Streptococcus pyogenes: susceptibilidad in vitro y papel de las bacterias productoras de betalactamasa en la persistencia de la faringoamigdalitis estreptocócica
Streptococcus pyogenes: in vitro susceptibility and the role of betalactamase producing bacteria in the persistence of streptococcal pharyngoamygdalitis
A. González Pedraza Avilés
, M.C. Ortiz Zaragoza
Autor para correspondencia
miguelaf@servidor.unam.mx
Correspondencia: Biólogo Alberto González Pedraza Avilés. Centro de Salud Dr. José Castro Villagrana, SSA/UNAM. Carrasco y Coapa, s/n., Col. Toriello Guerra, C.P. 14050, Tlalpan, México, D.F.
Correspondencia: Biólogo Alberto González Pedraza Avilés. Centro de Salud Dr. José Castro Villagrana, SSA/UNAM. Carrasco y Coapa, s/n., Col. Toriello Guerra, C.P. 14050, Tlalpan, México, D.F.
Centro de Salud Dr. José Castro Villagrana. Facultad de Medicina. UNAM. México.
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Paredes i Carbonell, C. Colomer Revuelta" "autores" => array:2 [ 0 => array:2 [ "nombre" => "J.J." "apellidos" => "Paredes i Carbonell" ] 1 => array:2 [ "nombre" => "C." "apellidos" => "Colomer Revuelta" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0212656700785635?idApp=UINPBA00004N" "url" => "/02126567/0000002500000008/v1_201307091441/S0212656700785635/v1_201307091441/es/main.assets" ] "es" => array:15 [ "idiomaDefecto" => true "titulo" => "<span class="elsevierStyleItalic">Streptococcus pyogenes</span>: susceptibilidad in <span class="elsevierStyleItalic">vitro</span> y papel de las bacterias productoras de betalactamasa en la persistencia de la faringoamigdalitis estreptocócica" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "542" "paginaFinal" => "545" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "A. González Pedraza Avilés, M.C. Ortiz Zaragoza" "autores" => array:2 [ 0 => array:4 [ "nombre" => "A." "apellidos" => "González Pedraza Avilés" "email" => array:1 [ 0 => "miguelaf@servidor.unam.mx" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "M.C." "apellidos" => "Ortiz Zaragoza" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Centro de Salud Dr. José Castro Villagrana. Facultad de Medicina. UNAM. México." ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Correspondencia: Biólogo Alberto González Pedraza Avilés. Centro de Salud Dr. José Castro Villagrana, SSA/UNAM. Carrasco y Coapa, s/n., Col. Toriello Guerra, C.P. 14050, Tlalpan, México, D.F." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "<span class="elsevierStyleItalic">Streptococcus pyogenes: in vitro</span> susceptibility and the role of betalactamase producing bacteria in the persistence of streptococcal pharyngoamygdalitis" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "1999-11-22" "fechaAceptado" => "1999-11-22" "PalabrasClave" => array:1 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec194448" "palabras" => array:5 [ 0 => "Betalactamasas" 1 => "Fallos tratamientos" 2 => "Faringoamigdalitis" 3 => "Penicilina" 4 => "<span class="elsevierStyleItalic">Streptococcus pyogenes</span>" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Determinar la frecuencia de asociación entre Streptococcus pyogenes y bacterias productoras de betalactamasa en la faringoamigdalitis y evaluar su sensibilidad antimicrobiana in vitro.</p> <span class="elsevierStyleSectionTitle">Diseño</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Estudio prospectivo, descriptivo y transversal.</p> <span class="elsevierStyleSectionTitle">Emplazamiento</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">El estudio de realizó en el Centro de Salud Dr. José Castro Villagrana, en Tlalpan, México, D.F., de enero de 1996 a febrero de 1999.</p> <span class="elsevierStyleSectionTitle">Pacientes</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">A 394 pacientes con diagnóstico de faringoamigdalitis se les aisló igual número de Streptococcus pyogenes, así como posibles bacterias productoras de betalactamasa.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">En 180 pacientes (45,7%), se aisló cuando menos una bacteria posible productora de betalactamasa. De éstos, en 138 pacientes (35% del total) se confirmó la presencia de al menos una bacteria productora de la enzima. En total se aislaron 218 bacterias reconocidas como productoras, y de éstas 152 (69,7%) resultaron betalactamasa positivas. No se encontraron cepas resistentes a antibióticos betalactámicos, mientras que un 9,6% fue resistente a eritromicina y el 45% a trimetoprimsulfametoxazol.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Más de la tercera parte de los pacientes presentaron al menos una bacteria productora de betalactamasa. Streptococcus pyogenes continúa siendo 100% sensible in vitro a las penicilinas. El uso de la eritromicina no debe ser promovido como primera alternativa de terapia debido al notable incremento de cepas resistentes, lo que podría llegar a provocar dificultades en el tratamiento de pacientes alérgicos. Debido a su pobre actividad in vitro, el trimetoprim-sulfametoxazol no debe considerarse antibiótico de elección.</p>" ] "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">To assess the frequency of association between Streptococcus pyogenes and betalactamase- producing-bacteria in the pharyngotonsillitis and the evaluate the in vitro susceptibility.</p> <span class="elsevierStyleSectionTitle">Design</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Prospective, descriptive, transverse study.</p> <span class="elsevierStyleSectionTitle">Setting</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">The present study was carried out in the Health Center Dr. José Castro Villagrana, in Tlalpan, México, D.F., from Juanary, 1996 to February 1999.</p> <span class="elsevierStyleSectionTitle">Participants</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">In three hundred and ninety four patients with pharyngotonsillitis diagnosis we isolated the same number of Streptococcus pyogenes, and possible beta-lactamase-producing-bacteria.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">In 180 patients (45.7%) we isolated at least one possible beta-lactamase-producingbacteria. Of these, in 138 patients (35%) were confirmed the enzyme presence. In total, we isolated 218 possible beta-lactamase-producing bacteria, and 152 (69.7%) were beta-lactamase positive.We found no significant change in the in vitro susceptibility of group A Streptococcus to penicillin, but erythromycin resistance is relatively common, approximately 10% in this study.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Streptococcus pyogenes was uniformly susceptible to all penicillins and cephalosporins in vitro. Erythromycin treatment should not be promoted as first-line therapy because the consequent increase of bacterial resistance could create difficulty in treating penicillinallergic patients. Because of the poor activity of trimetoprimsulfametoxazol, this drug no longer can be considered the drug of choice for the management of group A Streptococcal infections.</p>" ] ] "NotaPie" => array:1 [ 0 => array:1 [ "nota" => "<p class="elsevierStyleNotepara">Este trabajo se ha realizado con el apoyo económico del Departamento de Medicina Familiar de la UNAM.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Biblografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:23 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Treatment failure in streptococcal pharyngotonsillitis. An attempt to identify penicillin tolerant Streptococcus pyogenes Scand J" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A. Orrling" 1 => "A. Stjernquist-Desatnik" 2 => "C. Schalén" 3 => "C. 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| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 3 | 6 | 9 |
| 2024 Octubre | 77 | 26 | 103 |
| 2024 Septiembre | 67 | 29 | 96 |
| 2024 Agosto | 69 | 20 | 89 |
| 2024 Julio | 64 | 30 | 94 |
| 2024 Junio | 80 | 45 | 125 |
| 2024 Mayo | 60 | 15 | 75 |
| 2024 Abril | 66 | 37 | 103 |
| 2024 Marzo | 65 | 55 | 120 |
| 2024 Febrero | 68 | 37 | 105 |
| 2024 Enero | 85 | 37 | 122 |
| 2023 Diciembre | 95 | 52 | 147 |
| 2023 Noviembre | 80 | 64 | 144 |
| 2023 Octubre | 125 | 53 | 178 |
| 2023 Septiembre | 64 | 36 | 100 |
| 2023 Agosto | 43 | 47 | 90 |
| 2023 Julio | 65 | 57 | 122 |
| 2023 Junio | 80 | 30 | 110 |
| 2023 Mayo | 76 | 8 | 84 |
| 2023 Abril | 74 | 12 | 86 |
| 2023 Marzo | 68 | 19 | 87 |
| 2023 Febrero | 64 | 16 | 80 |
| 2023 Enero | 84 | 13 | 97 |
| 2022 Diciembre | 49 | 20 | 69 |
| 2022 Noviembre | 91 | 22 | 113 |
| 2022 Octubre | 61 | 28 | 89 |
| 2022 Septiembre | 76 | 28 | 104 |
| 2022 Agosto | 48 | 28 | 76 |
| 2022 Julio | 41 | 22 | 63 |
| 2022 Junio | 32 | 17 | 49 |
| 2022 Mayo | 50 | 29 | 79 |
| 2022 Abril | 60 | 25 | 85 |
| 2022 Marzo | 53 | 17 | 70 |
| 2022 Febrero | 52 | 14 | 66 |
| 2022 Enero | 59 | 9 | 68 |
| 2021 Diciembre | 41 | 16 | 57 |
| 2021 Noviembre | 55 | 18 | 73 |
| 2021 Octubre | 60 | 16 | 76 |
| 2021 Septiembre | 38 | 23 | 61 |
| 2021 Agosto | 40 | 21 | 61 |
| 2021 Julio | 46 | 23 | 69 |
| 2021 Junio | 22 | 9 | 31 |
| 2021 Mayo | 27 | 34 | 61 |
| 2021 Abril | 74 | 58 | 132 |
| 2021 Marzo | 75 | 22 | 97 |
| 2021 Febrero | 43 | 7 | 50 |
| 2021 Enero | 30 | 11 | 41 |
| 2020 Diciembre | 25 | 7 | 32 |
| 2020 Noviembre | 50 | 20 | 70 |
| 2020 Octubre | 31 | 5 | 36 |
| 2020 Septiembre | 19 | 16 | 35 |
| 2020 Agosto | 25 | 6 | 31 |
| 2020 Julio | 8 | 5 | 13 |
| 2020 Junio | 13 | 6 | 19 |
| 2020 Mayo | 13 | 15 | 28 |
| 2020 Abril | 12 | 11 | 23 |
| 2020 Marzo | 11 | 16 | 27 |
| 2020 Febrero | 7 | 10 | 17 |
| 2020 Enero | 21 | 36 | 57 |
| 2019 Diciembre | 33 | 35 | 68 |
| 2019 Noviembre | 3 | 8 | 11 |
| 2019 Octubre | 3 | 8 | 11 |
| 2019 Septiembre | 6 | 5 | 11 |
| 2019 Agosto | 2 | 4 | 6 |
| 2019 Julio | 10 | 7 | 17 |
| 2019 Junio | 41 | 73 | 114 |
| 2019 Mayo | 94 | 180 | 274 |
| 2019 Abril | 24 | 82 | 106 |
| 2019 Marzo | 3 | 12 | 15 |
| 2019 Febrero | 6 | 29 | 35 |
| 2019 Enero | 3 | 23 | 26 |
| 2018 Diciembre | 4 | 28 | 32 |
| 2018 Noviembre | 4 | 37 | 41 |
| 2018 Octubre | 5 | 10 | 15 |
| 2018 Septiembre | 1 | 30 | 31 |
| 2018 Agosto | 3 | 45 | 48 |
| 2018 Julio | 1 | 20 | 21 |
| 2018 Junio | 3 | 19 | 22 |
| 2018 Mayo | 2 | 13 | 15 |
| 2018 Abril | 6 | 17 | 23 |
| 2018 Marzo | 1 | 8 | 9 |
| 2018 Febrero | 3 | 3 | 6 |
| 2018 Enero | 2 | 2 | 4 |
| 2017 Diciembre | 1 | 2 | 3 |
| 2017 Noviembre | 4 | 6 | 10 |
| 2017 Octubre | 5 | 5 | 10 |
| 2017 Septiembre | 2 | 8 | 10 |
| 2017 Agosto | 5 | 3 | 8 |
| 2017 Julio | 1 | 2 | 3 |
| 2017 Junio | 6 | 14 | 20 |
| 2017 Mayo | 8 | 8 | 16 |
| 2017 Abril | 11 | 3 | 14 |
| 2017 Marzo | 29 | 33 | 62 |
| 2017 Febrero | 13 | 2 | 15 |
| 2017 Enero | 6 | 0 | 6 |
| 2016 Diciembre | 7 | 1 | 8 |
| 2016 Noviembre | 8 | 1 | 9 |
| 2016 Octubre | 10 | 3 | 13 |
| 2016 Septiembre | 10 | 2 | 12 |
| 2016 Agosto | 10 | 1 | 11 |
| 2016 Julio | 12 | 0 | 12 |
| 2016 Junio | 38 | 2 | 40 |
| 2016 Mayo | 37 | 0 | 37 |
| 2016 Abril | 31 | 3 | 34 |
| 2016 Marzo | 15 | 0 | 15 |
| 2016 Febrero | 21 | 1 | 22 |
| 2016 Enero | 26 | 0 | 26 |
| 2015 Diciembre | 22 | 0 | 22 |
| 2015 Noviembre | 30 | 0 | 30 |
| 2015 Octubre | 38 | 0 | 38 |
| 2015 Septiembre | 30 | 0 | 30 |
| 2015 Agosto | 42 | 0 | 42 |
| 2015 Julio | 40 | 0 | 40 |
| 2015 Junio | 14 | 0 | 14 |
| 2015 Mayo | 17 | 0 | 17 |
| 2015 Abril | 13 | 0 | 13 |
| 2015 Marzo | 14 | 0 | 14 |
| 2015 Febrero | 7 | 0 | 7 |
| 2015 Enero | 16 | 0 | 16 |
| 2014 Diciembre | 24 | 0 | 24 |
| 2014 Noviembre | 6 | 0 | 6 |
| 2014 Octubre | 13 | 0 | 13 |
| 2014 Septiembre | 24 | 0 | 24 |
| 2014 Agosto | 13 | 0 | 13 |
| 2014 Julio | 6 | 0 | 6 |
| 2014 Junio | 7 | 0 | 7 |
| 2014 Mayo | 5 | 0 | 5 |
| 2014 Abril | 12 | 0 | 12 |
| 2014 Marzo | 12 | 0 | 12 |
| 2014 Febrero | 7 | 0 | 7 |
| 2014 Enero | 7 | 0 | 7 |
| 2013 Diciembre | 13 | 0 | 13 |
| 2013 Noviembre | 11 | 0 | 11 |
| 2013 Octubre | 15 | 0 | 15 |
| 2013 Septiembre | 11 | 0 | 11 |
| 2013 Agosto | 16 | 0 | 16 |
| 2000 Mayo | 1496 | 0 | 1496 |
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