Estadísticas

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  "cita" => "Cir Esp. 1999;66:13-7"
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      "titulo" => "Riesgo de extensión extratiroidea en el carcinoma papilar de tiroides"
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      "titulo" => "Efecto de la desfuncionalización colónica sobre la aparición de tumores anastomóticos. Estudio experimental"
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          "titulo" => "EFFECT OF COLONIC DEFUNCTIONALIZATION ON THE DEVELOPMENT OF ANASTOMOTIC TUMORS. EXPERIMENTAL STUDY"
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    "titulo" => "Glucoproteína asociada a tumores 72 (TAG-72) en el adenocarcinoma gástrico: expresión tisular y dosificación sérica en comparación con otros marcadores tumorales"
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        "titulo" => "TUMOR-ASSOCIATED GLYCOPROTEIN-72 (TAG-72) IN GASTRIC ADENOCARCINOMA: COMPARISON OF THE TISSUE EXPRESSION AND SERUM LEVEL WITH THOSE OF OTHER TUMOR MARKERS"
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        "resumen" => "<span class="elsevierStyleBold">Introducci&#243;n&#46;</span> En los &#250;ltimos a&#241;os se ha investigado la utilidad de la glucoprote&#237;na asociada a tumores 72 &#40;TAG-72&#41; como marcador tumoral g&#225;strico&#46; El objetivo de este trabajo es estudiar el comportamiento s&#233;rico y tisular de la TAG-72&#46; <br/> <span class="elsevierStyleBold">Pacientes y m&#233;todos&#46;</span> Se dosificaron las concentraciones de TAG-72&#44; ant&#237;geno carcinoembrionario &#40;CEA&#41; y CA 195 en <br/>68 muestras s&#233;ricas de pacientes con adenocarcinoma g&#225;strico y se estudi&#243; la expresi&#243;n h&#237;stica de la TAG-72 en citosol &#40;TAG-72c&#41; y membrana &#40;TAG-72m&#41;&#44; en 68 muestras de c&#225;ncer g&#225;strico y en 40 de mucosa g&#225;strica sana&#46; <br/> <span class="elsevierStyleBold">Resultados&#46;</span> La TAG-72 s&#233;rica proporcion&#243; un porcentaje global de positividades mayor que el CEA &#40;p &#61; 0&#44;00008&#41; y que el CA 195 &#40;p &#61; 0&#44;05&#41;&#46; En el estadio B&#44; el CA 195 demostr&#243; mayor sensibilidad que la TAG-72 &#40;p &#61; 0&#44;001&#41;&#46; La expresi&#243;n de la TAG-72c fue mayor en el grupo tumoral que en el control &#40;p &#61; 0&#44;03&#41;&#46; No existi&#243; correlaci&#243;n entre las concentraciones de ant&#237;geno circulante y las de glucoprote&#237;na de membrana o citos&#243;lica en el grupo tumoral global&#46; <br/> <span class="elsevierStyleBold">Conclusiones&#46;</span> La TAG-72 es un marcador tumoral g&#225;strico con elevada sensibilidad&#44; que puede incrementarse al combinarlo con CA 195&#46; La ausencia de correlaci&#243;n entre las concentraciones s&#233;ricas y tisulares de la glucoprote&#237;na impedir&#237;a su uso para la selecci&#243;n de candidatos a las nuevas estrategias inmunoterap&#233;uticas"
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        "resumen" => "<span class="elsevierStyleBold">Introduction&#46;</span> The utility of tumor-associated glycoprotein-72 &#40;TAG-72&#41; as a gastric tumor marker has been widely investigated in recent years&#46; The objective of the present report is to assess the serum and tissue levels of this antigen&#46; <br/> <span class="elsevierStyleBold">Material and methods&#46;</span> The concentrations of TAG-72&#44; carcinoembryonic antigen &#40;CEA&#41; and cancer antigen &#40;CA&#41; 195 were determined in 68 serum specimens from gastric adenocarcinoma patients and the tissue expression of TAG-72 was studied in cytosol &#40;TAG-72c&#41; and membrane &#40;TAG-72m&#41; from 68 gastric cancer specimens and 40 samples of healthy gastric mucosa&#46; <br/> <span class="elsevierStyleBold">Results&#46;</span> The overall percentage of positive specimens was greater according to serum TAG-72 than to CEA &#40;p &#61; 0&#46;00008&#41; or CA 195 &#40;p &#61; 0&#46;05&#41;&#46; In stage B cancers&#44; CA 195 was more sensitive than TAG-72 &#40;p &#61; 0&#46;001&#41;&#46; TAG-72c expression was greater in the tumor samples than in controls &#40;p &#61; 0&#46;03&#41;&#46; There was no correlation between the concentration of circulating antigen and that of TAG-72m or TAG-72c in the tumor spe- <br/>cimens&#46; <br/> <span class="elsevierStyleBold">Conclusions&#46;</span> TAG-72 is a highly sensitive gastric tumor marker&#44; the level of which can increase when combined with CA 195&#46; The lack of correlation between the serum and tissue TAG-72 concentrations render these parameters of little use <br/>in the selection of candidates for new immunotherapeutic strategies"
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