agosto	4	2	6
2013 Julio	1	0	1
2009 Marzo	410	0	410

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