Estadísticas

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  "cita" => "Cir Esp. 1998;64:14-6"
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      "titulo" => "Estadificación preoperatoria del adenocarcinoma gástrico. Estudio prospectivo del rendimiento diagnóstico de la tomografía axial computarizada, la videolaparoscopia y la laparotomía"
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          "autoresLista" => "VJ Escrig Sos, J Ruiz del Castillo, JL Salvador Sanchís, G Todolí Tomás, R Gómez Melchor, R Corell Planelles, JH García Vila, J Navarro Navarro"
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      "titulo" => "Aumento de roturas 16q en sangre periférica en pacientes con un liposarcoma mixoide"
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          "titulo" => "Increased rate of chromosome 16q breakage in peripheral blood from myxoid liposarcoma patients"
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    "titulo" => "Valor clínico del análisis del ADN en familias con síndrome de neoplasia endocrina múltiple tipo IIA (MEN IIA)"
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        "autoresLista" => "R Palasí Giménez, MC Orellana Alonso, JL Ponce Marco, F Martínez-Castellano, E Castillo García, F Prieto García, P Yunta Abarca, R Estevan Estevan, S Sancho-Fornos"
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        "titulo" => "Clinical value of dna analysis in families with multiple endocrine neoplasia type IIA (MEN IIA)"
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        "resumen" => "<span class="elsevierStyleBold">Introduction&#46;</span> The syndrome of multiple endocrine neoplasia type IIA &#40;MEN IIA&#41; is an autosomal dominant disease characterized by the association of medullary thyroid carcinoma &#40;MTC&#41;&#44; pheochromocytoma and hyperparathyroidism&#46; The gene responsible for this syndrome was mapped to the 10q 11&#46;2 chromosomal region of the RET oncogene&#46; <br/>Objective&#46; The objective of this report is to present our experience in the use of DNA analysis in the diagnosis of MEN IIA in two families treated in our service&#46; <br/> <span class="elsevierStyleBold">Patients and methods&#46;</span> The study dealt with two MEN IIA families comprised of a total of 14 members&#58; 9 with the disease and 5 healthy at the time of the study according to the analysis of DNA extracted from peripheral blood&#46; Exons 10 and 11 of the RET oncogene were amplified in genomic DNA by polymerase chain reaction &#40;PCR&#41; and mutations were detected by means of single-strand conformation polymorphism &#40;SSCP&#41; analysis&#46; <br/> <span class="elsevierStyleBold">Results&#46;</span> The mutation responsible for MEN IIA was located at codon 634 of exon 11 in both families studied here&#46; <br/> <span class="elsevierStyleBold">Conclusions&#46;</span>&#46; The diagnosis of MEN IIA by detecting the mutation of the RET oncogene in the DNA of the patients has certain advantages over other methods of screening employed to date&#46;"
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