Estadísticas

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      "titulo" => "Estado de la función renal y de las hormonas reguladoras del metabolismo hidrosalino en los enfermos con ictericia obstructiva"
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          "autoresLista" => "JM Gallardo Valverde, FJ Padillo Ruiz, G Solórzano Peck, P Montilla López, C Muñoz de Agueda, I Túnez Fiñana, G Miño Fugarolas, A Sitges Serra, C Pera Madrazo"
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    "titulo" => "Seudodiverticulosis intramural esofágica. Un nuevo caso"
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        "titulo" => "Changes in gastric phosphatidylcholine and prostanoid synthesis in an experimental model of sepsis&#58; effect of pentoxifylline and somatostatin"
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        "resumen" => "La seudodiverticulosis intramural esof&#225;gica es una enfermedad rara&#44; de origen desconocido&#44; que cursa de forma benigna y que afecta en especial a enfermos varones en la quinta d&#233;cada de su vida&#46; Se presenta el caso de un enfermo var&#243;n en edad temprana con disfagia de larga evoluci&#243;n&#44; en quien el diagn&#243;stico se consigui&#243; mediante estudios radiol&#243;gicos&#46; El tratamiento con dilataciones fue eficaz tanto en controles cl&#237;nicos como radiol&#243; gicos"
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        "resumen" => "<span class="elsevierStyleBold">Introduction&#46;</span> Changes in the gastric mucosal barrier appear to play a fundamental role in the physiopathology of acute gastric mucosal lesions secondary to sepsis&#46; The efficacy and integrity of this barrier depend to a great extent on its hydrophobicity&#44; which requires the presence of a phospholipid layer&#44; of which phosphatidylcholine &#40;PC&#41; is the major component&#46; Somatostatin &#40;SS&#41; has been found to exert a protective effect on the gastric mucosa&#44; while pentoxifylline &#40;PTXF&#41; is known to reduce tissue damage in different experimental models of sepsis&#46; Objectives&#46; To investigate PC synthesis by the gastric mucosa in a model of sepsis induced by lipopolysaccharide &#40;LPS&#41; in rats&#44; as well as the possible involvement of arachidonic acid metabolites and oxygen free radicals in gastric mucosal damage&#46; <span class="elsevierStyleBold">Material and methods&#46;</span> The animals were divided into 6 groups&#58; control &#40;saline&#47;saline&#41;&#44; control &#40;SS&#47;SS&#41;&#44; control &#40;PTXF&#47;PTXF&#41;&#44; LPS&#47;saline&#44; LPS&#47;SS and LPS&#47;PTXF&#46; LPS &#40;10 mg&#47;kg body weight&#41; was administered intraperitoneally 30 or 120 minutes prior to treatment&#46; Tritiated choline was administered simultaneously with saline&#44; SS or PTXF as a marker of PC synthesis&#46; All the rats were sacrificed 2 hours after treatment &#40;150 or 240 minutes after LPS administration&#41; and their stomachs were resected and rinsed&#46; PC&#44; prostanoids &#40;PGE2&#44; PGI2&#44; TXB2 and LTB4&#41; and malondialdehyde &#40;MDA&#41; were extracted and measured and myeloperoxidase &#40;MPO&#41; activity was assessed&#46; <br/> <span class="elsevierStyleBold">Results&#46;</span> LPS administration induced a decrease in PC synthesis as well as changes in prostanoid production&#46; We observed an increment in polymorphonuclear cell infiltration&#44; as indicated by the MPO activity&#44; and increased lipid peroxidation&#44; according to the MDA concentration&#46; Both SS and PTXF totally or partially reversed these effects&#46; <br/> <span class="elsevierStyleBold">Conclusions&#46;</span>&#46; Our results show that PTXF and SS counteract some of the physiopathologic mechanisms involved in acute gastric mucosa lesions secondary to sepsis and&#44; thus&#44; may prove beneficial in the treatment of these lesions"
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