Estadísticas

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      "titulo" => "Utilidad de la gammagrafía con Sestamibi y la determinación de hormona paratiroidea intacta como técnicas de localización de tejido paratiroideo hiperfuncionante"
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    "titulo" => "Gammagrafía paratiroidea con 99mTc tetrofosmina en el diagnóstico de localización del hiperparatiroidismo"
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        "titulo" => "PARATHYROID SCINTIGRAPHY WITH 99mTc-TETROFOSMIN IN THE DIAGNOSIS AND LOCALIZATION OF HYPERPARATHYROIDISM"
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        "resumen" => "<span class="elsevierStyleBold">Introducci&#243;n&#46;</span> El 99mTc tetrofosmina es una sustancia similar al sestamibi&#44; empleada en la localizaci&#243;n de gl&#225;ndulas paratiroideas anormales&#46; El objetivo de este trabajo es valorar la utilidad de la gammagraf&#237;a paratiroidea con 99mTc tetrofosmina como m&#233;todo de localizaci&#243;n preoperatoria en una serie consecutiva de pacientes con hiperparatiroidismo&#46; <span class="elsevierStyleBold"><span class="elsevierStyleBold">Pacientes y M&#233;todos&#46;</span></span> Estudiamos a 27 pacientes con diagn&#243;stico bioqu&#237;mico de hiperparatiroidismo sometidos a intervenci&#243;n quir&#250;rgica a los que se realiz&#243; gammagraf&#237;a paratiroidea con 99mTc tetrofosmina como m&#233;todo de localizaci&#243;n de gl&#225;ndulas paratiroides anormales&#46; La intervenci&#243;n quir&#250;rgica en todos los pacientes consisti&#243; en la exploraci&#243;n bilateral del cuello extirpando la gl&#225;ndula o gl&#225;ndulas aumentadas de tama&#241;o&#46; Los resultados del estudio con 99mTc tetrofosmina se correlacionaron con los hallazgos quir&#250;rgicos y anatomopatol&#243;gicos para determinar la sensibilidad y el valor predictivo de la prueba&#46; <br/> <span class="elsevierStyleBold">Resultados&#46;</span> La gammagraf&#237;a paratiroidea con 99mTc tetrofosmina localiz&#243; 20 de los 23 adenomas &#250;nicos observando un falso negativo y dos falsos positivos&#46; La sensibilidad de la t&#233;cnica fue del 95&#37; y el valor predictivo positivo del 86&#37;&#46; La gammagraf&#237;a paratiroidea localiz&#243; todos los pacientes con enfermedad multiglandular con una sensibilidad del 100&#37;&#46; Seis pacientes &#40;25&#37;&#41; presentaron patolog&#237;a tiroidea asociada y en todos menos uno la t&#233;cnica localiz&#243; correctamente el adenoma&#46; <br/> <span class="elsevierStyleBold">Conclusiones&#46;</span> El 99mTc tetrofosmina puede ser empleado como alternativa al sestamibi para la detecci&#243;n de gl&#225;ndulas paratiroideas anormales en pacientes con hiperparatiroidismo debido a su alta sensibilidad&#46; El empleo de la t&#233;cnica de sustracci&#243;n mejora la detecci&#243;n de gl&#225;ndulas hiperpl&#225;sicas y permite diferenciar la enfermedad nodular asociada&#46; Adem&#225;s&#44; identifica tejido ect&#243;pico de forma sencilla evitando as&#237; cirug&#237;as fallidas&#46;"
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        "resumen" => "<span class="elsevierStyleBold">Introduction&#46;</span> 99mTc-tetrofosmin is a substance similar to the 99mTc-sestamibi employed in the localization of abnormal parathyroid glands&#46; The objective of this report is to assess the utility of parathyroid scintigraphy with 99mTc-tetrofosmin in the preoperative localization of hyperparathyroidism&#46; <br/> <span class="elsevierStyleBold">Patients and methods&#46;</span> We studied 27 consecutive patients&#44; diagnosed as having hyperparathyroidism on the basis of laboratory findings&#44; who underwent preoperative parathyroid scintigraphy with 99mTc-tetrofosmin for the localization of abnormal parathyroid glands&#46; The surgical procedure consisted of bilateral exploration of the neck and excision of the enlarged gland or glands in every case&#46; The results of 99mTc-tetrofosmin scintigraphy were correlated with the surgical and pathological findings to determine the sensitivity and predictive value of the method&#46; <br/> <span class="elsevierStyleBold">Results&#46;</span> Parathyroid scintigraphy with 99mTc-tetrofosmin located 20 of the 23 solitary adenomas&#44; there being one false negative and two false positives&#46; The sensitivity of the technique was 95&#37; and the positive predictive value was 86&#37;&#46; Parathyroid scintigraphy identified all the patients with multiglandular disease&#44; showing a sensitivity of 100&#37;&#46; Six patients &#40;25&#37;&#41; presented associated thyroid disease and in all but one&#44; the technique located the adenoma correctly&#46; <br/> <span class="elsevierStyleBold">Conclusions&#46;</span>&#46; Given its elevated rate of sensitivity&#44; 99mTc-tetrofosmin can be employed as an alternative to 99mTc-sestamibi for the detection of abnormal parathyroid glands in patients with hyperparathyroidism&#46; The use of the subtraction technique improves the detection of hyperplastic glands and enables the differentiation of the associated nodular involvement&#46; Moreover&#44; it is a simple method for identifying ectopic tissue&#44; thus avoiding surgical failures&#46;"
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