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Características clínico-epidemiológicas de la infección por el virus SARS-CoV-2 en médicos de familia: un estudio de casos y controles
Clinical and epidemiological characteristics of SARS-CoV-2 infections in family physicians: A case-control study
Ignacio Párraga Martíneza,
Autor para correspondencia
iparraga@sescam.jccm.es

Autor para correspondencia.
, Luis Angel Pérula de Torresb, Jesús González Lamac, Celia Jiménez Garcíad, Rosa Sánchez Monteroe, Faustino Rider Garridof, en representación del Grupo EPICOVID
a Sección de Investigación de la Sociedad Española de Medicina Familiar y Comunitaria (semFYC), Centro de Salud Zona VIII de Albacete, Gerencia Atención Integrada de Albacete, Facultad de Medicina de Albacete, Universidad de Castilla-La Mancha, Albacete, España
b Atención Primaria de Salud (APS), Unidad Docente Multiprofesional de Atención Familiar y Comunitaria de Córdoba, Grupo de evaluación y mejora del PAPPS-semFYC, Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Hospital Reina Sofía, Universidad de Córdoba, Córdoba, España
c Grupo de Evaluación y Mejora del PAPPS-semFYC, Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Hospital Reina Sofía, Universidad de Córdoba, Centro de Salud Matrona Antonia Mesa Fernández, Área de Gestión Sanitaria Sur de Córdoba, Córdoba, España
d Atención Primaria de Salud (APS), Sistemas de Información del Distrito Sanitario Córdoba y Guadalquivir, España
e Unidad de Calidad, Formación e Investigación, Distrito Sanitario Córdoba y Guadalquivir, España
f Servicio Andaluz de Salud, España
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Introducci&#243;n</span><p id="par0005" class="elsevierStylePara elsevierViewall">Desde la declaraci&#243;n por la OMS de la pandemia ocasionada por el virus SARS-CoV-2&#44; se ha producido un incremento exponencial del n&#250;mero de infectados<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">1</span></a>&#46; Espa&#241;a es uno de los pa&#237;ses europeos m&#225;s afectados&#44; declarando hasta el segundo d&#237;a del mes de julio m&#225;s de 249&#46;000 casos confirmados<a class="elsevierStyleCrossRefs" href="#bib0165"><span class="elsevierStyleSup">2&#44;3</span></a>&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Las caracter&#237;sticas cl&#237;nicas de la enfermedad producida por este virus &#40;COVID-19&#41; se han identificado en estudios realizados en Espa&#241;a y otros pa&#237;ses&#44; indicando como s&#237;ntomas de presentaci&#243;n m&#225;s frecuentes la fiebre&#44; la tos seca&#44; el cansancio o la fatiga&#44; la disnea&#44; el dolor far&#237;ngeo&#44; los escalofr&#237;os y la diarrea<a class="elsevierStyleCrossRefs" href="#bib0175"><span class="elsevierStyleSup">4&#8211;6</span></a>&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">El mecanismo de trasmisi&#243;n del virus sit&#250;a a los sanitarios en una posici&#243;n de especial riesgo tanto de infecci&#243;n como de trasmisi&#243;n del mismo&#46; As&#237;&#44; el Ministerio de Sanidad clasifica a los sanitarios en el grupo de mayor vulnerabilidad y riesgo laboral<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">7</span></a>&#46; Resultados preliminares del Proyecto Factores de Difusi&#243;n COVID-19 en Espa&#241;a<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">8</span></a> demuestra que el porcentaje de personal sanitario infectado es uno de los factores relevantes para la difusi&#243;n de la pandemia durante el periodo de ascenso<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">8</span></a>&#46; En nuestro pa&#237;s&#44; el 24&#44;1&#37; de los casos de COVID-19 declarados hasta el 11 de mayo de 2020 a la Red Nacional de Vigilancia Epidemiol&#243;gica &#40;RENAVE&#41; correspond&#237;an a sanitarios<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">9</span></a>&#46; Datos del estudio espa&#241;ol de seroprevalencia muestran una prevalencia de anticuerpos superior en el sector sanitario que en el resto de grupos de poblaci&#243;n<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">10</span></a>&#44; representando aproximadamente un 10&#37;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">10</span></a>&#46; Estos resultados reflejan la importancia de conocer la situaci&#243;n de los sanitarios que prestan la atenci&#243;n inicial a los pacientes con sospecha o enfermedad de COVID-19&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Desde la aparici&#243;n de los primeros casos de infecci&#243;n por el virus SARS-CoV-2 se han incorporado nuevos datos sobre las caracter&#237;sticas cl&#237;nicas y epidemiol&#243;gicas de estos pacientes&#44; basados principalmente en estudios realizados sobre poblaci&#243;n general&#44; sin embargo son pocos los que ofrecen evidencias sobre la forma de expresarse esta enfermedad en sanitarios y apenas existen estudios llevados a cabo en m&#233;dicos de familia que desempe&#241;an su actividad&#44; primordialmente&#44; en atenci&#243;n primaria &#40;AP&#41;<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">11</span></a>&#46; Por tanto&#44; considerando todo lo anterior&#44; nuestro estudio se centra en una poblaci&#243;n especialmente afectada por la infecci&#243;n del SARS-CoV-2&#44; debido al mayor riesgo de exposici&#243;n<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">12</span></a>&#44; as&#237; el objetivo fue identificar las caracter&#237;sticas sociodemogr&#225;ficas&#44; cl&#237;nicas y epidemiol&#243;gicas asociadas a la presencia de infecci&#243;n por el virus SARS-CoV-2 en m&#233;dicos de familia que desempe&#241;an su actividad laboral en AP o en servicios de urgencias de hospital&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Material y m&#233;todos</span><p id="par0025" class="elsevierStylePara elsevierViewall">Se trata de un estudio de casos y controles en el que participaron 969 m&#233;dicos de familia de 12 comunidades aut&#243;nomas &#40;Andaluc&#237;a&#44; Arag&#243;n&#44; Asturias&#44; Baleares&#44; Castilla-Le&#243;n&#44; Castilla-La-Mancha&#44; Euskadi&#44; Galicia&#44; Madrid&#44; Murcia&#44; Navarra y la Rioja&#41;&#46; Se llev&#243; a cabo entre el 28 de marzo y el 15 de junio de 2020&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">La poblaci&#243;n diana estaba constituida por los m&#233;dicos de la &#193;reas Sanitarias de las comunidades participantes que realizaran su actividad laboral en AP&#44; servicios de urgencias de hospital u otro centro del &#225;mbito extrahospitalario&#44; y a los que se les hubiera solicitado una prueba reacci&#243;n en cadena de la polimerasa transcriptasa inversa &#40;RT-PCR&#41; para la detecci&#243;n del virus SARS-CoV-2&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Se consideraron como casos a los infectados por el virus SARS-CoV-2 que dispon&#237;an de un resultado positivo en la prueba PCR frente al virus&#46; Aquellos con resultado negativo de la PCR se incluyeron entre los no infectados &#40;controles&#41;&#46; El tama&#241;o muestral fue calculado para estimar una <span class="elsevierStyleItalic">odds ratio</span> &#40;OR&#41; de asociaci&#243;n entre infecci&#243;n por el virus SARS-CoV-2 y potenciales factores de riesgo de 2&#44; para prevalencias de los factores de riesgo en los controles del 15&#37;&#44; y una relaci&#243;n entre controles y casos de 6&#58;1&#44; manteniendo un riesgo alfa de 0&#44;05 y un riesgo beta de 0&#44;20&#46; Finalmente se incluyeron 133 casos y 836 controles&#46; Los controles fueron seleccionados a partir de la misma poblaci&#243;n en la que se seleccionaron los casos&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Cada participante respondi&#243; a un cuestionario precodificado&#44; espec&#237;ficamente dise&#241;ado para este estudio&#46; El cuestionario fue cumplimentado mediante entrevista telef&#243;nica en el &#193;rea de Gesti&#243;n Sanitaria Sur de C&#243;rdoba y Distrito Sanitario C&#243;rdoba y Guadalquivir&#44; mientras que en el resto de comunidades aut&#243;nomas se difundi&#243; el enlace al mismo para su autocumplimentaci&#243;n a trav&#233;s del correo electr&#243;nico desde las Vocal&#237;as de Investigaci&#243;n de la Sociedades Federadas de la semFYC participantes&#46; El estudio fue aprobado por el Comit&#233; de &#201;tica e Investigaci&#243;n Cl&#237;nica del Hospital Reina Sof&#237;a de C&#243;rdoba&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">El cuestionario fue creado en Google drive &#40;<a href="https://docs.google.com/forms/d/e/1FAIpQLSeYTw5lmJnQKNN6SDp73KN5M0e7kFIFTZkOSOdDuEpKcZkUuA/viewform">https&#58;&#47;&#47;docs&#46;google&#46;com&#47;forms&#47;d&#47;e&#47;1FAIpQLSeYTw5lmJnQKNN6SDp73KN5M0e7kFIFTZkOSOdDuEpKcZkUuA&#47;viewform</a>&#41; y conten&#237;a las siguientes variables&#58; sociodemogr&#225;ficas &#40;edad&#44; sexo&#44; &#225;mbito de residencia &#8212;urbano&#47;rural&#8212;&#41;&#44; &#225;mbito laboral del m&#233;dico &#40;atenci&#243;n primaria&#44; urgencias de hospital&#44; residencias de mayores&#44; otro extrahospitalario&#41;&#44; contacto con paciente enfermo de COVID-19&#44; s&#237;ntomas presentes en las &#250;ltimas semanas &#40;dolor de garganta&#44; cefalea&#44; tos&#44; congesti&#243;n nasal&#44; fiebre&#44; sudoraci&#243;n&#44; hipotermia&#44; disnea&#44; dolor tor&#225;cico&#44; cansancio&#44; dolores articulares&#44; mialgias&#44; malestar general&#44; trastornos del olfato o del gusto&#44; afon&#237;a&#44; ronquera&#44; v&#243;mitos&#44; n&#225;useas&#44; dolor de est&#243;mago&#44; hemoptisis&#44; disfon&#237;a&#44; afecciones oculares&#44; lesiones cut&#225;neas&#44; mareos&#44; v&#233;rtigos&#44; temblores&#44; otros&#41;&#44; primer s&#237;ntoma acontecido&#44; enfermedades cr&#243;nicas previas &#40;hipertensi&#243;n arterial&#44; diabetes mellitus&#44; asma&#44; enfermedad pulmonar obstructiva cr&#243;nica&#44; dislipemia&#44; sobrepeso&#47;obesidad&#44; cardiopat&#237;as&#44; c&#225;ncer&#44; inmunodeficiencias&#44; insuficiencia renal o hep&#225;tica&#44; depresi&#243;n&#44; ansiedad&#44; enfermedad cerebrovascular&#44; enfermedades endocrinas&#44; otras&#41;&#44; consumo de tabaco y resultado de la prueba &#40;PCR coronavirus SARS-CoV-2 positivo o negativo&#41;&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Respecto al an&#225;lisis estad&#237;stico&#44; en primer lugar&#44; se realiz&#243; un an&#225;lisis descriptivo mediante el c&#225;lculo de distribuci&#243;n de frecuencias en el caso de variables cualitativas y medidas de tendencia central y dispersi&#243;n en las variables cuantitativas&#46; Se compararon las caracter&#237;sticas de los grupos &#40;casos positivos frente a negativos&#41; mediante an&#225;lisis bivariante&#44; utilizando la prueba de la Chi-cuadrado&#44; el test exacto de Fisher o la t de Student &#40;previa comprobaci&#243;n de ajuste a una distribuci&#243;n normal&#44; mediante el test de Kolmogorov-Smirnov&#41;&#46; Para comprobar la magnitud de la asociaci&#243;n se calcul&#243; la OR cruda y su correspondiente intervalo de confianza del 95&#37; &#40;IC 95&#37;&#41;&#46; Una vez detectadas las variables relacionadas con la presencia de PCR positiva&#44; se realiz&#243; un an&#225;lisis multivariante&#44; mediante regresi&#243;n log&#237;stica binaria no condicional&#44; con el c&#225;lculo de las OR ajustadas&#46; Se incluyeron en el modelo como variables independientes las sociodemogr&#225;ficas&#44; las laborales&#44; las cl&#237;nicas y las de comorbilidad&#44; y como variable dependiente&#44; la presencia o no de enfermedad COVID-19 &#40;seg&#250;n resultado PCR&#41;&#46; Se utiliz&#243; el test de Hosmer-Lemeshow para comprobar el ajuste del modelo&#46; Para analizar la validez predictiva de los s&#237;ntomas presentes en aquellos con infecci&#243;n por SARS-CoV-2&#44; se calcularon los par&#225;metros de sensibilidad&#44; especificidad&#44; valores predictivos y cocientes de probabilidad <span class="elsevierStyleItalic">&#40;likelihood ratio&#41;</span> de cada s&#237;ntoma que result&#243; asociado de manera independiente con la presencia de infecci&#243;n por virus SARS-CoV-2 en el modelo multivariante&#46; Los an&#225;lisis se realizaron mediante el programa SPSS&#174; Statistics-v&#46;20&#46;0&#46;<elsevierMultimedia ident="fig0005"></elsevierMultimedia></p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Resultados</span><p id="par0055" class="elsevierStylePara elsevierViewall">Del total de la muestra&#44; el 13&#44;7&#37; &#40;IC 95&#37;&#58; 11&#44;7-16&#44;0&#41;&#44; eran casos infectados con el SARS-CoV-2&#46; Un total de 417 m&#233;dicos de familia &#40;43&#44;0&#37;&#41; respondieron el cuestionario mediante entrevista telef&#243;nica y 552 &#40;57&#37;&#41; de manera autocumplimentada&#46; La edad media fue de 45&#44;6 &#40;desviaci&#243;n est&#225;ndar &#91;DE&#93;&#58; 11&#44;5&#59; rango entre 25 y 69&#41; a&#241;os&#44; sin diferencias entre los 2 grupos&#46; Un 73&#44;7&#37; eran mujeres&#44; el 84&#44;2&#37; resid&#237;an en medio urbano y el 80&#44;3&#37; trabajaban en AP&#46; En la <a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a> se muestran las caracter&#237;sticas socio-laborales y cl&#237;nicas de los participantes&#44; pudiendo apreciar la ausencia de diferencias estad&#237;sticamente significativas&#44; al comparar ambos grupos&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0060" class="elsevierStylePara elsevierViewall">Los s&#237;ntomas manifestados con mayor frecuencia por los m&#233;dicos de familia con infecci&#243;n fueron sensaci&#243;n de fatiga&#47;cansancio &#40;69&#44;2&#37;&#59; IC 95&#37;&#58; 60&#44;9-77&#44;4&#37;&#41;&#44; tos &#40;56&#44;4&#37;&#59; IC 95&#37;&#58; 47&#44;6-65&#44;2&#37;&#41;&#44; cefalea &#40;55&#44;6&#37;&#59; IC 95&#37;&#58; 46&#44;8-64&#44;4&#41; y malestar general &#40;55&#44;6&#37;&#59; IC 95&#37;&#58; 46&#44;8-64&#44;4&#37;&#41;&#46; El grupo de infectados present&#243; una proporci&#243;n estad&#237;sticamente diferente respecto al grupo control en cuanto a la presencia de dolor far&#237;ngeo&#44; cefalea&#44; dolor osteomuscular&#44; cansancio&#44; disnea&#44; alteraci&#243;n del gusto&#44; alteraci&#243;n del olfato&#44; tos&#44; fiebre&#44; malestar general&#44; p&#233;rdida de apetito&#44; congesti&#243;n nasal&#44; sudoraci&#243;n&#44; escalofr&#237;os&#44; disfon&#237;a&#44; dolor tor&#225;cico&#44; dolor de espalda&#44; opresi&#243;n tor&#225;cica&#44; diarrea&#44; n&#225;useas&#44; hipotermia&#44; molestias en ojos&#44; afectaci&#243;n de la piel&#44; mareos y secreci&#243;n bronquial&#44; v&#243;mitos&#44; eritema facial&#44; lesiones en dedos y temblores &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#46; La proporci&#243;n de asintom&#225;ticos fue significativamente inferior en el grupo de casos &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#46; En la <a class="elsevierStyleCrossRef" href="#tbl0010">tabla 2</a> se muestran los s&#237;ntomas manifestados con mayor frecuencia en ambos grupos &#40;casos y controles&#41; y las correspondientes OR crudas&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0065" class="elsevierStylePara elsevierViewall">En la <a class="elsevierStyleCrossRef" href="#tbl0010">tabla 2</a> tambi&#233;n se observa un aumento del riesgo de infecci&#243;n al incrementarse el n&#250;mero de s&#237;ntomas manifestados &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#46; La mediana de tiempo con manifestaciones cl&#237;nicas en los participantes sintom&#225;ticos fue de 21 d&#237;as &#40;rango intercuart&#237;lico&#58; 7-50&#41;&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">Respecto al primer s&#237;ntoma manifestado por los participantes con PCR positiva&#44; fueron los m&#225;s frecuentes fiebre &#40;19&#44;5&#37;&#59; IC 95&#37;&#58; 12&#44;4-26&#44;7&#37;&#41;&#44; dolor far&#237;ngeo &#40;15&#44;0&#37;&#59; IC 95&#37;&#58; 8&#44;6-21&#44;5&#37;&#41;&#44; cefalea &#40;10&#44;5&#37;&#59; IC 95&#37;&#58; 4&#44;9-16&#44;1&#37;&#41;&#44; cansancio &#40;9&#44;8&#37;&#59; IC 95&#37;&#58; 4&#44;4-15&#44;2&#37;&#41; y tos &#40;9&#44;8&#37;&#59; IC 95&#37;&#58; 4&#44;4-15&#44;2&#37;&#41;&#46; En la <a class="elsevierStyleCrossRef" href="#tbl0015">tabla 3</a> se muestran los s&#237;ntomas de inicio relacionados con la presencia de infecci&#243;n y los que no resultaron relacionados&#44; incluyendo las correspondientes OR crudas&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0075" class="elsevierStylePara elsevierViewall">Manifest&#243; un contacto previo con un enfermo de COVID-19 el 78&#44;2&#37; de los que presentaron la infecci&#243;n y el 52&#44;3&#37; de los controles&#44; siendo la diferencia observada estad&#237;sticamente significativa &#40;OR&#58; 3&#44;27&#59; IC 95&#37;&#58; 2&#44;12-5&#44;05&#41;&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">Mediante regresi&#243;n log&#237;stica&#44; se comprob&#243; que las variables asociadas de manera independiente con la presencia de infecci&#243;n por virus SARS-CoV-2 en m&#233;dicos de familia fueron&#58; contacto previo con enfermo COVID-19&#44; presentar fatiga&#47;cansancio&#44; alteraci&#243;n del olfato&#44; alteraci&#243;n del gusto&#44; tos y fiebre&#46; En la <a class="elsevierStyleCrossRef" href="#tbl0020">tabla 4</a> se muestran estas variables con sus OR e IC del 95&#37;&#46;</p><elsevierMultimedia ident="tbl0020"></elsevierMultimedia><p id="par0085" class="elsevierStylePara elsevierViewall">Por &#250;ltimo&#44; en la <a class="elsevierStyleCrossRef" href="#tbl0025">tabla 5</a> se presentan los par&#225;metros de validez predictiva de los s&#237;ntomas que se podr&#237;an utilizar en el proceso diagn&#243;stico de sospecha de enfermedad por COVID-19 en m&#233;dicos de familia&#46; Se incluyen los s&#237;ntomas asociados de forma independiente con la presencia de infecci&#243;n por el virus SARS-CoV-2&#44; mediante an&#225;lisis multivariante&#46; Tambi&#233;n se incluyen las asociaciones de los s&#237;ntomas que mostraron un valor m&#225;s alto del cociente de probabilidad positivo&#46;</p><elsevierMultimedia ident="tbl0025"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Discusi&#243;n</span><p id="par0095" class="elsevierStylePara elsevierViewall">El diagn&#243;stico definitivo de enfermedad COVID-19 implica identificar la presencia de infecci&#243;n activa por el virus SARS-CoV-2&#44; siendo la t&#233;cnica de elecci&#243;n la detecci&#243;n de &#225;cidos nucleicos mediante RT-PCR<a class="elsevierStyleCrossRefs" href="#bib0220"><span class="elsevierStyleSup">13&#44;14</span></a>&#46; Sin embargo&#44; el diagn&#243;stico inicial se apoya&#44; especialmente en casos menos graves&#44; en la sintomatolog&#237;a que caracteriza esta enfermedad&#46; Nuestros resultados muestran que los s&#237;ntomas m&#225;s frecuentes en los m&#233;dicos de familia infectados por el virus SARS-CoV-2 son fatiga o cansancio&#44; tos&#44; cefalea&#44; dolor osteomuscular&#44; fiebre y alteraci&#243;n del olfato y del gusto&#44; mientras que los relacionados de forma independiente con la presencia de infecci&#243;n son fatiga o cansancio&#44; tos&#44; fiebre&#44; la alteraci&#243;n del olfato y la del gusto&#46; De ellos&#44; los que muestran una mayor fuerza de asociaci&#243;n&#44; seg&#250;n la OR&#44; y mejores par&#225;metros de validez predictiva como s&#237;ntomas diagn&#243;sticos de sospecha de enfermedad COVID-19 son la fiebre&#44; la alteraci&#243;n del gusto y del olfato&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">Tanto las caracter&#237;sticas de la poblaci&#243;n de nuestro estudio como las diferencias metodol&#243;gicas pueden limitar la comparabilidad de los datos&#46; Nuestros resultados sobre los s&#237;ntomas m&#225;s frecuentes en m&#233;dicos de familia con la infecci&#243;n son similares a los del conjunto de sanitarios con COVID-19 notificados a la RENAVE en nuestro pa&#237;s<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">9</span></a>&#44; aunque la proporci&#243;n de pacientes con fiebre&#44; disnea y tos fue inferior en nuestro estudio&#46; Posiblemente este hecho se pueda explicar por las diferentes caracter&#237;sticas de ambas poblaciones y por la mayor gravedad o el distinto grado de evoluci&#243;n de la enfermedad de los casos de la RENAVE&#44; aunque el rango de edades y la proporci&#243;n por sexo de ambos son similares&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">Hemos comprobado que los s&#237;ntomas relacionados de forma independiente con la infecci&#243;n por este virus fueron presentar fatiga o cansancio&#44; alteraci&#243;n del gusto&#44; tos&#44; fiebre y la alteraci&#243;n del olfato&#46; Estos resultados son concordantes con los de estudios previos&#44; que destacan la tos&#44; la fiebre y la fatiga como s&#237;ntomas caracter&#237;sticos de la COVID-19<a class="elsevierStyleCrossRefs" href="#bib0210"><span class="elsevierStyleSup">11&#44;15&#44;16</span></a>&#46; Aunque al inicio de la pandemia la alteraci&#243;n del gusto y del olfato&#44; no se inclu&#237;an entre los s&#237;ntomas de sospecha&#44; estudios posteriores muestran igualmente su papel preponderante&#44; destacando una elevada proporci&#243;n de enfermos con estas manifestaciones<a class="elsevierStyleCrossRefs" href="#bib0240"><span class="elsevierStyleSup">17&#8211;20</span></a>&#46; Estas publicaciones y otras recientes<a class="elsevierStyleCrossRefs" href="#bib0260"><span class="elsevierStyleSup">21&#8211;23</span></a> ponen de manifiesto la amplia variabilidad de s&#237;ntomas de esta enfermedad&#44; por tanto&#44; resulta de inter&#233;s conocer aquellos que con su presencia incrementan la probabilidad de diagnosticarla de forma m&#225;s precoz&#46; As&#237;&#44; nuestros resultados muestran no solo que existe una serie de s&#237;ntomas asociados de forma independiente a la infecci&#243;n por SARS-CoV-2 en m&#233;dicos de familia&#44; sino que algunos de ellos muestran par&#225;metros de validez predictiva adecuados para el diagn&#243;stico de sospecha de COVID-19 en este colectivo como son la presencia de fiebre y las alteraciones del gusto y del olfato&#46; Tambi&#233;n hemos comprobado que la presencia conjunta de estos s&#237;ntomas podr&#237;a tenerse en consideraci&#243;n en el proceso diagn&#243;stico&#46; Los estudios realizados para evaluar la exactitud diagn&#243;stica de los signos y s&#237;ntomas para determinar si un paciente tiene COVID-19 muestran una amplia variabilidad de metodolog&#237;a y de resultados&#44; trat&#225;ndose en su mayor&#237;a de dise&#241;os transversales y realizados en poblaci&#243;n general atendida en hospital&#46; Nuestros resultados son coincidentes con los publicados&#44; en donde destacan el aumento de la probabilidad de la enfermedad COVID-19 con la presencia de la alteraci&#243;n o p&#233;rdida del olfato<a class="elsevierStyleCrossRefs" href="#bib0275"><span class="elsevierStyleSup">24&#44;25</span></a> o de fiebre<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">11</span></a>&#44; aunque hemos observado superiores valores de cocientes de probabilidad positiva para fiebre&#44; cansancio&#44; tos&#44; alteraci&#243;n del gusto y del olfato a los de estudios previos<a class="elsevierStyleCrossRefs" href="#bib0285"><span class="elsevierStyleSup">26&#8211;28</span></a>&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">De forma consistente con el conocimiento previo respecto al mecanismo de transmisi&#243;n del virus<a class="elsevierStyleCrossRefs" href="#bib0300"><span class="elsevierStyleSup">29&#44;30</span></a> nuestros resultados muestran superior proporci&#243;n de contagiados en aquellos con un contacto previo con una persona infectada&#46; Tambi&#233;n son concordantes con los datos de enfermos con COVID-19 en sanitarios notificados a la RENAVE<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">11</span></a>&#44; con un 71&#37; de ellos con antecedente epidemiol&#243;gico de contacto estrecho con casos de COVID-19 probable o confirmado<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">11</span></a>&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">Una de las posibles limitaciones de nuestro estudio es la ausencia de una selecci&#243;n aleatoria de los participantes&#44; pudiendo comprometer su validez externa al producirse un sesgo de selecci&#243;n&#46; Sin embargo&#44; consideramos nuestra muestra bastante representativa de la poblaci&#243;n de su misma profesi&#243;n&#44; participando m&#233;dicos de 12 comunidades aut&#243;nomas con actividad laboral en diferentes &#225;mbitos&#46; Igualmente&#44; debemos tener en cuenta que parte de los resultados proceden de un cuestionario autocumplimentado y&#44; por tanto&#44; su validez depende de la veracidad de las respuestas&#44; aunque se intent&#243; facilitar &#233;sta asegurando el anonimato del encuestado&#46; Adem&#225;s&#44; las caracter&#237;sticas y la profesi&#243;n de los participantes minimizar&#225;n las limitaciones propias del uso de este tipo de cuestionario&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">Considerando la posibilidad de una potencial alta tasa de infecci&#243;n por el virus SARS-CoV-2 no diagnosticada en m&#233;dicos de primera l&#237;nea<a class="elsevierStyleCrossRef" href="#bib0310"><span class="elsevierStyleSup">31</span></a>&#44; son necesarios nuevos estudios prospectivos que identifiquen combinaciones de signos y s&#237;ntomas que caractericen el cuadro sindr&#243;mico inicial de enfermedad COVID-19&#46; Sus resultados podr&#237;an facilitar la toma de posteriores decisiones tanto en el proceso diagn&#243;stico de la enfermedad como en la adopci&#243;n precoz de las medidas de aislamiento y organizaci&#243;n necesarias en los equipos y servicios&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">En conclusi&#243;n&#44; los resultados de nuestro estudio han permitido identificar s&#237;ntomas relacionados de forma independiente con la infecci&#243;n por el virus SARS-CoV-2 y otros cuya presencia aumenta la probabilidad de la enfermedad COVID-19 en m&#233;dicos que desempe&#241;an su actividad en AP&#44; urgencias de hospital u otros servicios extrahospitalarios&#46; Tambi&#233;n se han puesto de manifiesto los s&#237;ntomas m&#225;s frecuentes manifestados por los profesionales infectados y aquellos que con m&#225;s asiduidad se manifiestan como s&#237;ntoma inicial&#46; Adem&#225;s&#44; nos han permitido establecer la capacidad predictiva de los mismos en este colectivo&#44; lo cual resulta de utilidad pr&#225;ctica desde el punto de vista de su detecci&#243;n precoz&#46;<elsevierMultimedia ident="tb0005"></elsevierMultimedia></p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0135">Conflicto de intereses</span><p id="par0170" class="elsevierStylePara elsevierViewall">Los autores declaran no tener ning&#250;n conflicto de intereses&#46;</p></span></span>"
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    "fechaRecibido" => "2020-09-03"
    "fechaAceptado" => "2020-12-01"
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            0 => "COVID-19"
            1 => "Evaluaci&#243;n de s&#237;ntoma"
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        "titulo" => "Resumen"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Objetivo</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Identificar las caracter&#237;sticas sociodemogr&#225;ficas&#44; cl&#237;nicas y epidemiol&#243;gicas asociadas a la presencia de infecci&#243;n por el virus SARS-CoV-2 en m&#233;dicos de familia que desempe&#241;an su actividad laboral en atenci&#243;n primaria &#40;AP&#41; o en urgencias de hospital&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Dise&#241;o</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Estudio observacional anal&#237;tico de casos y controles&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Emplazamiento</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Atenci&#243;n primaria&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Participantes</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Un total de 969 m&#233;dicos de AP&#44; urgencias hospitalarias y otros centros extrahospitalarios que dispusieran de RT-PCR para la detecci&#243;n del virus SARS-CoV-2&#46; De estos&#44; 133 participaron como casos &#40;PCR positiva&#41; y 836 como controles &#40;PCR negativa&#41;&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Intervenciones</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">No&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Mediciones principales</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Variables sociodemogr&#225;ficas y laborales&#44; contacto con enfermo de COVID-19&#44; s&#237;ntomas presentes durante el proceso&#44; primer s&#237;ntoma manifestado&#44; enfermedades cr&#243;nicas previas y consumo de tabaco&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Del total de la muestra el 13&#44;7&#37; &#40;IC 95&#37;&#58; 11&#44;6-16&#44;0&#41;&#44; eran casos infectados con el SARS-CoV-2&#46; Los s&#237;ntomas declarados m&#225;s frecuentemente por los infectados fueron sensaci&#243;n de fatiga&#47;cansancio &#40;69&#44;2&#37;&#59; IC 95&#37;&#58; 60&#44;9-77&#44;4&#37;&#41;&#44; tos &#40;56&#44;4&#37;&#59; IC 95&#37;&#58; 47&#44;6-65&#44;2&#37;&#41; y cefalea &#40;55&#44;6&#37;&#59; IC 95&#37;&#58; 46&#44;8-64&#44;4&#37;&#41;&#46; Mediante regresi&#243;n log&#237;stica&#44; las variables asociadas de manera independiente con la infecci&#243;n por virus SARS-CoV-2 en m&#233;dicos de familia fueron&#58; contacto previo con enfermo COVID-19 &#40;OR&#58; 2&#44;3&#59; IC 95&#37;&#58; 1&#44;2-4&#44;2&#41;&#44; presentar fatiga&#47;cansancio &#40;OR&#58; 2&#44;2&#59; IC 95&#37;&#58; 1&#44;2-3&#44;9&#41;&#44; alteraci&#243;n del olfato &#40;4&#44;6&#59; IC 95&#37;&#58; 1&#44;7-12&#44;5&#41;&#44; alteraci&#243;n del gusto &#40;OR&#58; 32&#44;0&#59; IC 95&#37;&#58; 9&#44;6-106&#44;8&#41;&#44; tos &#40;OR&#58; 3&#44;0&#59; IC 95&#37;&#58; 1&#44;7-5&#44;3&#41; y fiebre &#40;OR&#58; 6&#44;1&#59; IC 95&#37;&#58; 3&#44;2-11&#44;4&#41;&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Los s&#237;ntomas relacionados de forma independiente con la infecci&#243;n por el virus SARS-CoV-2 en m&#233;dicos de familia fueron la fatiga&#44; la fiebre&#44; la tos y la alteraci&#243;n del gusto y del olfato&#46; La presencia de estos s&#237;ntomas podr&#237;a facilitar el diagn&#243;stico de sospecha de enfermedad COVID-19 y la selecci&#243;n m&#225;s precoz de aquellos que precisan pruebas de confirmaci&#243;n&#46;</p></span>"
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      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Objective</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">To identify the sociodemographic&#44; clinical and epidemiological characteristics associated with the presence of infection by the SARS-CoV-2 virus in family physicians who carry out their work in Primary Care &#40;PC&#41; or in Hospital Emergencies&#46;</p></span> <span id="abst0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Desing</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Observational analytical case-control study&#46;</p></span> <span id="abst0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Site</span><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Primary care&#46;</p></span> <span id="abst0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Participants</span><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">969 Primare Care Physicians&#44; Hospital Emergency physicians and other extrahospitalry centers that had PCR for the detection of the SARS-CoV-2&#46; Of these&#44; 133 participated as cases &#40;PCR positive&#41; and 836 as controls &#40;PCR negative&#41;&#46;</p></span> <span id="abst0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Interventions</span><p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">No&#46;</p></span> <span id="abst0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Main measurements</span><p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Sociodemographic and work&#44; contact with a COVID-19 patient&#44; symptoms present during the process&#44; first manifested symptom&#44; previous chronic pathologies&#44; and tobacco use&#46;</p></span> <span id="abst0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Results</span><p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">13&#46;7&#37; &#40;95&#37; CI&#58; 11&#46;6-16&#46;0&#41; were cases infected with SARS-CoV-2&#46; The most frequently declared symptoms by those infected were a feeling of fatigue&#47;tiredness &#40;69&#46;2&#37;&#59; 95&#37; CI&#58; 60&#46;9-77&#46;4&#37;&#41;&#44; cough &#40;56&#46;4&#37;&#59; 95&#37; CI&#58; 47&#46;6-65&#46;2&#37;&#41; and headache &#40;55&#46;6&#37;&#59; 95&#37; CI&#58; 46&#46;8-64&#46;4&#37;&#41;&#46;Using logistic regression&#44; the variables independently associated with SARS-CoV-2 virus infection in Family Physicians were&#58; previous contact with a COVID-19 patient &#40;OR&#58; 2&#46;3&#59; 95&#37; CI&#58; 1&#46;2-4&#46;2&#41;&#44; present fatigue &#47; tiredness &#40;OR&#58; 2&#46;2&#59; 95&#37; CI&#58; 1&#46;2-3&#46;9&#41;&#44; smell alteration &#40;4&#46;6&#59; 95&#37; CI&#58; 1&#46;7-12&#46;5&#41;&#44; taste alteration &#40;OR&#58; 32&#46;0&#59; 95&#37; CI&#58; 9&#46;6-106&#46;8&#41;&#44; cough &#40;OR&#58; 3&#46;0&#59; 95&#37; CI&#58; 1&#46;7-5&#46;3&#41; and fever &#40;OR&#58; 6&#46;1&#59; 95&#37; CI&#58; 3&#46;2-11&#46;4&#41;&#46;</p></span> <span id="abst0080" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Conclusions</span><p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">Symptoms independently related to SARS-CoV-2 virus infection in Family Physicians were fatigue&#44; fever&#44; cough&#44; and altered taste and smell&#46; The presence of these symptoms could facilitate the diagnosis of suspected COVID-19 disease and the earlier selection of those that require confirmatory tests&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0015">Los nombres de los componentes del Grupo EPICOVID est&#225;n relacionados en el <a class="elsevierStyleCrossRef" href="#sec0040">anexo 1</a>&#46;</p>"
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            "apendice" => "<p id="par0180" class="elsevierStylePara elsevierViewall">Inmaculada Olaya Caro&#44; Yolanda Ortega L&#243;pez&#44; Diego Pajares Conde&#44; Miguel Ram&#237;rez Baena&#44; Jorge Rafael Padilla Maestre&#44; Vocales de Investigaci&#243;n de la semFYC&#58; Sara Ares Blanco&#44; Jaime Barrio Cortes&#44; Francisco Javier Bartolom&#233; Resano&#44; Ana Claver&#237;a Font&#225;&#44; Ana Dosio Revenga&#44; Yolanda Gonz&#225;lez Silva&#44; Jorge Lema Bartolom&#233;&#44; Carmen Mart&#237;nez Cervell&#44; Bernardino Oliva Fanlo&#44; Santiago Poveda Siles&#44; Raquel Regla Mar&#237;n y Rub&#233;n Villa Est&#233;banez&#46;</p>"
            "etiqueta" => "Anexo 1"
            "titulo" => "Grupo EPICOVID"
            "identificador" => "sec0040"
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Mujer&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">&#193;mbito geogr&#225;fico de residencia</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Atenci&#243;n primaria&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Atenci&#243;n hospitalaria&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Residencia de mayores&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Atenci&#243;n primaria y hospitalaria&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Otros&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">7&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">28&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">3&#44;4&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>NS&#47;NC&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">3&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " colspan="6" align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Consumo de tabaco</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No fumador&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">96&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">72&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">538&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">64&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;210&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Exfumador&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">27&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">195&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">23&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Fumador espor&#225;dico&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">53&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Fumador diario&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">49&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>NS&#47;NC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="6" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Problemas de salud previos</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Alg&#250;n problema de salud&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">66&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">49&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">438&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">52&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;553&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Ning&#250;n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">67&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">50&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">398&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">47&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="6" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Sobrepeso u obesidad</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">26&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">19&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">146&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;559&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">107&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">80&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">690&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">82&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Asma</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">76&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;242&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">125&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">94&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">760&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">90&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="6" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Hipertensi&#243;n arterial</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">67&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;619&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">124&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">93&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">769&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">92&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="6" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Enfermedad endocrina &#40;salvo diabetes&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">57&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;767&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">123&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">92&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">779&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">93&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="6" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Dislipemia</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">66&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;651&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">124&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">93&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">770&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">92&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="6" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Diabetes</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;206&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">32&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">99&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">815&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">97&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="6" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Ansiedad</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">52&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;263&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">128&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">96&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">784&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">93&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="6" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Enfermedad autoinmune</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">33&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;599&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">129&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">Tos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">13 &#40;9&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">72 &#40;8&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;62-2&#44;14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Dolor osteomuscular&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7 &#40;5&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">22 &#40;2&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;06&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;86-4&#44;91&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Congesti&#243;n nasal&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18 &#40;2&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;41&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;47-4&#44;23&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Malestar general&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11 &#40;1&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;33&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;73-7&#44;41&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Disnea&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;1&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7 &#40;0&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;81&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;67-8&#44;80&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Diarrea&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;1&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11 &#40;1&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;25-5&#44;22&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Escalofr&#237;os&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;1&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;0&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#44;37&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;89-45&#44;59&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Molestias oculares&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;1&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;0&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#44;18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;58-17&#44;51&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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          "es" => "<p id="spar0115" class="elsevierStyleSimplePara elsevierViewall">S&#237;ntomas de inicio del cuadro manifestado con mayor frecuencia en ambos grupos &#40;casos y controles&#41;</p>"
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          "leyenda" => "<p id="spar0130" class="elsevierStyleSimplePara elsevierViewall">IC 95&#37;&#58; intervalo de confianza del 95&#37;&#59; OR&#58; <span class="elsevierStyleItalic">odds ratio&#46;</span></p>"
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">OR&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">IC 95&#37;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Valor de p&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Contacto previo con enfermo de COVID-19&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">2&#44;25&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1&#44;22-4&#44;16&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;010&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Fatiga&#47;cansancio&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">2&#44;16&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;19-3&#44;91&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;012&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Alteraci&#243;n del olfato&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">4&#44;61&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;70-12&#44;46&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;003&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Alteraci&#243;n del gusto&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">31&#44;97&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&#44;57-106&#44;76&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tos&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">3&#44;02&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1&#44;71-5&#44;34&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
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                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab2554057.png"
              ]
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        ]
        "descripcion" => array:1 [
          "es" => "<p id="spar0125" class="elsevierStyleSimplePara elsevierViewall">Factores de riesgo asociados a infecci&#243;n mediante an&#225;lisis multivariante &#40;regresi&#243;n log&#237;stica&#41;</p>"
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      4 => array:8 [
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        "tipo" => "MULTIMEDIATABLA"
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            "identificador" => "at5"
            "detalle" => "Tabla "
            "rol" => "short"
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          "leyenda" => "<p id="spar0140" class="elsevierStyleSimplePara elsevierViewall">Cocientes de probabilidad&#44; sensibilidad y especificidad&#44; y valores predictivos&#46;</p><p id="spar0145" class="elsevierStyleSimplePara elsevierViewall">CP&#43;&#58; cociente de probabilidad positivo&#59; CP&#8722;&#58; cociente de probabilidad negativo&#59; E&#58; especificidad&#59; IC 95&#37;&#58; intervalo de confianza del 95&#37;&#59; S&#58; sensibilidad&#59; VPN&#58; valor predictivo negativo&#59; VPP&#58; valor predictivo positivo&#46;</p>"
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">CP&#43;&#40;IC 95&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">CP&#8722;&#40;IC 95&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">S&#40;IC 95&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">E&#40;IC 95&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">VPP&#40;IC 95&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Fatiga o cansancio&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">94&#44;18&#40;92&#44;20-95&#44;69&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Alteraci&#243;n del olfato&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">34&#44;57&#40;16&#44;57-70&#44;74&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">98&#44;57&#40;97&#44;51-99&#44;18&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">84&#44;62&#40;74&#44;83-91&#44;05&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">92&#44;48&#40;90&#44;56-94&#44;04&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Alteraci&#243;n del gusto&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">66&#44;00&#40;25&#44;05-200&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">47&#44;37&#40;39&#44;08-55&#44;81&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">99&#44;28&#40;98&#44;44-99&#44;67&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">91&#44;30&#40;81&#44;97-96&#44;04&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">92&#44;22&#40;90&#44;28-93&#44;80&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#44;02&#40;2&#44;26-3&#44;99&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;54&#40;0&#44;66-0&#44;42&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">56&#44;39&#40;47&#44;90-64&#44;52&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">81&#44;34&#40;78&#44;56-83&#44;84&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">32&#44;47&#40;26&#44;74-38&#44;77&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">92&#44;14&#40;89&#44;97-93&#44;88&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Fiebre&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&#44;34&#40;5&#44;28-12&#44;84&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;54&#40;0&#44;64-0&#44;45&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">48&#44;87&#40;40&#44;53-57&#44;28&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">94&#44;1492&#44;33-95&#44;54&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">57&#44;02&#40;47&#44;80-65&#44;78&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">92&#44;05&#40;90&#44;03-93&#44;68&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Alteraci&#243;n del gusto y de la fiebre&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11&#44;06&#40;7&#44;59-15&#44;75&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;31&#40;0&#44;40-0&#44;23&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">71&#44;43&#40;63&#44;23-78&#44;42&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">93&#44;54&#40;91&#44;67-95&#44;02&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">63&#44;76&#40;55&#44;75-71&#44;07&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">95&#44;37&#40;93&#44;70-96&#44;61&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Alteraci&#243;n del gusto y del olfato&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t">Fiebre y alteraci&#243;n del olfato&nbsp;\t\t\t\t\t\t\n
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          "es" => "<p id="spar0135" class="elsevierStyleSimplePara elsevierViewall">Par&#225;metros de utilidad para analizar la validez predictiva de los s&#237;ntomas asociados de manera independiente con la presencia de infecci&#243;n por virus SARS-CoV-2</p>"
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          "es" => "<p id="spar0085" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Esquema del estudio</span>&#46; Esquema general del estudio&#58; estudio de casos y controles de los s&#237;ntomas de los m&#233;dicos de familia con enfermedad COVID-19&#46;</p>"
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          "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Lo conocido sobre el tema</span><p id="par0130" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">&#8226;</span><p id="par0135" class="elsevierStylePara elsevierViewall">El n&#250;mero de casos de infectados por este virus ha experimentado un importante aumento tanto en nuestro pa&#237;s como en todo el mundo&#46;</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">&#8226;</span><p id="par0140" class="elsevierStylePara elsevierViewall">El retraso en la identificaci&#243;n de los s&#237;ntomas que caracterizan a una enfermedad infecciosa facilitan la propagaci&#243;n de la misma&#46;</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">&#8226;</span><p id="par0145" class="elsevierStylePara elsevierViewall">Dado el escaso tiempo que ha pasado desde el descubrimiento de esta enfermedad&#44; apenas se sabe a&#250;n sobre cu&#225;les son sus caracter&#237;sticas cl&#237;nico-epidemiol&#243;gicas&#44; sobre todo entre una de las poblaciones de mayor riesgo&#44; como son los m&#233;dicos de atenci&#243;n primaria&#46;</p></li></ul></p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">Qu&#233; aporta este estudio</span><p id="par0150" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="lis0010"><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">&#8226;</span><p id="par0155" class="elsevierStylePara elsevierViewall">Entre los s&#237;ntomas que aparecen con mayor frecuencia en m&#233;dicos de familia con infecci&#243;n por virus SARS-CoV-2 figuran tanto los habituales de la poblaci&#243;n en general como otros menos frecuentes y m&#225;s espec&#237;ficos que afectan al gusto y al olfato&#46;</p></li><li class="elsevierStyleListItem" id="lsti0025"><span class="elsevierStyleLabel">&#8226;</span><p id="par0160" class="elsevierStylePara elsevierViewall">Se han identificado los s&#237;ntomas relacionados de forma independiente con la infecci&#243;n por el virus SARS-CoV-2 en m&#233;dicos de familia que desempe&#241;an su actividad en atenci&#243;n primaria&#44; urgencias de hospital u otros servicios extrahospitalarios&#46;</p></li><li class="elsevierStyleListItem" id="lsti0030"><span class="elsevierStyleLabel">&#8226;</span><p id="par0165" class="elsevierStylePara elsevierViewall">Algunos de los s&#237;ntomas m&#225;s frecuentes de los facultativos infectados por SARS-CoV-2 pueden facilitar la detecci&#243;n precoz ante la sospecha de enfermedad de COVID-19 y la selecci&#243;n de las pruebas necesarias para confirmar su diagn&#243;stico&#46;</p></li></ul></p></span></span>"
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                          "etal" => true
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                            1 => "J&#46;J&#46; Deeks"
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                            3 => "Y&#46; Takwoingi"
                            4 => "C&#46; Davenport"
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                      "titulo" => "Seroprevalence of antibodies against SARS-CoV-2 among health care workers in a large Spanish reference hospital"
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                      "titulo" => "Interpreting a covid-19 test result"
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                          "autores" => array:3 [
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Información del artículo
ISSN: 02126567
Idioma original: Español
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2023 Enero 80 15 95
2022 Diciembre 83 21 104
2022 Noviembre 97 33 130
2022 Octubre 124 40 164
2022 Septiembre 120 28 148
2022 Agosto 95 44 139
2022 Julio 78 26 104
2022 Junio 100 22 122
2022 Mayo 136 44 180
2022 Abril 122 42 164
2022 Marzo 119 47 166
2022 Febrero 104 39 143
2022 Enero 119 35 154
2021 Diciembre 106 63 169
2021 Noviembre 185 62 247
2021 Octubre 185 67 252
2021 Septiembre 176 62 238
2021 Agosto 148 44 192
2021 Julio 119 38 157
2021 Junio 184 48 232
2021 Mayo 113 71 184
2021 Abril 294 154 448
2021 Marzo 42 5 47
2021 Febrero 7 0 7
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es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos