Alternativa terapéutica para el dolor pélvico crónico de origen vesical
New approach in treatment of pelvic chronic pain syndrome (CPPS)
Pedro A. López González1
, Jesús I. Tornero Ruiz, Pedro López Cubillana, Gloria Doñate Iñiguez, Jose C. Ruíz Morcillo, Mariano Pérez Albacete
Autor para correspondencia
peterangel@ono.com
Correspondencia autor: Pedro A. López González Servicio de Urología Hospital Universitario Virgen de la Arrixaca Ctra. Madrid-Cartagena, s/n - 30120 El Palmar. Murcia Tel.: 968 369 500
Correspondencia autor: Pedro A. López González Servicio de Urología Hospital Universitario Virgen de la Arrixaca Ctra. Madrid-Cartagena, s/n - 30120 El Palmar. Murcia Tel.: 968 369 500
Servicio de Urología. Hospital Universitario Virgen de la Arrixaca. El Palmar. Murcia. España
Leído
2469
Vecesse ha leído el artículo
1263
Total PDF
1206
Total HTML
Compartir estadísticas
array:24 [ "pii" => "S021048060974207X" "issn" => "02104806" "doi" => "10.1016/S0210-4806(09)74207-X" "estado" => "S300" "fechaPublicacion" => "2009-01-01" "aid" => "74207" "copyright" => "Asociación Española de Urología (AEU)" "copyrightAnyo" => "2009" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Urol Esp. 2009;33:681-5" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1992 "formatos" => array:3 [ "EPUB" => 8 "HTML" => 1203 "PDF" => 781 ] ] "itemSiguiente" => array:18 [ "pii" => "S0210480609742081" "issn" => "02104806" "doi" => "10.1016/S0210-4806(09)74208-1" "estado" => "S300" "fechaPublicacion" => "2009-01-01" "aid" => "74208" "copyright" => "Asociación Española de Urología (AEU)" "documento" => "article" "crossmark" => 0 "subdocumento" => "sco" "cita" => "Actas Urol Esp. 2009;33:686-90" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1843 "formatos" => array:3 [ "EPUB" => 6 "HTML" => 961 "PDF" => 876 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Linfoma prostático y revisión de la literatura" "tienePdf" => array:2 [ 0 => "es" 1 => "en" ] "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "686" "paginaFinal" => "690" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Prostatic Lymphoma and review of the literature" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:2 [ "es" => true "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Jorge Rioja Zuazu, Rebeca Iglesias, David Rosell Costa, Anibal Rincón Mayans, Xavier Brugarolas i Roselló, Ángel Panizo Santos, José Mª Berián Polo" "autores" => array:7 [ 0 => array:2 [ "nombre" => "Jorge" "apellidos" => "Rioja Zuazu" ] 1 => array:2 [ "nombre" => "Rebeca" "apellidos" => "Iglesias" ] 2 => array:2 [ "nombre" => "David" "apellidos" => "Rosell Costa" ] 3 => array:2 [ "nombre" => "Anibal" "apellidos" => "Rincón Mayans" ] 4 => array:2 [ "nombre" => "Xavier" "apellidos" => "Brugarolas i Roselló" ] 5 => array:2 [ "nombre" => "Ángel" "apellidos" => "Panizo Santos" ] 6 => array:2 [ "nombre" => "José Mª" "apellidos" => "Berián Polo" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210480609742081?idApp=UINPBA00004N" "url" => "/02104806/0000003300000006/v1_201304251934/S0210480609742081/v1_201304251934/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0210480609742068" "issn" => "02104806" "doi" => "10.1016/S0210-4806(09)74206-8" "estado" => "S300" "fechaPublicacion" => "2009-01-01" "aid" => "74206" "copyright" => "Asociación Española de Urología (AEU)" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Urol Esp. 2009;33:670-80" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1959 "formatos" => array:3 [ "EPUB" => 5 "HTML" => 934 "PDF" => 1020 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Complicaciones en cirugía laparoscópica renal en la edad pediátrica: análisis de nuestra experiencia y revisión de la literatura" "tienePdf" => array:2 [ 0 => "es" 1 => "en" ] "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "670" "paginaFinal" => "680" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Complications in laparoscopy renal surgery in pediatric age: Analysis of our experience and literature review" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:2 [ "es" => true "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Alberto Pérez-Lanzac de Lorca, Andrés Gómez Fraile, Adolfo Aransay Bramtot, Daniel Cabezalí Brabancho, Francisco López Vázquez, Jesús Castiñeiras Fernández" "autores" => array:6 [ 0 => array:2 [ "nombre" => "Alberto" "apellidos" => "Pérez-Lanzac de Lorca" ] 1 => array:2 [ "nombre" => "Andrés" "apellidos" => "Gómez Fraile" ] 2 => array:2 [ "nombre" => "Adolfo" "apellidos" => "Aransay Bramtot" ] 3 => array:2 [ "nombre" => "Daniel" "apellidos" => "Cabezalí Brabancho" ] 4 => array:2 [ "nombre" => "Francisco" "apellidos" => "López Vázquez" ] 5 => array:2 [ "nombre" => "Jesús" "apellidos" => "Castiñeiras Fernández" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210480609742068?idApp=UINPBA00004N" "url" => "/02104806/0000003300000006/v1_201304251934/S0210480609742068/v1_201304251934/es/main.assets" ] "es" => array:14 [ "idiomaDefecto" => true "titulo" => "Alternativa terapéutica para el dolor pélvico crónico de origen vesical" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "681" "paginaFinal" => "685" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Pedro A. López González, Jesús I. Tornero Ruiz, Pedro López Cubillana, Gloria Doñate Iñiguez, Jose C. Ruíz Morcillo, Mariano Pérez Albacete" "autores" => array:6 [ 0 => array:4 [ "nombre" => "Pedro" "apellidos" => "A. López González" "email" => array:1 [ 0 => "peterangel@ono.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "Jesús" "apellidos" => "I. Tornero Ruiz" ] 2 => array:2 [ "nombre" => "Pedro" "apellidos" => "López Cubillana" ] 3 => array:2 [ "nombre" => "Gloria" "apellidos" => "Doñate Iñiguez" ] 4 => array:2 [ "nombre" => "Jose" "apellidos" => "C. Ruíz Morcillo" ] 5 => array:2 [ "nombre" => "Mariano" "apellidos" => "Pérez Albacete" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Urología. Hospital Universitario Virgen de la Arrixaca. El Palmar. Murcia. España" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "1" "correspondencia" => "Correspondencia autor: Pedro A. López González Servicio de Urología Hospital Universitario Virgen de la Arrixaca Ctra. Madrid-Cartagena, s/n - 30120 El Palmar. Murcia Tel.: 968 369 500" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "New approach in treatment of pelvic chronic pain syndrome (CPPS)" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2009-01-01" "fechaAceptado" => "2009-02-01" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec89001" "palabras" => array:3 [ 0 => "Dolor pélvico crónico" 1 => "Cistitis intersticial" 2 => "Tratamiento médico" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec89002" "palabras" => array:3 [ 0 => "Pelvic pain" 1 => "Interstitial cystitis" 2 => "Treatment outcome" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Introducción</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">El dolor pélvico crónico (DPC) es un problema complejo e importante tanto por su frecuencia como por su morbilidad. Cuando se presenta asociado con síntomas miccionales deberemos pensar en un origen vesical.</p> <span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Evaluar la respuesta a un tratamiento intravesical, al que denominamos Formula Sedante, en pacientes con dolor pélvico crónico de origen vesical, refractarios a otros tratamientos.</p> <span class="elsevierStyleSectionTitle">Material y métodos</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Entre junio 2005 y septiembre de 2008, 14 pacientes (edad media de 59 años), 12 mujeres y 2 hombres, con DPC de origen vesical siguieron un tratamiento intravesical con “Formula Sedante”, como terapia de segunda línea. Su composición es Dexametasona, Nitrofurantoína, Lidocaína y Suero salino. Evaluamos el dolor (escala 0-10), la frecuencia miccional y la mejoría subjetiva del paciente.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">El dolor global medio fue de 6’4 de base, al mes y a los 6 meses fue de 4’7 y 3’5 respectivamente. El 75% de los pacientes mostró una disminución de los valores en la escala de dolor. La frecuencia miccional diurna mejoró un 28% al mes del tratamiento y un 40% a los 6 meses. Un 70 % de los pacientes refirió sentir mejoría tras la pauta de instilaciones, de los cuales en torno a un 80% la evaluó como “moderadamente mejor” o “mucho mejor”, tanto al mes como a los 6 meses del tratamiento. Ninguno de los pacientes presento efectos secundarios reseñables.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Consideramos el tratamiento de instilación intravesical con “Formula Sedante” una opción útil y segura, como segunda línea de tratamiento, para el dolor pélvico crónico de origen vesical.</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Chronic pelvic pain syndrome (CPPS) is a complex problem that is a major cause of morbidity and disability.</p> <span class="elsevierStyleSectionTitle">Objective</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">To evaluate the feasibility, safety and efficacy of intravesical instillation of a new therapeutic tool in patients suffering from CPPS.</p> <span class="elsevierStyleSectionTitle">Methods</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Between june 2005 and september 2008 we recruited 14 patients (mean age 59) who had been diagnosed with CPPS, and refractory to previous treatments. The intravesical solution consisted of steroids, local anaesthetic, antibiotic and saline solution. Was evaluated the intensity of pain; voiding frequency and subjective improvement (with patient global improvement impression PGI-I).</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Global pain at baseline was 6,4, at 1 month and 6 months 4,7 and 3,5. 75% of the patients showed improvement in the reduction of pain. Voiding frequency at baseline was 22’5 daily. At one and six months, voiding frequency was 16,2 and 13,5 respectively. According to the PGI-I test 30% of patients were much better, 30% moderate improvement, 10% slight improvement and 30% with no changes at 1 month. At 6 months, 15% of patients were much better, 40% moderated improvement, 15% slight improvement and 30% with no changes. None of the patients felt worse than before treatment.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Therapeutic results of our intravesical solution traduces in an improvement of pain and voiding frequency reduction with no side-effects. Patients benefit of this improvement in the PGI-I test that reflects an improvement in quality of life. We consider this treatment a second-line approach for CPPS in which gold standard management is still a challenge.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:18 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Chronic pelvic pain of bladder origin: epidemiology, pathogenesis and quality of life" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "R.T. Burkman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "J Reprod Med" "fecha" => "2004" "volumen" => "49" "numero" => "3 Suppl" "paginaInicial" => "225" "paginaFinal" => "229" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15088860" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Chronic pelvic pain: an integrated approach to diagnosis and treatment" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J. Gunter" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/01.OGX.0000083225.90017.01" "Revista" => array:7 [ "tituloSerie" => "Obstet Gynecol Surv" "fecha" => "2003" "volumen" => "58" "numero" => "9" "paginaInicial" => "615" "paginaFinal" => "623" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12972837" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Chronic pelvic pain in men" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "O.W. Hakenberg" 1 => "M.P. Wirth" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "48438" "Revista" => array:7 [ "tituloSerie" => "Urol Int" "fecha" => "2002" "volumen" => "68" "numero" => "3" "paginaInicial" => "138" "paginaFinal" => "143" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11919456" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Endometriosis and pain" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "D. Martin" 1 => "F. Ling" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Clin Obstet Gynecol" "fecha" => "1999" "volumen" => "42" "numero" => "3" "paginaInicial" => "664" "paginaFinal" => "692" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10451777" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Endometriosis and pelvic pain" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "D.H. Barlow" 1 => "C.J. Glynn" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ballieres Clin Obstet Gynecol" "fecha" => "1993" "volumen" => "7" "numero" => "4" "paginaInicial" => "775" "paginaFinal" => "789" ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Self-care regimens for patients with interstitial cystitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "K.E. Whitmore" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Urol Clin North Am" "fecha" => "1994" "volumen" => "21" "numero" => "1" "paginaInicial" => "121" "paginaFinal" => "130" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8284835" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pelvic floor myofascial trigger points: Manual therapy for interstitial cystitis and the urgency-frequency syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J. Weiss" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "J Urol" "fecha" => "2001" "volumen" => "166" "numero" => "6" "paginaInicial" => "2226" "paginaFinal" => "2231" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11696740" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The use of amitriptyline in patients with urgency, frequency and pain" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "K. Pranikoff" 1 => "G. Costantino" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Urology" "fecha" => "1998" "volumen" => "51" "numero" => "suppl 5" "paginaInicial" => "179" "paginaFinal" => "181" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9610578" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Amitriptyline in the treatment of interstitial cystitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "P.M. Hanno" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Urol Clin North Am" "fecha" => "1994" "volumen" => "21" "numero" => "1" "paginaInicial" => "89" "paginaFinal" => "91" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8284851" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hydroxyzine therapy for interstitial cystitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "T.C. Theoharides" 1 => "G.R. Sant" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Urology" "fecha" => "1997" "volumen" => "49" "numero" => "suppl 5ª" "paginaInicial" => "108" "paginaFinal" => "110" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9146011" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0055" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Analysis of long-term Elmiron therapy for interstitial cystitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "P.M. Hanno" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Uology" "fecha" => "1997" "volumen" => "49" "numero" => "suppl 5ª" "paginaInicial" => "93" "paginaFinal" => "99" ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0060" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Randomized, double-blinded, dose-ranging study of pentosan polysulfate sodium for interstitial cystitis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "J.C. Nickel" 1 => "J. Barkin" 2 => "J. Forrest" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Urol" "fecha" => "2001" "volumen" => "165" "numero" => "5 suppl" "paginaInicial" => "67" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11125366" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0065" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Efficacy of prednisone for severe refractory ulcerative interstitial cystitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "F. Soucy" 1 => "M. Gregoire" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/01.ju.0000153612.14639.19" "Revista" => array:7 [ "tituloSerie" => "J Urol" "fecha" => "2005" "volumen" => "173" "numero" => "3" "paginaInicial" => "841" "paginaFinal" => "843" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15711286" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0070" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Intravesical dimethyl sulfoxido (DMSO) for interstitial cystitis-A practical approach" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J. Parkin" 1 => "C. Shea" 2 => "G.R. Sant" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Urology" "fecha" => "1997" "volumen" => "49" "numero" => "Suppl 5A" "paginaInicial" => "105" "paginaFinal" => "107" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9146010" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0075" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Intravesical hyaluronic acid in the treatment of refractory interstitial cystitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A. Morales" 1 => "L. Emerson" 2 => "J.C. Nickel" 3 => "M. Lundie" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "J Urol" "fecha" => "1996" "volumen" => "156" "numero" => "1" "paginaInicial" => "45" "paginaFinal" => "48" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8648835" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0080" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The efficacy of intravesical Tice srain bacillus Calmette- Guerin in the treatment of interstitial cystitis:a double blind, prospective, placebo controlled trial" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "K. Peters" 1 => "A. Diokno" 2 => "B. Steinert" 3 => "M. Yuhico" 4 => "B. Mitchell" 5 => "S. Krohta" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:8 [ "tituloSerie" => "J Urol" "fecha" => "1997" "volumen" => "157" "numero" => "6" "paginaInicial" => "2090" "paginaFinal" => "2094" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9146587" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0022347609012487" "estado" => "S300" "issn" => "00223476" ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0085" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sacral nerve stimulation in patients with chronic intractable pelvic pain" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "S. Siegel" 1 => "E. Paszkiewicz" 2 => "C. Kirkpatrick" 3 => "B. Hinkel" 4 => "K. Oleson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Urol" "fecha" => "2001" "volumen" => "165" "numero" => "5" "paginaInicial" => "1742" "paginaFinal" => "1745" ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0090" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cistitis intersticial: actualización de su patogenia, diagnóstico y tratamiento" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J.M. Cózar Olmo" 1 => "A. Martínez Morcillo" 2 => "J. Vicente Prados" 3 => "M. Tallada Buñuel" 4 => "E. Espejo Maldonado" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Arch Esp Urol" "fecha" => "2002" "volumen" => "55" "numero" => "9" "paginaInicial" => "1153" "paginaFinal" => "1164" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12564075" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/02104806/0000003300000006/v1_201304251934/S021048060974207X/v1_201304251934/es/main.assets" "Apartado" => array:4 [ "identificador" => "6429" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Original" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/02104806/0000003300000006/v1_201304251934/S021048060974207X/v1_201304251934/es/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S021048060974207X?idApp=UINPBA00004N" "pdfAlternativo" => array:1 [ 0 => array:3 [ "idioma" => "en" "documentoPdf" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/file/02104806/addon/S021048060974207X/S300/en/292v33n06a13143231pdf001_2.pdf" "portada" => "292v33n06a13143231pdf001_2.png" ] ] ]
| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 0 | 1 | 1 |
| 2024 Octubre | 0 | 4 | 4 |
| 2024 Septiembre | 0 | 6 | 6 |
| 2024 Agosto | 0 | 9 | 9 |
| 2024 Julio | 0 | 6 | 6 |
| 2024 Junio | 0 | 11 | 11 |
| 2024 Mayo | 0 | 6 | 6 |
| 2024 Abril | 0 | 19 | 19 |
| 2024 Marzo | 0 | 25 | 25 |
| 2024 Febrero | 0 | 16 | 16 |
| 2024 Enero | 0 | 13 | 13 |
| 2023 Diciembre | 0 | 15 | 15 |
| 2023 Noviembre | 0 | 41 | 41 |
| 2023 Octubre | 0 | 26 | 26 |
| 2023 Septiembre | 0 | 18 | 18 |
| 2023 Agosto | 0 | 5 | 5 |
| 2023 Julio | 0 | 41 | 41 |
| 2023 Junio | 0 | 8 | 8 |
| 2023 Mayo | 0 | 2 | 2 |
| 2023 Abril | 0 | 2 | 2 |
| 2023 Marzo | 1 | 0 | 1 |
| 2023 Febrero | 0 | 13 | 13 |
| 2023 Enero | 0 | 14 | 14 |
| 2022 Diciembre | 0 | 7 | 7 |
| 2022 Noviembre | 0 | 5 | 5 |
| 2022 Octubre | 0 | 7 | 7 |
| 2022 Septiembre | 0 | 29 | 29 |
| 2022 Agosto | 0 | 17 | 17 |
| 2022 Julio | 0 | 4 | 4 |
| 2022 Junio | 0 | 6 | 6 |
| 2022 Mayo | 0 | 3 | 3 |
| 2022 Abril | 0 | 5 | 5 |
| 2022 Marzo | 0 | 2 | 2 |
| 2022 Febrero | 0 | 2 | 2 |
| 2022 Enero | 0 | 2 | 2 |
| 2021 Diciembre | 0 | 7 | 7 |
| 2021 Noviembre | 0 | 4 | 4 |
| 2021 Octubre | 0 | 1 | 1 |
| 2021 Agosto | 0 | 4 | 4 |
| 2021 Julio | 0 | 2 | 2 |
| 2021 Junio | 0 | 3 | 3 |
| 2021 Mayo | 0 | 2 | 2 |
| 2021 Abril | 0 | 2 | 2 |
| 2021 Marzo | 0 | 6 | 6 |
| 2021 Febrero | 0 | 9 | 9 |
| 2021 Enero | 0 | 6 | 6 |
| 2020 Diciembre | 0 | 4 | 4 |
| 2020 Noviembre | 0 | 6 | 6 |
| 2020 Octubre | 0 | 2 | 2 |
| 2020 Septiembre | 0 | 6 | 6 |
| 2020 Agosto | 0 | 4 | 4 |
| 2020 Julio | 0 | 2 | 2 |
| 2020 Junio | 0 | 3 | 3 |
| 2020 Mayo | 0 | 8 | 8 |
| 2020 Marzo | 2 | 10 | 12 |
| 2020 Febrero | 0 | 1 | 1 |
| 2020 Enero | 0 | 12 | 12 |
| 2019 Diciembre | 0 | 18 | 18 |
| 2019 Noviembre | 0 | 8 | 8 |
| 2019 Octubre | 1 | 5 | 6 |
| 2019 Septiembre | 0 | 6 | 6 |
| 2019 Agosto | 0 | 3 | 3 |
| 2019 Julio | 0 | 16 | 16 |
| 2019 Junio | 1 | 24 | 25 |
| 2019 Mayo | 2 | 58 | 60 |
| 2019 Abril | 0 | 10 | 10 |
| 2019 Marzo | 0 | 4 | 4 |
| 2019 Febrero | 2 | 16 | 18 |
| 2019 Enero | 0 | 2 | 2 |
| 2018 Diciembre | 0 | 8 | 8 |
| 2018 Noviembre | 0 | 15 | 15 |
| 2018 Octubre | 0 | 19 | 19 |
| 2018 Septiembre | 0 | 3 | 3 |
| 2018 Agosto | 1 | 1 | 2 |
| 2018 Julio | 0 | 3 | 3 |
| 2018 Junio | 0 | 1 | 1 |
| 2018 Marzo | 0 | 1 | 1 |
| 2018 Febrero | 4 | 4 | 8 |
| 2018 Enero | 1 | 6 | 7 |
| 2017 Diciembre | 2 | 8 | 10 |
| 2017 Noviembre | 5 | 9 | 14 |
| 2017 Octubre | 6 | 3 | 9 |
| 2017 Septiembre | 6 | 12 | 18 |
| 2017 Agosto | 13 | 9 | 22 |
| 2017 Julio | 11 | 12 | 23 |
| 2017 Junio | 14 | 9 | 23 |
| 2017 Mayo | 9 | 6 | 15 |
| 2017 Abril | 13 | 12 | 25 |
| 2017 Marzo | 16 | 14 | 30 |
| 2017 Febrero | 14 | 4 | 18 |
| 2017 Enero | 12 | 9 | 21 |
| 2016 Diciembre | 30 | 18 | 48 |
| 2016 Noviembre | 32 | 6 | 38 |
| 2016 Octubre | 27 | 10 | 37 |
| 2016 Septiembre | 22 | 9 | 31 |
| 2016 Agosto | 10 | 13 | 23 |
| 2016 Julio | 16 | 1 | 17 |
| 2016 Junio | 16 | 20 | 36 |
| 2016 Mayo | 17 | 16 | 33 |
| 2016 Abril | 14 | 34 | 48 |
| 2016 Marzo | 16 | 14 | 30 |
| 2016 Febrero | 14 | 16 | 30 |
| 2016 Enero | 12 | 21 | 33 |
| 2015 Diciembre | 18 | 12 | 30 |
| 2015 Noviembre | 13 | 17 | 30 |
| 2015 Octubre | 23 | 18 | 41 |
| 2015 Septiembre | 11 | 8 | 19 |
| 2015 Agosto | 10 | 7 | 17 |
| 2015 Julio | 10 | 4 | 14 |
| 2015 Junio | 14 | 4 | 18 |
| 2015 Mayo | 10 | 11 | 21 |
| 2015 Abril | 15 | 12 | 27 |
| 2015 Marzo | 14 | 10 | 24 |
| 2015 Febrero | 17 | 11 | 28 |
| 2015 Enero | 12 | 5 | 17 |
| 2014 Diciembre | 14 | 14 | 28 |
| 2014 Noviembre | 9 | 7 | 16 |
| 2014 Octubre | 17 | 4 | 21 |
| 2014 Septiembre | 23 | 4 | 27 |
| 2014 Agosto | 24 | 2 | 26 |
| 2014 Julio | 22 | 11 | 33 |
| 2014 Junio | 20 | 7 | 27 |
| 2014 Mayo | 10 | 6 | 16 |
| 2014 Abril | 7 | 4 | 11 |
| 2014 Marzo | 15 | 4 | 19 |
| 2014 Febrero | 10 | 4 | 14 |
| 2014 Enero | 9 | 6 | 15 |
| 2013 Diciembre | 12 | 3 | 15 |
| 2013 Noviembre | 8 | 5 | 13 |
| 2013 Octubre | 8 | 22 | 30 |
| 2013 Septiembre | 5 | 13 | 18 |
| 2013 Agosto | 5 | 14 | 19 |
| 2013 Julio | 3 | 4 | 7 |
| 2009 Mayo | 456 | 0 | 456 |
Mostrar todo
