Trasplante de pulmón experimental: desarrollo de un modelo anestésico en el cerdo
Experimental lung transplantation: A model of anesthesia developed in the pig
Servicio de Cirugía Experimental. Hospital Universitario Clínica Puerta de Hierro. Madrid
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array:22 [ "pii" => "S0009739X01716752" "issn" => "0009739X" "doi" => "10.1016/S0009-739X(01)71675-2" "estado" => "S300" "fechaPublicacion" => "2001-01-01" "aid" => "71675" "copyright" => "Asociación Española de Cirujanos" "copyrightAnyo" => "2001" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Cir Esp. 2001;69:3-7" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 3435 "formatos" => array:3 [ "EPUB" => 10 "HTML" => 2749 "PDF" => 676 ] ] "itemSiguiente" => array:18 [ "pii" => "S0009739X01716764" "issn" => "0009739X" "doi" => "10.1016/S0009-739X(01)71676-4" "estado" => "S300" "fechaPublicacion" => "2001-01-01" "aid" => "71676" "copyright" => "Asociación Española de Cirujanos" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Cir Esp. 2001;69:8-12" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 5064 "formatos" => array:3 [ "EPUB" => 10 "HTML" => 3868 "PDF" => 1186 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Valor de la mamografía isotópica en el diagnóstico del cáncer de mama" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "8" "paginaFinal" => "12" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Value of scintimammography in the diagnosis of breast cancer" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J. Giménez Climent, M.V. Fliquete Péris, C.A. Fuster Diana, C. Vázquez Forner, F. Sancho Merle, J. Campos Mañez, C. Vázquez Albaladejo" "autores" => array:7 [ 0 => array:2 [ "nombre" => "J." "apellidos" => "Giménez Climent" ] 1 => array:2 [ "nombre" => "M.V." "apellidos" => "Fliquete Péris" ] 2 => array:2 [ "nombre" => "C.A." "apellidos" => "Fuster Diana" ] 3 => array:2 [ "nombre" => "C." "apellidos" => "Vázquez Forner" ] 4 => array:2 [ "nombre" => "F." "apellidos" => "Sancho Merle" ] 5 => array:2 [ "nombre" => "J." "apellidos" => "Campos Mañez" ] 6 => array:2 [ "nombre" => "C." "apellidos" => "Vázquez Albaladejo" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0009739X01716764?idApp=UINPBA00004N" "url" => "/0009739X/0000006900000001/v1_201307101134/S0009739X01716764/v1_201307101134/es/main.assets" ] "es" => array:13 [ "idiomaDefecto" => true "titulo" => "Trasplante de pulmón experimental: desarrollo de un modelo anestésico en el cerdo" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "3" "paginaFinal" => "7" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "M. Fuente, M. Santos, F.J. Tendillo, L. Álvarez, P. García, J.L. Castillo-Olivares" "autores" => array:6 [ 0 => array:3 [ "nombre" => "M." "apellidos" => "Fuente" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "M." "apellidos" => "Santos" ] 2 => array:2 [ "nombre" => "F.J." "apellidos" => "Tendillo" ] 3 => array:2 [ "nombre" => "L." "apellidos" => "Álvarez" ] 4 => array:2 [ "nombre" => "P." "apellidos" => "García" ] 5 => array:2 [ "nombre" => "J.L." "apellidos" => "Castillo-Olivares" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Cirugía Experimental. Hospital Universitario Clínica Puerta de Hierro. Madrid" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "1" "correspondencia" => "Correspondencia: Dr. F.J. Tendillo. Servicio de Cirugía Experimental. Hospital Universitario Clínica Puerta de Hierro. San Martín de Porres, 4. 28035 Madrid." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Experimental lung transplantation: A model of anesthesia developed in the pig" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaAceptado" => "2000-05-31" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec196922" "palabras" => array:3 [ 0 => "Trasplante pulmonar" 1 => "Anestesia intravenosa total" 2 => "Animal de experimentación" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec196923" "palabras" => array:3 [ 0 => "Lung transplantation" 1 => "Total intravenous anesthesia" 2 => "Experimental animal" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Introducción</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Actualmente, el cerdo es el animal de experimentación y el modelo quirúrgico experimental elegido por su gran similitud con el hombre, lo que hace necesario un constante desarrollo paralelo de las técnicas anestésicas que se emplean en esta especie.</p> <span class="elsevierStyleSectionTitle">Material y métodos.</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">En 20 cerdos se realizaron 10 trasplantes de pulmón unilaterales, tras haber sufrido el pulmón 3 h de isquemia. La técnica anestésica empleada incluyó propofol + fentanilo + midazolam + pancuronio.</p> <span class="elsevierStyleSectionTitle">Resultados.</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">No se observaron variaciones estadísticamente significativas en ninguno de los parámetros cardiovasculares ni respiratorios registrados, a excepción del gasto cardíaco, que disminuyó de forma estadísticamente significativa de 3,4 ± 1,1 l/min en el momento basal, hasta 2,8 ± 0,9 l/min en el momento 1 h posreperfusión. La presión parcial de oxígeno en sangre venosa mixta experimenta una disminución en este mismo momento. La presión parcial de CO2 arterial sufrió un incremento significativo en el momento de la neumonectomía.</p> <span class="elsevierStyleSectionTitle">Conclusiones.</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">El protocolo anestésico empleado mantiene una estabilidad cardiovascular y respiratoria adecuada para la realización del trasplante pulmonar; tan sólo el gasto cardíaco se reduce a los 60 min de la finalización del trasplante, lo que en principio se puede atribuir al síndrome de isquemia- reperfusión.</p>" ] "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">The pig is currently the animal and surgical model of choice for experimental lung transplantation given its marked similarity to humans. Thus, this technique requires a constant parallel development of the anesthetic techniques employed in this species.</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Twenty pigs were used to perform 10 single-lung transplantation procedures after the transplanted lungs had been subjected to 3 hours of ischemia. The anesthetic technique employed included propofol plus fentanyl plus midazolam plus pancuronium.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">No statistically significant differences were observed in any of the cardiovascular or respiratory parameters monitored, with the exception of cardiac output which fell significantly from a basal level of 3.4 ± 1.1 to 2.8 ± 0.9 l/min 1 hour postreperfusion. In that same moment, PvO2 also decreased. PaCO2 was observed to increase significantly at the time of lung resection.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">The anesthetic protocol employed maintains adequate cardiovascular and respiratory stability for the performance of lung transplantation. Only the cardiac output decreases 60 minutes after the transplantation procedure has been completed, a change that may be attributed to the ischemia- reperfusion to which the lungs are subjected.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:24 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." 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| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Octubre | 4 | 10 | 14 |
| 2024 Septiembre | 9 | 21 | 30 |
| 2024 Agosto | 12 | 9 | 21 |
| 2024 Julio | 9 | 14 | 23 |
| 2024 Junio | 9 | 24 | 33 |
| 2024 Mayo | 14 | 23 | 37 |
| 2024 Abril | 12 | 16 | 28 |
| 2024 Marzo | 23 | 20 | 43 |
| 2024 Febrero | 27 | 23 | 50 |
| 2024 Enero | 15 | 41 | 56 |
| 2023 Diciembre | 30 | 33 | 63 |
| 2023 Noviembre | 25 | 60 | 85 |
| 2023 Octubre | 36 | 54 | 90 |
| 2023 Septiembre | 17 | 31 | 48 |
| 2023 Agosto | 20 | 7 | 27 |
| 2023 Julio | 19 | 25 | 44 |
| 2023 Junio | 20 | 8 | 28 |
| 2023 Mayo | 26 | 11 | 37 |
| 2023 Abril | 38 | 4 | 42 |
| 2023 Marzo | 27 | 17 | 44 |
| 2023 Febrero | 14 | 10 | 24 |
| 2023 Enero | 12 | 12 | 24 |
| 2022 Diciembre | 42 | 10 | 52 |
| 2022 Noviembre | 41 | 38 | 79 |
| 2022 Octubre | 21 | 14 | 35 |
| 2022 Septiembre | 21 | 24 | 45 |
| 2022 Agosto | 25 | 22 | 47 |
| 2022 Julio | 15 | 22 | 37 |
| 2022 Junio | 13 | 10 | 23 |
| 2022 Mayo | 19 | 22 | 41 |
| 2022 Abril | 20 | 17 | 37 |
| 2022 Marzo | 14 | 13 | 27 |
| 2022 Febrero | 7 | 4 | 11 |
| 2022 Enero | 9 | 7 | 16 |
| 2021 Diciembre | 7 | 9 | 16 |
| 2021 Noviembre | 21 | 12 | 33 |
| 2021 Octubre | 7 | 17 | 24 |
| 2021 Septiembre | 10 | 9 | 19 |
| 2021 Agosto | 7 | 5 | 12 |
| 2021 Julio | 15 | 16 | 31 |
| 2021 Junio | 9 | 8 | 17 |
| 2021 Mayo | 8 | 6 | 14 |
| 2021 Abril | 22 | 34 | 56 |
| 2021 Marzo | 20 | 20 | 40 |
| 2021 Febrero | 22 | 9 | 31 |
| 2021 Enero | 5 | 14 | 19 |
| 2020 Diciembre | 6 | 15 | 21 |
| 2020 Noviembre | 10 | 12 | 22 |
| 2020 Octubre | 14 | 13 | 27 |
| 2020 Septiembre | 17 | 20 | 37 |
| 2020 Agosto | 14 | 14 | 28 |
| 2020 Julio | 8 | 6 | 14 |
| 2020 Junio | 8 | 13 | 21 |
| 2020 Mayo | 7 | 25 | 32 |
| 2020 Abril | 3 | 7 | 10 |
| 2020 Marzo | 8 | 8 | 16 |
| 2020 Febrero | 2 | 6 | 8 |
| 2020 Enero | 12 | 19 | 31 |
| 2019 Diciembre | 26 | 18 | 44 |
| 2019 Noviembre | 5 | 7 | 12 |
| 2019 Octubre | 4 | 8 | 12 |
| 2019 Septiembre | 4 | 5 | 9 |
| 2019 Agosto | 4 | 12 | 16 |
| 2019 Julio | 12 | 18 | 30 |
| 2019 Junio | 30 | 44 | 74 |
| 2019 Mayo | 118 | 114 | 232 |
| 2019 Abril | 27 | 30 | 57 |
| 2019 Marzo | 4 | 5 | 9 |
| 2019 Febrero | 8 | 13 | 21 |
| 2019 Enero | 4 | 8 | 12 |
| 2018 Diciembre | 5 | 10 | 15 |
| 2018 Noviembre | 2 | 5 | 7 |
| 2018 Octubre | 16 | 5 | 21 |
| 2018 Septiembre | 17 | 11 | 28 |
| 2018 Agosto | 2 | 13 | 15 |
| 2018 Julio | 1 | 10 | 11 |
| 2018 Junio | 1 | 8 | 9 |
| 2018 Mayo | 2 | 11 | 13 |
| 2018 Abril | 1 | 5 | 6 |
| 2018 Marzo | 2 | 4 | 6 |
| 2018 Febrero | 0 | 3 | 3 |
| 2018 Enero | 1 | 0 | 1 |
| 2017 Diciembre | 6 | 4 | 10 |
| 2017 Noviembre | 9 | 6 | 15 |
| 2017 Octubre | 10 | 4 | 14 |
| 2017 Septiembre | 15 | 16 | 31 |
| 2017 Agosto | 2 | 3 | 5 |
| 2017 Julio | 11 | 5 | 16 |
| 2017 Junio | 10 | 1 | 11 |
| 2017 Mayo | 9 | 2 | 11 |
| 2017 Abril | 7 | 0 | 7 |
| 2017 Marzo | 8 | 49 | 57 |
| 2017 Febrero | 10 | 2 | 12 |
| 2017 Enero | 5 | 2 | 7 |
| 2016 Diciembre | 17 | 6 | 23 |
| 2016 Noviembre | 29 | 4 | 33 |
| 2016 Octubre | 28 | 0 | 28 |
| 2016 Septiembre | 17 | 5 | 22 |
| 2016 Agosto | 24 | 5 | 29 |
| 2016 Julio | 19 | 3 | 22 |
| 2016 Junio | 28 | 12 | 40 |
| 2016 Mayo | 54 | 9 | 63 |
| 2016 Abril | 24 | 6 | 30 |
| 2016 Marzo | 22 | 8 | 30 |
| 2016 Febrero | 20 | 7 | 27 |
| 2016 Enero | 17 | 8 | 25 |
| 2015 Diciembre | 14 | 5 | 19 |
| 2015 Noviembre | 29 | 3 | 32 |
| 2015 Octubre | 29 | 7 | 36 |
| 2015 Septiembre | 32 | 13 | 45 |
| 2015 Agosto | 10 | 12 | 22 |
| 2015 Julio | 21 | 3 | 24 |
| 2015 Junio | 9 | 2 | 11 |
| 2015 Mayo | 22 | 1 | 23 |
| 2015 Abril | 8 | 6 | 14 |
| 2015 Marzo | 14 | 3 | 17 |
| 2015 Febrero | 7 | 2 | 9 |
| 2015 Enero | 20 | 5 | 25 |
| 2014 Diciembre | 23 | 3 | 26 |
| 2014 Noviembre | 14 | 3 | 17 |
| 2014 Octubre | 11 | 2 | 13 |
| 2014 Septiembre | 8 | 1 | 9 |
| 2014 Agosto | 8 | 1 | 9 |
| 2014 Julio | 9 | 1 | 10 |
| 2014 Junio | 10 | 3 | 13 |
| 2014 Mayo | 7 | 4 | 11 |
| 2014 Abril | 5 | 3 | 8 |
| 2014 Marzo | 7 | 1 | 8 |
| 2014 Febrero | 6 | 2 | 8 |
| 2014 Enero | 3 | 1 | 4 |
| 2013 Diciembre | 8 | 2 | 10 |
| 2013 Noviembre | 8 | 8 | 16 |
| 2013 Octubre | 11 | 5 | 16 |
| 2013 Septiembre | 6 | 8 | 14 |
| 2013 Agosto | 15 | 10 | 25 |
| 2013 Julio | 3 | 2 | 5 |
| 2001 Enero | 1661 | 0 | 1661 |
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