metricas
covid
Buscar en
Atención Primaria
Toda la web
Inicio Atención Primaria ¿Cuántos pacientes precisan tratamiento para la hipercolesteremia?
Información de la revista

Estadísticas

Siga este enlace para acceder al texto completo del artículo

¿Cuántos pacientes precisan tratamiento para la hipercolesteremia?
How many patients need treatment for hypercholesterolemia?
C. Serna Arnáiza,*, L. Montull Navarroa, A. Vázquez Torgueta, E. Gascó Eguíluzb, M. Peremiquel Lluchc, M. Ortega Bravoa
a Medicina Familiar y Comunitaria. CAP Eixample y Hospital Arnau de Vilanova. Lleida
b Unidad de Cuidados Intensivos. CAP Eixample y Hospital Arnau de Vilanova. Lleida
c Servicio de Análisis Clínicos. CAP Eixample y Hospital Arnau de Vilanova. Lleida
Leído
3845
Veces
se ha leído el artículo
1627
Total PDF
2218
Total HTML
Compartir estadísticas
 array:24 [
  "pii" => "S0212656700785295"
  "issn" => "02126567"
  "doi" => "10.1016/S0212-6567(00)78529-5"
  "estado" => "S300"
  "fechaPublicacion" => "2000-01-01"
  "aid" => "78529"
  "copyright" => "Elsevier España, S.L.. Todos los derechos reservados"
  "copyrightAnyo" => "2000"
  "documento" => "article"
  "crossmark" => 0
  "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
  "subdocumento" => "fla"
  "cita" => "Aten Primaria. 2000;25:395-9"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 1790
    "formatos" => array:3 [
      "EPUB" => 30
      "HTML" => 1261
      "PDF" => 499
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S0212656700785301"
    "issn" => "02126567"
    "doi" => "10.1016/S0212-6567(00)78530-1"
    "estado" => "S300"
    "fechaPublicacion" => "2000-01-01"
    "aid" => "78530"
    "copyright" => "Elsevier España, S.L."
    "documento" => "article"
    "crossmark" => 0
    "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
    "subdocumento" => "fla"
    "cita" => "Aten Primaria. 2000;25:400-4"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 4175
      "formatos" => array:3 [
        "EPUB" => 34
        "HTML" => 3570
        "PDF" => 571
      ]
    ]
    "es" => array:10 [
      "idiomaDefecto" => true
      "titulo" => "Prevalencia de insomnio y consumo de psicofármacos en ancianos de una zona básica de salud de Cuenca"
      "tienePdf" => "es"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "400"
          "paginaFinal" => "404"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Insomnia prevalence and psychotropic medication consumption in elderly population in cuenca"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "M.P. Redondo-Martínez, F. Salcedo-Aguilar, M.A. García-Jiménez, M.L. Monterde-Aznar, F.M. Rodríguez-Almonacid, A.I. Marcos-Navarro"
          "autores" => array:6 [
            0 => array:2 [
              "nombre" => "M.P."
              "apellidos" => "Redondo-Martínez"
            ]
            1 => array:2 [
              "nombre" => "F."
              "apellidos" => "Salcedo-Aguilar"
            ]
            2 => array:2 [
              "nombre" => "M.A."
              "apellidos" => "García-Jiménez"
            ]
            3 => array:2 [
              "nombre" => "M.L."
              "apellidos" => "Monterde-Aznar"
            ]
            4 => array:2 [
              "nombre" => "F.M."
              "apellidos" => "Rodríguez-Almonacid"
            ]
            5 => array:2 [
              "nombre" => "A.I."
              "apellidos" => "Marcos-Navarro"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0212656700785301?idApp=UINPBA00004N"
    "url" => "/02126567/0000002500000006/v1_201307091809/S0212656700785301/v1_201307091809/es/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S0212656700785283"
    "issn" => "02126567"
    "doi" => "10.1016/S0212-6567(00)78528-3"
    "estado" => "S300"
    "fechaPublicacion" => "2000-01-01"
    "aid" => "78528"
    "copyright" => "Elsevier España, S.L."
    "documento" => "article"
    "crossmark" => 0
    "licencia" => "http://www.elsevier.com/open-access/userlicense/1.0/"
    "subdocumento" => "fla"
    "cita" => "Aten Primaria. 2000;25:390-4"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 4444
      "formatos" => array:3 [
        "EPUB" => 30
        "HTML" => 3145
        "PDF" => 1269
      ]
    ]
    "es" => array:10 [
      "idiomaDefecto" => true
      "titulo" => "Anticuerpos frente a <span class="elsevierStyleItalic">Helicobacter pylori</span> en saliva&#46; Estudio de su validez frente a la prueba del aliento y de su concordancia con la serolog&#237;a"
      "tienePdf" => "es"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "390"
          "paginaFinal" => "394"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "<span class="elsevierStyleItalic">Helicobacter pylori</span> antibodies in saliva&#46; study of their validity versus the breath test and their concordance with serology"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "R&#46; Garc&#237;a Valriberas, J&#46;P&#46; Gisbert, C&#46; Hermida, M&#46;M&#46; Cabrera, J&#46; D&#237;az Blasco, J&#46;M&#46; Pajares"
          "autores" => array:6 [
            0 => array:2 [
              "nombre" => "R&#46;"
              "apellidos" => "Garc&#237;a Valriberas"
            ]
            1 => array:2 [
              "nombre" => "J&#46;P&#46;"
              "apellidos" => "Gisbert"
            ]
            2 => array:2 [
              "nombre" => "C&#46;"
              "apellidos" => "Hermida"
            ]
            3 => array:2 [
              "nombre" => "M&#46;M&#46;"
              "apellidos" => "Cabrera"
            ]
            4 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "D&#237;az Blasco"
            ]
            5 => array:2 [
              "nombre" => "J&#46;M&#46;"
              "apellidos" => "Pajares"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0212656700785283?idApp=UINPBA00004N"
    "url" => "/02126567/0000002500000006/v1_201307091809/S0212656700785283/v1_201307091809/es/main.assets"
  ]
  "es" => array:14 [
    "idiomaDefecto" => true
    "titulo" => "&#191;Cu&#225;ntos pacientes precisan tratamiento para la hipercolesteremia&#63;"
    "tieneTextoCompleto" => 0
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "395"
        "paginaFinal" => "399"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "C&#46; Serna Arn&#225;iz, L&#46; Montull Navarro, A&#46; V&#225;zquez Torguet, E&#46; Gasc&#243; Egu&#237;luz, M&#46; Peremiquel Lluch, M&#46; Ortega Bravo"
        "autores" => array:6 [
          0 => array:3 [
            "nombre" => "C&#46;"
            "apellidos" => "Serna Arn&#225;iz"
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "L&#46;"
            "apellidos" => "Montull Navarro"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "A&#46;"
            "apellidos" => "V&#225;zquez Torguet"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "E&#46;"
            "apellidos" => "Gasc&#243; Egu&#237;luz"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "M&#46;"
            "apellidos" => "Peremiquel Lluch"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
          5 => array:3 [
            "nombre" => "M&#46;"
            "apellidos" => "Ortega Bravo"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:3 [
          0 => array:3 [
            "entidad" => "Medicina Familiar y Comunitaria&#46; CAP Eixample y Hospital Arnau de Vilanova&#46; Lleida"
            "etiqueta" => "<span class="elsevierStyleSup">a</span>"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Unidad de Cuidados Intensivos&#46; CAP Eixample y Hospital Arnau de Vilanova&#46; Lleida"
            "etiqueta" => "<span class="elsevierStyleSup">b</span>"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Servicio de An&#225;lisis Cl&#237;nicos&#46; CAP Eixample y Hospital Arnau de Vilanova&#46; Lleida"
            "etiqueta" => "<span class="elsevierStyleSup">c</span>"
            "identificador" => "aff0015"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#42;"
            "correspondencia" => "Correspondencia&#58; C&#47; Mestre Tonet&#44; 30&#44; 3&#46;<span class="elsevierStyleUnderline">&#176;</span>&#44; 2&#46;<span class="elsevierStyleUnderline"><span class="elsevierStyleSup">a</span></span>&#46; 25003 Lleida&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "en" => array:1 [
        "titulo" => "How many patients need treatment for hypercholesterolemia&#63;"
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "1999-11-15"
    "fechaAceptado" => "1999-11-15"
    "PalabrasClave" => array:1 [
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec195134"
          "palabras" => array:3 [
            0 => "Colesterol"
            1 => "Factores riesgo"
            2 => "Prevenci&#243;n"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "es" => array:1 [
        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Calcular el porcentaje de individuos de una poblaci&#243;n que precisa tratamiento farmacol&#243;gico seg&#250;n las diferentes gu&#237;as para el tratamiento de la hipercolesteremia&#46;</p> <span class="elsevierStyleSectionTitle">Dise&#241;o</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Estudio descriptivo transversal&#46;</p> <span class="elsevierStyleSectionTitle">Emplazamiento</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Poblaci&#243;n de 6 comarcas de Lleida&#58; cinco pirenaicas y una en el llano&#44; donde se emplaza la capital de la provincia&#46;</p> <span class="elsevierStyleSectionTitle">M&#233;todo</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">En 401 individuos procedentes de una muestra aleatoria de 6 comarcas de Lleida se calcul&#243; el riesgo cardiovascular seg&#250;n la tabla de c&#225;lculo del estudio de Framingham y el porcentaje de individuos que precisan f&#225;rmacos hipolipemiantes seg&#250;n el US National Cholesterol Education Program&#44; la Sociedad Europea de Aterosclerosis y la Sociedad Espa&#241;ola de Aterosclerosis&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">La prevalencia de individuos con colesterol total &#62; 250 mg&#47;dl fue del 16&#44;2&#37; en los varones y del 22&#44;4&#37; en las mujeres&#46; Precisaban tratamiento farmacol&#243;gico para la hipercolesteremia un 20&#44;5&#37; de los varones y un 17&#44;6&#37; de las mujeres de los 383 individuos mayores de 6 a&#241;os de la poblaci&#243;n&#44; seg&#250;n el NCEP&#46; La ecuaci&#243;n de Framingham se aplic&#243; a 281 individuos &#40;mayores de 30 y menores de 75 a&#241;os&#41;&#59; estima un riesgo superior al 20&#37; en 10 a&#241;os en un 13&#44;7&#37; de la poblaci&#243;n&#44; siendo de un 23&#44;9&#37; en los varones y un 3&#44;5&#37; en las mujeres&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">El porcentaje de pacientes que precisa tratamiento farmacol&#243;gico para la hipercolesteremia var&#237;a seg&#250;n las diferentes gu&#237;as utilizadas&#46; Consideramos necesario el c&#225;lculo del riesgo cardiovascular seg&#250;n la ecuaci&#243;n de Framingham en el uso de f&#225;rmacos para que &#233;ste se ajuste a la poblaci&#243;n con mayor riesgo&#44; dado el origen multifactorial de la enfermedad cardiovascular&#46;</p>"
      ]
      "en" => array:1 [
        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">To find out the percentage of individuals from a population who need pharmacologic treatment for their hypercholesterolemia according to different guidelines&#46;</p> <span class="elsevierStyleSectionTitle">Design</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Descriptive transversal study&#46;</p> <span class="elsevierStyleSectionTitle">Setting</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Population from 6 areas of Lleida &#40;province&#41; including the city of Lleida&#46;</p> <span class="elsevierStyleSectionTitle">Method</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">The study has been done on a randomized sample of 401 individuals&#46; First the cardiovascular risk from the equation in the Framingham study was calculated&#44; then the percentage of individuals who should be treated with lipid-lowering medication according to the US National Cholesterol Education Program&#44; The European Society of Atherosclerosis and The Spanish Society of Atherosclerosis&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">The prevalence of individuals wiht cholesterolemia &#62; 250 mg&#47;dl has been 16&#46;3&#37; among men and 22&#46;4&#37; in women&#46; According to NCEP&#44; 20&#46;5&#37; of men and 17&#46;6&#37; of women from 383 individuals older then 6 years old need pharmacologic treatment for hypercholesterolemia&#46; The Framingham equation was applied to 281 individuals &#40;over 30 and under 75 years old&#41; estimating a risk higher than 20&#37; in 10 years for 13&#46;7&#37; of the population under study &#40;23&#46;9&#37; in men and 3&#46;5&#37; in women&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">The percentage of patients who need pharmacologic treatment for hypercholesterolemia varies according to the different guidelines employed&#46;We consider necessary the calculation of the cardiovascular risk with the Framingham equation to use lipid-lowering medication in order to achieve a better protection of the population at higher risk of developing a cardiovascular disease&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "Bibliograf&#237;a"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:28 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "the Minnesota Heart Survey Investigators&#46; Recent trends in acute coronary heart disease&#58; mortality&#44; morbidity&#44; medical care&#44; and risk factors"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "P&#46;G&#46; McGovern"
                            1 => "J&#46;S&#46; Pankow"
                            2 => "E&#46; Shahar"
                            3 => "K&#46;M&#46; Dolixzny"
                            4 => "A&#46;R&#46; Folsom"
                            5 => "H&#46; Blackburn"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "N Engl Med"
                        "fecha" => "1996"
                        "volumen" => "334"
                        "paginaInicial" => "884"
                        "paginaFinal" => "890"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Multiple risk functions for predicting coronary heart disease&#58; the concept&#44; accuracy&#44; and application"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "T&#46; Gordon"
                            1 => "W&#46;B&#46; Kannel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am Heart J"
                        "fecha" => "1982"
                        "volumen" => "103"
                        "paginaInicial" => "1031"
                        "paginaFinal" => "1039"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7044082"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Report of the National Cholesterol Education Program&#46; Expert panel on detection&#44; evaluation&#44; and treatment of high blood cholesterol in adults"
                      "autores" => array:1 [
                        0 => array:2 [
                          "colaboracion" => "The Expert Panel"
                          "etal" => false
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Arch Intern Med"
                        "fecha" => "1988"
                        "volumen" => "34"
                        "paginaInicial" => "193"
                        "paginaFinal" => "201"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Randomise trial of cholesterol lowering in 4444 patients with coronary heart disease&#58; the Scandinavian Simvastatin Survival Study &#40;4S&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "colaboracion" => "Scandinavian Simvastatin Survival Study Group"
                          "etal" => false
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "1994"
                        "volumen" => "344"
                        "paginaInicial" => "1383"
                        "paginaFinal" => "1389"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7968073"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Macfarlane PW and the West of Scotland Corornary Prevention Study Group&#46; Prevention of coronary heart disease with pravastatin in men with hypercholesterolaemia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46; Shepherd"
                            1 => "S&#46;M&#46; Cobbe"
                            2 => "I&#46; Ford"
                            3 => "C&#46;G&#46; Isles"
                            4 => "A&#46;R&#46; Lorimer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJM199511163332001"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "1995"
                        "volumen" => "333"
                        "paginaInicial" => "1301"
                        "paginaFinal" => "1307"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7566020"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "F&#46;M&#46; Sacks"
                            1 => "M&#46;A&#46; Pfeffer"
                            2 => "L&#46;A&#46; Moye"
                            3 => "J&#46;L&#46; Rouleau"
                            4 => "J&#46;D&#46; Rutherford"
                            5 => "T&#46;G&#46; Cole"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJM199610033351401"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "1996"
                        "volumen" => "335"
                        "paginaInicial" => "1001"
                        "paginaFinal" => "1009"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8801446"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Factores que condicionan la efectividad y las indicaciones de las estatinas en prevenci&#243;n cardiovascular"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "X&#46; Pint&#243;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Aten Primaria"
                        "fecha" => "1999"
                        "volumen" => "23"
                        "paginaInicial" => "227"
                        "paginaFinal" => "234"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10333608"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cholesterol lowering and mortality&#58; the importance of considering initial level of risk"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "G&#46; Davey Smith"
                            1 => "F&#46; Song"
                            2 => "T&#46;A&#46; Sheldon"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "BMJ"
                        "fecha" => "1993"
                        "volumen" => "306"
                        "paginaInicial" => "1367"
                        "paginaFinal" => "1373"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8518602"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "9&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prevention of coronary heart disease in clinical practice&#58; recommendations of the Task Force of the European Society of Cardiology&#44; European Atherosclerosis Society and European Society of Hypertension"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "K&#46; Py&#246;r&#228;l&#228;"
                            1 => "G&#46; De Backer"
                            2 => "I&#46; Graham"
                            3 => "P&#46; Poole-Wilson"
                            4 => "D&#46; Wood"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Atherosclerosis"
                        "fecha" => "1994"
                        "volumen" => "110"
                        "paginaInicial" => "121"
                        "paginaFinal" => "161"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7848365"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "10&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Summary of the second report of the National Cholesterol Education Program &#40;NCEP&#41; Expert Panel on Detection&#44; Evaluation&#44; and Treatment of High Blood Cholesterol in Adults &#40;Adult Treatment Panel II&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "colaboracion" => "Expert Panel on Detection&#44; Evaluation&#44; and Treatment of High Blood Cholesterol in Adults"
                          "etal" => false
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "JAMA"
                        "fecha" => "1993"
                        "volumen" => "269"
                        "paginaInicial" => "3015"
                        "paginaFinal" => "3023"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8501844"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "11&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Second report of the Expert Panel on Detection&#44; Evaluation&#44; and Treatment of High Blood Cholesterol in Adults &#40;Adults Treatment Panel II&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "colaboracion" => "National Cholesterol Education Program"
                          "etal" => false
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "1994"
                        "volumen" => "89"
                        "paginaInicial" => "1329"
                        "paginaFinal" => "1445"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "12&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hu X-P&#46; Identifying adults at increased risk of coronary heart disease&#58; how well do the current cholesterol guidelines work&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S&#46;A&#46; Grover"
                            1 => "L&#46; Coupal"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "JAMA"
                        "fecha" => "1995"
                        "volumen" => "274"
                        "paginaInicial" => "801"
                        "paginaFinal" => "806"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7650803"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "13&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Estudio epidemiol&#243;gico de los factores de riesgo cardiovascular en la poblaci&#243;n espa&#241;ola de 35 a 64 a&#241;os"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;R&#46; Banegas"
                            1 => "F&#46; Villar"
                            2 => "C&#46; P&#233;rez de Andr&#233;s"
                            3 => "R&#46; Jim&#233;nez Garc&#237;a-Pascual"
                            4 => "E&#46; Gil"
                            5 => "J&#46; Mu&#241;iz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Rev San Hig Pub"
                        "fecha" => "1993"
                        "volumen" => "67"
                        "paginaInicial" => "419"
                        "paginaFinal" => "445"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "14&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prediction of coronary heart disease using risk factor categories"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "P&#46;W&#46;F&#46; Wilson"
                            1 => "R&#46;B&#46; D&#8217;Agostino"
                            2 => "D&#46; Levy"
                            3 => "A&#46;M&#46; Belanger"
                            4 => "H&#46; Sibershatz"
                            5 => "W&#46;B&#46; Kannel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "1998"
                        "volumen" => "97"
                        "paginaInicial" => "1837"
                        "paginaFinal" => "1847"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9603539"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "15&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Recommendations of the European Atherosclerosis Society preparedby the International Task Force for Prevention of Coronary Heart Disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "colaboracion" => "Prevention of coronary heart disease&#58; scientific background and new clinical guidelines"
                          "etal" => false
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Nutr Metab Cardiovas Dis"
                        "fecha" => "1992"
                        "volumen" => "2"
                        "paginaInicial" => "113"
                        "paginaFinal" => "156"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "16&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "titulo" => "Sociedad Espa&#241;ola de Arteriosclerosis y Sociedad Espa&#241;ola de Diabetes&#46; Dislipemia diab&#233;tica&#58; Documento de Consenso de la Sociedad Espa&#241;ola de Arteriosclerosis y la Sociedad Espa&#241;ola de Diabetes"
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Clin Invest Arterioscl"
                        "fecha" => "1998"
                        "volumen" => "10"
                        "paginaInicial" => "55"
                        "paginaFinal" => "64"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "17&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Estimaci&#243;n de la prevalencia de diabetes mellitus en seis comarcas de la provincia de Lleida"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "M&#46;C&#46; Serna"
                            1 => "M&#46; Madrid"
                            2 => "I&#46; Cruz"
                            3 => "E&#46; Gasc&#243;E"
                            4 => "M&#46; Ribelles"
                            5 => "Ll&#46; Serra"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Endocrinolog&#237;a"
                        "fecha" => "1999"
                        "volumen" => "46"
                        "numero" => "3"
                        "paginaInicial" => "83"
                        "paginaFinal" => "86"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "18&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Estimation of the concentration of LDL-cholesterol in plasma&#44; without the use of preparative ultracentrifuge"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "W&#46;T&#46; Friedewald"
                            1 => "R&#46;I&#46; Levy"
                            2 => "D&#46;S&#46; Frederickson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Chem"
                        "fecha" => "1972"
                        "volumen" => "18"
                        "paginaInicial" => "499"
                        "paginaFinal" => "502"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4337382"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "19&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Diabetes mellitus&#46; Technical Report Series&#44; n&#46;&#176; 727"
                      "autores" => array:1 [
                        0 => array:2 [
                          "colaboracion" => "WHO Study Group"
                          "etal" => false
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:1 [
                        "serieFecha" => "1985"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "20&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Factores de riesgo cardiovascular en la poblaci&#243;n adulta del Valle de los Pedroches &#40;C&#243;rdoba&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46;J&#46; Garc&#237;a Alegr&#237;a"
                            1 => "R&#46;M&#46; Due&#241;as Herrero"
                            2 => "F&#46; Gasc&#243;n Luna"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Cl&#237;nica e Investigaci&#243;n de Arteriosclerosis"
                        "fecha" => "1991"
                        "volumen" => "3"
                        "paginaInicial" => "97"
                        "paginaFinal" => "106"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0105"
              "etiqueta" => "21&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J&#46;l&#46; Mann"
                            1 => "B&#46; Lewis"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Prevalencia de factores de riesgo cardiovascular en Gran Breta&#241;a&#46; Br Med J &#40;ed esp&#46;&#41;"
                        "fecha" => "1988"
                        "volumen" => "3"
                        "paginaInicial" => "28"
                        "paginaFinal" => "35"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0110"
              "etiqueta" => "22&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Indications for cholesterol-lowering medication&#58; comparison of risk-assessment methods"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "P&#46; Durrington"
                            1 => "H&#46; Prais"
                            2 => "D&#46; Bhatnagar"
                            3 => "M&#46; France"
                            4 => "V&#46; Crowley"
                            5 => "J&#46; Khan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "1999"
                        "volumen" => "23"
                        "paginaInicial" => "278"
                        "paginaFinal" => "281"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib0115"
              "etiqueta" => "23&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Standing Medical Advisory Committee Statement on the use of statins Executive Letter El &#40;97&#41;41"
                      "autores" => array:1 [
                        0 => array:2 [
                          "colaboracion" => "NHS Executive"
                          "etal" => false
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:1 [
                        "serieFecha" => "1997"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib0120"
              "etiqueta" => "24&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Plasma triglyceride and coronary heart disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "M&#46;A&#46; Austin"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arterioscler Thromb"
                        "fecha" => "1991"
                        "volumen" => "11"
                        "paginaInicial" => "2"
                        "paginaFinal" => "14"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1987999"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib0125"
              "etiqueta" => "25&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Epidemiology as a guide to clinical decisions&#58; the association between triglyceride and coronary heart disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "S&#46;B&#46; Hulley"
                            1 => "R&#46;H&#46; Rosenman"
                            2 => "R&#46;D&#46; Bawol"
                            3 => "R&#46;J&#46; Brand"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJM198006193022503"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "1980"
                        "volumen" => "302"
                        "paginaInicial" => "1383"
                        "paginaFinal" => "1389"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7374696"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib0130"
              "etiqueta" => "26&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "High-density lipoprotein&#44; low-density lipoprotein&#44; and coronary artery disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "P&#46;W&#46; Wilson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Am J Cardiol"
                        "fecha" => "1990"
                        "volumen" => "66"
                        "paginaInicial" => "7"
                        "paginaFinal" => "10"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib0135"
              "etiqueta" => "27&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "C&#243;rdoba Garc&#237;a R&#46; Medici&#243;n del riesgo cardiovascular en atenci&#243;n primaria"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "A&#46; Hern&#225;ndez Moreno"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Aten Primaria"
                        "fecha" => "1999"
                        "volumen" => "23"
                        "paginaInicial" => "376"
                        "paginaFinal" => "383"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10372462"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib0140"
              "etiqueta" => "28&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "autores" => array:1 [
                        0 => array:2 [
                          "colaboracion" => "National Cholesterol Education Program"
                          "etal" => false
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Progresos y perspectivas&#46; Jama &#40;ed esp&#46;&#41;"
                        "fecha" => "1999"
                        "volumen" => "8"
                        "paginaInicial" => "296"
                        "paginaFinal" => "304"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "es"
  "url" => "/02126567/0000002500000006/v1_201307091809/S0212656700785295/v1_201307091809/es/main.assets"
  "Apartado" => array:4 [
    "identificador" => "14695"
    "tipo" => "SECCION"
    "es" => array:2 [
      "titulo" => "Originales"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "es"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/02126567/0000002500000006/v1_201307091809/S0212656700785295/v1_201307091809/es/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0212656700785295?idApp=UINPBA00004N"
]
Información del artículo
ISSN: 02126567
Idioma original: Español
Datos actualizados diariamente
año/Mes Html Pdf Total
2024 Noviembre 8 2 10
2024 Octubre 6 9 15
2024 Septiembre 12 11 23
2024 Agosto 15 18 33
2024 Julio 11 25 36
2024 Junio 10 17 27
2024 Mayo 19 16 35
2024 Abril 15 26 41
2024 Marzo 19 52 71
2024 Febrero 11 33 44
2024 Enero 16 27 43
2023 Diciembre 25 51 76
2023 Noviembre 22 84 106
2023 Octubre 36 54 90
2023 Septiembre 15 23 38
2023 Agosto 9 20 29
2023 Julio 9 45 54
2023 Junio 25 27 52
2023 Mayo 35 5 40
2023 Abril 20 4 24
2023 Marzo 16 4 20
2023 Febrero 7 9 16
2023 Enero 3 10 13
2022 Diciembre 13 12 25
2022 Noviembre 37 20 57
2022 Octubre 29 54 83
2022 Septiembre 19 33 52
2022 Agosto 28 58 86
2022 Julio 18 18 36
2022 Junio 7 9 16
2022 Mayo 19 25 44
2022 Abril 30 25 55
2022 Marzo 17 16 33
2022 Febrero 19 9 28
2022 Enero 18 4 22
2021 Diciembre 19 20 39
2021 Noviembre 28 20 48
2021 Octubre 21 14 35
2021 Septiembre 8 13 21
2021 Agosto 8 6 14
2021 Julio 21 9 30
2021 Junio 13 11 24
2021 Mayo 17 8 25
2021 Abril 26 23 49
2021 Marzo 11 15 26
2021 Febrero 24 8 32
2021 Enero 13 10 23
2020 Diciembre 13 16 29
2020 Noviembre 15 11 26
2020 Octubre 17 7 24
2020 Septiembre 16 14 30
2020 Agosto 8 15 23
2020 Julio 19 8 27
2020 Junio 15 1 16
2020 Mayo 8 7 15
2020 Abril 7 13 20
2020 Marzo 8 16 24
2020 Febrero 9 13 22
2020 Enero 17 15 32
2019 Diciembre 27 42 69
2019 Noviembre 6 8 14
2019 Octubre 7 5 12
2019 Septiembre 10 8 18
2019 Agosto 10 9 19
2019 Julio 6 10 16
2019 Junio 45 46 91
2019 Mayo 67 73 140
2019 Abril 1 6 7
2019 Marzo 2 3 5
2019 Febrero 5 5 10
2019 Enero 3 2 5
2018 Diciembre 4 4 8
2018 Noviembre 6 3 9
2018 Octubre 4 11 15
2018 Septiembre 2 5 7
2018 Agosto 0 2 2
2018 Julio 0 1 1
2018 Junio 1 1 2
2018 Mayo 3 2 5
2018 Abril 2 1 3
2018 Marzo 1 1 2
2018 Febrero 2 5 7
2017 Diciembre 0 4 4
2017 Noviembre 1 3 4
2017 Octubre 1 2 3
2017 Septiembre 1 8 9
2017 Agosto 3 0 3
2017 Julio 5 2 7
2017 Junio 1 10 11
2017 Mayo 3 10 13
2017 Abril 7 0 7
2017 Marzo 13 29 42
2017 Febrero 1 2 3
2017 Enero 3 1 4
2016 Diciembre 7 0 7
2016 Noviembre 10 1 11
2016 Octubre 12 2 14
2016 Septiembre 11 1 12
2016 Agosto 13 0 13
2016 Julio 11 1 12
2016 Junio 19 0 19
2016 Mayo 19 15 34
2016 Abril 11 0 11
2016 Marzo 19 1 20
2016 Febrero 24 1 25
2016 Enero 15 10 25
2015 Diciembre 12 13 25
2015 Noviembre 13 13 26
2015 Octubre 20 28 48
2015 Septiembre 14 28 42
2015 Agosto 8 30 38
2015 Julio 7 11 18
2015 Junio 5 0 5
2015 Mayo 5 0 5
2015 Abril 9 0 9
2015 Marzo 8 0 8
2015 Febrero 24 0 24
2015 Enero 10 0 10
2014 Diciembre 23 0 23
2014 Noviembre 8 0 8
2014 Octubre 13 0 13
2014 Septiembre 13 0 13
2014 Agosto 15 0 15
2014 Julio 9 0 9
2014 Junio 4 0 4
2014 Mayo 7 0 7
2014 Abril 8 0 8
2014 Marzo 5 0 5
2014 Febrero 4 0 4
2014 Enero 6 0 6
2013 Diciembre 7 0 7
2013 Noviembre 9 0 9
2013 Octubre 8 0 8
2013 Septiembre 7 0 7
2013 Agosto 4 0 4
2013 Julio 2 0 2
2000 Abril 528 0 528
Mostrar todo

Siga este enlace para acceder al texto completo del artículo

es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos