Estadísticas

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  "cita" => "Cir Esp. 1999;66:5-12"
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      "titulo" => "Glucoproteína asociada a tumores 72 (TAG-72) en el adenocarcinoma gástrico: expresión tisular y dosificación sérica en comparación con otros marcadores tumorales"
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          "titulo" => "TUMOR-ASSOCIATED GLYCOPROTEIN-72 (TAG-72) IN GASTRIC ADENOCARCINOMA: COMPARISON OF THE TISSUE EXPRESSION AND SERUM LEVEL WITH THOSE OF OTHER TUMOR MARKERS"
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          "autoresLista" => "MC Peláez Buján, A Ruibal Morell, J Aza González"
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    "cita" => "Cir Esp. 1999;66:1"
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      "titulo" => "Marcadores tumorales en el cáncer gástrico"
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          "autoresLista" => "A González Fernández"
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              "apellidos" => "González Fernández"
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    "titulo" => "Efecto de la desfuncionalización colónica sobre la aparición de tumores anastomóticos. Estudio experimental"
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        "autoresLista" => "G Manzanet Andrés, R Corell Planelles, J Ruiz del Castillo"
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        "titulo" => "EFFECT OF COLONIC DEFUNCTIONALIZATION ON THE DEVELOPMENT OF ANASTOMOTIC TUMORS. EXPERIMENTAL STUDY"
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        "resumen" => "<span class="elsevierStyleBold">Introducci&#243;n&#46;</span> El grado de hiperplasia del epitelio col&#243;nico se relaciona con la aparici&#243;n de tumores&#46; Se sabe que la anastomosis col&#243;nica induce hiperplasia local&#44; mientras que la desfuncionalizaci&#243;n induce hipoplasia&#46; Empleando un modelo de carcinog&#233;nesis col&#243;nica en ratas&#44; estudiamos el efecto local que tienen la anastomosis y la desfuncionalizaci&#243;n col&#243;nica sobre la aparici&#243;n de tumores&#46; <br/> <span class="elsevierStyleBold">Material y m&#233;todos&#46;</span> Se distribuyeron 117 ratas Sprague-Dawley en cuatro grupos&#58; grupo A&#44; anastomosis de colon descendente m&#225;s colostom&#237;a proximal&#59; grupo B&#44; colostom&#237;a proximal&#59; grupo C&#44; no intervenido&#44; y grupo D&#44; anastomosis de colon descendente&#46; Se emple&#243; hilo de acero como material de sutura&#46; Posteriormente&#44; los 4 grupos recibieron dimetilhidrazina durante 26 semanas como carcin&#243;geno intestinal&#46; A las 27 semanas se resec&#243; la zona de colon que conten&#237;a la anastomosis o su &#225;rea equivalente y se estudi&#243; la producci&#243;n tumoral mediante tres par&#225;metros&#58; porcentaje de animales con tumor&#44; media de tumores &#40;X&#173;&#41; y superficie tumoral media &#40;STM&#41;&#59; tambi&#233;n se estudiaron las caracter&#237;sticas histol&#243;gicas de los tumores y la persistencia del material de sutura&#46; <br/> <span class="elsevierStyleBold">Resultados&#46;</span> La producci&#243;n tumoral fue mucho mayor en el grupo con anastomosis que en los dem&#225;s &#40;porcentaje &#61; 86&#59; X&#173; &#61; 1&#44;64&#59; STM &#61; 98&#44;36&#41;&#59; la anastomosis desfuncionalizada caus&#243; m&#225;s tumores &#40;porcentaje &#61; 35&#59; X&#173; &#61; 0&#44;55&#59; STM &#61; 59&#44;36&#41; que los grupos sin anastomosis&#44; control &#40;porcentaje &#61; 16&#59; X&#173; &#61; 0&#44;16&#59; STM &#61; 8&#44;5&#41; y colostom&#237;a &#40;porcentaje &#61; 10&#59; X&#173; &#61; 0&#44;10&#59; STM &#61; 10&#44;33&#41;&#44; sin que existieran diferencias entre estos dos &#250;ltimos&#46; Persistieron m&#225;s puntos de sutura en el grupo sometido a anastomosis desfuncionalizada que en el grupo anastomosis&#46; Las caracter&#237;sticas histol&#243;gicas fueron similares en todos los grupos&#44; excepto el grado de infiltraci&#243;n&#44; que fue mayor en los grupos con anastomosis&#46; <br/> <span class="elsevierStyleBold">Conclusiones&#46;</span> La sutura con hilo de acero favorece la producci&#243;n local de tumores&#44; mientras que la desfuncionalizaci&#243;n la reduce&#44; siendo la potencia de esta &#250;ltima inferior a la de la sutura&#44; pero de efecto opuesto&#46; No existi&#243; relaci&#243;n entre la persistencia de material de sutura y el desarrollo de tumores"
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        "resumen" => "<span class="elsevierStyleBold">Introduction&#46;</span> The degree of hyperplasia of the colonic epithelium is associated with the appearance of tumors&#46; Colonic anastomoses are known to induce hypoplasia&#46; Using a model of colonic carcinogenesis in rats&#44; we studied the local impact of the anastomosis and colonic defunctionalization on tumor development&#46; <br/> <span class="elsevierStyleBold">Material and methods&#46;</span> A total of 117 Sprague-Dawley rats were divided into 4 groups&#58; group A underwent anastomosis of descending colon plus proximal colostomy&#59; group B&#44; proximal colostomy&#59; group C&#44; no surgical procedure&#59; and group D&#44; anastomosis of descending colon&#46; Steel wire was employed for sutures&#46; All four groups then received dimethylhydrazine as an intestinal carcinogen for 26 weeks&#46; One week later&#44; the region of the colonic anastomosis or the equivalent area was resected and tumor development was assessed on the basis of three parameters&#58; percentage of animals presenting tumor &#40;&#37;&#41;&#44; the mean number of tumors &#40;X&#173;&#41; and the mean tumor surface &#40;MTS&#41;&#46; The histological features of the lesions and the persistence of suture material were also studied&#46; <br/> <span class="elsevierStyleBold">Results&#46;</span> All three parameters of tumor development were much higher in the group with anastomoses than in the other groups &#40;&#37; &#61; 86&#59; X&#173; &#61; 1&#46;64&#59; MTS &#61; 98&#46;36&#41;&#46; The group with defunctionalized anastomoses presented more tumors &#40;&#37; &#61; 35&#59; X&#173; &#61; 0&#46;55&#59; NTS &#61; 59&#46;36&#41; than the groups that were not subjected to anastomosis&#44; that is&#44; the control group &#40;&#37; &#61; 16&#59; X&#173; &#61; 0&#46;16&#59; MTS &#61; 85&#41; and the colostomy group &#40;&#37; &#61; 10&#59; X&#173; &#61; 0&#46;10&#59; MTS &#61; 10&#46;33&#41;&#59; there were no significant differences between the latter two groups&#46; A greater amount of suture material remained in the defunctionalized anastomosis group than in the animals that underwent anastomosis alone&#46; The histological features were similar in all the groups&#44; with the exception of the degree of infiltration&#44; which was greater in the two groups with anastomosis&#46; <br/> <span class="elsevierStyleBold">Conclusion&#46;</span> Steel sutures favor local tumor development&#44; while defunctionalization reduces it&#44; although the positive effect of the latter is less marked than the negative impact of the former&#46; There was no relationship between the persistence of suture material and tumor development&#46;"
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