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Correlación entre el polimorfismo de los genes LHCGR y NR5A1y el riesgo de infertilidad masculina
Correlation between LHCGR and NR5A1 genes polymorphism and male infertility risk
M. Behvarza, S.A. Rahmanib, E. Siasi Torbatia,
Autor para correspondencia
emi_biotech2006@yahoo.com

Autor para correspondencia.
, S. Danaei Mehrabadc, M. Bikhof Torbatid
a Departamento de Genética, Facultad de Ciencias, Sede del Norte de Teherán, Universidad Islámica Azad, Teherán, Irán
b Departamento de Genética Médica, Facultad de Medicina, Universidad de Ciencias Médicas de Tabriz, Tabriz, Irán
c Departamento de Ginecología, Centro ACECR ART, Sede ACECR Azerbaiyán Oriental, Tabriz, Irán
d Departamento de Biología, Sede Yadegar-e-Imam Khomeini (RAH) Shahr-e-Rey, Universidad Islámica Azad, Teherán, Irán
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introducci&#243;n</span><p id="par0005" class="elsevierStylePara elsevierViewall">La infertilidad representa un problema reproductivo grave que afecta al 10-15&#37; de las parejas en todo el mundo&#46; Aproximadamente el 20-30&#37; de los casos de infertilidad est&#225;n relacionados con factores masculinos<a class="elsevierStyleCrossRefs" href="#bib0200"><span class="elsevierStyleSup">1&#44;2</span></a>&#46; Una de las principales causas de infertilidad masculina se debe a defectos en la cantidad y calidad de los espermatozoides&#44; que a su vez pueden estar asociados a factores ambientales y gen&#233;ticos&#46; Sin embargo&#44; en el 30&#37; de los casos de infertilidad las causas siguen siendo desconocidas&#44; y estos se consideran como infertilidad idiop&#225;tica<a class="elsevierStyleCrossRefs" href="#bib0210"><span class="elsevierStyleSup">3&#44;4</span></a>&#46; La oligozoospermia y la azoospermia idiop&#225;tica&#44; trastornos comunes de la espermatog&#233;nesis&#44; afectan a un n&#250;mero elevado de varones inf&#233;rtiles<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">5</span></a>&#46; Por lo tanto&#44; es necesario investigar los mecanismos moleculares subyacentes de los defectos de la espermatog&#233;nesis para reconocer y tratar la infertilidad<a class="elsevierStyleCrossRefs" href="#bib0225"><span class="elsevierStyleSup">6&#44;7</span></a>&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Estudios anteriores han se&#241;alado que el polimorfismo de un solo nucle&#243;tido &#40;SNP&#44; por Single Nucleotide Polymorphism&#41; en varios genes implicados en la espermatog&#233;nesis son una causa importante de infertilidad masculina<a class="elsevierStyleCrossRefs" href="#bib0235"><span class="elsevierStyleSup">8&#44;9</span></a>&#46; En los &#250;ltimos a&#241;os&#44; numerosos estudios han investigado la asociaci&#243;n entre SNP y mutaciones en genes candidatos relacionados con la infertilidad masculina y la infertilidad masculina idiop&#225;tica<a class="elsevierStyleCrossRefs" href="#bib0245"><span class="elsevierStyleSup">10&#44;11</span></a>&#46; Se han identificado ciertos polimorfismos en los genes <span class="elsevierStyleItalic">LHCGR</span> y <span class="elsevierStyleItalic">NR5A1</span> que desempe&#241;an funciones cr&#237;ticas en la oligozoospermia y la azoospermia idiop&#225;tica<a class="elsevierStyleCrossRefs" href="#bib0255"><span class="elsevierStyleSup">12&#44;13</span></a>&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">El gen <span class="elsevierStyleItalic">LHCGR</span> &#40;receptor de la hormona luteinizante&#47;coriogonadotropina&#41; codifica receptores acoplados a prote&#237;nas G &#40;GPCR&#41; que participan en la transducci&#243;n de se&#241;ales extracelulares mediante la activaci&#243;n de la cascada de prote&#237;nas G<a class="elsevierStyleCrossRefs" href="#bib0265"><span class="elsevierStyleSup">14&#44;15</span></a>&#46; Este gen se expresa en las c&#233;lulas de la granulosa del estroma&#44; de la teca&#44; luteales y de fase tard&#237;a &#40;luteinizante&#41; del ovario y los test&#237;culos<a class="elsevierStyleCrossRef" href="#bib0275"><span class="elsevierStyleSup">16</span></a>&#46; Hasta la fecha se han identificado m&#225;s de 300 polimorfismos del gen <span class="elsevierStyleItalic">LHCGR</span>&#59; sin embargo&#44; solo en 4 de estos se trata de mutaciones no sin&#243;nimas y se producen dentro de los exones&#46; El polimorfismo no sin&#243;nimo rs2293275 &#40;c&#46;935G&#62;A&#47;p&#46;Ser312Asn&#41;&#44; localizado en el ex&#243;n 11 del gen <span class="elsevierStyleItalic">LHCGR</span>&#44; ha sido descrito como un SNP importante en la asociaci&#243;n con la infertilidad masculina<a class="elsevierStyleCrossRefs" href="#bib0280"><span class="elsevierStyleSup">17&#44;18</span></a>&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">El gen receptor nuclear del miembro 1 del grupo A de la subfamilia 5 &#40;<span class="elsevierStyleItalic">NR5A1</span>&#44; anteriormente denominado SF-1&#41; codifica un factor de transcripci&#243;n esencial que desempe&#241;a un papel importante en la regulaci&#243;n de la reproducci&#243;n y la diferenciaci&#243;n sexual<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">19</span></a>&#46; Este gen se expresa en las c&#233;lulas de Leydig y de Sertoli en los test&#237;culos&#44; en el ovario maduro y en las c&#233;lulas fetales&#46; Seg&#250;n estudios previos&#44; el gen <span class="elsevierStyleItalic">NR5A1</span> es esencial en el desarrollo gonadal y su polimorfismo se asocia a la infertilidad masculina<a class="elsevierStyleCrossRefs" href="#bib0295"><span class="elsevierStyleSup">20-22</span></a>&#46; El polimorfismo de sentido err&#243;neo &#40;o <span class="elsevierStyleItalic">missense</span>&#41; rs1057517779 &#40;c&#46;938G&#62;A&#47;p&#46;Arg313Cys&#41;&#44; localizado en el ex&#243;n 7 del gen <span class="elsevierStyleItalic">NR5A1</span>&#44; se ha descrito como un SNP altamente asociado a la infertilidad masculina<a class="elsevierStyleCrossRef" href="#bib0310"><span class="elsevierStyleSup">23</span></a>&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Hasta la fecha no se ha descrito una correlaci&#243;n entre los polimorfismos de los genes <span class="elsevierStyleItalic">LHCGR</span> &#40;rs2293275&#41; y <span class="elsevierStyleItalic">NR5A1</span> &#40;rs1057517779&#41; y el riesgo de infertilidad masculina en la poblaci&#243;n azer&#237; en Ir&#225;n&#46; En el presente estudio&#44; nos propusimos investigar la correlaci&#243;n entre el polimorfismo de los genes <span class="elsevierStyleItalic">LHCGR</span> &#40;rs2293275&#41; y <span class="elsevierStyleItalic">NR5A1</span> &#40;rs1057517779&#41; y la infertilidad masculina idiop&#225;tica por primera vez en la poblaci&#243;n azer&#237; de Ir&#225;n&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">M&#233;todos</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Sujetos del estudio</span><p id="par0030" class="elsevierStylePara elsevierViewall">Este estudio de casos y controles incluy&#243; a 200 varones azer&#237;es iran&#237;es de la provincia de Azerbaiy&#225;n Oriental de Ir&#225;n&#46; El grupo de casos estaba compuesto por 100 varones con confirmaci&#243;n de azoospermia y oligozoospermia idiop&#225;tica remitidos al Servicio de Infertilidad del Hospital Valiasr de Tabriz &#40;Ir&#225;n&#41; entre enero de 2018 y diciembre de 2020&#46; El grupo de control inclu&#237;a 100 varones sanos f&#233;rtiles sin anomal&#237;as esperm&#225;ticas&#44; no emparentados gen&#233;ticamente y emparejados por edad&#44; raza y etnia&#46; Los criterios de exclusi&#243;n para el grupo de casos fueron un cariotipo anormal y&#47;o microdeleciones en el cromosoma Y&#44; hipogonadismo hipogonadrot&#243;pico&#44; orquitis&#44; obstrucci&#243;n del conducto eyaculador&#44; criptorquidia e hipogonadismo&#46; Se recogieron variables demogr&#225;ficas y caracter&#237;sticas de los pacientes y los controles sanos mediante cuestionarios y entrevistas &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#41;&#46; Este estudio fue aprobado por el comit&#233; de revisi&#243;n &#233;tica de la Universidad Isl&#225;mica de Azad&#44; Sede del Norte de Teher&#225;n&#44; Teher&#225;n&#44; Ir&#225;n &#40;C&#243;digo &#233;tico&#58; IR&#46;IAU&#46;TNB&#46;REC&#46;1399&#46;030&#41;&#46; Tras firmar un formulario de consentimiento informado&#44; se solicit&#243; a todos los sujetos su participaci&#243;n en el presente estudio&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Extracci&#243;n de ADN y genotipificaci&#243;n</span><p id="par0035" class="elsevierStylePara elsevierViewall">Se recogieron muestras de sangre venosa &#40;3<span class="elsevierStyleHsp" style=""></span>ml&#41; de todos los sujetos y se vertieron en tubos con un agente anticoagulante &#40;EDTA&#58; &#225;cido etilendiaminotetraac&#233;tico&#41;&#46; Para el aislamiento de ADN gen&#243;mico a partir de las muestras de sangre total se utiliz&#243; el m&#233;todo de la proteinasa K&#46; La cantidad y calidad de las muestras de ADN gen&#243;mico aisladas se confirmaron mediante un equipo Nanodrop y electroforesis en gel de agarosa&#46; Para la genotipificaci&#243;n se utiliz&#243; el sistema de amplificaci&#243;n por reacci&#243;n en cadena de la polimerasa refractario a mutaciones Tetra-primer &#40;Tetra-ARMS-PCR&#41;&#46; Los cebadores dise&#241;ados espec&#237;ficamente para amplificar los polimorfismos de los genes <span class="elsevierStyleItalic">LHCGR</span> &#40;rs2293275&#41; y <span class="elsevierStyleItalic">NR5A1</span> &#40;rs1057517779&#41; se presentan en la <a class="elsevierStyleCrossRef" href="#tbl0010">tabla 2</a>&#46; La amplificaci&#243;n se realiz&#243; en un volumen total de 25<span class="elsevierStyleHsp" style=""></span>&#956;l &#40;50<span class="elsevierStyleHsp" style=""></span>ng de ADN molde&#44; 7&#44;5<span class="elsevierStyleHsp" style=""></span>&#956;l de agua bidestilada est&#233;ril&#44; 1<span class="elsevierStyleHsp" style=""></span>&#956;l de cada cebador y 12&#44;5<span class="elsevierStyleHsp" style=""></span>&#956;l de PCR Master Mix&#41; de la siguiente manera&#58; una primera etapa de desnaturalizaci&#243;n que se mantuvo por 4<span class="elsevierStyleHsp" style=""></span>min a 94<span class="elsevierStyleHsp" style=""></span>&#176;C&#44; 40 ciclos de desnaturalizaci&#243;n durante 40<span class="elsevierStyleHsp" style=""></span>s en 94<span class="elsevierStyleHsp" style=""></span>&#176;C&#44; un recocido durante 30<span class="elsevierStyleHsp" style=""></span>s y extensi&#243;n durante 25<span class="elsevierStyleHsp" style=""></span>s en 72<span class="elsevierStyleHsp" style=""></span>&#176;C&#44; y un ciclo de extensi&#243;n final durante 5<span class="elsevierStyleHsp" style=""></span>min en 72<span class="elsevierStyleHsp" style=""></span>&#176;C&#46; Se realiz&#243; una electroforesis de los productos de PCR amplificados en gel de agarosa al 2&#37; con tinci&#243;n Safe y se visualizaron mediante un instrumento de documentaci&#243;n de geles&#46; Los alelos se identificaron seg&#250;n el tama&#241;o de las bandas de ADN estimadas por un marcador de ADN &#40;escalera de 50<span class="elsevierStyleHsp" style=""></span>pb&#41; <a class="elsevierStyleCrossRef" href="#fig0005">figura 1</a>&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">An&#225;lisis estad&#237;stico</span><p id="par0040" class="elsevierStylePara elsevierViewall">Se utiliz&#243; el programa inform&#225;tico Statistical Package for the Social Sciences &#40;SPSS&#41; para analizar los datos obtenidos&#46; Se realiz&#243; regresi&#243;n log&#237;stica para investigar la correlaci&#243;n de los polimorfismos de los genes <span class="elsevierStyleItalic">LHCGR</span> &#40;rs2293275&#41; y <span class="elsevierStyleItalic">NR5A1</span> &#40;rs1057517779&#41; con la azoospermia y la oligozoospermia&#46; Adem&#225;s&#44; se utilizaron la prueba de Chi-cuadrado &#40;&#967;<span class="elsevierStyleSup">2</span>&#41; y la prueba exacta de Fisher para investigar el equilibrio de Hardy-Weinberg &#40;HWE&#41; en las frecuencias de genotipos de pacientes inf&#233;rtiles y controles sanos&#46; Se calcularon las <span class="elsevierStyleItalic">odds ratio</span> &#40;OR&#41; con un intervalo de confianza &#40;IC&#41; del 95&#37; para afirmar la significaci&#243;n estad&#237;stica de los genotipos con la infertilidad&#46; Mediante una prueba t de muestras independientes se compararon las caracter&#237;sticas demogr&#225;ficas de todos los sujetos de los grupos de casos y controles&#46; Un valor p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05 se consider&#243; estad&#237;sticamente significativo&#46;</p></span></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Resultados</span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Caracter&#237;sticas demogr&#225;ficas</span><p id="par0045" class="elsevierStylePara elsevierViewall">El an&#225;lisis estad&#237;stico indic&#243; la presencia de un numero significativamente superior de pacientes fumadores en el grupo de pacientes inf&#233;rtiles que en el grupo controles sanos &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;004&#41;&#46; Se observ&#243; que los antecedentes familiares positivos de infertilidad era un factor importante significativamente mayor en los pacientes inf&#233;rtiles que en los controles sanos &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;008&#41;&#46; Adem&#225;s&#44; seg&#250;n el an&#225;lisis de semen&#44; la concentraci&#243;n&#44; movilidad y volumen de espermatozoides en los pacientes inf&#233;rtiles eran significativamente superiores a los de los controles sanos &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;0001&#41;&#46; Sin embargo&#44; no se encontraron diferencias significativas entre los grupos de casos y controles en cuanto a edad&#44; &#237;ndice de masa corporal &#40;IMC&#41; o consumo de alcohol &#40;p<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#46; Las caracter&#237;sticas demogr&#225;ficas de todos los sujetos se presentan en la <a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Equilibrio de Hardy-Weinberg</span><p id="par0050" class="elsevierStylePara elsevierViewall">Seg&#250;n los resultados obtenidos&#44; la distribuci&#243;n genot&#237;pica de los polimorfismos <span class="elsevierStyleItalic">LHCGR</span> &#40;rs2293275&#41; y <span class="elsevierStyleItalic">NR5A1</span> &#40;rs1057517779&#41; se encontr&#243; en equilibrio Hardy-Weinberg &#40;HWE&#41; en los grupos de casos y de controles &#40;p<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Frecuencia genot&#237;pica y frecuencias al&#233;licas</span><p id="par0055" class="elsevierStylePara elsevierViewall">En la <a class="elsevierStyleCrossRef" href="#tbl0015">tabla 3</a> se presenta la frecuencia genot&#237;pica y al&#233;lica de los polimorfismos <span class="elsevierStyleItalic">LHCGR</span> &#40;rs2293275&#41; y <span class="elsevierStyleItalic">NR5A1</span> &#40;rs1057517779&#41; en pacientes inf&#233;rtiles y controles sanos&#46; El an&#225;lisis estad&#237;stico indic&#243; una correlaci&#243;n significativa entre los polimorfismos <span class="elsevierStyleItalic">LHCGR</span> &#40;rs2293275&#41; y <span class="elsevierStyleItalic">NR5A1</span> &#40;rs1057517779&#41; y el riesgo de infertilidad masculina en la poblaci&#243;n azer&#237; de Ir&#225;n&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Polimorfismo del gen <span class="elsevierStyleItalic">LHCGR</span> &#40;rs2293275&#41;</span><p id="par0060" class="elsevierStylePara elsevierViewall">El an&#225;lisis genot&#237;pico del polimorfismo <span class="elsevierStyleItalic">LHCGR</span> &#40;rs2293275&#41; indic&#243; que la frecuencia de los genotipos homocigoto TT&#44; heterocigoto TC y homocigoto CC en pacientes inf&#233;rtiles era del 90&#44; 6 y 4&#37;&#44; respectivamente&#46; En cambio&#44; en los controles sanos la frecuencia de homocigoto TT&#44; heterocigoto TC y homocigoto CC fue del 96&#44; 4 y 0&#37;&#44; respectivamente&#46; Adem&#225;s&#44; la frecuencia de los alelos T y C en los pacientes inf&#233;rtiles fue del 93 y el 7&#37;&#44; respectivamente&#44; mientras que en los controles sanos fue del 98 y el 2&#37;&#46; El an&#225;lisis estad&#237;stico indic&#243; que la frecuencia del alelo C &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;016&#59; OR&#58; 3&#44;69&#59; IC 95&#37;&#58; 1&#44;2-10&#44;4&#41; en pacientes inf&#233;rtiles era significativamente mayor que en los controles sanos &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">tabla 3</a>&#41;&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Polimorfismo del gen <span class="elsevierStyleItalic">NR5A1</span> &#40;rs1057517779&#41;</span><p id="par0065" class="elsevierStylePara elsevierViewall">El an&#225;lisis genot&#237;pico del polimorfismo <span class="elsevierStyleItalic">NR5A1</span> &#40;rs1057517779&#41; indic&#243; una frecuencia genot&#237;pica del 89&#44; 9 y 2&#37; para los homocigotos GG&#44; heterocigotos GA y homocigotos AA&#44; respectivamente en los pacientes inf&#233;rtiles&#46; En los controles sanos&#44; la frecuencia genot&#237;pica de los homocigotos GG&#44; heterocigotos GA y homocigotos AA fue del 98&#44; 2 y 0&#37;&#44; respectivamente&#46; Adem&#225;s&#44; la frecuencia de los alelos G y A en los pacientes inf&#233;rtiles fue del 93&#44;5 y el 6&#44;5&#37;&#44; mientras que la frecuencia de los alelos G y A en los controles sanos fue del 99 y el 1&#37;&#44; respectivamente&#46; El an&#225;lisis estad&#237;stico indic&#243; que las frecuencias del alelo A &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;004&#59; OR&#58; 6&#44;88&#59; IC 95&#37;&#58; 1&#44;7-30&#44;9&#41; y del genotipo heterocigoto GA &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;032&#59; OR&#58; 4&#44;95&#59; IC 95&#37;&#58; 1&#44;24-23&#44;2&#41; en el grupo de casos fueron significativamente superiores a las del grupo control &#40;abtla 3&#41;&#46;</p></span></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Discusi&#243;n</span><p id="par0070" class="elsevierStylePara elsevierViewall">La infertilidad es la incapacidad para lograr el embarazo tras 12 meses de relaciones sexuales regulares y sin protecci&#243;n<a class="elsevierStyleCrossRef" href="#bib0315"><span class="elsevierStyleSup">24</span></a>&#46; Siendo la oligozoospermia y la azoospermia idiop&#225;tica las principales causas de infertilidad masculina&#44; numerosos estudios recientes se han centrado en esta cuesti&#243;n&#46; Las principales causas de oligozoospermia y azoospermia son la infecci&#243;n&#44; las anomal&#237;as en la estructura y en la cantidad de espermatozoides&#44; alteraciones inmunol&#243;gicas&#44; cromos&#243;micas&#44; varicocele y disfunci&#243;n endocrina&#46; La oligozoospermia y la azoospermia idiop&#225;tica con recuento anormal de espermatozoides constituyen las principales causas de infertilidad masculina<a class="elsevierStyleCrossRefs" href="#bib0320"><span class="elsevierStyleSup">25&#44;26</span></a>&#46; Recientemente se han llevado a cabo amplios estudios para identificar los mecanismos moleculares subyacentes de la infertilidad masculina&#59; sin embargo&#44; muchos casos de infertilidad masculina siguen siendo idiop&#225;ticos&#46; Se sugiere que la presencia de mutaciones y SNP en genes relacionados con la espermatog&#233;nesis son la causa com&#250;n de la oligozoospermia o la azoospermia masculinas<a class="elsevierStyleCrossRefs" href="#bib0230"><span class="elsevierStyleSup">7&#44;27</span></a>&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">En este estudio se han llevado a cabo an&#225;lisis genot&#237;picos a 100 varones inf&#233;rtiles &#40;azoospermia y&#47;o oligozoospermia&#41; y 100 controles sanos de la poblaci&#243;n azer&#237; iran&#237; para investigar la asociaci&#243;n entre los polimorfismos de los genes <span class="elsevierStyleItalic">LHCGR</span> &#40;rs2293275&#41; y <span class="elsevierStyleItalic">NR5A1</span> &#40;rs1057517779&#41; y la infertilidad masculina idiop&#225;tica&#46; Los resultados indicaron una asociaci&#243;n significativa entre los polimorfismos rs2293275 y rs1057517779 y la infertilidad masculina idiop&#225;tica en esta poblaci&#243;n&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">Seg&#250;n estudios anteriores&#44; el gen <span class="elsevierStyleItalic">LHCGR</span> normal es esencial para la fertilidad de varones y mujeres&#44; mientras que los defectos en el gen <span class="elsevierStyleItalic">LHCGR</span> pueden causar infertilidad<a class="elsevierStyleCrossRefs" href="#bib0335"><span class="elsevierStyleSup">28&#44;29</span></a>&#46; Varios estudios han informado de que los polimorfismos del gen <span class="elsevierStyleItalic">LHCGR</span> est&#225;n asociados a la fecundaci&#243;n <span class="elsevierStyleItalic">in vitro</span> &#40;FIV&#41; y a los niveles de testosterona<a class="elsevierStyleCrossRefs" href="#bib0280"><span class="elsevierStyleSup">17&#44;30</span></a>&#46; El &#250;nico estudio realizado por Simoni et al&#46; inform&#243; de que los polimorfismos del gen <span class="elsevierStyleItalic">LHCGR</span> se asocian significativamente con test&#237;culos mal descendidos e infertilidad masculina&#46; Los autores demostraron que el alelo C del polimorfismo rs2293275 en el ex&#243;n 10 del gen <span class="elsevierStyleItalic">LHCGR</span> era significativamente menos frecuente en hombres con test&#237;culos mal descendidos que en controles sanos<a class="elsevierStyleCrossRef" href="#bib0350"><span class="elsevierStyleSup">31</span></a>&#46; Nuestro estudio es el primer informe sobre la correlaci&#243;n significativa entre el polimorfismo rs2845570 de <span class="elsevierStyleItalic">LHCGR</span>&#44; la azoospermia y la oligozoospermia en todo el mundo&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">Inicialmente se inform&#243; de funciones anormales del gen <span class="elsevierStyleItalic">NR5A1</span> en pacientes con defectos de insuficiencia suprarrenal primaria&#44; estructuras m&#252;llerianas y trastornos del desarrollo sexual<a class="elsevierStyleCrossRef" href="#bib0355"><span class="elsevierStyleSup">32</span></a>&#46; Adem&#225;s&#44; estudios anteriores sugirieron que las variantes del gen <span class="elsevierStyleItalic">NR5A1</span> est&#225;n asociadas con la infertilidad masculina<a class="elsevierStyleCrossRefs" href="#bib0360"><span class="elsevierStyleSup">33&#44;34</span></a>&#46; Hasta ahora&#44; varios estudios con resultados diferentes han informado de la correlaci&#243;n entre los polimorfismos del gen <span class="elsevierStyleItalic">NR5A1</span> y la infertilidad masculina&#46; En un estudio de R&#246;pke et al&#46; se inform&#243; de una correlaci&#243;n significativa entre las variantes del gen <span class="elsevierStyleItalic">NR5A1</span> y la infertilidad masculina en la poblaci&#243;n alemana<a class="elsevierStyleCrossRef" href="#bib0370"><span class="elsevierStyleSup">35</span></a>&#46; Sin embargo&#44; 2 estudios realizados por Sudhakar et al&#46; y Adamovic et al&#46; informaron de la ausencia de asociaci&#243;n significativa entre los polimorfismos del gen <span class="elsevierStyleItalic">NR5A1</span> y la infertilidad masculina en las poblaciones india y china<a class="elsevierStyleCrossRefs" href="#bib0310"><span class="elsevierStyleSup">23&#44;36</span></a>&#46; Nuestro estudio es el primer informe en confirmar la asociaci&#243;n significativa entre el polimorfismo del gen <span class="elsevierStyleItalic">NR5A1</span> rs1057517779 y la infertilidad masculina en la poblaci&#243;n iran&#237;&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">La contradicci&#243;n en los resultados de los estudios mencionados puede deberse a los efectos de otros genes o polimorfismos implicados en la infertilidad masculina&#44; al sesgo de selecci&#243;n de la muestra y al tama&#241;o de esta&#44; a los antecedentes gen&#233;ticos de la poblaci&#243;n&#44; a factores ambientales&#44; a diferencias en la zona geogr&#225;fica y a la heterogeneidad en el origen &#233;tnico y la raza<a class="elsevierStyleCrossRefs" href="#bib0380"><span class="elsevierStyleSup">37-39</span></a>&#46;</p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Conclusiones</span><p id="par0095" class="elsevierStylePara elsevierViewall">En t&#233;rminos generales&#44; nuestro estudio sugiri&#243; que los polimorfismos de los genes <span class="elsevierStyleItalic">LHCGR</span> &#40;rs2293275&#41; y <span class="elsevierStyleItalic">NR5A1</span> &#40;rs1057517779&#41; se asocian significativamente con el riesgo de infertilidad masculina en la poblaci&#243;n azer&#237; iran&#237;&#46; Sin embargo&#44; se requieren m&#225;s estudios con un tama&#241;o de muestra mayor en otras poblaciones&#44; or&#237;genes &#233;tnicos y razas&#46; Adem&#225;s&#44; se necesitan experimentos funcionales para comprender el papel de estos polimorfismos en las v&#237;as moleculares implicadas en la fertilidad masculina&#46;</p></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">Responsabilidades &#233;ticas</span><p id="par0100" class="elsevierStylePara elsevierViewall">Este estudio fue aprobado por el Comit&#233; de Revisi&#243;n &#201;tica de la Universidad Isl&#225;mica de Azad&#44; Sede del Norte de Teher&#225;n&#44; Teher&#225;n&#44; Ir&#225;n &#40;C&#243;digo &#233;tico&#58; IR&#46;IAU&#46;TNB&#46;REC&#46;1399&#46;030&#41;&#46; Se solicit&#243; a todos los sujetos la participaci&#243;n en el presente estudio tras la firma del consentimiento informado&#46;</p></span><span id="sec0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0135">Financiaci&#243;n</span><p id="par0105" class="elsevierStylePara elsevierViewall">Los autores declaran no haber recibido financiaci&#243;n para la realizaci&#243;n de este trabajo&#46;</p></span><span id="sec0080" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0140">Autor&#237;as</span><p id="par0110" class="elsevierStylePara elsevierViewall">M-B&#44; SA-R y E-ST&#58; ejecuci&#243;n&#44; an&#225;lisis e interpretaci&#243;n de los datos&#59; M-B y S-D&#58; redacci&#243;n y an&#225;lisis del manuscrito&#59; M-B y M-BT&#58; consultor cl&#237;nico&#59; S-D&#58; consultor cl&#237;nico&#59; SA-R&#58; participaci&#243;n en el dise&#241;o del estudio&#44; redacci&#243;n del manuscrito y discusi&#243;n cr&#237;tica&#46;</p></span><span id="sec0085" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0145">Conflicto de intereses</span><p id="par0115" class="elsevierStylePara elsevierViewall">Los autores declaran no tener ning&#250;n conflicto de intereses&#46;</p></span></span>"
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          "titulo" => "Abstract"
          "secciones" => array:4 [
            0 => array:2 [
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              "titulo" => "Introduction"
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            1 => array:2 [
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              "titulo" => "Methods"
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          "titulo" => "Introducci&#243;n"
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            0 => array:2 [
              "identificador" => "sec0015"
              "titulo" => "Sujetos del estudio"
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            1 => array:2 [
              "identificador" => "sec0020"
              "titulo" => "Extracci&#243;n de ADN y genotipificaci&#243;n"
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            2 => array:2 [
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              "titulo" => "An&#225;lisis estad&#237;stico"
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          "titulo" => "Resultados"
          "secciones" => array:5 [
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              "titulo" => "Caracter&#237;sticas demogr&#225;ficas"
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            1 => array:2 [
              "identificador" => "sec0040"
              "titulo" => "Equilibrio de Hardy-Weinberg"
            ]
            2 => array:2 [
              "identificador" => "sec0045"
              "titulo" => "Frecuencia genot&#237;pica y frecuencias al&#233;licas"
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            3 => array:2 [
              "identificador" => "sec0050"
              "titulo" => "Polimorfismo del gen LHCGR &#40;rs2293275&#41;"
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              "identificador" => "sec0055"
              "titulo" => "Polimorfismo del gen NR5A1 &#40;rs1057517779&#41;"
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          "titulo" => "Discusi&#243;n"
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          "identificador" => "sec0065"
          "titulo" => "Conclusiones"
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        9 => array:2 [
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          "titulo" => "Responsabilidades &#233;ticas"
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          "titulo" => "Financiaci&#243;n"
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          "identificador" => "sec0080"
          "titulo" => "Autor&#237;as"
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          "titulo" => "Conflicto de intereses"
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        13 => array:2 [
          "identificador" => "xack736907"
          "titulo" => "Agradecimientos"
        ]
        14 => array:1 [
          "titulo" => "Bibliograf&#237;a"
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      ]
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    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2022-07-09"
    "fechaAceptado" => "2023-08-04"
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          "clase" => "keyword"
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          "palabras" => array:4 [
            0 => "Infertilidad masculina"
            1 => "<span class="elsevierStyleItalic">LHCGR</span>"
            2 => "<span class="elsevierStyleItalic">NR5A1</span>"
            3 => "Polimorfismo"
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        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec1803363"
          "palabras" => array:4 [
            0 => "Male infertility"
            1 => "<span class="elsevierStyleItalic">LHCGR</span>"
            2 => "<span class="elsevierStyleItalic">NR5A1</span>"
            3 => "Polymorphism"
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        ]
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    "resumen" => array:2 [
      "es" => array:3 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introducci&#243;n</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">La infertilidad constituye un problema de salud que afecta gravemente la reproducci&#243;n humana&#46; En el caso de la infertilidad masculina&#44; la mayor&#237;a de los casos se deben a factores gen&#233;ticos&#46; En este estudio nos propusimos realizar un an&#225;lisis de correlaci&#243;n entre la infertilidad masculina idiop&#225;tica y el polimorfismo de un solo nucle&#243;tido &#40;SNP&#44; por Single Nucleotide Polymorphism&#41; de los genes <span class="elsevierStyleItalic">LHCGR</span> &#40;rs2293275&#41; y <span class="elsevierStyleItalic">NR5A1</span> &#40;rs1057517779&#41; en la poblaci&#243;n azer&#237; de Ir&#225;n&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">M&#233;todos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">En este estudio de casos y controles participaron 100 varones inf&#233;rtiles y 100 varones sanos procedentes de la poblaci&#243;n azer&#237; iran&#237;&#46; La genotipificaci&#243;n se realiz&#243; mediante el aislamiento del ADN gen&#243;mico a partir de muestras de sangre total con el sistema de amplificaci&#243;n por reacci&#243;n en cadena de la polimerasa refractario a mutaciones Tetra-primer &#40;Tetra-ARMS-PCR&#41;&#46; El an&#225;lisis de los datos se llev&#243; a cabo mediante la prueba de Chi-cuadrado &#40;&#967;<span class="elsevierStyleSup">2</span>&#41; y la prueba exacta de Fisher&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Seg&#250;n el an&#225;lisis de genotipificaci&#243;n del polimorfismo <span class="elsevierStyleItalic">LHCGR</span> &#40;rs2293275&#41;&#44; la frecuencia del alelo C en el grupo de casos era significativamente mayor que en el grupo de control &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#46; El an&#225;lisis del polimorfismo <span class="elsevierStyleItalic">NR5A1</span> &#40;rs1057517779&#41; indic&#243; que la frecuencia del alelo A y del genotipo heterocigoto GA en el grupo de casos era significativamente superior a la del grupo de control &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusi&#243;n</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Nuestro estudio demostr&#243; que los SNP de los genes <span class="elsevierStyleItalic">LHCGR</span> &#40;rs2293275&#41; y <span class="elsevierStyleItalic">NR5A1</span> &#40;rs1057517779&#41; pueden desempe&#241;ar un papel crucial en la infertilidad masculina de la poblaci&#243;n azer&#237; en Ir&#225;n&#46; Sin embargo&#44; se requieren m&#225;s estudios realizados en otros or&#237;genes &#233;tnicos con muestras de mayor tama&#241;o para obtener resultados m&#225;s precisos&#46; Adem&#225;s&#44; podr&#237;an ser necesarios experimentos funcionales para comprender el papel de estos polimorfismos en las v&#237;as moleculares implicadas en la fertilidad masculina&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Introducci&#243;n"
          ]
          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "M&#233;todos"
          ]
          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Resultados"
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          3 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Conclusi&#243;n"
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      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Introduction</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Infertility is one of the important phenomena in human reproduction&#46; Genetic factors are the most important cause of male infertility&#46; Here&#44; we aimed to investigate the correlation between idiopathic male infertility and SNPs of the <span class="elsevierStyleItalic">LHCGR</span> &#40;rs2293275&#41; and <span class="elsevierStyleItalic">NR5A1</span> &#40;rs1057517779&#41; genes in the Iranian-Azeri population&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">This case-control study consisted of 100 males with infertility and 100 healthy males from the Iranian Azeri population&#46; Genomic DNA isolation from whole blood samples and Tetra-primer amplification refractory mutation system-polymerase chain reaction &#40;Tetra-ARMS-PCR&#41; method was used for genotyping&#46; The data analysis was performed by Chi-square &#40;&#967;<span class="elsevierStyleSup">2</span>&#41; and Fisher&#39;s exact tests&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Genotyping analysis for <span class="elsevierStyleItalic">LHCGR</span> &#40;rs2293275&#41; polymorphism indicated that the frequency of C in the case group was significantly higher than in the control group &#40;<span class="elsevierStyleItalic">P</span>&#60;&#46;05&#41;&#46; Moreover&#44; genotyping analysis for <span class="elsevierStyleItalic">NR5A1</span> &#40;rs1057517779&#41; polymorphism indicated that the frequencies of the A allele and heterozygote GA genotype in the case group were significantly higher than those in the control group &#40;<span class="elsevierStyleItalic">P</span>&#60;&#46;05&#41;&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusion</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Our study demonstrated that the SNPs of <span class="elsevierStyleItalic">LHCGR</span> &#40;rs2293275&#41; and <span class="elsevierStyleItalic">NR5A1</span> &#40;rs1057517779&#41; genes may play a critical role in male infertility in the Iranian Azeri population&#46; However&#44; further studies on other ethnic origins with larger sample sizes are essential for accessing more accurate results&#46; Moreover&#44; functional experiments might be needed to understand the role of these polymorphisms in the molecular pathways involved in male fertility&#46;</p></span>"
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            "titulo" => "Introduction"
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            "titulo" => "Methods"
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            "titulo" => "Results"
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          "es" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Se seleccionaron 100 controles sanos y 100 pacientes varones inf&#233;rtiles&#46; Se investigaron los polimorfismos de nucle&#243;tido &#250;nico &#40;SNP&#41; de los genes <span class="elsevierStyleItalic">LHCGR</span> &#40;rs2293275&#41; y <span class="elsevierStyleItalic">NR5A1</span> &#40;rs1057517779&#41; mediante el m&#233;todo PCR Tetra-ARMS&#46; El an&#225;lisis estad&#237;stico revel&#243; que la frecuencia del alelo C en el polimorfismo <span class="elsevierStyleItalic">LHCGR</span> &#40;rs2293275&#41; y la frecuencia del alelo A en el polimorfismo <span class="elsevierStyleItalic">NR5A1</span> &#40;rs1057517779&#41; en pacientes con infertilidad masculina eran significativamente superiores a las de los controles sanos&#46; Estos alelos pueden ser factores de riesgo de infertilidad masculina&#46;</p>"
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                  <table border="0" frame="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Gen &#40;polimorfismo&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Secuencia primer &#40;5&#8217;&#8594;3&#8217;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Tama&#241;o productos&#58; tipo alelo&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">LHCGR</span> &#40;rs2293275&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">Forward outer&#58; ATGGTGCAGAACGAGATGCTReverse outer&#58; TGCAACAGCTCCGTAACCAAForward inner&#58; TGTGAAAGCACAGTAAGGAAAGTGAAReverse inner&#58; GCATGCAAATACTTACAGTGTTTTGTTAC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">150 bp&#58; alelo A &#40;A&#41;321 bp&#58; &#8722;225 bp&#58; alelo G &#40;B&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">NR5A1</span> &#40;rs1057517779&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Forward outer&#58; ACAAAAGACAGAGGTGGGGCCTGAAReverse outer&#58; TGGGGAAAGGGCTGATAATTAGGGTForward inner&#58; GCTGGTGTTCGACCACATCTACCReverse inner&#58; TTGCCGTGCTGGACCTGGCA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">212 bp&#58; alelo C &#40;A&#41;492 bp&#58; &#8722;322 bp&#58; alelo T &#40;B&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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          "es" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Caracter&#237;sticas y secuencias de los cebadores utilizados para la detecci&#243;n de polimorfismos gen&#233;ticos</p>"
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          "leyenda" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">DE&#58; desviaci&#243;n est&#225;ndar&#59; IMC&#58; &#237;ndice de masa corporal&#46;</p>"
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            0 => array:2 [
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Variables&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Pacientes &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>100&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Controles &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>100&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Edad &#40;a&#241;os</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#177;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">DE&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">29&#44;33<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#44;78&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">27&#44;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#44;06&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;298&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">IMC &#40;kg&#47;m</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#177;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">DE&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">26&#44;25<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#44;18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">26&#44;48<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#44;34&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;699&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Fumador</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No fumador&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">76 &#40;76&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">89 &#40;89&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8212;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Fumador&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">34 &#40;34&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11 &#40;11&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;004<a class="elsevierStyleCrossRef" href="#tblfn0005">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Consumo de alcohol</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No bebedor&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">39 &#40;39&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">31 &#40;31&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8212;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Bebedor&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">61 &#40;61&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">69 &#40;69&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;376&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Antecedentes familiares</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Negativos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">79 &#40;79&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">100 &#40;100&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8212;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Positivos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">21 &#40;21&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;008<a class="elsevierStyleCrossRef" href="#tblfn0005">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Par&#225;metros seminales</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Concentraci&#243;n &#40;&#215;10<span class="elsevierStyleSup">6</span>&#47;ml&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Mediana&#58; 3&#44;5 &#40;0-6&#44;37&#41;Media&#58; 3&#44;71<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#44;94&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">125&#44;5 &#40;94-156&#44;3&#41;126<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>40&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;0001<a class="elsevierStyleCrossRef" href="#tblfn0005">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Movilidad &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Mediana&#58; 48&#44;5 &#40;0-63&#41;Media&#58; 33&#44;95<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>30&#44;48&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">60 &#40;49-70&#41;59&#44;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>11&#44;55&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;0001<a class="elsevierStyleCrossRef" href="#tblfn0005">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Volumen &#40;ml&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Mediana&#58; 3&#44;5 &#40;2&#44;35-4&#41;Media&#58; 3&#44;23<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;3-5&#41;4&#44;18<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#44;19&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;0001<a class="elsevierStyleCrossRef" href="#tblfn0005">&#42;</a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Gen &#40;polimorfismo&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Modelos de transmisi&#243;n hereditaria&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">LHCGR</span> &#40;rs2293275&#41;</td><td class="td" title="\n
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                  \t\t\t\t  " rowspan="3" align="left" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">TT&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">90 &#40;90&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">96 &#40;96&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Ref&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Ref&#46;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">TC&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">6 &#40;6&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">4 &#40;4&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;531&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1&#44;6 &#40;0&#44;41-5&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;058&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">infinito &#40;1&#44;02-infinito&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Dominante</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">TT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">90 &#40;90&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">96 &#40;96&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ref&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ref&#46;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">TC<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>CC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10 &#40;10&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;164&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;67 &#40;0&#44;85-7&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CC&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ref&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ref&#46;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">TC<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>TT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">96 &#40;96&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">100 &#40;100&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;121&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">infinito &#40;1&#44;0-infinito&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
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                  \t\t\t\t">Sobredominante</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">TC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ref&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ref&#46;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">94 &#40;94&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">96 &#40;96&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;747&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;53 &#40;0&#44;39-4&#44;92&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Alelos</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">T salvaje&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">186 &#40;93&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">196 &#40;98&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ref&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ref&#46;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">C mutante&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14 &#40;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;016<a class="elsevierStyleCrossRef" href="#tblfn0010">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#44;69 &#40;1&#44;2-10&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="11" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">NR5A1</span> &#40;rs1057517779&#41;</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Codominante</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">GG&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">89 &#40;89&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">98 &#40;98&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ref&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ref&#46;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">GA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9 &#40;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;032<a class="elsevierStyleCrossRef" href="#tblfn0010">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#44;95 &#40;1&#44;24-23&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">AA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;230&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">infinito &#40;0&#44;5-infinito&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Dominante</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">GG&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">89 &#40;89&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">98 &#40;98&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ref&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ref&#46;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">GA<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>AA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11 &#40;11&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;018<a class="elsevierStyleCrossRef" href="#tblfn0010">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#44;05 &#40;1&#44;4-27&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Recesivo</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">AA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ref&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ref&#46;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">GA<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>GG&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">98 &#40;98&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">100 &#40;100&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;497&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">infinito &#40;0&#44;46-infinito&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sobredominante</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">GA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9 &#40;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ref&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ref&#46;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">GG<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>AA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">91 &#40;91&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">98 &#40;98&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;004<a class="elsevierStyleCrossRef" href="#tblfn0010">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#44;88 &#40;1&#44;7-30&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Alelos</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">G salvaje&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">187 &#40;93&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">198 &#40;99&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ref&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ref&#46;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">A mutante&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13 &#40;6&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;004<a class="elsevierStyleCrossRef" href="#tblfn0010">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#44;88 &#40;1&#44;7-30&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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Información del artículo
ISSN: 02104806
Idioma original: Español
DOI:10.1016/j.acuro.2023.08.002
Datos actualizados diariamente
año/Mes Html Pdf Total
2024 Octubre 0 4 4
2024 Julio 1 0 1
2024 Abril 9 0 9
2023 Noviembre 1 0 1

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