Avances sobre la influencia del tejido adiposo en el adenocarcinoma de próstata
Advances on the influence of adipose tissue on prostate cancer
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"apellidos" => "Sabater Martí" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210480609741361?idApp=UINPBA00004N" "url" => "/02104806/0000003300000003/v1_201304251925/S0210480609741361/v1_201304251925/es/main.assets" ] "es" => array:12 [ "idiomaDefecto" => true "titulo" => "Avances sobre la influencia del tejido adiposo en el adenocarcinoma de próstata" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "242" "paginaFinal" => "248" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Constanza López Fontana, M. Eugenia Maselli Artola, M. Cristina Vanrell Rodríguez, Nicolás A. Di Milta Mónaco, Rafael Pérez Elizalde, José D. López Laur" "autores" => array:6 [ 0 => array:4 [ "nombre" => "Constanza" "apellidos" => "López Fontana" "email" => array:1 [ 0 => "investigacioncap@yahoo.com.ar" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "cor0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0010" ] ] ] 1 => array:3 [ "nombre" => "M." "apellidos" => "Eugenia Maselli Artola" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "M." "apellidos" => "Cristina Vanrell Rodríguez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "Nicolás A." "apellidos" => "Di Milta Mónaco" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0010" ] ] ] 4 => array:3 [ "nombre" => "Rafael" "apellidos" => "Pérez Elizalde" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0010" ] ] ] 5 => array:3 [ "nombre" => "José D." "apellidos" => "López Laur" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Cátedra Clínica Urológica. Facultad de Ciencias Médicas. Universidad Nacional de Cuyo. Mendoza. Argentina" "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Laboratorio de Enfermedades Metabólicas y Cáncer. Facultad de Farmacia y Bioquímica. Universidad Juan Agustín Maza. Mendoza. Argentina" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "1" "correspondencia" => "Correspondencia autor: Dra. Constanza López Fontana Acceso Este 2245 (Lateral Sur) San José, Guaymallén. Mendoza Argentina. CP: 5519. Fax: 54-261-4299350" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Advances on the influence of adipose tissue on prostate cancer" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec88867" "palabras" => array:4 [ 0 => "Tejido adiposo" 1 => "Adipoquinas" 2 => "Obesidad" 3 => "Cáncer de próstata" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec88868" "palabras" => array:4 [ 0 => "Adipose tissue" 1 => "Adipokines" 2 => "Obesity" 3 => "Prostate cancer" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Numerosos estudios han intentado interpretar la asociación entre la obesidad y el cáncer de próstata (CaP), aunque los resultados no han sido concluyentes debido a que existe una gran dificultad para evaluar sus efectos de sobre el desarrollo del CaP. Dicha dificultad radica en que no solo implica un exceso de grasa corporal, sino también una alteración de diversos parámetros fisiológicos que aumentan la agresividad del tumor.</p> <span class="elsevierStyleSectionTitle">Objetivos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Realizar una puesta al día sobre el rol del tejido adiposo en el desarrollo del CaP. Material y métodos: se realizó una búsqueda bibliográfica y lectura compresiva de artículos relacionados con “tejido adiposo”, “obesidad”, “adipoquinas” y “cáncer de próstata” en Pubmed y revistas científicas.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Estudios recientes indican que la obesidad influiría en la carcinogénesis prostática mediante factores promotores (andrógenos, leptina, VEGF, IL-6, insulina e IGF-1) y factores protectores (adiponectina e IGFBP-3). Los mecanismos potenciales mediante los cuales la obesidad podría iniciar, promover o favorecer la progresión del CaP son los bajos niveles de testosterona y altos niveles de estrógenos, el síndrome metabólico coexistente, el aumento en la secreción de leptina, VEGF, IL-6 y TNF-αy disminución de adiponectina, y la excesiva ingesta de grasas saturadas.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">El exceso de tejido adiposo en el organismo podría promover la progresión del CaP, más que ser un factor de riesgo. Sin embargo, futuros estudios son necesarios para esclarecer aún más la relación entre las adipoquinas y el CaP con el fin de desarrollar nuevas medidas de prevención y tratamiento de este tumor.</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Numerous studies have investigated the association between obesity and prostate cancer (CaP), although the results have not been concluding due to the great difficulty to evaluate the effects of obesity on the development of this type of tumor.</p> <span class="elsevierStyleSectionTitle">The aim of this study</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">was to carry out a comprehensive over-view of the existing evidence about the role of adipose tissue in the prostate carcinogenesis. Recent evidence suggests that androgens, leptin, IL-6, VEGF, insulin and IGF-1 may play a role in PC progression, while adiponectin and IGFBP-3 may act as “anti- prostatic cancer” adipokines. The potential mechanisms by which obesity may initiate, promote or facilitate the progression of CaP are low levels of testosterone and high levels of estrogen, coexisting metabolic syndrome, increased secretion of leptin, VEGF, IL-6 and TNF-αand decreased adiponectin, and excessive intake of saturated fat.</p> <span class="elsevierStyleSectionTitle">Conclusion</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Obesity may promote the progression of established PC rather than being a risk factor for the development of this tumour. 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| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Octubre | 0 | 4 | 4 |
| 2024 Septiembre | 0 | 15 | 15 |
| 2024 Agosto | 0 | 8 | 8 |
| 2024 Julio | 0 | 7 | 7 |
| 2024 Junio | 0 | 7 | 7 |
| 2024 Mayo | 0 | 11 | 11 |
| 2024 Abril | 0 | 8 | 8 |
| 2024 Marzo | 0 | 35 | 35 |
| 2024 Febrero | 0 | 15 | 15 |
| 2024 Enero | 0 | 15 | 15 |
| 2023 Diciembre | 0 | 15 | 15 |
| 2023 Noviembre | 0 | 28 | 28 |
| 2023 Octubre | 0 | 48 | 48 |
| 2023 Septiembre | 0 | 10 | 10 |
| 2023 Agosto | 0 | 16 | 16 |
| 2023 Julio | 0 | 45 | 45 |
| 2023 Junio | 0 | 10 | 10 |
| 2023 Mayo | 0 | 4 | 4 |
| 2023 Abril | 0 | 7 | 7 |
| 2023 Marzo | 0 | 11 | 11 |
| 2023 Febrero | 0 | 15 | 15 |
| 2023 Enero | 0 | 6 | 6 |
| 2022 Diciembre | 0 | 9 | 9 |
| 2022 Noviembre | 0 | 16 | 16 |
| 2022 Octubre | 0 | 7 | 7 |
| 2022 Septiembre | 0 | 28 | 28 |
| 2022 Agosto | 0 | 10 | 10 |
| 2022 Julio | 0 | 6 | 6 |
| 2022 Junio | 0 | 7 | 7 |
| 2022 Mayo | 0 | 8 | 8 |
| 2022 Abril | 0 | 7 | 7 |
| 2022 Marzo | 0 | 5 | 5 |
| 2022 Febrero | 0 | 7 | 7 |
| 2022 Enero | 0 | 5 | 5 |
| 2021 Diciembre | 0 | 9 | 9 |
| 2021 Noviembre | 0 | 5 | 5 |
| 2021 Septiembre | 0 | 2 | 2 |
| 2021 Agosto | 0 | 4 | 4 |
| 2021 Julio | 0 | 5 | 5 |
| 2021 Junio | 0 | 9 | 9 |
| 2021 Mayo | 0 | 1 | 1 |
| 2021 Abril | 0 | 1 | 1 |
| 2021 Marzo | 0 | 5 | 5 |
| 2021 Febrero | 0 | 2 | 2 |
| 2021 Enero | 0 | 2 | 2 |
| 2020 Diciembre | 0 | 6 | 6 |
| 2020 Noviembre | 0 | 2 | 2 |
| 2020 Octubre | 0 | 6 | 6 |
| 2020 Septiembre | 0 | 4 | 4 |
| 2020 Agosto | 0 | 7 | 7 |
| 2020 Junio | 0 | 6 | 6 |
| 2020 Mayo | 0 | 14 | 14 |
| 2020 Abril | 0 | 1 | 1 |
| 2020 Marzo | 0 | 3 | 3 |
| 2020 Febrero | 0 | 4 | 4 |
| 2020 Enero | 0 | 5 | 5 |
| 2019 Diciembre | 0 | 14 | 14 |
| 2019 Noviembre | 0 | 5 | 5 |
| 2019 Octubre | 0 | 1 | 1 |
| 2019 Septiembre | 0 | 3 | 3 |
| 2019 Agosto | 0 | 3 | 3 |
| 2019 Julio | 0 | 14 | 14 |
| 2019 Junio | 0 | 12 | 12 |
| 2019 Mayo | 0 | 68 | 68 |
| 2019 Abril | 0 | 27 | 27 |
| 2019 Marzo | 0 | 2 | 2 |
| 2019 Febrero | 0 | 11 | 11 |
| 2019 Enero | 0 | 2 | 2 |
| 2018 Diciembre | 0 | 9 | 9 |
| 2018 Noviembre | 0 | 13 | 13 |
| 2018 Octubre | 0 | 10 | 10 |
| 2018 Julio | 0 | 1 | 1 |
| 2018 Junio | 0 | 1 | 1 |
| 2018 Febrero | 3 | 4 | 7 |
| 2018 Enero | 0 | 1 | 1 |
| 2017 Diciembre | 0 | 4 | 4 |
| 2017 Noviembre | 9 | 4 | 13 |
| 2017 Octubre | 4 | 3 | 7 |
| 2017 Septiembre | 7 | 14 | 21 |
| 2017 Agosto | 2 | 11 | 13 |
| 2017 Julio | 5 | 4 | 9 |
| 2017 Junio | 15 | 11 | 26 |
| 2017 Mayo | 15 | 5 | 20 |
| 2017 Abril | 8 | 1 | 9 |
| 2017 Marzo | 11 | 29 | 40 |
| 2017 Febrero | 1 | 4 | 5 |
| 2017 Enero | 4 | 3 | 7 |
| 2016 Diciembre | 26 | 8 | 34 |
| 2016 Noviembre | 25 | 3 | 28 |
| 2016 Octubre | 28 | 8 | 36 |
| 2016 Septiembre | 18 | 5 | 23 |
| 2016 Agosto | 10 | 2 | 12 |
| 2016 Julio | 8 | 3 | 11 |
| 2016 Junio | 18 | 15 | 33 |
| 2016 Mayo | 18 | 30 | 48 |
| 2016 Abril | 9 | 44 | 53 |
| 2016 Marzo | 9 | 32 | 41 |
| 2016 Febrero | 10 | 33 | 43 |
| 2016 Enero | 11 | 30 | 41 |
| 2015 Diciembre | 11 | 28 | 39 |
| 2015 Noviembre | 9 | 16 | 25 |
| 2015 Octubre | 15 | 12 | 27 |
| 2015 Septiembre | 9 | 12 | 21 |
| 2015 Agosto | 8 | 3 | 11 |
| 2015 Julio | 4 | 2 | 6 |
| 2015 Junio | 6 | 5 | 11 |
| 2015 Mayo | 3 | 4 | 7 |
| 2015 Abril | 6 | 11 | 17 |
| 2015 Marzo | 6 | 3 | 9 |
| 2015 Febrero | 6 | 4 | 10 |
| 2015 Enero | 13 | 6 | 19 |
| 2014 Diciembre | 14 | 11 | 25 |
| 2014 Noviembre | 6 | 2 | 8 |
| 2014 Octubre | 11 | 7 | 18 |
| 2014 Septiembre | 20 | 5 | 25 |
| 2014 Agosto | 3 | 2 | 5 |
| 2014 Julio | 10 | 2 | 12 |
| 2014 Junio | 9 | 7 | 16 |
| 2014 Mayo | 9 | 3 | 12 |
| 2014 Abril | 7 | 3 | 10 |
| 2014 Marzo | 9 | 4 | 13 |
| 2014 Febrero | 3 | 2 | 5 |
| 2014 Enero | 9 | 2 | 11 |
| 2013 Diciembre | 3 | 7 | 10 |
| 2013 Noviembre | 9 | 3 | 12 |
| 2013 Octubre | 3 | 7 | 10 |
| 2013 Septiembre | 4 | 9 | 13 |
| 2013 Agosto | 4 | 10 | 14 |
| 2013 Julio | 0 | 2 | 2 |
| 2009 Marzo | 357 | 0 | 357 |
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